Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

Journal of Clinical Investigation

Volumn 119, Issue 5, 2009, Pages 1359-1372

  Salazar, María ^a,b   Carracedo, Arkaitz ^a,g   Salanueva, Íñigo J ^a   Hernández Tiedra, Sonia ^a   Lorente, Mar ^a,b   Egia, Ainara ^a,g   Vázquez, Patricia ^c   Blázquez, Cristina ^a,b   Torres, Sofía ^a   García, Stephane ^d   Nowak, Jonathan ^d   Fimia, Gian María ^e   Piacentini, Mauro ^e   Cecconi, Francesco ^f   Pandolfi, Pier Paolo ^g   González Feria, Luis ^h   Iovanna, Juan L ^d   Guzmán, Manuel ^a,b   Boya, Patricia ^c   Velasco, Guillermo ^a,b  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^c CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^d INSERM   (France)

^e NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

^f UNIVERSITY OF ROME TOR VERGATA   (Italy)

^g HARVARD MEDICAL SCHOOL   (United States)

^h University Hospital   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID; CANNABIS; CELL PROTEIN; CERAMIDE; DRONABINOL; INITIATION FACTOR 2ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; TRIBBLES HOMOLOG 3 PROTEIN; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BENZYLOXYCARBONYLVALYL ALANYL ASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CELL CYCLE PROTEIN; ENZYME INHIBITOR; INITIATION FACTOR 2; LIGHT CHAIN 3, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; MTORC1 PROTEIN, HUMAN; P8 PROTEIN, HUMAN; PEPTIDE CHLOROMETHYL KETONE; PROTEIN SERINE THREONINE KINASE; REPRESSOR PROTEIN; S6 KINASE; TETRAHYDROCANNABINOL; TRANSCRIPTION FACTOR; TRIB3 PROTEIN, HUMAN; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; BIOACCUMULATION; CANCER CELL; CANCER CELL DESTRUCTION; CELL DEATH; CELL SURVIVAL; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; GLIOMA CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ANIMAL; BIOLOGICAL MODEL; CELL LINE; DRUG EFFECT; DRUG SCREENING; GENETICS; GLIOMA; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; TUMOR CELL LINE;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; AUTOPHAGY; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CANNABINOIDS; CASPASE 3; CELL CYCLE PROTEINS; CELL DEATH; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; EUKARYOTIC INITIATION FACTOR-2; GLIOMA; HUMANS; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, BIOLOGICAL; NEOPLASM PROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REPRESSOR PROTEINS; RIBOSOMAL PROTEIN S6 KINASES; TETRAHYDROCANNABINOL; TRANSCRIPTION FACTORS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 66449115318     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI37948     Document Type: Article

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