Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

Trends in Immunology

Volumn 23, Issue 11, 2002, Pages 549-555

  Mantovani, Alberto ^a,b   Sozzani, Silvano ^a,c   Locati, Massimo ^b   Allavena, Paola ^a   Sica, Antonio ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF BRESCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13;

ANGIOGENESIS; ANIMAL CELL; CELL MATURATION; CELL TYPE; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNITY; MACROPHAGE; MONONUCLEAR PHAGOCYTE; NONHUMAN; PASSIVE IMMUNIZATION; PHENOTYPE; POLARIZATION; REVIEW; T LYMPHOCYTE; TUMOR ASSOCIATED LEUKOCYTE; TUMOR DIFFERENTIATION; TUMOR GROWTH;

ANIMALS; CELL DIFFERENTIATION; CHEMOKINES; CYTOKINES; HUMANS; MACROPHAGE ACTIVATION; MACROPHAGES; MODELS, IMMUNOLOGICAL; NEOPLASMS; PHAGOCYTES; SIGNAL TRANSDUCTION;

EID: 0036839143     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(02)02302-5     Document Type: Review

References (74)

1. Stein M., et al. Interleukin-4 potently enhances murine mannose receptor activity: a marker of alternative immunologic macrophage activation. J. Exp. Med. 176:1992;287-292.
2. Goerdt S., et al. Other functions, other genes: alternative activation of antigen-presenting cells. Immunity. 10:1999;137-142.
3. Mantovani A., et al. The origin and function of tumor-associated macrophages. Immunol. Today. 13:1992;265-270.
4. Balkwill F., et al. Inflammation and cancer: back to Virchow? Lancet. 357:2001;539-545.
5. Mills C.D., et al. M-1/M-2 macrophages and the Th1/Th2 paradigm. J. Immunol. 164:2000;6166-6173.
6. Hamilton, T.A. (2002) Molecular basis of macrophage activation: from gene expression to phenotypic diversity. In The Macrophage, 2nd Edition (Bourke, B.L., C., ed.), Oxford University Press, Oxford, UK (in press)
7. Mantovani A. The chemokine system: redundancy for robust outputs. Immunol. Today. 20:1999;254-257.
8. Watanabe K., et al. Eotaxin-2 generation is differentially regulated by lipopolysaccharide and IL-4 in monocytes and macrophages. J. Immunol. 168:2002;1911-1918.
9. Bonecchi R., et al. Divergent effects of IL-4 and interferon-γ on macrophage-derived chemokine (MDC) production: an amplification circuit of polarized T helper 2 responses. Blood. 92:1998;2668-2671.
10. Kodelja V., et al. Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 α with a Th2-associated expression pattern. J. Immunol. 160:1998;1411-1418.
11. Rollins B. Chemokines and Cancer. 1999;Humana Press, Totowa, NJ, USA.
12. Yang J., et al. Constitutive IκB kinase activity correlates with nuclear factor-κB activation in human melanoma cells. Cancer Res. 61:2001;4901-4909.
13. Bottazzi B., et al. Regulation of the macrophage content of neoplasms by chemoattractants. Science. 220:1983;210-212.
14. Nesbit M., et al. Low-level monocyte chemoattractant protein-1 stimulation of monocytes leads to tumor formation in nontumorigenic melanoma cells. J. Immunol. 166:2001;6483-6490.
15. Azenshtein E., et al. The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity. Cancer Res. 62:2002;1093-1102.
16. Haghnegahdar H., et al. The tumorigenic and angiogenic effects of MGSA/GRO proteins in melanoma. J. Leukocyte Biol. 67:2000;53-62.
17. Bonecchi R., et al. Induction of functional IL-8 receptors by IL-4 and IL-13 in human monocytes. J. Immunol. 164:2000;3862-3869.
18. Lin E.Y., et al. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J. Exp. Med. 193:2001;727-740.
19. Barleon B., et al. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the flt-1/VEGF receptor. Blood. 87:1996;3336-3343.
20. Duyndam M.C., et al. Vascular endothelial growth factor-165 overexpression stimulates angiogenesis and induces cyst formation and macrophage infiltration in human ovarian cancer xenografts. Am. J. Pathol. 160:2002;537-548.
21. Adini A., et al. Placental growth factor is a survival factor for tumor endothelial cells and macrophages. Cancer Res. 62:2002;2749-2752.
22. Nowicki A., et al. Impaired tumor growth in colony-stimulating factor 1 (CSF-1)-deficient, macrophage-deficient op/op mouse: evidence for a role of CSF-1-dependent macrophages in formation of tumor stroma. Int. J. Cancer. 65:1996;112-119.
23. Locati M., et al. Analysis of the gene expression profile activated by the CC chemokine ligand 5/RANTES and by lipopolysaccharide in human monocytes. J. Immunol. 168:2002;3557-3562.
24. Keane M.P., et al. The role of CXC chemokines in the regulation of angiogenesis. Mantovani A., Chemokines - Chemical Immunology. 72:1999;86-101 Karger, Basel, Switzerland.
25. Wang J.M., et al. Purification and identification of chemokines potentially involved in kidney-specific metastasis by a murine lymphoma variant: induction of migration and NFκB activation. Int. J. Cancer. 75:1998;900-907.
26. Muller A., et al. Involvement of chemokine receptors in breast cancer metastasis. Nature. 410:2001;50-56.
27. Scotton C.J., et al. Epithelial cancer cell migration: a role for chemokine receptors? Cancer Res. 61:2001;4961-4965.
28. Opdenakker G., et al. Chemotactic factors, passive invasion and metastasis of cancer cells. Immunol. Today. 13:1992;463-464.
29. Sica A., et al. Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma. J. Immunol. 164:2000;733-738.
30. Sica A., et al. Bacterial lipopolysaccharide rapidly inhibits expression of C-C chemokine receptors in human monocytes. J. Exp. Med. 185:1997;969-974.
31. Naylor M.S., et al. Tumor necrosis factor and its receptors in human ovarian cancer. Potential role in disease progression. J. Clin. Invest. 91:1993;2194-2206.
32. Sica A., et al. Autocrine production of IL-10 mediates defective IL-12 production and NF-κB activation in tumor-associated macrophages. J. Immunol. 164:2000;762-767.
33. Kambayashi T., et al. Potential involvement of IL-10 in suppressing tumor-associated macrophages. Colon-26-derived prostaglandin E2 inhibits TNF-α release via a mechanism involving IL-10. J. Immunol. 154:1995;3383-3390.
34. Loercher A.E., et al. Identification of an IL-10-producing HLA-DR-negative monocyte subset in the malignant ascites of patients with ovarian carcinoma that inhibits cytokine protein expression and proliferation of autologous T cells. J. Immunol. 163:1999;6251-6260.
35. Maeda H., et al. TGF-β enhances macrophage ability to produce IL-10 in normal and tumor-bearing mice. J. Immunol. 155:1995;4926-4932.
36. Kim J., et al. IL-10 production in cutaneous basal and squamous cell carcinomas. A mechanism for evading the local T-cell immune response. J. Immunol. 155:1995;2240-2247.
37. Allavena P., et al. The chemokine receptor switch paradigm and dendritic cell migration: its significance in tumor tissues. Immunol. Rev. 177:2000;141-149.
38. Scarpino S., et al. Papillary carcinoma of the thyroid: hepatocyte growth factor (HGF) stimulates tumor cells to release chemokines active in recruiting dendritic cells. Am. J. Pathol. 156:2000;831-837.
39. DiNapoli M.R., et al. The altered tumoricidal capacity of macrophages isolated from tumor-bearing mice is related to reduced expression of the inducible nitric oxide synthase gene. J. Exp. Med. 183:1996;1323-1329.
40. Klimp A.H., et al. Expression of cyclooxygenase-2 and inducible nitric oxide synthase in human ovarian tumors and tumor-associated macrophages. Cancer Res. 61:2001;7305-7309.
41. Gu L., et al. Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1. Nature. 404:2000;407-411.
42. van den Berg A., et al. High expression of the CC chemokine TARC in Reed-Sternberg cells. A possible explanation for the characteristic T-cell infiltrate in Hodgkin's lymphoma. Am. J. Pathol. 154:1999;1685-1691.
43. Cossman J., et al. Reed-Sternberg cell genome expression supports a B-cell lineage. Blood. 94:1999;411-416.
44. Iellem A., et al. Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. J. Exp. Med. 194:2001;847-853.
45. Schutyser E., et al. Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma. J. Biol. Chem. 277:2002;24584-24593.
46. Ibe S., et al. Tumor rejection by disturbing tumor stroma-cell interactions. J. Exp. Med. 194:2001;1549-1559.
47. Berrebi, D. et al. Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory immunosuppressive mechanism shared by glucocorticoid and IL-10. Blood (in press)
48. Young M.R., et al. Human squamous-cell carcinomas of the head and neck chemoattract immune suppressive CD34(+) progenitor cells. Hum. Immunol. 62:2001;332-341.
49. Vicari A.P., et al. Chemokines in cancer. Cytokine Growth Factor Rev. 13:2002;143-154.
50. Bell D., et al. In breast carcinoma tissue, immature dendritic cells reside within the tumor, whereas mature dendritic cells are located in peritumoral areas. J. Exp. Med. 190:1999;1417-1426.
51. Zou W., et al. Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells. Nat. Med. 7:2001;1339-1346.
52. Kleeff J., et al. Detection and localization of MIP-3α/LARC/Exodus, a macrophage proinflammatory chemokine, and its CCR6 receptor in human pancreatic cancer. Int. J. Cancer. 81:1999;650-657.
53. Fushimi T., et al. Macrophage inflammatory protein 3α transgene attracts dendritic cells to established murine tumors and suppresses tumor growth. J. Clin. Invest. 105:2000;1383-1393.
54. Fioretti F., et al. Reduced tumorigenicity and augmented leukocyte infiltration after MCP-3 gene transfer: perivascular accumulation of dendritic cells in peritumoral tissue and neutrophil recruitment within the tumor. J. Immunol. 161:1998;342-346.
55. Menetrier-Caux C., et al. Inhibition of the differentiation of dendritic cells from CD34(+) progenitors by tumor cells: role of interleukin-6 and macrophage colony-stimulating factor. Blood. 92:1998;4778-4791.
56. Vicari A.P., et al. Reversal of tumor-induced dendritic-cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor antibody. J. Exp. Med. 196:2002;541-549.
57. Coussens L.M., et al. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell. 103:2000;481-490.
58. Bergers G., et al. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat. Cell Biol. 2:2000;737-744.
59. Dong Z., et al. Angiostatin-mediated suppression of cancer metastases by primary neoplasms engineered to produce granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 188:1998;755-763.
60. Grimshaw M.J., et al. Inhibition of monocyte and macrophage chemotaxis by hypoxia and inflammation - a potential mechanism. Eur. J. Immunol. 31:2001;480-489.
61. Leek R.D., et al. Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res. 56:1996;4625-4629.
62. Leek R.D., et al. Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast. Br. J. Cancer. 79:1999;991-995.
63. Lewis J.S., et al. Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas. J. Pathol. 192:2000;150-158.
64. Talks K.L., et al. The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages. Am. J. Pathol. 157:2000;411-421.
65. Crowther M., et al. Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors. J. Leukocyte Biol. 70:2001;478-490.
66. Moore B.B., et al. Protection from pulmonary fibrosis in the absence of CCR2 signaling. J. Immunol. 167:2001;4368-4377.
67. Lee C.G., et al. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor β (1). J. Exp. Med. 194:2001;809-821.
68. Coussens L.M., et al. Inflammatory cells and cancer: think different! J. Exp. Med. 193:2001;F23-F26.
69. Dobashi K., et al. Regulation of LPS induced IL-12 production by IFN-γ and IL-4 through intracellular glutathione status in human alveolar macrophages. Clin. Exp. Immunol. 124:2001;290-296.
70. Mantovani A., et al. Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines. Trends Immunol. 22:2001;328-336.
71. Sozzani S., et al. Interleukin-10 increases CCR5 expression and HIV infection in human monocytes. J. Exp. Med. 187:1998;439-444.
72. Penton-Rol G., et al. Upregulation of CCR2 chemokine receptor expression and increased susceptibility to the multitropic HIV strain 89.6 in monocytes exposed to glucocorticoid hormones. J. Immunol. 163:1999;3524-3529.
73. Penton-Rol G., et al. Selective inhibition of expression of the chemokine receptor CCR2 in human monocytes by IFN-γ J. Immunol. 160:1998;3869-3873.
74. D'Amico G., et al. Uncoupling of inflammatory chemokine receptors by IL-10: generation of functional decoys. Nat. Immunol. 1:2000;387-391.