Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

eLife

Volumn 5, Issue 2016JULY, 2016, Pages

  Plate, Lars ^a   Cooley, Christina B ^a   Chen, John J ^a   Paxman, Ryan J ^a   Gallagher, Ciara M ^b   Madoux, Franck ^a,c   Genereux, Joseph C ^a   Dobbs, Wesley ^d   Garza, Dan ^d   Spicer, Timothy P ^a,c   Scampavia, Louis ^a,c   Brown, Steven J ^a   Rosen, Hugh ^a   Powers, Evan T ^a   Walter, Peter ^b   Hodder, Peter ^a,c   Luke Wiseman, R ^a   Kelly, Jeffery W ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c Translational Research Institute   (United States)

^d Proteostasis Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; SULFUR 35;

ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION PROFILING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MULTIPLEX POLYMERASE CHAIN REACTION; NUCLEAR REPROGRAMMING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN AGGREGATION; PROTEIN HOMEOSTASIS; PROTEIN LOCALIZATION; PROTEOMICS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; BIOSYNTHESIS; CELL LINE; DRUG EFFECTS; PRECLINICAL STUDY; PROCEDURES; PROTEINOSIS; UNFOLDED PROTEIN RESPONSE;

ACTIVATING TRANSCRIPTION FACTOR 6; CELL LINE; DRUG EVALUATION, PRECLINICAL; HUMANS; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEOSTASIS; UNFOLDED PROTEIN RESPONSE;

EID: 84979515521     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.15550     Document Type: Article

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