메뉴 건너뛰기




Volumn 38, Issue 3, 2015, Pages

Quinoline-based antimalarial drugs: A novel class of autophagy inhibitors

Author keywords

Antimalaria compound; Autophagy; Chloroquine; Endoplasmic reticulum stress; Glioma

Indexed keywords

ANTIMALARIAL AGENT; ANTINEOPLASTIC AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; QUINOLINE; QUINOLINE DERIVATIVE;

EID: 84929648600     PISSN: None     EISSN: 10920684     Source Type: Journal    
DOI: 10.3171/2014.12.FOCUS14748     Document Type: Article
Times cited : (132)

References (42)
  • 1
    • 33846794896 scopus 로고    scopus 로고
    • Autophagy inhibition enhances therapyinduced apoptosis in a Myc-induced model of lymphoma
    • Amaravadi RK, Yu D, Lum JJ, Bui T, Christophorou MA, Evan GI, et al: Autophagy inhibition enhances therapyinduced apoptosis in a Myc-induced model of lymphoma. J Clin Invest 117:326-336, 2007.
    • (2007) J Clin Invest , vol.117 , pp. 326-336
    • Amaravadi, R.K.1    Yu, D.2    Lum, J.J.3    Bui, T.4    Christophorou, M.A.5    Evan, G.I.6
  • 2
    • 0034610012 scopus 로고    scopus 로고
    • Interaction of chloroquine and its analogues with heme: an isothermal titration calorimetric study
    • Bachhawat K, Thomas CJ, Surolia N, Surolia A: Interaction of chloroquine and its analogues with heme: an isothermal titration calorimetric study. Biochem Biophys Res Commun 276:1075-1079, 2000.
    • (2000) Biochem Biophys Res Commun , vol.276 , pp. 1075-1079
    • Bachhawat, K.1    Thomas, C.J.2    Surolia, N.3    Surolia, A.4
  • 3
    • 16844376016 scopus 로고    scopus 로고
    • Effectiveness of antimalarial drugs
    • Baird JK: Effectiveness of antimalarial drugs. N Engl J Med 352:1565-1577, 2005.
    • (2005) N Engl J Med , vol.352 , pp. 1565-1577
    • Baird, J.K.1
  • 4
    • 38449097771 scopus 로고    scopus 로고
    • Current antimalarial drugs recommended by the World Health Organization for the treatment and prevention of malaria
    • (Russian)
    • Baranova AM: [Current antimalarial drugs recommended by the World Health Organization for the treatment and prevention of malaria.] Med Parazitol (Mosk) 3:56-59, 2007 (Russian).
    • (2007) Med Parazitol (Mosk) , vol.3 , pp. 56-59
    • Baranova, A.M.1
  • 5
    • 2342638285 scopus 로고    scopus 로고
    • Cerebral uptake of mefloquine enantiomers with and without the P-gp inhibitor elacridar (GF1210918) in mice
    • Barraud de Lagerie S, Comets E, Gautrand C, Fernandez C, Auchere D, Singlas E, et al: Cerebral uptake of mefloquine enantiomers with and without the P-gp inhibitor elacridar (GF1210918) in mice. Br J Pharmacol 141:1214-1222, 2004.
    • (2004) Br J Pharmacol , vol.141 , pp. 1214-1222
    • Barraud de Lagerie, S.1    Comets, E.2    Gautrand, C.3    Fernandez, C.4    Auchere, D.5    Singlas, E.6
  • 6
    • 33847685719 scopus 로고    scopus 로고
    • Institutional experience with chloroquine as an adjuvant to the therapy for glioblastoma multiforme
    • Briceño E, Calderon A, Sotelo J: Institutional experience with chloroquine as an adjuvant to the therapy for glioblastoma multiforme. Surg Neurol 67:388-391, 2007.
    • (2007) Surg Neurol , vol.67 , pp. 388-391
    • Briceño, E.1    Calderon, A.2    Sotelo, J.3
  • 7
    • 0346729710 scopus 로고    scopus 로고
    • Stereoselectivity in the pharmacodynamics and pharmacokinetics of the chiral antimalarial drugs
    • Brocks DR, Mehvar R: Stereoselectivity in the pharmacodynamics and pharmacokinetics of the chiral antimalarial drugs. Clin Pharmacokinet 42:1359-1382, 2003.
    • (2003) Clin Pharmacokinet , vol.42 , pp. 1359-1382
    • Brocks, D.R.1    Mehvar, R.2
  • 9
  • 10
    • 38649134796 scopus 로고    scopus 로고
    • Mefloquine-induced disruption of calcium homeostasis in mammalian cells is similar to that induced by ionomycin
    • Caridha D, Yourick D, Cabezas M, Wolf L, Hudson TH, Dow GS: Mefloquine-induced disruption of calcium homeostasis in mammalian cells is similar to that induced by ionomycin. Antimicrob Agents Chemother 52:684-693, 2008.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 684-693
    • Caridha, D.1    Yourick, D.2    Cabezas, M.3    Wolf, L.4    Hudson, T.H.5    Dow, G.S.6
  • 11
    • 0034746828 scopus 로고    scopus 로고
    • Present trends and future strategy in chemotherapy of malaria
    • Chauhan PM, Srivastava SK: Present trends and future strategy in chemotherapy of malaria. Curr Med Chem 8:1535-1542, 2001.
    • (2001) Curr Med Chem , vol.8 , pp. 1535-1542
    • Chauhan, P.M.1    Srivastava, S.K.2
  • 12
    • 69349094578 scopus 로고    scopus 로고
    • Role and regulation of au-tophagy in cancer
    • Chen N, Karantza-Wadsworth V: Role and regulation of au-tophagy in cancer. Biochim Biophys Acta 1793:1516-1523, 2009.
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 1516-1523
    • Chen, N.1    Karantza-Wadsworth, V.2
  • 13
    • 67649398848 scopus 로고    scopus 로고
    • Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress
    • Cho HY, Thomas S, Golden EB, Gaffney KJ, Hofman FM, Chen TC, et al: Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress. Cancer Lett 282:87-97, 2009.
    • (2009) Cancer Lett , vol.282 , pp. 87-97
    • Cho, H.Y.1    Thomas, S.2    Golden, E.B.3    Gaffney, K.J.4    Hofman, F.M.5    Chen, T.C.6
  • 14
    • 84905663623 scopus 로고    scopus 로고
    • NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas
    • Cho HY, Wang W, Jhaveri N, Lee DJ, Sharma N, Dubeau L, et al: NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas. Mol Cancer Ther 13: 2004-2017, 2014.
    • (2014) Mol Cancer Ther , vol.13 , pp. 2004-2017
    • Cho, H.Y.1    Wang, W.2    Jhaveri, N.3    Lee, D.J.4    Sharma, N.5    Dubeau, L.6
  • 15
    • 53749104349 scopus 로고    scopus 로고
    • Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents
    • Degtyarev M, De Mazière A, Orr C, Lin J, Lee BB, Tien JY, et al: Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents. J Cell Biol 183:101-116, 2008.
    • (2008) J Cell Biol , vol.183 , pp. 101-116
    • Degtyarev, M.1    De Mazière, A.2    Orr, C.3    Lin, J.4    Lee, B.B.5    Tien, J.Y.6
  • 16
    • 26244436176 scopus 로고    scopus 로고
    • Transcriptional profiling of mefloquine-induced disruption of calcium homeostasis in neurons in vitro
    • Dow GS, Caridha D, Goldberg M, Wolf L, Koenig ML, Yourick DL, et al: Transcriptional profiling of mefloquine-induced disruption of calcium homeostasis in neurons in vitro. Genomics 86:539-550, 2005.
    • (2005) Genomics , vol.86 , pp. 539-550
    • Dow, G.S.1    Caridha, D.2    Goldberg, M.3    Wolf, L.4    Koenig, M.L.5    Yourick, D.L.6
  • 17
    • 0032900483 scopus 로고    scopus 로고
    • Detection and prevention of maculopathy associated with antimalarial agents
    • Easterbrook M: Detection and prevention of maculopathy associated with antimalarial agents. Int Ophthalmol Clin 39:49-57, 1999.
    • (1999) Int Ophthalmol Clin , vol.39 , pp. 49-57
    • Easterbrook, M.1
  • 19
    • 33745632805 scopus 로고    scopus 로고
    • Accelerated denaturation of hemoglobin and the antimalarial action of chloroquine
    • Fitch CD, Russell NV: Accelerated denaturation of hemoglobin and the antimalarial action of chloroquine. Antimicrob Agents Chemother 50:2415-2419, 2006.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 2415-2419
    • Fitch, C.D.1    Russell, N.V.2
  • 20
    • 33847692349 scopus 로고    scopus 로고
    • Structural analysis of the anti-malaria active agent chloroquine under physiological conditions
    • Frosch T, Schmitt M, Bringmann G, Kiefer W, Popp J: Structural analysis of the anti-malaria active agent chloroquine under physiological conditions. J Phys Chem B 111:1815-1822, 2007.
    • (2007) J Phys Chem B , vol.111 , pp. 1815-1822
    • Frosch, T.1    Schmitt, M.2    Bringmann, G.3    Kiefer, W.4    Popp, J.5
  • 21
    • 14644389457 scopus 로고    scopus 로고
    • A possible pharmacological explanation for quinacrine failure to treat prion diseases: pharmacokinetic investigations in a ovine model of scrapie
    • Gayrard V, Picard-Hagen N, Viguié C, Laroute V, Andréoletti O, Toutain PL: A possible pharmacological explanation for quinacrine failure to treat prion diseases: pharmacokinetic investigations in a ovine model of scrapie. Br J Pharmacol 144:386-393, 2005.
    • (2005) Br J Pharmacol , vol.144 , pp. 386-393
    • Gayrard, V.1    Picard-Hagen, N.2    Viguié, C.3    Laroute, V.4    Andréoletti, O.5    Toutain, P.L.6
  • 23
    • 51649117107 scopus 로고    scopus 로고
    • Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity
    • Hegi ME, Liu L, Herman JG, Stupp R, Wick W, Weller M, et al: Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity. J Clin Oncol 26:4189-4199, 2008.
    • (2008) J Clin Oncol , vol.26 , pp. 4189-4199
    • Hegi, M.E.1    Liu, L.2    Herman, J.G.3    Stupp, R.4    Wick, W.5    Weller, M.6
  • 24
    • 38849191201 scopus 로고    scopus 로고
    • Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib
    • Kardosh A, Golden EB, Pyrko P, Uddin J, Hofman FM, Chen TC, et al: Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib. Cancer Res 68:843-851, 2008.
    • (2008) Cancer Res , vol.68 , pp. 843-851
    • Kardosh, A.1    Golden, E.B.2    Pyrko, P.3    Uddin, J.4    Hofman, F.M.5    Chen, T.C.6
  • 25
    • 28844442877 scopus 로고    scopus 로고
    • Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib
    • Kardosh A, Soriano N, Liu YT, Uddin J, Petasis NA, Hofman FM, et al: Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib. Blood 106:4330-4338, 2005.
    • (2005) Blood , vol.106 , pp. 4330-4338
    • Kardosh, A.1    Soriano, N.2    Liu, Y.T.3    Uddin, J.4    Petasis, N.A.5    Hofman, F.M.6
  • 26
    • 46749085536 scopus 로고    scopus 로고
    • A new model for hemoglobin ingestion and transport by the human malaria parasite Plasmodium falciparum
    • Lazarus MD, Schneider TG, Taraschi TF: A new model for hemoglobin ingestion and transport by the human malaria parasite Plasmodium falciparum. J Cell Sci 121:1937-1949, 2008.
    • (2008) J Cell Sci , vol.121 , pp. 1937-1949
    • Lazarus, M.D.1    Schneider, T.G.2    Taraschi, T.F.3
  • 27
    • 65649150048 scopus 로고    scopus 로고
    • Pharmacokinetics of hydroxychloroquine and its clinical implications in chemoprophylaxis against malaria caused by Plasmodium vivax
    • Lim HS, Im JS, Cho JY, Bae KS, Klein TA, Yeom JS, et al: Pharmacokinetics of hydroxychloroquine and its clinical implications in chemoprophylaxis against malaria caused by Plasmodium vivax. Antimicrob Agents Chemother 53: 1468-1475, 2009.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 1468-1475
    • Lim, H.S.1    Im, J.S.2    Cho, J.Y.3    Bae, K.S.4    Klein, T.A.5    Yeom, J.S.6
  • 28
    • 33645789803 scopus 로고    scopus 로고
    • Mefloquine is highly efficacious against chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria in Papua, Indonesia
    • Maguire JD, Krisin, Marwoto H, Richie TL, Fryauff DJ, Baird JK: Mefloquine is highly efficacious against chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria in Papua, Indonesia. Clin Infect Dis 42:1067-1072, 2006.
    • (2006) Clin Infect Dis , vol.42 , pp. 1067-1072
    • Maguire, J.D.1    Krisin2    Marwoto, H.3    Richie, T.L.4    Fryauff, D.J.5    Baird, J.K.6
  • 29
    • 71049122853 scopus 로고    scopus 로고
    • Vacuolar ATPase-mediated cellular concentration and retention of quinacrine: a model for the distribution of lipophilic cationic drugs to autophagic vacuoles
    • Marceau F, Bawolak MT, Bouthillier J, Morissette G: Vacuolar ATPase-mediated cellular concentration and retention of quinacrine: a model for the distribution of lipophilic cationic drugs to autophagic vacuoles. Drug Metab Dispos 37:2271-2274, 2009.
    • (2009) Drug Metab Dispos , vol.37 , pp. 2271-2274
    • Marceau, F.1    Bawolak, M.T.2    Bouthillier, J.3    Morissette, G.4
  • 30
    • 65249187333 scopus 로고    scopus 로고
    • Enhancing immunity through autophagy
    • Münz C: Enhancing immunity through autophagy. Annu Rev Immunol 27:423-449, 2009.
    • (2009) Annu Rev Immunol , vol.27 , pp. 423-449
    • Münz, C.1
  • 31
    • 57649166494 scopus 로고    scopus 로고
    • Eating the enemy within: autophagy in infectious diseases
    • Orvedahl A, Levine B: Eating the enemy within: autophagy in infectious diseases. Cell Death Differ 16:57-69, 2009.
    • (2009) Cell Death Differ , vol.16 , pp. 57-69
    • Orvedahl, A.1    Levine, B.2
  • 33
    • 11144279334 scopus 로고    scopus 로고
    • Evidence for a substrate specific and inhibitable drug efflux system in chloroquine resistant Plasmodium falciparum strains
    • Sanchez CP, McLean JE, Stein W, Lanzer M: Evidence for a substrate specific and inhibitable drug efflux system in chloroquine resistant Plasmodium falciparum strains. Biochemistry 43:16365-16373, 2004.
    • (2004) Biochemistry , vol.43 , pp. 16365-16373
    • Sanchez, C.P.1    McLean, J.E.2    Stein, W.3    Lanzer, M.4
  • 34
    • 59349111783 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and autophagy as targets for cancer therapy
    • Schönthal AH: Endoplasmic reticulum stress and autophagy as targets for cancer therapy. Cancer Lett 275:163-169, 2009.
    • (2009) Cancer Lett , vol.275 , pp. 163-169
    • Schönthal, A.H.1
  • 35
    • 84866844292 scopus 로고    scopus 로고
    • Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent
    • Sharma N, Thomas S, Golden EB, Hofman FM, Chen TC, Petasis NA, et al: Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent. Cancer Lett 326:143-154, 2012.
    • (2012) Cancer Lett , vol.326 , pp. 143-154
    • Sharma, N.1    Thomas, S.2    Golden, E.B.3    Hofman, F.M.4    Chen, T.C.5    Petasis, N.A.6
  • 36
    • 0036173666 scopus 로고    scopus 로고
    • Apoptosis induced by adenovirus-mediated p53 gene transfer in human glioma correlates with site-specific phosphorylation
    • Shono T, Tofilon PJ, Schaefer TS, Parikh D, Liu TJ, Lang FF: Apoptosis induced by adenovirus-mediated p53 gene transfer in human glioma correlates with site-specific phosphorylation. Cancer Res 62:1069-1076, 2002.
    • (2002) Cancer Res , vol.62 , pp. 1069-1076
    • Shono, T.1    Tofilon, P.J.2    Schaefer, T.S.3    Parikh, D.4    Liu, T.J.5    Lang, F.F.6
  • 37
    • 0027315687 scopus 로고
    • Chloroquine: mechanism of drug action and resistance in Plasmodium falciparum
    • Slater AF: Chloroquine: mechanism of drug action and resistance in Plasmodium falciparum. Pharmacol Ther 57:203-235, 1993.
    • (1993) Pharmacol Ther , vol.57 , pp. 203-235
    • Slater, A.F.1
  • 39
    • 64649085325 scopus 로고    scopus 로고
    • Autophagy and cancer: dynamism of the metabolism of tumor cells and tissues
    • Tsuchihara K, Fujii S, Esumi H: Autophagy and cancer: dynamism of the metabolism of tumor cells and tissues. Cancer Lett 278:130-138, 2009.
    • (2009) Cancer Lett , vol.278 , pp. 130-138
    • Tsuchihara, K.1    Fujii, S.2    Esumi, H.3
  • 40
    • 3042555873 scopus 로고    scopus 로고
    • The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids
    • Warhurst DC, Craig JC, Adagu IS, Meyer DJ, Lee SY: The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids. Malar J 2:26, 2003.
    • (2003) Malar J , vol.2 , pp. 26
    • Warhurst, D.C.1    Craig, J.C.2    Adagu, I.S.3    Meyer, D.J.4    Lee, S.Y.5
  • 41
    • 0025883963 scopus 로고
    • Antimalarial activity of optical isomers of quinacrine dihydrochloride against chloroquine-sensitive and-resistant Plasmodium falciparum in vitro
    • Webster RV, Craig JC, Shyamala V, Kirby GC, Warhurst DC: Antimalarial activity of optical isomers of quinacrine dihydrochloride against chloroquine-sensitive and-resistant Plasmodium falciparum in vitro. Biochem Pharmacol 42 Suppl:S225-S227, 1991.
    • (1991) Biochem Pharmacol , vol.42 , pp. S225-S227
    • Webster, R.V.1    Craig, J.C.2    Shyamala, V.3    Kirby, G.C.4    Warhurst, D.C.5
  • 42
    • 0037784052 scopus 로고    scopus 로고
    • Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion
    • Zagzag D, Nomura M, Friedlander DR, Blanco CY, Gagner JP, Nomura N, et al: Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion. J Cell Physiol 196:394-402, 2003.
    • (2003) J Cell Physiol , vol.196 , pp. 394-402
    • Zagzag, D.1    Nomura, M.2    Friedlander, D.R.3    Blanco, C.Y.4    Gagner, J.P.5    Nomura, N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.