The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival

Gynecologic Oncology

Volumn 128, Issue 3, 2013, Pages 552-559

  Matsuo, Koji ^a   Gray, Michael J ^b   Yang, Dong Yun ^c   Srivastava, Sucheta A ^c   Tripathi, Prem B ^a   Sonoda, Laura A ^a   Yoo, Eun Jeong ^b   Dubeau, Louis ^a,b,c   Lee, Amy S ^a,b,c   Lin, Yvonne G ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Adipocyte; Endometrial cancer; Endoplasmic reticulum (ER) stress

Indexed keywords

GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153;

ADIPOCYTE; ADULT; ARTICLE; CANCER GROWTH; CANCER INVASION; CANCER PROGNOSIS; CANCER RISK; CANCER STAGING; CANCER SURVIVAL; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE FREE SURVIVAL; ENDOMETRIUM CANCER; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRAABDOMINAL FAT; MAJOR CLINICAL STUDY; MYOMETRIUM; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; RISK ASSESSMENT; SURVIVAL PREDICTION;

ADIPOCYTES; ADULT; AGED; AGED, 80 AND OVER; COHORT STUDIES; DISEASE PROGRESSION; DISEASE-FREE SURVIVAL; ENDOMETRIAL NEOPLASMS; ENDOPLASMIC RETICULUM STRESS; FEMALE; HEAT-SHOCK PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; PROGNOSIS; RETROSPECTIVE STUDIES; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84873729773     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2012.11.024     Document Type: Article

References (46)

1. R. Siegel, D. Naishadham, and A. Jemal Cancer statistics, 2012 CA Cancer J Clin 62 2012 10 29
2. T.W. Burke, W.C. Fowler Jr., and C.P. Morrow Clinical aspects of risk in women with endometrial carcinoma J Cell Biochem Suppl 23 1995 131 136
3. R. Kaaks, A. Lukanova, and M.S. Kurzer Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review Cancer Epidemiol Biomarkers Prev 11 2002 1531 1543
4. A. McTiernan, M. Irwin, and V. Vongruenigen Weight, physical activity, diet, and prognosis in breast and gynecologic cancers J Clin Oncol 28 2010 4074 4080
5. R.E. Schmandt, D.A. Iglesias, N.N. Co, and K.H. Lu Understanding obesity and endometrial cancer risk: opportunities for prevention Am J Obstet Gynecol 205 2011 518 525
6. K. Munstedt, M. Wagner, U. Kullmer, A. Hackethal, and F.E. Franke Influence of body mass index on prognosis in gynecological malignancies Cancer Causes Control 19 2008 909 916
7. S.M. Temkin, J.C. Pezzullo, M. Hellmann, Y.C. Lee, and O. Abulafia Is body mass index an independent risk factor of survival among patients with endometrial cancer? Am J Clin Oncol 30 2007 8 14
8. CDC Vital signs: state-specific obesity prevalence among adults - United States, 2009 MMWR Morb Mortal Wkly Rep 59 2010 951 955
9. S.C. Modesitt, and J.R. van Nagell Jr. The impact of obesity on the incidence and treatment of gynecologic cancers: a review Obstet Gynecol Surv 60 2005 683 692
10. J.M. Grodin, P.K. Siiteri, and P.C. MacDonald Source of estrogen production in postmenopausal women J Clin Endocrinol Metab 36 1973 207 214
11. K.T. Pfaffenbach, and A.S. Lee The critical role of GRP78 in physiologic and pathologic stress Curr Opin Cell Biol 23 2011 150 156
12. L. Ozcan, A.S. Ergin, A. Lu, J. Chung, S. Sarkar, and D. Nie Endoplasmic reticulum stress plays a central role in development of leptin resistance Cell Metab 9 2009 35 51
13. U. Ozcan, Q. Cao, E. Yilmaz, A.H. Lee, N.N. Iwakoshi, and E. Ozdelen Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes Science 306 2004 457 461
14. N.K. Sharma, S.K. Das, A.K. Mondal, O.G. Hackney, W.S. Chu, and P.A. Kern Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects J Clin Endocrinol Metab 93 2008 4532 4541
15. M. Wang, S. Wey, Y. Zhang, R. Ye, and A.S. Lee Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders Antioxid Redox Signal 11 2009 2307 2316
16. C.C. Chiu, C.Y. Lin, L.Y. Lee, Y.J. Chen, Y.C. Lu, and H.M. Wang Molecular chaperones as a common set of proteins that regulate the invasion phenotype of head and neck cancer Clin Cancer Res 17 2011 4629 4641
17. A.S. Lee GRP78 induction in cancer: therapeutic and prognostic implications Cancer Res 67 2007 3496 3499
18. L. Pootrakul, R.H. Datar, S.R. Shi, J. Cai, D. Hawes, and S.G. Groshen Expression of stress response protein Grp78 is associated with the development of castration-resistant prostate cancer Clin Cancer Res 12 2006 5987 5993
19. S. Daneshmand, M.L. Quek, E. Lin, C. Lee, R.J. Cote, and D. Hawes Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival Hum Pathol 38 2007 1547 1552
20. G. de Ridder, R. Ray, U.K. Misra, and S.V. Pizzo Modulation of the unfolded protein response by GRP78 in prostate cancer Methods Enzymol 489 2011 245 257
21. R. Langer, M. Feith, J.R. Siewert, H.J. Wester, and H. Hoefler Expression and clinical significance of glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus BMC Cancer 8 2008 70
22. S.O. Lim, S.G. Park, J.H. Yoo, Y.M. Park, H.J. Kim, and K.T. Jang Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules World J Gastroenterol 11 2005 2072 2079
23. C.Y. Lin, W.H. Chen, C.T. Liao, I.H. Chen, C.C. Chiu, and H.M. Wang Positive association of glucose-regulated protein 78 during oral cancer progression and the prognostic value in oral precancerous lesions Head Neck 32 2010 1028 1039
24. S.J. Marcinak, and D. Ron The unfolded protein response in lung disease Proc Am Thorac Soc 7 2010 356 362
25. U.K. Misra, S. Payne, and S.V. Pizzo Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen J Biol Chem 286 2011 1248 1259
26. K. Uematsu, S. Ogata, K. Nakanishi, S. Hiroi, S. Tominaga, and S. Aida Glucose-regulated protein 78 expression in urothelial carcinoma of the upper urinary tract BJU Int 106 2010 873 878
27. H. Uramoto, K. Sugio, T. Oyama, S. Nakata, K. Ono, and T. Yoshimastu Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance Lung Cancer 49 2005 55 62
28. Q. Wang, Z. He, J. Zhang, Y. Wang, T. Wang, and S. Tong Overexpression of endoplasmic reticulum molecular chaperone GRP94 and GRP78 in human lung cancer tissues and its significance Cancer Detect Prev 29 2005 544 551
29. J. Zhang, Y. Jiang, Z. Jia, Q. Li, W. Gong, and L. Wang Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer Clin Exp Metastasis 23 2006 401 410
30. L.H. Zhang, and X. Zhang Roles of GRP78 in physiology and cancer J Cell Biochem 110 2010 1299 1305
31. H.C. Zheng, H. Takahashi, X.H. Li, T. Hara, S. Masuda, and Y.F. Guan Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas Hum Pathol 39 2008 1042 1049
32. L. Zhuang, R.A. Scolyer, C.S. Lee, S.W. McCarthy, W.A. Cooper, and X.D. Zhang Expression of glucose-regulated stress protein GRP78 is related to progression of melanoma Histopathology 54 2009 462 470
33. A.S. Lee The Par-4-GRP78 TRAIL, more twists and turns Cancer Biol Ther 8 2009 2103 2105
34. B. Dirat, L. Bochet, M. Dabek, D. Daviaud, S. Dauvillier, and B. Majed Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion Cancer Res 71 2011 2455 2465
35. E. Lee, P. Nichols, D. Spicer, S. Groshen, M.C. Yu, and A.S. Lee GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer Cancer Res 66 2006 7849 7853
36. T. Byers, and R.L. Sedjo Does intentional weight loss reduce cancer risk? Diabetes Obes Metab 13 2011 1063 1072
37. E. Guzel, M. Basar, N. Ocak, A. Arici, and U.A. Kayisli Bidirectional interaction between unfolded-protein-response key protein HSPA5 and estrogen signaling in human endometrium Biol Reprod 85 2011 121 127
38. S. Ray, X. Hou, H.E. Zhou, H. Wang, and S.K. Das Bip is a molecular link between the phase I and phase II estrogenic responses in uterus Mol Endocrinol 20 2006 1825 1837
39. S. Ray, F. Xu, P. Li, N.S. Sanchez, H. Wang, and S.K. Das Increased level of cellular Bip critically determines estrogenic potency for a xenoestrogen kepone in the mouse uterus Endocrinology 148 2007 4774 4785
40. G. Bifulco, C. Miele, B. Di Jeso, F. Beguinot, C. Nappi, and C. Di Carlo Endoplasmic reticulum stress is activated in endometrial adenocarcinoma Gynecol Oncol 125 2012 220 225
41. S.A. Adham, and B.L. Coomber Glucose is a key regulator of VEGFR2/KDR in human epithelial ovarian carcinoma cells Biochem Biophys Res Commun 390 2009 130 135
42. G.S. Hotamisligil Endoplasmic reticulum stress and the inflammatory basis of metabolic disease Cell 140 2010 900 917
43. M.G. Kolonin, P.K. Saha, L. Chan, R. Pasqualini, and W. Arap Reversal of obesity by targeted ablation of adipose tissue Nat Med 10 2004 625 632
44. K.M. Nieman, H.A. Kenny, C.V. Penicka, A. Ladanyi, R. Buell-Gutbrod, and M.R. Zillhardt Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth Nat Med 17 2011 1498 1503
45. NCT 01262664: Prohibitin Targeting Peptide 1 [database on the Internet] 2011 U.S. National Institutes of Health [Available from http://www. clinicaltrials.gov/ct2/show/study/NT01262664 ]
46. A.H. Klopp, Y. Zhang, T. Solley, F. Amaya-Manzanares, F. Marini, and M. Andreeff Omental adipose tissue-derived stromal cells promote vascularization and growth of endometrial tumors Clin Cancer Res 18 2012 771 782