Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells

Neuro-Oncology

Volumn 16, Issue 10, 2014, Pages 1354-1364

  Kim, Tae Hyong ^a,b   Song, Jieun ^a,b   Kim, Sung Hak ^a   Parikh, Arav Krishnavadan ^a,b   Mo, Xiaokui ^a   Palanichamy, Kamalakannan ^a   Kaur, Balveen ^a   Yu, Jianhua ^a   Yoon, Sung Ok ^c   Nakano, Ichiro ^a   Kwon, Chang Hyuk ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

Author keywords

Endoplasmic reticulum stress; High grade glioma; Peroxiredoxin 4; Piperlongumine; Reactive oxygen species

Indexed keywords

ANTINEOPLASTIC AGENT; PEROXIREDOXIN 4; PIPERLONGUMINE; UNCLASSIFIED DRUG; 1,3 DIOXOLANE DERIVATIVE; PEROXIREDOXIN; PIPERLONGUMININE; PRDX4 PROTEIN, HUMAN; REACTIVE OXYGEN METABOLITE;

ARTICLE; CANCER GRADING; CANCER GROWTH; CANCER INHIBITION; CANCER SURVIVAL; CELL LEVEL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG TARGETING; ENDOPLASMIC RETICULUM STRESS; GLIOMA; GLIOMA CELL; GROWTH RATE; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN FOLDING; SIGNAL TRANSDUCTION; SURVIVAL RATE; TARGET CELL DESTRUCTION; ANIMAL; APOPTOSIS; BRAIN NEOPLASMS; DRUG EFFECTS; FACTUAL DATABASE; METABOLISM; MORTALITY; MOUSE; SURVIVAL; TUMOR CELL CULTURE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BRAIN NEOPLASMS; DATABASES, FACTUAL; DIOXOLANES; ENDOPLASMIC RETICULUM STRESS; GLIOMA; HUMANS; MICE; PEROXIREDOXINS; REACTIVE OXYGEN SPECIES; SURVIVAL ANALYSIS; TUMOR CELLS, CULTURED;

EID: 84906302724     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/nou088     Document Type: Article

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