메뉴 건너뛰기




Volumn 28, Issue 2, 1997, Pages 191-204

Transcellular and paracellular contribution to transport processes in the colorectal route

Author keywords

Absorption enhancer; Capric acid; Equivalent radius; Intracellular calcium level; Membrane perturbation; Membrane resistance; Perijunctional actomyosin ring; Rectal suppository; Tight junction

Indexed keywords

ABSORPTION; AMINO ACIDS; CAPACITANCE; CELL MEMBRANES; COMPOSITION EFFECTS; ELECTRIC RESISTANCE; FATTY ACIDS; IONIC DRUGS; MECHANICAL PERMEABILITY;

EID: 0031563891     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(97)00072-0     Document Type: Review
Times cited : (35)

References (30)
  • 1
    • 0019631483 scopus 로고
    • Barrier function of epithelia
    • D.W. Powell, Barrier function of epithelia, Am. J. Phys. 241 (1981) G275-G288.
    • (1981) Am. J. Phys. , vol.241
    • Powell, D.W.1
  • 2
    • 0344038063 scopus 로고
    • Physiological and anatomical factors affecting intestinal drug absorption and absorption enhancement by modifying their factors
    • M. Hayashi, Physiological and anatomical factors affecting intestinal drug absorption and absorption enhancement by modifying their factors. Xenobiotic Metab. Dispos. (in Japanese, with summary in English) 7 (1992) 621-631.
    • (1992) Xenobiotic Metab. Dispos. (in Japanese, with Summary in English) , vol.7 , pp. 621-631
    • Hayashi, M.1
  • 3
    • 0015311097 scopus 로고
    • Ionic conductance of extracellular shunt pathway in rabbit ileum. Influence of shunt on transmural sodium transport and electrical potential difference
    • R.A. Frizzell, S.G. Schults, Ionic conductance of extracellular shunt pathway in rabbit ileum. Influence of shunt on transmural sodium transport and electrical potential difference, J. Gen. Physiol. 59 (1972) 318-346.
    • (1972) J. Gen. Physiol. , vol.59 , pp. 318-346
    • Frizzell, R.A.1    Schults, S.G.2
  • 4
    • 0017817129 scopus 로고
    • Effects of theophylline on salicylate transport in isolated rat jejunum
    • G. Barnett, S. Hui, L.Z. Benet, Effects of theophylline on salicylate transport in isolated rat jejunum. Biochim. Biophys. Acta 507 (1978) 517-523.
    • (1978) Biochim. Biophys. Acta , vol.507 , pp. 517-523
    • Barnett, G.1    Hui, S.2    Benet, L.Z.3
  • 5
    • 0023743080 scopus 로고
    • Enhancement of colonic drug absorption by the paracellular permeation route
    • M. Tomita, M. Shiga, M. Hayashi, S. Awazu, Enhancement of colonic drug absorption by the paracellular permeation route, Pharm. Res. 5 (1988) 341-346.
    • (1988) Pharm. Res. , vol.5 , pp. 341-346
    • Tomita, M.1    Shiga, M.2    Hayashi, M.3    Awazu, S.4
  • 6
    • 0023603431 scopus 로고
    • Enhancement of jejunal and colonic absorption of fosfomycin by promoters in the rat
    • T. Ishizawa, M. Hayashi, S. Awazu, Enhancement of jejunal and colonic absorption of fosfomycin by promoters in the rat, J. Pharm. Pharmacol. 39 (1988) 892-895.
    • (1988) J. Pharm. Pharmacol. , vol.39 , pp. 892-895
    • Ishizawa, T.1    Hayashi, M.2    Awazu, S.3
  • 7
    • 0026600829 scopus 로고
    • Diferences in the enhancing effects of sodium caprate on colonic and jejunal drug absorption
    • M. Tomita, T. Sawada, T. Ogawa, H. Ouchi, M. Hayashi, S. Awazu, Diferences in the enhancing effects of sodium caprate on colonic and jejunal drug absorption, Pharm. Res. 9 (1992) 648-653.
    • (1992) Pharm. Res. , vol.9 , pp. 648-653
    • Tomita, M.1    Sawada, T.2    Ogawa, T.3    Ouchi, H.4    Hayashi, M.5    Awazu, S.6
  • 8
    • 0024245937 scopus 로고
    • Enhancement of colonic drug absorption by the transcellular permeation route
    • M. Tomita, M. Hayashi, T. Horie, T. Ishizawa, S. Awazu, Enhancement of colonic drug absorption by the transcellular permeation route, Pharm. Res. 5 (1988) 786-789.
    • (1988) Pharm. Res. , vol.5 , pp. 786-789
    • Tomita, M.1    Hayashi, M.2    Horie, T.3    Ishizawa, T.4    Awazu, S.5
  • 10
    • 0344038062 scopus 로고
    • Mechanism of action of absorption enhancers
    • D.J.A. Crommelin, K.K. Midha (Eds.), 1991, ch. 9, Medpharm, Stuttgart
    • S. Muranishi, M. Murakami, Mechanism of action of absorption enhancers, in: D.J.A. Crommelin, K.K. Midha (Eds.), Topics in Pharmaceutical Sciences, 1991, ch. 9, Medpharm, Stuttgart, 1992, pp. 139-147.
    • (1992) Topics in Pharmaceutical Sciences , pp. 139-147
    • Muranishi, S.1    Murakami, M.2
  • 11
    • 0014285021 scopus 로고
    • Characterization of biological membrane by equivalent pores
    • A.K. Solomon, Characterization of biological membrane by equivalent pores, J. Gen. Physiol. 51 (1968) 335S-364S.
    • (1968) J. Gen. Physiol. , vol.51
    • Solomon, A.K.1
  • 12
    • 0025951357 scopus 로고
    • Role of paracellular pathway in nonelectrolyte permeation across rat colon epithelium enhanced by sodium caprate and sodium caprylate
    • T. Sawada, T. Ogawa, M. Tomita, M. Hayashi, S. Awazu, Role of paracellular pathway in nonelectrolyte permeation across rat colon epithelium enhanced by sodium caprate and sodium caprylate, Pharm. Res. 8 (1991) 1365-1371.
    • (1991) Pharm. Res. , vol.8 , pp. 1365-1371
    • Sawada, T.1    Ogawa, T.2    Tomita, M.3    Hayashi, M.4    Awazu, S.5
  • 13
    • 0016164621 scopus 로고
    • Routes of nonelectrolyte permeation across epithelial membranes
    • E.M. Wright, R.J. Pietras, Routes of nonelectrolyte permeation across epithelial membranes, J. Membrane Biol. 17 (1974) 293-312.
    • (1974) J. Membrane Biol. , vol.17 , pp. 293-312
    • Wright, E.M.1    Pietras, R.J.2
  • 14
    • 0021867176 scopus 로고
    • Characterization of enhanced intestinal permeability: Elecrophysiological study on the effects of dichlofenac and ethylenediaminetetraacetic acid
    • S. Yamashita, H. Saitoh, K. Nakanishi, T. Masada, T. Nadai, T. Kimura, Characterization of enhanced intestinal permeability: Elecrophysiological study on the effects of dichlofenac and ethylenediaminetetraacetic acid, J. Pharm, Pharmacol. 37 (1985) 512-513.
    • (1985) J. Pharm, Pharmacol. , vol.37 , pp. 512-513
    • Yamashita, S.1    Saitoh, H.2    Nakanishi, K.3    Masada, T.4    Nadai, T.5    Kimura, T.6
  • 15
    • 0023520885 scopus 로고
    • Physiological regulations of transepithelial impedance in the intestinal mucosa of rats and hamsters
    • J.R. Pappenheimer, Physiological regulations of transepithelial impedance in the intestinal mucosa of rats and hamsters, J. Membrane Biol. 100 (1987) 137-148.
    • (1987) J. Membrane Biol. , vol.100 , pp. 137-148
    • Pappenheimer, J.R.1
  • 16
    • 0025102678 scopus 로고
    • The use of cultured epithelial and endothelial cells for drug transport and metabolism studies
    • K.L. Audus, R.L. Bartel, I.J. Hidalgo, R.T. Borchardt, The use of cultured epithelial and endothelial cells for drug transport and metabolism studies, Pharm. Res. 7 (1990) 435-451.
    • (1990) Pharm. Res. , vol.7 , pp. 435-451
    • Audus, K.L.1    Bartel, R.L.2    Hidalgo, I.J.3    Borchardt, R.T.4
  • 17
    • 0025329248 scopus 로고
    • Epithelial transport of drug in cell culture. II. Effect of extracellular calcium concentration on the paracellular transport of drugs of different lipophilicities across monolayers of intestinal epithelial (Caco-2) cells
    • P. Artursson, C. Magnusson, Epithelial transport of drug in cell culture. II. Effect of extracellular calcium concentration on the paracellular transport of drugs of different lipophilicities across monolayers of intestinal epithelial (Caco-2) cells, J. Pharm. Sci. 79 (1990) 595-660.
    • (1990) J. Pharm. Sci. , vol.79 , pp. 595-660
    • Artursson, P.1    Magnusson, C.2
  • 18
    • 0028859877 scopus 로고
    • Absorption-enhancing mechanism of sodium caprate and decanoylcarnitine in Caco-2 cells
    • M. Tomita, M. Hayashi, S. Awazu, Absorption-enhancing mechanism of sodium caprate and decanoylcarnitine in Caco-2 cells, J. Pharmacol. Exp. Ther. 272 (1995) 739-743.
    • (1995) J. Pharmacol. Exp. Ther. , vol.272 , pp. 739-743
    • Tomita, M.1    Hayashi, M.2    Awazu, S.3
  • 19
    • 0027174290 scopus 로고
    • Sodium caprate elicits dilations in human intestinal tight junctions and enhances drug absorption by the paracellular route
    • E.K. Anderberg, T. Lindmark, P. Artursson, Sodium caprate elicits dilations in human intestinal tight junctions and enhances drug absorption by the paracellular route, Pharm. Res. 10 (1993) 857-864.
    • (1993) Pharm. Res. , vol.10 , pp. 857-864
    • Anderberg, E.K.1    Lindmark, T.2    Artursson, P.3
  • 20
    • 0028283321 scopus 로고
    • In vitro and in vivo analysis of the mechanism of absorption enhancement by palmitoylcarnitine
    • J.H. Hochman, J.A. Fix, E.L. LeCluyse, In vitro and in vivo analysis of the mechanism of absorption enhancement by palmitoylcarnitine, J. Pharmacol. Exp. Ther. 269 (1994) 813-822.
    • (1994) J. Pharmacol. Exp. Ther. , vol.269 , pp. 813-822
    • Hochman, J.H.1    Fix, J.A.2    LeCluyse, E.L.3
  • 21
    • 0024204607 scopus 로고
    • Clostridium difficile Toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayer
    • G. Hecht, J. Pothoulakis, J.T. Lament, J.L. Madara, Clostridium difficile Toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayer, J. Clin. Invest. 82 (1988) 1516-1524.
    • (1988) J. Clin. Invest. , vol.82 , pp. 1516-1524
    • Hecht, G.1    Pothoulakis, J.2    Lament, J.T.3    Madara, J.L.4
  • 22
    • 0023949917 scopus 로고
    • Functional coupling of tight junctions and microfilaments in T84 monolayers
    • J.L. Madara, J. Safford, D. Barenberg, S. Carlson, Functional coupling of tight junctions and microfilaments in T84 monolayers, Am. J. Physiol. 254 (1988) G416-G423.
    • (1988) Am. J. Physiol. , vol.254
    • Madara, J.L.1    Safford, J.2    Barenberg, D.3    Carlson, S.4
  • 23
    • 0027172392 scopus 로고
    • Regulation of tight junction permeability by calcium mediators and cell cytoskeleton in rabbit tracheal epithelium
    • M. Bhat, D. Toledo-Velasquez, L.Y. Wang, C.J. Malanga, J.K.H. Ma, Y. Rojanasakul, Regulation of tight junction permeability by calcium mediators and cell cytoskeleton in rabbit tracheal epithelium, Pharm. Res. 10 (1993) 991-997.
    • (1993) Pharm. Res. , vol.10 , pp. 991-997
    • Bhat, M.1    Toledo-Velasquez, D.2    Wang, L.Y.3    Malanga, C.J.4    Ma, J.K.H.5    Rojanasakul, Y.6
  • 24
    • 0014068020 scopus 로고
    • Cellular mechanism of intestinal permeability alterations produced by chelation depletion
    • M.M. Cassidy, C.S. Tidball, Cellular mechanism of intestinal permeability alterations produced by chelation depletion, J. Cell Biol. 32 (1967) 685-698.
    • (1967) J. Cell Biol. , vol.32 , pp. 685-698
    • Cassidy, M.M.1    Tidball, C.S.2
  • 26
    • 0028225819 scopus 로고
    • Comparison of absorption-enhancing effect between sodium caprate and disodium ethylenediaminetetraacetate in Caco-2 cells
    • M. Tomita, M. Hayashi, S. Awazu, Comparison of absorption-enhancing effect between sodium caprate and disodium ethylenediaminetetraacetate in Caco-2 cells, Biol. Pharm. Bull. 17 (1994) 753-755.
    • (1994) Biol. Pharm. Bull. , vol.17 , pp. 753-755
    • Tomita, M.1    Hayashi, M.2    Awazu, S.3
  • 27
    • 0019258703 scopus 로고
    • Occluding junctions and cytoskeletal components in a cultured transporting epithelium
    • I. Meza, G. Ibarra, M. Sabanero, A. Martinez-Palomo, M. Cereijido, Occluding junctions and cytoskeletal components in a cultured transporting epithelium, J. Cell Biol. 87 (1980) 746-754.
    • (1980) J. Cell Biol. , vol.87 , pp. 746-754
    • Meza, I.1    Ibarra, G.2    Sabanero, M.3    Martinez-Palomo, A.4    Cereijido, M.5
  • 28
    • 0023631266 scopus 로고
    • Alteration of intestinal tight junction structure and permeability by cytoskeletal contraction
    • J.L. Madara, R. Moore, S. Carlson, Alteration of intestinal tight junction structure and permeability by cytoskeletal contraction, Am. J. Physiol. 253 (1987) C854-C861.
    • (1987) Am. J. Physiol. , vol.253
    • Madara, J.L.1    Moore, R.2    Carlson, S.3
  • 29
    • 0342453870 scopus 로고    scopus 로고
    • Enhancing effects of capric acid (C10) on rectal drug absorption from a suppository
    • in Japanese, with summary in English
    • H. Takahashi, T. Shibasaki, K. Takeshita, K. Kato, F. Kaiho, M. Hayashi, Enhancing effects of capric acid (C10) on rectal drug absorption from a suppository (in Japanese, with summary in English), Yakuzaigaku 57 (1997) 50-56.
    • (1997) Yakuzaigaku , vol.57 , pp. 50-56
    • Takahashi, H.1    Shibasaki, T.2    Takeshita, K.3    Kato, K.4    Kaiho, F.5    Hayashi, M.6
  • 30
    • 0030919761 scopus 로고    scopus 로고
    • The enhancing mechanism of capric acid (C10) from a suppository on rectal drug absortion through a paracellular pathway
    • H. Takahashi, T. Shibasaki, K. Takeshita, F. Kaiho, M. Hayashi, The enhancing mechanism of capric acid (C10) from a suppository on rectal drug absortion through a paracellular pathway, Biol. Pharm. Bull. 20 (1997) 446-448.
    • (1997) Biol. Pharm. Bull. , vol.20 , pp. 446-448
    • Takahashi, H.1    Shibasaki, T.2    Takeshita, K.3    Kaiho, F.4    Hayashi, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.