Modulation of the permeability of H2 receptor antagonists cimetidine and ranitidine by P-glycoprotein in rat intestine and the human colonic cell line Caco-2

Journal of Pharmacology and Experimental Therapeutics

Volumn 288, Issue 1, 1999, Pages 171-178

  Collett, A ^a   Higgs, N B ^a   Sims, E ^a   Rowland, M ^b   Warhurst, Geoffrey ^a,c  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c HOPE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CIMETIDINE; GLYCOPROTEIN P; HISTAMINE H2 RECEPTOR ANTAGONIST; RANITIDINE; VERAPAMIL; VINBLASTINE;

ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG UPTAKE; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSPORT KINETICS; ANIMAL; COLON; DRUG EFFECT; GENE; GENETICS; IN VITRO STUDY; INTESTINE; INTESTINE ABSORPTION; INTESTINE MUCOSA; MALE; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CIMETIDINE; COLON; GENES, MDR; HISTAMINE H2 ANTAGONISTS; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; INTESTINES; MALE; P-GLYCOPROTEIN; RANITIDINE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032589932     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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