-
1
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003;3:721-32.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
2
-
-
0344081177
-
Minireview: The AMP-activated protein kinase cascade: the key sensor of cellular energy status
-
Hardie DG. Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology 2003;144:5179-83.
-
(2003)
Endocrinology
, vol.144
, pp. 5179-5183
-
-
Hardie, D.G.1
-
3
-
-
0029075014
-
Nutrient control of GLUT1 processing and turnover in 3T3-1 adipocytes
-
McMahon RJ, Frost SC. Nutrient control of GLUT1 processing and turnover in 3T3-1 adipocytes. J Biol Chem 1995;270:12094-9.
-
(1995)
J Biol Chem
, vol.270
, pp. 12094-12099
-
-
McMahon, R.J.1
Frost, S.C.2
-
4
-
-
0034038708
-
Glucose deprivation-induced oxidative stress in human tumor cells
-
Spitz DR. Glucose deprivation-induced oxidative stress in human tumor cells. Ann N Y Acad Sci 2000; 899:349-62.
-
(2000)
Ann N Y Acad Sci
, vol.899
, pp. 349-362
-
-
Spitz, D.R.1
-
5
-
-
10344222124
-
The role of the unfolded protein response in tumour development: Friend or foe?
-
Ma Y, Hendershot LM. The role of the unfolded protein response in tumour development: friend or foe? Nat Rev Cancer 2004;4:966-77.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 966-977
-
-
Ma, Y.1
Hendershot, L.M.2
-
6
-
-
0036086064
-
The unfolded protein response in nutrient sensing and differentiation
-
Kaufman RJ, Scheuner D, Schroder M, et al. The unfolded protein response in nutrient sensing and differentiation. Nat Rev Mol Cell Biol 2002;3:411-21.
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 411-421
-
-
Kaufman, R.J.1
Scheuner, D.2
Schroder, M.3
-
7
-
-
10444226462
-
ER stress and the unfolded protein response
-
Schroder M, Kaufman RJ. ER stress and the unfolded protein response. Mutat Res 2005;569:29-63.
-
(2005)
Mutat Res
, vol.569
, pp. 29-63
-
-
Schroder, M.1
Kaufman, R.J.2
-
8
-
-
0033590451
-
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
-
Harding HP, Zhang Y, Ron D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 1999;397:271-4.
-
(1999)
Nature
, vol.397
, pp. 271-274
-
-
Harding, H.P.1
Zhang, Y.2
Ron, D.3
-
9
-
-
0036837864
-
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2α
-
Koumenis C, Naczki C, Koritzinsky M, et al. Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2α. Mol Cell Biol 2002;22:7405-16.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7405-7416
-
-
Koumenis, C.1
Naczki, C.2
Koritzinsky, M.3
-
10
-
-
27144458505
-
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
-
Bi M, Naczki C, Koritzinsky M, et al. ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J 2005;24: 3470-81.
-
(2005)
EMBO J
, vol.24
, pp. 3470-3481
-
-
Bi, M.1
Naczki, C.2
Koritzinsky, M.3
-
11
-
-
33644852277
-
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control
-
Koritzinsky M, Magagnin MG, van den Beucken T, et al. Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. EMBO J 2006;25:1114-25.
-
(2006)
EMBO J
, vol.25
, pp. 1114-1125
-
-
Koritzinsky, M.1
Magagnin, M.G.2
van den Beucken, T.3
-
12
-
-
0035966269
-
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
-
Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 2001;107:881-91.
-
(2001)
Cell
, vol.107
, pp. 881-891
-
-
Yoshida, H.1
Matsui, T.2
Yamamoto, A.3
Okada, T.4
Mori, K.5
-
13
-
-
4344660747
-
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth
-
Romero-Ramirez L, Cao H, Nelson D, et al. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res 2004;64:5943-7.
-
(2004)
Cancer Res
, vol.64
, pp. 5943-5947
-
-
Romero-Ramirez, L.1
Cao, H.2
Nelson, D.3
-
15
-
-
0028870050
-
Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: Implications for tumor angiogenesis
-
Shweiki D, Neeman M, Itin A, Keshet E. Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis. Proc Natl Acad Sci U S A 1995;92:768-72.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 768-772
-
-
Shweiki, D.1
Neeman, M.2
Itin, A.3
Keshet, E.4
-
16
-
-
0036328117
-
Response of VEGF expression to amino acid deprivation and inducers of endoplasmic reticulum stress
-
Abcouwer SF, Marjon PL, Loper RK, Vander Jagt DL. Response of VEGF expression to amino acid deprivation and inducers of endoplasmic reticulum stress. Invest Ophthalmol Vis Sci 2002;43:2791-8.
-
(2002)
Invest Ophthalmol Vis Sci
, vol.43
, pp. 2791-2798
-
-
Abcouwer, S.F.1
Marjon, P.L.2
Loper, R.K.3
Vander Jagt, D.L.4
-
17
-
-
15444362131
-
Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma
-
Yun H, Lee M, Kim SS, Ha J. Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma. J Biol Chem 2005;280:9963-72.
-
(2005)
J Biol Chem
, vol.280
, pp. 9963-9972
-
-
Yun, H.1
Lee, M.2
Kim, S.S.3
Ha, J.4
-
18
-
-
0032578458
-
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
-
Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci U S A 1998;95:11715-20.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 11715-11720
-
-
Chandel, N.S.1
Maltepe, E.2
Goldwasser, E.3
Mathieu, C.E.4
Simon, M.C.5
Schumacker, P.T.6
-
19
-
-
0029103274
-
Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5′ enhancer
-
Liu Y, Cox SR, Morita T, Kourembanas S. Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5′ enhancer. Circ Res 1995;77:638-43.
-
(1995)
Circ Res
, vol.77
, pp. 638-643
-
-
Liu, Y.1
Cox, S.R.2
Morita, T.3
Kourembanas, S.4
-
20
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe JA, Jiang BH, Iyer NV, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 1996;16:4604-13.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
-
22
-
-
0033562569
-
Defective vascularization of HIF-1α-null embryos is not associated with VEGF deficiency but with mesenchymal cell death
-
Kotch LE, Iyer NV, Laughner E, Semenza GL. Defective vascularization of HIF-1α-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev Biol 1999;209:254-67.
-
(1999)
Dev Biol
, vol.209
, pp. 254-267
-
-
Kotch, L.E.1
Iyer, N.V.2
Laughner, E.3
Semenza, G.L.4
-
23
-
-
0030943461
-
Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
-
Maltepe E, Schmidt JV, Baunoch D, Bradfield CA, Simon MC. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 1997;386:403-7.
-
(1997)
Nature
, vol.386
, pp. 403-407
-
-
Maltepe, E.1
Schmidt, J.V.2
Baunoch, D.3
Bradfield, C.A.4
Simon, M.C.5
-
24
-
-
0032581277
-
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
-
Carmeliet P, Dor Y, Herbert JM, et al. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998;394:485-90.
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
-
25
-
-
0032100732
-
HIF-1 α is required for solid tumor formation and embryonic vascularization
-
Ryan HE, Lo J, Johnson RS. HIF-1 α is required for solid tumor formation and embryonic vascularization. EMBO J 1998;17:3005-15.
-
(1998)
EMBO J
, vol.17
, pp. 3005-3015
-
-
Ryan, H.E.1
Lo, J.2
Johnson, R.S.3
-
26
-
-
34347389910
-
Acute L-glutamine deprivation compromises VEGF-A up-regulation in A549/8 cells
-
Drogat B, Bouchecareilh M, North-Chassande S, et al. Acute L-glutamine deprivation compromises VEGF-A up-regulation in A549/8 cells. J Cell Physiol 2007;212: 463-72.
-
(2007)
J Cell Physiol
, vol.212
, pp. 463-472
-
-
Drogat, B.1
Bouchecareilh, M.2
North-Chassande, S.3
-
27
-
-
4344598305
-
Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress
-
Nguyen DT, Kebache S, Fazel A, et al. Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress. Mol Biol Cell 2004;15:4248-60.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 4248-4260
-
-
Nguyen, D.T.1
Kebache, S.2
Fazel, A.3
-
28
-
-
0032525990
-
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
-
Tirasophon W, Welihinda AA, Kaufman RJ. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev 1998;12:1812-24.
-
(1998)
Genes Dev
, vol.12
, pp. 1812-1824
-
-
Tirasophon, W.1
Welihinda, A.A.2
Kaufman, R.J.3
-
29
-
-
0034973982
-
Translational control is required for the unfolded protein response and in vivo glucose homeostasis
-
Scheuner D, Song B, McEwen E, et al. Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell 2001;7: 1165-76.
-
(2001)
Mol Cell
, vol.7
, pp. 1165-1176
-
-
Scheuner, D.1
Song, B.2
McEwen, E.3
-
30
-
-
13444263259
-
Accessing key steps of human tumor progression in vivo by using an avian embryo model
-
Hagedorn M, Javerzat S, Gilges D, et al. Accessing key steps of human tumor progression in vivo by using an avian embryo model. Proc Natl Acad Sci U S A 2005;102: 1643-8.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 1643-1648
-
-
Hagedorn, M.1
Javerzat, S.2
Gilges, D.3
-
31
-
-
11944269529
-
Impact of the coxsackie and adenovirus receptor (CAR) on glioma cell growth and invasion: Requirement for the C-terminal domain
-
Huang KC, Altinoz M, Wosik K, et al. Impact of the coxsackie and adenovirus receptor (CAR) on glioma cell growth and invasion: requirement for the C-terminal domain. Int J Cancer 2005;113:738-45.
-
(2005)
Int J Cancer
, vol.113
, pp. 738-745
-
-
Huang, K.C.1
Altinoz, M.2
Wosik, K.3
-
32
-
-
0037155247
-
Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect
-
Minchenko A, Leshchinsky I, Opentanova I, et al. Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect. J Biol Chem 2002;277:6183-7.
-
(2002)
J Biol Chem
, vol.277
, pp. 6183-6187
-
-
Minchenko, A.1
Leshchinsky, I.2
Opentanova, I.3
-
33
-
-
0026019757
-
The ubiquitous glucose transporter GLUT-1 belongs to the glucose-regulated protein family of stress-inducible proteins
-
Wertheimer E, Sasson S, Cerasi E, Ben-Neriah Y. The ubiquitous glucose transporter GLUT-1 belongs to the glucose-regulated protein family of stress-inducible proteins. Proc Natl Acad Sci U S A 1991;88:2525-9.
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 2525-2529
-
-
Wertheimer, E.1
Sasson, S.2
Cerasi, E.3
Ben-Neriah, Y.4
-
34
-
-
0037162965
-
Vascular endothelial growth factor gene expression in a retinal pigmented cell is up-regulated by glucose deprivation through 3′ UTR
-
Iida K, Kawakami Y, Sone H, et al. Vascular endothelial growth factor gene expression in a retinal pigmented cell is up-regulated by glucose deprivation through 3′ UTR. Life Sci 2002;71:1607-14.
-
(2002)
Life Sci
, vol.71
, pp. 1607-1614
-
-
Iida, K.1
Kawakami, Y.2
Sone, H.3
-
35
-
-
0036853914
-
Orchestrating the unfolded protein response in health and disease
-
Kaufman RJ. Orchestrating the unfolded protein response in health and disease. J Clin Invest 2002;110: 1389-98.
-
(2002)
J Clin Invest
, vol.110
, pp. 1389-1398
-
-
Kaufman, R.J.1
-
36
-
-
0042817965
-
Structure and inhibitory effects on angiogenesis and tumor development of a new vascular endothelial growth inhibitor
-
Zilberberg L, Shinkaruk S, Lequin O, et al. Structure and inhibitory effects on angiogenesis and tumor development of a new vascular endothelial growth inhibitor. J Biol Chem 2003;278:35564-73.
-
(2003)
J Biol Chem
, vol.278
, pp. 35564-35573
-
-
Zilberberg, L.1
Shinkaruk, S.2
Lequin, O.3
-
37
-
-
2342431428
-
Angiogenesis and invasion in gliomas
-
Bello L, Giussani C, Carrabba G, Pluderi M, Costa F, Bikfalvi A. Angiogenesis and invasion in gliomas. Cancer Treat Res 2004;117:263-84.
-
(2004)
Cancer Treat Res
, vol.117
, pp. 263-284
-
-
Bello, L.1
Giussani, C.2
Carrabba, G.3
Pluderi, M.4
Costa, F.5
Bikfalvi, A.6
-
38
-
-
0034648765
-
Angiogenesis in cancer and other diseases
-
Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000;407:249-57.
-
(2000)
Nature
, vol.407
, pp. 249-257
-
-
Carmeliet, P.1
Jain, R.K.2
-
39
-
-
0024408986
-
Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
-
Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 1989; 49:6449-65.
-
(1989)
Cancer Res
, vol.49
, pp. 6449-6465
-
-
Vaupel, P.1
Kallinowski, F.2
Okunieff, P.3
-
40
-
-
0035503093
-
Urea as a recovery marker for quantitative assessment of tumor interstitial solutes with microdialysis
-
Ettinger SN, Poellmann CC, Wisniewski NA, et al. Urea as a recovery marker for quantitative assessment of tumor interstitial solutes with microdialysis. Cancer Res 2001;61:7964-70.
-
(2001)
Cancer Res
, vol.61
, pp. 7964-7970
-
-
Ettinger, S.N.1
Poellmann, C.C.2
Wisniewski, N.A.3
-
41
-
-
0035878817
-
High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging
-
Ziegler A, von Kienlin M, Decorps M, Remy C. High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging. Cancer Res 2001;61:5595-600.
-
(2001)
Cancer Res
, vol.61
, pp. 5595-5600
-
-
Ziegler, A.1
von Kienlin, M.2
Decorps, M.3
Remy, C.4
-
42
-
-
0029082384
-
Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes
-
Stein I, Neeman M, Shweiki D, Itin A, Keshet E. Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes. Mol Cell Biol 1995; 15:5363-8.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 5363-5368
-
-
Stein, I.1
Neeman, M.2
Shweiki, D.3
Itin, A.4
Keshet, E.5
-
43
-
-
33745606008
-
-
Shen X, Ellis RE, Sakaki K, Kaufman RJ. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. PLoS Genet 2005;1:e37.
-
Shen X, Ellis RE, Sakaki K, Kaufman RJ. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. PLoS Genet 2005;1:e37.
-
-
-
-
44
-
-
33745893809
-
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response
-
Hollien J, Weissman JS. Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science 2006;313:104-7.
-
(2006)
Science
, vol.313
, pp. 104-107
-
-
Hollien, J.1
Weissman, J.S.2
-
45
-
-
0037119415
-
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 α-degradative pathway
-
Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, Neckers LM. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 α-degradative pathway. J Biol Chem 2002;277:29936-44.
-
(2002)
J Biol Chem
, vol.277
, pp. 29936-29944
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mimnaugh, E.G.3
Martinez, A.4
Cuttitta, F.5
Neckers, L.M.6
-
46
-
-
0032749463
-
Hypoxia-induced activation of HIF-1: Role of HIF-1α-Hsp90 interaction
-
Minet E, Mottet D, Michel G, et al. Hypoxia-induced activation of HIF-1: role of HIF-1α-Hsp90 interaction. FEBS Lett 1999;460:251-6.
-
(1999)
FEBS Lett
, vol.460
, pp. 251-256
-
-
Minet, E.1
Mottet, D.2
Michel, G.3
-
47
-
-
0034327361
-
Remarkable tolerance of tumor cells to nutrient deprivation: Possible new biochemical target for cancer therapy
-
Izuishi K, Kato K, Ogura T, Kinoshita T, Esumi H. Remarkable tolerance of tumor cells to nutrient deprivation: possible new biochemical target for cancer therapy. Cancer Res 2000;60:6201-7.
-
(2000)
Cancer Res
, vol.60
, pp. 6201-6207
-
-
Izuishi, K.1
Kato, K.2
Ogura, T.3
Kinoshita, T.4
Esumi, H.5
-
48
-
-
4444302042
-
Effect on tumor cells of blocking survival response to glucose deprivation
-
Park HR, Tomida A, Sato S, et al. Effect on tumor cells of blocking survival response to glucose deprivation. J Natl Cancer Inst 2004;96:1300-10.
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 1300-1310
-
-
Park, H.R.1
Tomida, A.2
Sato, S.3
-
49
-
-
3042642312
-
-
Lu J, Kunimoto S, Yamazaki Y, Kaminishi M, Esumi H. Kigamicin D, a novel anticancer agent based on a new anti-austerity strategy targeting cancer cells' tolerance to nutrient starvation. Cancer Sci 2004;95:547-52.
-
Lu J, Kunimoto S, Yamazaki Y, Kaminishi M, Esumi H. Kigamicin D, a novel anticancer agent based on a new anti-austerity strategy targeting cancer cells' tolerance to nutrient starvation. Cancer Sci 2004;95:547-52.
-
-
-
-
50
-
-
33845680589
-
Novel therapeutic target: The PERKs of inhibiting the integrated stress response
-
Blais J, Bell JC. Novel therapeutic target: the PERKs of inhibiting the integrated stress response. Cell Cycle 2006;5:2874-7.
-
(2006)
Cell Cycle
, vol.5
, pp. 2874-2877
-
-
Blais, J.1
Bell, J.C.2
|