Hypoxic activation of the PERK/eIF2α arm of the unfolded protein response promotes metastasis through induction of LAMP3

Clinical Cancer Research

Volumn 19, Issue 22, 2013, Pages 6126-6137

  Mujcic, Hilda ^a,d   Nagelkerke, Anika ^e   Rouschop, Kasper M A ^d   Chung, Stephen ^a   Chaudary, Naz ^a   Span, Paul N ^e   Clarke, Blaise ^b   Milosevic, Michael ^b   Sykes, Jenna ^a   Hill, Richard P ^a,b   Koritzinsky, Marianne ^a,b,c   Wouters, Bradly G ^a,b  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b Department of Laboratory Medicine and Pathobiology ^*  (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^e RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DENDRITIC CELL LYSOSOME ASSOCIATED MEMBRANE PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ELF 2ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENESIS; CELL MIGRATION; CONTROLLED STUDY; FEMALE; GENE ACTIVATION; GENE AMPLIFICATION; GENE FUNCTION; GENE INDUCTION; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXEMIA; LAMP3 GENE; LYMPH NODE METASTASIS; PRIMARY TUMOR; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TISSUE OXYGENATION; TUMOR GENE; UNFOLDED PROTEIN RESPONSE; UTERINE CERVIX CARCINOMA;

ANIMALS; CELL HYPOXIA; CELL LINE, TUMOR; CELL MOVEMENT; DNA COPY NUMBER VARIATIONS; EIF-2 KINASE; EUKARYOTIC INITIATION FACTOR-2; FEMALE; GENE DOSAGE; HUMANS; LYMPHATIC METASTASIS; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; MICE; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; PROTEIN PHOSPHATASE 1; SIGNAL TRANSDUCTION; TRANSPLANTATION, HETEROLOGOUS; UNFOLDED PROTEIN RESPONSE; UTERINE CERVICAL NEOPLASMS;

EID: 84888096859     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-0526     Document Type: Article

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