The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2)

Journal of Cell Science

Volumn 113, Issue 11, 2000, Pages 2011-2021

  Litman, Thomas ^a,c   Brangi, Mariafiorella ^a   Hudson, Eric ^a   Fetsch, Patricia ^a   Abati, Andrea ^a   Ross, Douglas D ^b   Miyake, Keisuke ^a   Resau, James H ^a   Bates, Susan E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

ABC half transporter; Atypical multidrug resistance; Cancer; Confocal microscopy; Mitoxantrone; MXR

Indexed keywords

ABC TRANSPORTER; ANTHRACYCLINE; BISANTRENE; CALCEIN; DAUNORUBICIN; ETOPOSIDE; GLYCOPROTEIN P; MITOXANTRONE; PACLITAXEL; PRAZOSIN; RHODAMINE 123; TOPOTECAN; VERAPAMIL; VINBLASTINE;

ARTICLE; BREAST CANCER; CELL STRAIN MCF 7; COLON CANCER; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CROSS RESISTANCE; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MULTIDRUG RESISTANCE; NUCLEOTIDE SEQUENCE; PHARMACODYNAMICS; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BLOTTING, NORTHERN; BREAST NEOPLASMS; COLONIC NEOPLASMS; DNA-BINDING PROTEINS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FLUORESCENT DYES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MEMBRANE TRANSPORT PROTEINS; MICROSCOPY, CONFOCAL; MITOXANTRONE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; POLYMERASE CHAIN REACTION; RIBOSOMAL PROTEINS; RNA, MESSENGER; TUMOR CELLS, CULTURED;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0034081847     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Allikmets, R., Gerrard, B., Hutchinson, A. and Dean, M. (1996). Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. Hum. Mol. Genet. 5, 1649-1655.
2. Allikmets, R., Schrim, L. M., Hutchinson, A., Romano-Spica, V. and Dean, M. (1998). A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Res. 58, 5337-5339.
3. r 190,000 multidrug resistance protein (MRP) in drug-selected and transfected human tumor cells. Cancer Res. 55, 102-110.
4. Bailly, J.-D., Skladanowski, A., Bettaieb, A., Mansat, V., Larsen, A. K. and Laurent, G. (1997). Natural resistance of acute myeloid leukemia cell lines to mitoxantrone is associated with lack of apoptosis. Leukemia 11, 1523-1532.
5. Bell, D. H. (1988). Characterization of the fluorescence of the antitumor agent, mitoxantrone. Biochim. Biophys. Acta 949, 132-137.
6. Blanz, J., Mewes, K., Ehninger, G., Proksch, B., Greger, B., Waidelich, D. and Zeller, K.-P. (1991a). Isolation and structure elucidation of urinary metabolites of mitoxantrone. Cancer Res. 51, 3427-3433.
7. Blanz, J., Mewes, K., Ehninger, G., Proksch, B., Waidelich, D., Greger, B. and Zeller, K.-P. (1991b). Evidence for oxidative activation of mitoxantrone in human, pig, and rat. Drug Metabol. Disp. 19, 871-880.
8. Brangi, M., Litman, T., Ciotti, M., Nishiyama, K., Kohlhagen, G., Takimoto, C., Robey, R., Pommier, Y., Fojo, T. and Bates, S. E. (2000). Camptothecin resistance: Role of the ATP-binding cassette (ABC) mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells. Cancer Res, in press.
9. Burchell, B., Baird, S. and Coughtrie, M. W. H. (1991). The role of xenobiotic glucuronidating enzymes in drug resistance of tumour tissues and cells. In Xenobiotics and Cancer (ed. L. Ernster et al.), pp. 263-275. Taylor & Francis Ltd, London.
10. Chen, Y.-N., Mickley, L. A., Schwartz, A. M., Acton, E. M., Hwang, J. and Fojo, A. T. (1990). Characterization of adriamycin-resistant human breast cancer cells which display overexpression of a novel resistance-related membrane protein. J. Biol. Chem. 265, 10073-10080.
11. Cole, S. P. C., Bhardwaj, G., Gerlach, J. H., Mackie, J. E., Grant, C. E., Almquist, K. C., Stewart, A. J., Kurz, E. U., Duncan, A. M. V. and Deeley, R. G. (1992). Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258, 1650-1654.