Multiple pathways for fluoroquinolone secretion by human intestinal epithelial (Caco-2) cells

British Journal of Pharmacology

Volumn 135, Issue 5, 2002, Pages 1263-1275

  Lowes, Simon ^a   Simmons, Nicholas L ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

ABC transporters; Caco 2 cells; Ciprofloxacin; Fluoroquinolone; Grepafloxacin; Intestinal secretion; MDR1 P glycoprotein; MRP2

Indexed keywords

ABC TRANSPORTER; BILE ACID; CHOLIC ACID; CIPROFLOXACIN; GREPAFLOXACIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; QUINOLINE DERIVED ANTIINFECTIVE AGENT; VERLUKAST;

ANIMAL CELL; ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG ELIMINATION; DRUG INHIBITION; DRUG TRANSPORT; DRUG UPTAKE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTESTINE SECRETION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0036199337     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704560     Document Type: Article

References (39)

1. Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump
2. Identification of two strains of cultures canine renal epithelial cells (MDCK cells) which display entirely different physiological properties
3. Enantioselective activation of the peroxisome proliferator-activated receptor
4. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cmrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
5. 4 response to irritant bile-acids
6. Transport and epithelial secretion of the cardiac glycoside by human intestinal epithelial Caco-2 cells
7. Fluoroquinolone (ciprofioxacin) secretion by human intestinal epithelial (Caco-2) cells
8. Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells
9. In vitro and in vivo investigations on fluoroquinolones; Effects of the P-glycoprotein efflux transporter on brain distribution of sparfloxacin
10. 4 synthesis in a human intestinal cell-line
11. Basolateral localisation and export activity of the human multidrug resistance-associated protein in polarised pig kidney cells
12. Active secretion of the fluoroquinolone ciprofioxacin by human intestinal epithelial Caco-2 cell layers
13. Active intestinal secretion of the fluoroquinolone antibacterials ciprofloxacin, norfloxacin and pefloxacin; a common secretory pathway?
14. Evidence for different ABC-transporters in Caco-2 cells modulating drug uptake
15. Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2)
16. Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia
17. Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers
18. Transepithelial secretion, cellular accumulation and cytotoxicity of vinblastine in defined MDCK cell strains
19. Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators
20. Distribution characteristics of levofioxacin and grepafloxacin in rat kidney
21. Gastrointestinal Secretion of Ciprofloxacin (CIP) in healthy volunteers
22. 4 receptor antagonist
23. Transporters on demand - Intrahepatic pools of canalicular ATP binding cassette transporters in rat liver
24. Analysis of the expression of cMOAT (MRP2), MRP3, MRP4, and MRP5 homologues of the multi-drug resistance protein gene (MRP1) in human cell lines
25. Human intestinal cell monolayers are preferentially sensitive to disruption of barrier function from basolateral exposure to cholic acid: Correlation with membrane transport and transepithelial secretion
26. Transport of quinolone antibacterial drugs in a kidney epithelial cell line. LLCPK1
27. Molecular aspects of hepatobiliary transport
28. Galactose transport in rabbit ileum
29. Hepatobiliary kinetics and excretion of ciprofioxacin
30. Transintestinal elimination of ciprofloxacin
31. Stereoselective and hepatobiliary transport of the quinolone antibiotic grepafloxacin and its glucuronide in the rat
32. Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms
33. Structure-activity relationship of P-glycoprotein substrates and modifiers
34. Brief report: Gastrointestinal secretion of ciprofloxacin. Evaluation of the charcoal model for investigations in healthy volunteers
35. Comparative pharmacokinetics of ciprofloxacin and temafloxacin in humans: A review
36. Kinetics of the multidrug transporter (P-Glycoprotein) and its reversal
37. Characterisation of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison with the multidrug resistance protein 3 (MRP3) gene
38. Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers
39. Secretory mechanisms of grepafloxacin and levofioxacin in the human intestinal cell line Caco-2