Increased expression of multidrug resistance-associated proteins in bladder cancer during clinical course and drug resistance to doxorubicin

International Journal of Cancer

Volumn 98, Issue 4, 2002, Pages 630-635

  Tada, Yasuhiro ^a   Wada, Morimasa ^a,b   Migita, Toshiro ^a   Nagayama, Jun ^a   Hinoshita, Eiji ^a   Mochida, Yasushi ^a   Maehara, Yoshihiko ^a   Tsuneyoshi, Masazumi ^a   Kuwano, Michihiko ^a   Naito, Seiji ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Bladder cancer; Chemotherapeutic treatment; Doxorubicin; Drug resistance; MDR1; MRP1; MRP2; MRP3

Indexed keywords

DOXORUBICIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3;

ADULT; AGED; ARTICLE; BLADDER CANCER; CANCER CHEMOTHERAPY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG RESPONSE; DRUG SENSITIVITY; ENZYME INHIBITION; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MEMBRANE TRANSPORT PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MULTIVARIATE ANALYSIS; P-GLYCOPROTEIN; RNA, MESSENGER; URINARY BLADDER NEOPLASMS;

EID: 0036533566     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10246     Document Type: Article

References (31)

1. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
2. Biochemistry of multidrug resistance mediated by the multidrug transporter
3. Multidrug resistance-associated protein subfamily transporters and drug resistance
4. Expression of multidrug resistance-associated protein (MRP), MDR1 and DNA topoisomerase II in human multidrug-resistant bladder cancer cell lines
5. Establishment and characterization of doxorubicin-resistant human bladder cancer cell line, KK47/ ADM
6. MDR1 overexpression and altered degree of methylation at the promoter region in bladder cancer during chemotherapeutic treatment
7. Clinical significance of multi-drug resistance associated protein and P-glycoprotein in patients with bladder cancer
8. Characterization of the human ABC superfamily: Isolation and mapping of 21 new genes using the expressed sequence tags database
9. Analysis of expression of cMOAT (MRP2), MRP3, MRP4 and MRP5 homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines
10. Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells
11. Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver
12. Transfected rat cMOAT is functionally expressed on the apical membrane in Madin-Darby canine kidney (MDCK) cell
13. Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport
14. MRP3, an organic anion transporter able to transport anti-cancer drugs
15. Expression of multidrug resistance protein-related genes in lung cancer: Correlation with drug response
16. Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, human colorectal carcinomas
17. Expression of glutathione S-transferase-pi and sensitivity of human gastric cancer cells to cisplatin
18. Poorly differentiated human gastric carcinoma is more sensitive to antitumor drugs than is well differentiated carcinoma
19. Reversal of P-glycoprotein and multidrug-resistance protein-mediated drug resistance in KB cells by 5-O-benzoylated taxinine K
20. The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance
21. Direct involvement of the Y-box binding protein YB-1 in genotoxic stress-induced activation of the human multidrug resistance 1 gene
22. Molecular mechanism of the stress induction of MDR1 gene
23. Non-P-glycoprotein-mediated atypical multidrug resistance in a human bladder cancer cell line
24. Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine
25. Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs
26. Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells
27. P-glycoprotein and multidrug resistance-associated protein, but not lung resistance protein, lower the intracellular daunorubicin accumulation in acute myeloid leukaemic cells
28. A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation
29. Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats
30. Transport of amphipathic anions by human multidrug resistance protein 3
31. Biliary excretion mechanism of CPT-11 and its metabolites in humans: Involvement of primary active transporters