Human placental transport of vinblastine, vincristine, digoxin and progesterone: Contribution of P-glycoprotein

European Journal of Pharmacology

Volumn 408, Issue 1, 2000, Pages 1-10

  Ushigome, Fumihiko ^a   Takanaga, Hitomi ^a   Matsuo, Hirotami ^a   Yanai, Shigeaki ^b   Tsukimori, Kiyomi ^b   Nakano, Hitoo ^b   Uchiumi, Takeshi ^b   Nakamura, Takanori ^b   Kuwano, Michihiko ^b   Ohtani, Hisakazu ^a   Sawada, Yasufumi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

BeWo cells; Blood placental barrier; Drug disposition; P Glycoprotein; Placenta

Indexed keywords

CYCLOSPORIN A; DIGOXIN; GLYCOPROTEIN P; MONOCLONAL ANTIBODY MRK 16; PROGESTERONE; SODIUM AZIDE; VERAPAMIL; VINBLASTINE; VINCRISTINE;

ARTICLE; BRUSH BORDER; CELLULAR DISTRIBUTION; CHORIOCARCINOMA; DRUG UPTAKE; HUMAN; HUMAN CELL; PLACENTAL TRANSFER; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCYTOSIS; TROPHOBLAST;

ANTIMETABOLITES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOLOGICAL TRANSPORT, ACTIVE; CALCIUM CHANNEL BLOCKERS; CARDIOTONIC AGENTS; CELL LINE; DIGOXIN; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INDICATORS AND REAGENTS; MICROVILLI; P-GLYCOPROTEIN; PLACENTA; PREGNANCY; PROGESTERONE; TROPHOBLASTS; VINBLASTINE; VINCRISTINE;

EID: 0034634387     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00743-3     Document Type: Article

References (53)

1. Steroid transport, accumulation, and antagonism of P-glycoprotein in multidrug-resistant cells
2. Placental transport of carbohydrates
3. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
4. Teratology in the Macaca mulatta
5. The transport of digoxin across the perfused human placental lobule
6. Congenital malformation in hamster embryos after treatment with vinblastine and vincristine
7. ASC system activity is altered by development of cell polarity in trophoblast from human placenta
8. P-glycoprotein and multidrug resistance
9. Thiamine transport in placental brush border membrane vesicles
10. Ontogeny of glucose transport systems in the placenta and its progenitor tissues
11. Functional role of the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies
12. Placental transport of nutrients to the fetus
13. Biotin uptake by basolateral membrane vesicles of human placenta: Normal characteristics and role of ethanol
14. The characteristic distribution of alkaline phosphatase in full-term human placenta
15. Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators
16. Insufficient transplacental digoxin transfer in severe hydrops fetalis
17. Teratogenic effects of vincristine in three lines of mice
18. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
19. Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell line
20. Detection of P-glycoprotein in multi-drug resistant cell line by monoclonal antibodies
21. Isolation and partial characterization of basal cell membrane of human placental trophoblast
22. Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae
23. Vincristine-resistant human cancer KB cell line and increased expression of multidrug-resistance gene
24. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
25. Permeability properties of monolayers of the human trophoblast cell line BeWo
26. Protein measurement with the Folin phenol reagent
27. Fetal renal malformation following treatment of Hodgkin's disease during pregnancy
28. Placental amino acid transport
29. Functional characterization of L-alanine transport in placental choriocarcinoma cell line (BeWo)
30. Function of P-glycoprotein expressed in placenta and mole
31. Placental transfer of drugs administered to the mother
32. In vitro identification of the trophoblast stem cell of the human villous placenta
33. Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate
34. Selective impairment of taurine transport by cyclosporin A in a human placental cell line
35. Further evidence for the presence of two facilitative glucose transporter isoforms in the brush border membrane of the syncytiotrophoblast of the human full term placenta
36. Gamma-glutamyltranspeptidase as a tumor marker
37. Human placental vitamin B6 (pyridoxal) transport: Normal characteristics and effects of ethanol
38. Monoclonal antibody JSB-1 detected a highly conserved epitope on the P-glycoprotein associated with multidrug resistance
39. Characterization of a microvillous membrane preparation from human placental syncytiotrophoblast: A morphologic, biochemical and physiologic study
40. Placental transfer of inorganic ions and water
41. Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16
42. Lung resistance protein (LRP) expression in human normal tissues in comparison with that of MDR1 and MRP
43. Vincristine-induced malformations in the rat embryo
44. Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1)
45. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
46. The investigation and management of Hodgkin's disease in the pregnant patient
47. P-Glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells
48. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil
49. Modification of cytotoxic drug resistance by non-immuno-suppresive cyclosporones
50. Human P-glycoprotein transports cortisol, aldosterone, and dexamethadone, but not progesterone
51. Mechanisms of drug transfer across the human placenta
52. Adipocyte β-adrenergic receptors
53. Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers