STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation

Cell Reports

Volumn 16, Issue 11, 2016, Pages 2914-2927

  Yan, Dongyao ^a   Wang, Hao Wei ^a   Bowman, Robert L ^a   Joyce, Johanna A ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; PROTEIN IRE1; PROTEIN IRE1ALPHA; STAT3 PROTEIN; STAT6 PROTEIN; UNCLASSIFIED DRUG; CYTOKINE; ERN1 PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE; RIBONUCLEASE; STAT6 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CARCINOGENESIS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME INDUCTION; ENZYME RELEASE; GENE DELETION; GENE EXPRESSION REGULATION; GENE INDUCTION; IN VIVO STUDY; INTRACELLULAR SIGNALING; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PANCREATIC NEUROENDOCRINE TUMOR; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TH2 CELL; TRANSCRIPTION REGULATION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR GROWTH; TUMOR INVASION; TUMOR MICROENVIRONMENT; TUMOR PROMOTION; UNFOLDED PROTEIN RESPONSE; ANIMAL; DRUG EFFECTS; GENETIC TRANSCRIPTION; GENETICS; MACROPHAGE; METABOLISM; PATHOLOGY; PHENOTYPE; SECRETION (PROCESS);

ANIMALS; CARCINOGENESIS; CATHEPSINS; CYTOKINES; ENDORIBONUCLEASES; GENE DELETION; GENE EXPRESSION REGULATION; MACROPHAGES; MICE; NEOPLASM INVASIVENESS; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; STAT6 TRANSCRIPTION FACTOR; TH2 CELLS; TRANSCRIPTION, GENETIC; UNFOLDED PROTEIN RESPONSE;

EID: 84991706068     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.08.035     Document Type: Article

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