Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 16, 2011, Pages 6561-6566

  Mahadevan, Navin R ^a   Rodvold, Jeffrey ^a   Sepulveda, Homero ^b   Rossi, Steven ^c   Drew, Angela F ^d   Zanetti, Maurizio ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b BD BIOSCIENCES   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INTERLEUKIN 6 RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE PRODUCTION; ENDOPLASMIC RETICULUM STRESS; INFLAMMATION; LIVER; MACROPHAGE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SPLICING DEFECT; TUMOR CELL; TUMOR GROWTH; UPREGULATION;

ANIMALS; CELL LINE, TUMOR; CULTURE MEDIA, CONDITIONED; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION, NEOPLASTIC; LIVER; MACROPHAGES; MICE; MICE, KNOCKOUT; NEOPLASM PROTEINS; NEOPLASMS; UNFOLDED PROTEIN RESPONSE;

MUS;

EID: 79955632933     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1008942108     Document Type: Article

References (38)

1. Serafini P, Borrello I, Bronte V (2006) Myeloid suppressor cells in cancer: Recruitment, phenotype, properties, and mechanisms of immune suppression. Semin Cancer Biol 16:53-65. (Pubitemid 43139709)
2. Grivennikov SI, Greten FR, Karin M (2010) Immunity, inflammation, and cancer. Cell 140:883-899.
3. Pikarsky E, et al. (2004) NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 431:461-466. (Pubitemid 39329586)
4. Greten FR, et al. (2004) IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118:285-296. (Pubitemid 39061110)
5. Ammirante M, Luo JL, Grivennikov S, Nedospasov S, Karin M (2010) B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature 464:302-305.
6. Kim S, et al. (2009) Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature 457:102-106.
7. Harding HP, Calfon M, Urano F, Novoa I, Ron D (2002) Transcriptional and translational control in the Mammalian unfolded protein response. Annu Rev Cell Dev Biol 18:575-599. (Pubitemid 35387362)
8. Schröder M, Kaufman RJ (2005) ER stress and the unfolded protein response. Mutat Res 569:29-63. (Pubitemid 39643256)
9. Lee AH, Iwakoshi NN, Glimcher LH (2003) XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 23:7448-7459. (Pubitemid 37271447)
10. Ma Y, Hendershot LM (2004) The role of the unfolded protein response in tumour development: Friend or foe? Nat Rev Cancer 4:966-977.
11. Bi M, et al. (2005) ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J 24:3470-3481. (Pubitemid 41486784)
12. Daneshmand S, et al. (2007) Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival. Hum Pathol 38: 1547-1552. (Pubitemid 47418966)
13. Fu Y, et al. (2008) Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium. Proc Natl Acad Sci USA 105:19444-19449.
14. Romero-Ramirez L, et al. (2009) X box-binding protein 1 regulates angiogenesis in human pancreatic adenocarcinomas. Transl Oncol 2:31-38.
15. Goodall JC, et al. (2010) Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression. Proc Natl Acad Sci USA 107: 17698-17703.
16. Wheeler MC, et al. (2008) KDEL-retained antigen in B lymphocytes induces a proinflammatory response: A possible role for endoplasmic reticulum stress in adaptive T cell immunity. J Immunol 181:256-264.
17. Thastrup O, Cullen PJ, Drøbak BK, Hanley MR, Dawson AP (1990) Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase. Proc Natl Acad Sci USA 87:2466-2470.
18. Mahadevan NR, Fernandez A, Rodvold J, Almanza G, Zanetti M (2010) Prostate cells undergioing ER stress in vitro and in vivo activate transcription of pro-inflammatory cytokines. J Inflam Res. 3:99-103.
19. Spiotto MT, et al. (2010) Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth. Cancer Res 70:78-88.
20. Driscoll KE (1994) Macrophage inflammatory proteins: Biology and role in pulmonary inflammation. Exp Lung Res 20:473-490.
21. Kuhlicke J, Frick JS, Morote-Garcia JC, Rosenberger P, Eltzschig HK (2007) Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia. PLoS ONE 2:e1364.
22. Benson SA, Ernst JD (2009) TLR2-dependent inhibition of macrophage responses to IFN-gamma is mediated by distinct, gene-specific mechanisms. PLoS ONE 4:e6329.
23. Puliti M, Uematsu S, Akira S, Bistoni F, Tissi L (2009) Toll-like receptor 2 deficiency is associated with enhanced severity of group B streptococcal disease. Infect Immun 77: 1524-1531.
24. Martinon F, Chen X, Lee AH, Glimcher LH (2010) TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol 11: 411-418.
25. DeLay ML, et al. (2009) HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats. Arthritis Rheum 60:2633-2643.
26. Miller MB, Bassler BL (2001) Quorum sensing in bacteria. Annu Rev Microbiol 55: 165-199. (Pubitemid 32978104)
27. Qin S, et al. (1993) "Infectious" transplantation tolerance. Science 259:974-977.
28. Burikhanov R, et al. (2009) The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis. Cell 138:377-388.
29. Erridge C (2010) Endogenous ligands of TLR2 and TLR4: Agonists or assistants? J Leukoc Biol 87:989-999.
30. Allavena P, Sica A, Garlanda C, Mantovani A (2008) The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance. Immunol Rev 222: 155-161. (Pubitemid 351430369)
31. Mantovani A, Sozzani S, Locati M, Allavena P, Sica A (2002) Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 23:549-555. (Pubitemid 35223554)
32. Schenk S, Saberi M, Olefsky JM (2008) Insulin sensitivity: Modulation by nutrients and inflammation. J Clin Invest 118:2992-3002.
33. Jamora C, Dennert G, Lee AS (1996) Inhibition of tumor progression by suppression of stress protein GRP78/BiP induction in fibrosarcoma B/C10ME. Proc Natl Acad Sci USA 93:7690-7694. (Pubitemid 26277098)
34. Langowski JL, et al. (2006) IL-23 promotes tumour incidence and growth. Nature 442: 461-465. (Pubitemid 44264796)
35. Teng MW, et al. (2010) IL-23 suppresses innate immune response independently of IL- 17A during carcinogenesis and metastasis. Proc Natl Acad Sci USA 107:8328-8333.
36. Kortylewski M, et al. (2009) Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment. Cancer Cell 15:114-123.
37. McFarland-Mancini MM, et al. (2010) Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor. J Immunol 184:7219-7228.
38. Zhang X, Goncalves R, Mosser DM (November 1, 2008) Unit 14 11. The isolation and characterization of murine macrophages. Current Protocols in Immunology, 10.1002/ 0471142735.im1401s83.