Molecular mechanism of cytotoxicity induced by Hsp90-targeted Antp-TPR hybrid peptide in glioblastoma cells

Molecular Cancer

Volumn 11, Issue , 2012, Pages

  Horibe, Tomohisa ^a   Torisawa, Aya ^a   Kohno, Masayuki ^a   Kawakami, Koji ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Client proteins; Glioblastoma; Heat shock protein 90; Hybrid peptide; Molecular chaperone; Unfolded protein response

Indexed keywords

ANTINEOPLASTIC AGENT; ANTP TPR PEPTIDE; CYCLIN DEPENDENT KINASE 4; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HYBRID PROTEIN; PROTEIN KINASE B; PROTEIN P53; RAF PROTEIN; TANESPIMYCIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL KILLING; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG TARGETING; ENDOPLASMIC RETICULUM STRESS; GLIOBLASTOMA; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

ANTENNAPEDIA HOMEODOMAIN PROTEIN; ANTINEOPLASTIC AGENTS; BENZOQUINONES; CELL LINE, TUMOR; CELL SURVIVAL; GLIOBLASTOMA; HSP90 HEAT-SHOCK PROTEINS; HUMANS; INHIBITORY CONCENTRATION 50; LACTAMS, MACROCYCLIC; NUCLEAR PORE COMPLEX PROTEINS; PEPTIDES; PROTO-ONCOGENE PROTEINS; UNFOLDED PROTEIN RESPONSE;

EID: 84865180666     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-11-59     Document Type: Article

References (43)

1. Stupp R, Hegi ME, van den Bent MJ, Mason WP, Weller M, Mirimanoff RO, Cairncross JG, et al. Changing paradigms-an update on the multidisciplinary management of malignant glioma. Oncologist 2006, 11:165-180. 10.1634/theoncologist.11-2-165, 16476837.
2. Omuro AM, Faivre S, Raymond E. Lessons learned in the development of targeted therapy for malignant gliomas. Mol Cancer Ther 2007, 6:1909-1919. 10.1158/1535-7163.MCT-07-0047, 17620423.
3. Collins VP. Brain tumors: classification and genes. J Neurol Neurosurg Psychiatry 2004, 75(Suppl 2):ii2-ii11. 1765661, 15146033.
4. Westerheide SD, Morimoto RI. Heat shock response modulators as therapeutic tools for diseases of protein conformation. J Biol Chem 2005, 280:33097-33100. 10.1074/jbc.R500010200, 16076838.
5. Welch WJ. The role of heat-shock proteins as molecular chaperones. Curr Opin Cell Biol 1991, 3:1033-1038. 10.1016/0955-0674(91)90125-I, 1687649.
6. McClellan AJ, Xia Y, Deutschbauer AM, Davis RW, Gerstein M, Frydman J. Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approach. Cell 2007, 131:121-135. 10.1016/j.cell.2007.07.036, 17923092.
7. Falsone SF, Gesslbauer B, Tirk F, Piccinini AM, Kungl AJ. A proteomic snapshot of the human heat shock protein 90 interactome. FEBS Lett 2005, 579:6350-6354. 10.1016/j.febslet.2005.10.020, 16263121.
8. Kamal A, Boehm MF, Burrows FJ. Therapeutic and diagnostic implications of Hsp90 activation. Trends Mol Med 2004, 10:283-290. 10.1016/j.molmed.2004.04.006, 15177193.
9. Schroder M, Kaufman RJ. The mammalian unfolded protein response. Annu Rev Biochem 2005, 74:739-789. 10.1146/annurev.biochem.73.011303.074134, 15952902.
10. Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 2007, 8:519-529. 10.1038/nrm2199, 17565364.
11. Harding HP, Zhang Y, Bertolotti A, Zeng H, Ron D. Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell 2000, 5:897-904. 10.1016/S1097-2765(00)80330-5, 10882126.
12. Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Negishi M, Mori K. ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol Cell Biol 2000, 20:6755-6767. 10.1128/MCB.20.18.6755-6767.2000, 86199, 10958673.
13. Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 2001, 107:881-891. 10.1016/S0092-8674(01)00611-0, 11779464.
14. Dong D, Ni M, Li J, Xiong S, Ye W, Virrey JJ, Mao C, Ye R, Wang M, Pen L, et al. Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development. Cancer Res 2008, 68:498-505. 10.1158/0008-5472.CAN-07-2950, 18199545.
15. Fu Y, Lee AS. Glucose regulated proteins in cancer progression during resistance and immunotherapy. Cancer Biol Ther 2006, 5:741-744. 10.4161/cbt.5.7.2970, 16861902.
16. Ubeda M, Wang XZ, Zinszner H, Wu I, Habener JF, Ron D. Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element. Mol Cell Biol 1996, 16:1479-1489. 231132, 8657121.
17. Puthalakath H, O'Reilly LA, Gunn P, Lee L, Kelly PN, Huntington ND, Hughes PD, Michalak EM, McKimm-Breschkin J, Motoyama N, et al. ER stress triggers apoptosis by activating BH3-only protein Bim. Cell 2007, 129:1337-1349. 10.1016/j.cell.2007.04.027, 17604722.
18. Davenport EL, Morgan GJ, Davies FE. Untangling the unfolded protein response. Cell Cycle 2008, 7:865-869. 10.4161/cc.7.7.5615, 18414035.
19. Wang G, Yang ZQ, Zhang K. Endoplasmic reticulum stress response in cancer: molecular mechanism and therapeutic potential. Am J Transl Res 2010, 2:65-74. 2826823, 20182583.
20. Horibe T, Kohno M, Haramoto M, Ohara K, Kawakami K. Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent. J Transl Med 2011, 9:8. 10.1186/1479-5876-9-8, 3032679, 21235734.
21. Taiyab A, Sreedhar AS, Rao CM. Hsp90 inhibitors, GA and 17AAG, lead to ER stress-induced apoptosis in rat histiocytoma. Biochem Pharmacol 2009, 78:142-152. 10.1016/j.bcp.2009.04.001, 19464431.
22. Patterson J, Palombella VJ, Fritz C, Normant E. IPI-504, a novel and soluble HSP-90 inhibitor, blocks the unfolded protein response in multiple myeloma cells. Cancer Chemother Pharmacol 2008, 61:923-932. 10.1007/s00280-007-0546-0, 17624530.
23. Ohgaki H. Genetic pathways to glioblastomas. Neuropathology 2005, 25:1-7. 10.1111/j.1440-1789.2004.00600.x, 15920826.
24. Zhang H, Chung D, Yang YC, Neely L, Tsurumoto S, Fan J, Zhang L, Biamonte M, Brekken J, Lundgren K, Burrows F. Identification of new biomarkers for clinical trials of Hsp90 inhibitors. Mol Cancer Ther 2006, 5:1256-1264. 10.1158/1535-7163.MCT-05-0537, 16731758.
25. Song D, Chaerkady R, Tan AC, García-García E, Nalli A, Suárez-Gauthier A, López-Ríos F, Zhang XF, Solomon A, Tong J, et al. Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer. Mol Cancer Ther 2008, 7:3275-3284. 10.1158/1535-7163.MCT-08-0508, 18852131.
26. Leu JI, Pimkina J, Frank A, Murphy ME, George DL. A small molecule inhibitor of inducible heat shock protein 70. Mol Cell 2009, 36:15-27. 10.1016/j.molcel.2009.09.023, 2771108, 19818706.
27. Leu JI, Pimkina J, Pandey P, Murphy ME, George DL. Heat shock protein-70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells. Mol Cancer Res 2011, 9:936-947. 10.1158/1541-7786.MCR-11-0019, 3140602, 21636681.
28. Aldridge J, Horibe T, Hoogenraad N. Discovery of gene activated by the mitochondrial unfolded protein response (mtUPR) and cognate promoter elements. PLoS One 2007, 2:e874. 10.1371/journal.pone.0000874, 1964532, 17849004.
29. Oku M, Tanakura S, Uemura A, Sohda M, Misumi Y, Taniguchi M, Wakabayashi S, Yoshida H. Novel cis-acting element GASE regulates transcriptional induction by the Golgi stress response. Cell Struct Funct 2011, 36:1-12. 10.1247/csf.10014, 21150128.
30. Stewart LA. Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet 2002, 359:1011-1018.
31. Butcher EC. Can cell systems biology rescue drug discovery?. Nat Rev Drug Discov 2005, 4:461-467. 10.1038/nrd1754, 15915152.
32. Isaacs JS, Xu W, Neckers L. Heat shock protein 90 as a molecular target for cancer therapeutics. Cancer Cell 2003, 3:213-217. 10.1016/S1535-6108(03)00029-1, 12676580.
33. Drysdale MJ, Brough PA, Massey A, Jensen MR, Schoepfer J. Targeting Hsp90 for the treatment of cancer. Curr Opin Drug Discov Devel 2006, 9:483-495.
34. McCollum AK, TenEyck CJ, Sauer BM, Toft DO, Erlichman C. Up-regulation of heat shock protein 27 induces resistance to 17-allylamino-demethoxygeldanamycin through a glutathione-mediated mechanism. Cancer Res 2006, 66:10967-10975. 10.1158/0008-5472.CAN-06-1629, 17108135.
35. Saito S, Furuno A, Sakurai J, Sakamoto A, Park HR, Shin-ya K, Tsuruno T, Tomida A. Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation. Cancer Res 2009, 69:4225-4234. 10.1158/0008-5472.CAN-08-2689, 19435925.
36. Obeng EA, Carlson LM, Gutman DM, Harrington WJ, Lee KP, Boise LH. Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood 2006, 107:4907-4916. 10.1182/blood-2005-08-3531, 1895817, 16507771.
37. Davenport EL, Moore HE, Dunlop AS, Sharp SY, Workman P, Morgan GJ, Davies FE. Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells. Blood 2007, 110:2641-2649. 10.1182/blood-2006-11-053728, 17525289.
38. Ellerby HM, Arap W, Ellerby LM, Kain R, Andrusiak R, Rio GD, Krajewski S, Lombardo CR, Rao R, Ruoslahti E, et al. Anti-cancer activity if targeted pro-apoptotic peptides. Nat Med 1999, 5:1032-1038. 10.1038/12469, 10470080.
39. Plescia J, Salz W, Xia F, Pennati M, Zaffaroni N, Daidone MG, Meli M, Dohi T, Fortugno P, Nefedova Y, et al. Rational design of shepherdin, a novel anticancer agent. Cancer Cell 2005, 7:457-468. 10.1016/j.ccr.2005.03.035, 15894266.
40. Kabouridis PS. Biological application of protein transuction technology. Trends Biotechnol 2003, 21:498-503. 10.1016/j.tibtech.2003.09.008, 2597147, 14573363.
41. Zhao Q, Wang J, Levichkin IV, Stasinopoulos S, Ryan MT, Hoogenraad NJ. A mitochondrial specific stress response in mammalian cells. EMBO J 2002, 21:4411-4419. 10.1093/emboj/cdf445, 126185, 12198143.
42. Kohno M, Horibe T, Haramoto M, Yano Y, Ohara K, Nakajima O, Matsuzaki K, Kawakami K. A novel hybrid peptide targeting EGFR-expressing cancers. Eur J Cancer 2011, 47:773-783. 10.1016/j.ejca.2010.10.021, 21112771.
43. Fossati G, Moulding DA, Spiller DG, Moots RJ, White MR, Edwards SW. The mitochondrial network of human neutrophils: role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis. J Immunol 2003, 170:1964-1972.