-
1
-
-
33846794896
-
Autophagy inhibition enhances therapyinduced apoptosis in a Myc-induced model of lymphoma
-
Amaravadi RK, Yu D, Lum JJ, Bui T, Christophorou MA, Evan GI, et al: Autophagy inhibition enhances therapyinduced apoptosis in a Myc-induced model of lymphoma. J Clin Invest 117:326-336, 2007.
-
(2007)
J Clin Invest
, vol.117
, pp. 326-336
-
-
Amaravadi, R.K.1
Yu, D.2
Lum, J.J.3
Bui, T.4
Christophorou, M.A.5
Evan, G.I.6
-
2
-
-
0034610012
-
Interaction of chloroquine and its analogues with heme: an isothermal titration calorimetric study
-
Bachhawat K, Thomas CJ, Surolia N, Surolia A: Interaction of chloroquine and its analogues with heme: an isothermal titration calorimetric study. Biochem Biophys Res Commun 276:1075-1079, 2000.
-
(2000)
Biochem Biophys Res Commun
, vol.276
, pp. 1075-1079
-
-
Bachhawat, K.1
Thomas, C.J.2
Surolia, N.3
Surolia, A.4
-
3
-
-
16844376016
-
Effectiveness of antimalarial drugs
-
Baird JK: Effectiveness of antimalarial drugs. N Engl J Med 352:1565-1577, 2005.
-
(2005)
N Engl J Med
, vol.352
, pp. 1565-1577
-
-
Baird, J.K.1
-
4
-
-
38449097771
-
Current antimalarial drugs recommended by the World Health Organization for the treatment and prevention of malaria
-
(Russian)
-
Baranova AM: [Current antimalarial drugs recommended by the World Health Organization for the treatment and prevention of malaria.] Med Parazitol (Mosk) 3:56-59, 2007 (Russian).
-
(2007)
Med Parazitol (Mosk)
, vol.3
, pp. 56-59
-
-
Baranova, A.M.1
-
5
-
-
2342638285
-
Cerebral uptake of mefloquine enantiomers with and without the P-gp inhibitor elacridar (GF1210918) in mice
-
Barraud de Lagerie S, Comets E, Gautrand C, Fernandez C, Auchere D, Singlas E, et al: Cerebral uptake of mefloquine enantiomers with and without the P-gp inhibitor elacridar (GF1210918) in mice. Br J Pharmacol 141:1214-1222, 2004.
-
(2004)
Br J Pharmacol
, vol.141
, pp. 1214-1222
-
-
Barraud de Lagerie, S.1
Comets, E.2
Gautrand, C.3
Fernandez, C.4
Auchere, D.5
Singlas, E.6
-
6
-
-
33847685719
-
Institutional experience with chloroquine as an adjuvant to the therapy for glioblastoma multiforme
-
Briceño E, Calderon A, Sotelo J: Institutional experience with chloroquine as an adjuvant to the therapy for glioblastoma multiforme. Surg Neurol 67:388-391, 2007.
-
(2007)
Surg Neurol
, vol.67
, pp. 388-391
-
-
Briceño, E.1
Calderon, A.2
Sotelo, J.3
-
7
-
-
0346729710
-
Stereoselectivity in the pharmacodynamics and pharmacokinetics of the chiral antimalarial drugs
-
Brocks DR, Mehvar R: Stereoselectivity in the pharmacodynamics and pharmacokinetics of the chiral antimalarial drugs. Clin Pharmacokinet 42:1359-1382, 2003.
-
(2003)
Clin Pharmacokinet
, vol.42
, pp. 1359-1382
-
-
Brocks, D.R.1
Mehvar, R.2
-
8
-
-
56749178706
-
Cell death and autophagy: cytokines, drugs, and nutritional factors
-
Bursch W, Karwan A, Mayer M, Dornetshuber J, Fröhwein U, Schulte-Hermann R, et al: Cell death and autophagy: cytokines, drugs, and nutritional factors. Toxicology 254:147-157, 2008.
-
(2008)
Toxicology
, vol.254
, pp. 147-157
-
-
Bursch, W.1
Karwan, A.2
Mayer, M.3
Dornetshuber, J.4
Fröhwein, U.5
Schulte-Hermann, R.6
-
10
-
-
38649134796
-
Mefloquine-induced disruption of calcium homeostasis in mammalian cells is similar to that induced by ionomycin
-
Caridha D, Yourick D, Cabezas M, Wolf L, Hudson TH, Dow GS: Mefloquine-induced disruption of calcium homeostasis in mammalian cells is similar to that induced by ionomycin. Antimicrob Agents Chemother 52:684-693, 2008.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 684-693
-
-
Caridha, D.1
Yourick, D.2
Cabezas, M.3
Wolf, L.4
Hudson, T.H.5
Dow, G.S.6
-
11
-
-
0034746828
-
Present trends and future strategy in chemotherapy of malaria
-
Chauhan PM, Srivastava SK: Present trends and future strategy in chemotherapy of malaria. Curr Med Chem 8:1535-1542, 2001.
-
(2001)
Curr Med Chem
, vol.8
, pp. 1535-1542
-
-
Chauhan, P.M.1
Srivastava, S.K.2
-
12
-
-
69349094578
-
Role and regulation of au-tophagy in cancer
-
Chen N, Karantza-Wadsworth V: Role and regulation of au-tophagy in cancer. Biochim Biophys Acta 1793:1516-1523, 2009.
-
(2009)
Biochim Biophys Acta
, vol.1793
, pp. 1516-1523
-
-
Chen, N.1
Karantza-Wadsworth, V.2
-
13
-
-
67649398848
-
Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress
-
Cho HY, Thomas S, Golden EB, Gaffney KJ, Hofman FM, Chen TC, et al: Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress. Cancer Lett 282:87-97, 2009.
-
(2009)
Cancer Lett
, vol.282
, pp. 87-97
-
-
Cho, H.Y.1
Thomas, S.2
Golden, E.B.3
Gaffney, K.J.4
Hofman, F.M.5
Chen, T.C.6
-
14
-
-
84905663623
-
NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas
-
Cho HY, Wang W, Jhaveri N, Lee DJ, Sharma N, Dubeau L, et al: NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas. Mol Cancer Ther 13: 2004-2017, 2014.
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 2004-2017
-
-
Cho, H.Y.1
Wang, W.2
Jhaveri, N.3
Lee, D.J.4
Sharma, N.5
Dubeau, L.6
-
15
-
-
53749104349
-
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents
-
Degtyarev M, De Mazière A, Orr C, Lin J, Lee BB, Tien JY, et al: Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents. J Cell Biol 183:101-116, 2008.
-
(2008)
J Cell Biol
, vol.183
, pp. 101-116
-
-
Degtyarev, M.1
De Mazière, A.2
Orr, C.3
Lin, J.4
Lee, B.B.5
Tien, J.Y.6
-
16
-
-
26244436176
-
Transcriptional profiling of mefloquine-induced disruption of calcium homeostasis in neurons in vitro
-
Dow GS, Caridha D, Goldberg M, Wolf L, Koenig ML, Yourick DL, et al: Transcriptional profiling of mefloquine-induced disruption of calcium homeostasis in neurons in vitro. Genomics 86:539-550, 2005.
-
(2005)
Genomics
, vol.86
, pp. 539-550
-
-
Dow, G.S.1
Caridha, D.2
Goldberg, M.3
Wolf, L.4
Koenig, M.L.5
Yourick, D.L.6
-
17
-
-
0032900483
-
Detection and prevention of maculopathy associated with antimalarial agents
-
Easterbrook M: Detection and prevention of maculopathy associated with antimalarial agents. Int Ophthalmol Clin 39:49-57, 1999.
-
(1999)
Int Ophthalmol Clin
, vol.39
, pp. 49-57
-
-
Easterbrook, M.1
-
18
-
-
40649122026
-
Four distinct pathways of hemoglobin uptake in the malaria parasite Plasmodium falciparum
-
Elliott DA, McIntosh MT, Hosgood HD III, Chen S, Zhang G, Baevova P, et al: Four distinct pathways of hemoglobin uptake in the malaria parasite Plasmodium falciparum. Proc Natl Acad Sci U S A 105:2463-2468, 2008.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 2463-2468
-
-
Elliott, D.A.1
McIntosh, M.T.2
Hosgood, H.D.3
Chen, S.4
Zhang, G.5
Baevova, P.6
-
19
-
-
33745632805
-
Accelerated denaturation of hemoglobin and the antimalarial action of chloroquine
-
Fitch CD, Russell NV: Accelerated denaturation of hemoglobin and the antimalarial action of chloroquine. Antimicrob Agents Chemother 50:2415-2419, 2006.
-
(2006)
Antimicrob Agents Chemother
, vol.50
, pp. 2415-2419
-
-
Fitch, C.D.1
Russell, N.V.2
-
20
-
-
33847692349
-
Structural analysis of the anti-malaria active agent chloroquine under physiological conditions
-
Frosch T, Schmitt M, Bringmann G, Kiefer W, Popp J: Structural analysis of the anti-malaria active agent chloroquine under physiological conditions. J Phys Chem B 111:1815-1822, 2007.
-
(2007)
J Phys Chem B
, vol.111
, pp. 1815-1822
-
-
Frosch, T.1
Schmitt, M.2
Bringmann, G.3
Kiefer, W.4
Popp, J.5
-
21
-
-
14644389457
-
A possible pharmacological explanation for quinacrine failure to treat prion diseases: pharmacokinetic investigations in a ovine model of scrapie
-
Gayrard V, Picard-Hagen N, Viguié C, Laroute V, Andréoletti O, Toutain PL: A possible pharmacological explanation for quinacrine failure to treat prion diseases: pharmacokinetic investigations in a ovine model of scrapie. Br J Pharmacol 144:386-393, 2005.
-
(2005)
Br J Pharmacol
, vol.144
, pp. 386-393
-
-
Gayrard, V.1
Picard-Hagen, N.2
Viguié, C.3
Laroute, V.4
Andréoletti, O.5
Toutain, P.L.6
-
22
-
-
33646336877
-
Conventional and experimental treatment of cerebral malaria
-
Golenser J, McQuillan J, Hee L, Mitchell AJ, Hunt NH: Conventional and experimental treatment of cerebral malaria. Int J Parasitol 36:583-593, 2006.
-
(2006)
Int J Parasitol
, vol.36
, pp. 583-593
-
-
Golenser, J.1
McQuillan, J.2
Hee, L.3
Mitchell, A.J.4
Hunt, N.H.5
-
23
-
-
51649117107
-
Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity
-
Hegi ME, Liu L, Herman JG, Stupp R, Wick W, Weller M, et al: Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity. J Clin Oncol 26:4189-4199, 2008.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4189-4199
-
-
Hegi, M.E.1
Liu, L.2
Herman, J.G.3
Stupp, R.4
Wick, W.5
Weller, M.6
-
24
-
-
38849191201
-
Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib
-
Kardosh A, Golden EB, Pyrko P, Uddin J, Hofman FM, Chen TC, et al: Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib. Cancer Res 68:843-851, 2008.
-
(2008)
Cancer Res
, vol.68
, pp. 843-851
-
-
Kardosh, A.1
Golden, E.B.2
Pyrko, P.3
Uddin, J.4
Hofman, F.M.5
Chen, T.C.6
-
25
-
-
28844442877
-
Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib
-
Kardosh A, Soriano N, Liu YT, Uddin J, Petasis NA, Hofman FM, et al: Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib. Blood 106:4330-4338, 2005.
-
(2005)
Blood
, vol.106
, pp. 4330-4338
-
-
Kardosh, A.1
Soriano, N.2
Liu, Y.T.3
Uddin, J.4
Petasis, N.A.5
Hofman, F.M.6
-
26
-
-
46749085536
-
A new model for hemoglobin ingestion and transport by the human malaria parasite Plasmodium falciparum
-
Lazarus MD, Schneider TG, Taraschi TF: A new model for hemoglobin ingestion and transport by the human malaria parasite Plasmodium falciparum. J Cell Sci 121:1937-1949, 2008.
-
(2008)
J Cell Sci
, vol.121
, pp. 1937-1949
-
-
Lazarus, M.D.1
Schneider, T.G.2
Taraschi, T.F.3
-
27
-
-
65649150048
-
Pharmacokinetics of hydroxychloroquine and its clinical implications in chemoprophylaxis against malaria caused by Plasmodium vivax
-
Lim HS, Im JS, Cho JY, Bae KS, Klein TA, Yeom JS, et al: Pharmacokinetics of hydroxychloroquine and its clinical implications in chemoprophylaxis against malaria caused by Plasmodium vivax. Antimicrob Agents Chemother 53: 1468-1475, 2009.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 1468-1475
-
-
Lim, H.S.1
Im, J.S.2
Cho, J.Y.3
Bae, K.S.4
Klein, T.A.5
Yeom, J.S.6
-
28
-
-
33645789803
-
Mefloquine is highly efficacious against chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria in Papua, Indonesia
-
Maguire JD, Krisin, Marwoto H, Richie TL, Fryauff DJ, Baird JK: Mefloquine is highly efficacious against chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria in Papua, Indonesia. Clin Infect Dis 42:1067-1072, 2006.
-
(2006)
Clin Infect Dis
, vol.42
, pp. 1067-1072
-
-
Maguire, J.D.1
Krisin2
Marwoto, H.3
Richie, T.L.4
Fryauff, D.J.5
Baird, J.K.6
-
29
-
-
71049122853
-
Vacuolar ATPase-mediated cellular concentration and retention of quinacrine: a model for the distribution of lipophilic cationic drugs to autophagic vacuoles
-
Marceau F, Bawolak MT, Bouthillier J, Morissette G: Vacuolar ATPase-mediated cellular concentration and retention of quinacrine: a model for the distribution of lipophilic cationic drugs to autophagic vacuoles. Drug Metab Dispos 37:2271-2274, 2009.
-
(2009)
Drug Metab Dispos
, vol.37
, pp. 2271-2274
-
-
Marceau, F.1
Bawolak, M.T.2
Bouthillier, J.3
Morissette, G.4
-
30
-
-
65249187333
-
Enhancing immunity through autophagy
-
Münz C: Enhancing immunity through autophagy. Annu Rev Immunol 27:423-449, 2009.
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 423-449
-
-
Münz, C.1
-
31
-
-
57649166494
-
Eating the enemy within: autophagy in infectious diseases
-
Orvedahl A, Levine B: Eating the enemy within: autophagy in infectious diseases. Cell Death Differ 16:57-69, 2009.
-
(2009)
Cell Death Differ
, vol.16
, pp. 57-69
-
-
Orvedahl, A.1
Levine, B.2
-
32
-
-
0032896317
-
Cerebral uptake of mefloquine enantiomers in fatal cerebral malaria
-
Pham YT, Nosten F, Farinotti R, White NJ, Gimenez F: Cerebral uptake of mefloquine enantiomers in fatal cerebral malaria. Int J Clin Pharmacol Ther 37:58-61, 1999.
-
(1999)
Int J Clin Pharmacol Ther
, vol.37
, pp. 58-61
-
-
Pham, Y.T.1
Nosten, F.2
Farinotti, R.3
White, N.J.4
Gimenez, F.5
-
33
-
-
11144279334
-
Evidence for a substrate specific and inhibitable drug efflux system in chloroquine resistant Plasmodium falciparum strains
-
Sanchez CP, McLean JE, Stein W, Lanzer M: Evidence for a substrate specific and inhibitable drug efflux system in chloroquine resistant Plasmodium falciparum strains. Biochemistry 43:16365-16373, 2004.
-
(2004)
Biochemistry
, vol.43
, pp. 16365-16373
-
-
Sanchez, C.P.1
McLean, J.E.2
Stein, W.3
Lanzer, M.4
-
34
-
-
59349111783
-
Endoplasmic reticulum stress and autophagy as targets for cancer therapy
-
Schönthal AH: Endoplasmic reticulum stress and autophagy as targets for cancer therapy. Cancer Lett 275:163-169, 2009.
-
(2009)
Cancer Lett
, vol.275
, pp. 163-169
-
-
Schönthal, A.H.1
-
35
-
-
84866844292
-
Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent
-
Sharma N, Thomas S, Golden EB, Hofman FM, Chen TC, Petasis NA, et al: Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent. Cancer Lett 326:143-154, 2012.
-
(2012)
Cancer Lett
, vol.326
, pp. 143-154
-
-
Sharma, N.1
Thomas, S.2
Golden, E.B.3
Hofman, F.M.4
Chen, T.C.5
Petasis, N.A.6
-
36
-
-
0036173666
-
Apoptosis induced by adenovirus-mediated p53 gene transfer in human glioma correlates with site-specific phosphorylation
-
Shono T, Tofilon PJ, Schaefer TS, Parikh D, Liu TJ, Lang FF: Apoptosis induced by adenovirus-mediated p53 gene transfer in human glioma correlates with site-specific phosphorylation. Cancer Res 62:1069-1076, 2002.
-
(2002)
Cancer Res
, vol.62
, pp. 1069-1076
-
-
Shono, T.1
Tofilon, P.J.2
Schaefer, T.S.3
Parikh, D.4
Liu, T.J.5
Lang, F.F.6
-
37
-
-
0027315687
-
Chloroquine: mechanism of drug action and resistance in Plasmodium falciparum
-
Slater AF: Chloroquine: mechanism of drug action and resistance in Plasmodium falciparum. Pharmacol Ther 57:203-235, 1993.
-
(1993)
Pharmacol Ther
, vol.57
, pp. 203-235
-
-
Slater, A.F.1
-
38
-
-
46049107832
-
TROSY-based NMR evidence for a novel class of 20S proteasome inhibitors
-
Sprangers R, Li X, Mao X, Rubinstein JL, Schimmer AD, Kay LE: TROSY-based NMR evidence for a novel class of 20S proteasome inhibitors. Biochemistry 47:6727-6734, 2008.
-
(2008)
Biochemistry
, vol.47
, pp. 6727-6734
-
-
Sprangers, R.1
Li, X.2
Mao, X.3
Rubinstein, J.L.4
Schimmer, A.D.5
Kay, L.E.6
-
39
-
-
64649085325
-
Autophagy and cancer: dynamism of the metabolism of tumor cells and tissues
-
Tsuchihara K, Fujii S, Esumi H: Autophagy and cancer: dynamism of the metabolism of tumor cells and tissues. Cancer Lett 278:130-138, 2009.
-
(2009)
Cancer Lett
, vol.278
, pp. 130-138
-
-
Tsuchihara, K.1
Fujii, S.2
Esumi, H.3
-
40
-
-
3042555873
-
The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids
-
Warhurst DC, Craig JC, Adagu IS, Meyer DJ, Lee SY: The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids. Malar J 2:26, 2003.
-
(2003)
Malar J
, vol.2
, pp. 26
-
-
Warhurst, D.C.1
Craig, J.C.2
Adagu, I.S.3
Meyer, D.J.4
Lee, S.Y.5
-
41
-
-
0025883963
-
Antimalarial activity of optical isomers of quinacrine dihydrochloride against chloroquine-sensitive and-resistant Plasmodium falciparum in vitro
-
Webster RV, Craig JC, Shyamala V, Kirby GC, Warhurst DC: Antimalarial activity of optical isomers of quinacrine dihydrochloride against chloroquine-sensitive and-resistant Plasmodium falciparum in vitro. Biochem Pharmacol 42 Suppl:S225-S227, 1991.
-
(1991)
Biochem Pharmacol
, vol.42
, pp. S225-S227
-
-
Webster, R.V.1
Craig, J.C.2
Shyamala, V.3
Kirby, G.C.4
Warhurst, D.C.5
-
42
-
-
0037784052
-
Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion
-
Zagzag D, Nomura M, Friedlander DR, Blanco CY, Gagner JP, Nomura N, et al: Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion. J Cell Physiol 196:394-402, 2003.
-
(2003)
J Cell Physiol
, vol.196
, pp. 394-402
-
-
Zagzag, D.1
Nomura, M.2
Friedlander, D.R.3
Blanco, C.Y.4
Gagner, J.P.5
Nomura, N.6
|