Targeting the IRE1α-XBP1 branch of the unfolded protein response in human diseases

Seminars in Cancer Biology

Volumn 33, Issue , 2015, Pages 48-56

  Jiang, Dadi ^a   Niwa, Maho ^b   Koong, Albert C ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Compounds; Drug discovery; ER stress; Protein folding; Therapy

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; INOSITOL REQUIRING KINASE 1 ALPHA; MCK 3946; MKC 9989; OIRC 464; OIRC 573; SALICYLALDEHYDE; STF 083010; TOYOCAMYCIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; ALDEHYDE; COUMARIN DERIVATIVE; DNA BINDING PROTEIN; ERN1 PROTEIN, HUMAN; MKC9989; PROTEIN SERINE THREONINE KINASE; QUERCETIN; REGULATORY FACTOR X TRANSCRIPTION FACTOR; RIBONUCLEASE; SULFONAMIDE; THIOPHENE DERIVATIVE; XBP1 PROTEIN, HUMAN; XBP1 PROTEIN, MOUSE;

AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; CELL SURVIVAL; DEGENERATIVE DISEASE; DISEASE COURSE; DRUG MECHANISM; DRUG STRUCTURE; ENDOPLASMIC RETICULUM STRESS; FLUORESCENCE; HIGH THROUGHPUT SCREENING; HUMAN; HYDROLYSIS; INFLAMMATION; METABOLIC DISORDER; NEOPLASM; NONHUMAN; OLIGOMERIZATION; PROGNOSIS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN SYNTHESIS; PROTEIN TARGETING; REVIEW; RNA CLEAVAGE; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; ANIMAL; CHEMISTRY; DISEASE MODEL; DRUG DESIGN; DRUG DEVELOPMENT; ENDOPLASMIC RETICULUM; HOMEOSTASIS; METABOLISM; MOUSE;

ALDEHYDES; ANIMALS; APOPTOSIS; CELL SURVIVAL; COUMARINS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DNA-BINDING PROTEINS; DRUG DESIGN; DRUG DISCOVERY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; HOMEOSTASIS; HUMANS; MICE; NEOPLASMS; NEURODEGENERATIVE DISEASES; PROGNOSIS; PROTEIN FOLDING; PROTEIN-SERINE-THREONINE KINASES; QUERCETIN; REGULATORY FACTOR X TRANSCRIPTION FACTORS; SIGNAL TRANSDUCTION; SULFONAMIDES; THIOPHENES; TOYOCAMYCIN; TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE; X-BOX BINDING PROTEIN 1;

EID: 84938212067     PISSN: 1044579X     EISSN: 10963650     Source Type: Journal    
DOI: 10.1016/j.semcancer.2015.04.010     Document Type: Review

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