Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

eLife

Volumn 5, Issue 2016JULY, 2016, Pages

  Gallagher, Ciara M ^a   Garri, Carolina ^a,b   Cain, Erica L ^a   Ang, Kenny Kean Hooi ^a   Wilson, Christopher G ^a   Chen, Steven ^a   Hearn, Brian R ^a   Jaishankar, Priyadarshini ^a   Aranda Diaz, Andres ^a   Arkin, Michelle R ^a   Renslo, Adam R ^a   Walter, Peter ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Fundacion Ciencia para la Vida   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

5 (FURAN 2 YL) N (1 METHYL 1H PYRA ZOL 4 YL) 1,2 OXAZOLE 3 CARBOXAMIDE; ACTIVATING TRANSCRIPTION FACTOR 6; ACTIVATING TRANSCRIPTION FACTOR 6 ALPHA; CEAPIN DERIVATIVE; GLUCOSE REGULATED PROTEIN 78; N (1 BENZYL 1H PYRAZOL 4 YL) 5 (FURAN 2 YL) 1,2 OXAZOLE 3 CARBOXAMIDE; N (1 {[2 (TRIFLUOROMETHYL)PHENYL]METHYL} 1H PYRAZOL 4 YL) 5 (FURAN 2 YL) 1,2 OXAZOLE 3 CARBOXAMIDE; N (1 {[2,4 BIS(TRIFLUOROMETHYL)PHENYL]METHYL} 1H PYRAZOL 4 YL) 5 (FURAN 2 YL) 1,2 OXAZOLE 3 CARBOXAMIDE; N (1 {[2,4 DIBROMOPHENYL]METHYL} 1H PYRAZOL 4 YL) 5 (FURAN 2 YL) 1,2 OXAZOLE 3 CARBOXAMIDE; N (1 {[4 (TRIFLUOROMETHYL)PHENYL]METHYL} 1H PYRAZOL 4 YL) 5 (FURAN 2 YL) 1,2 OXAZOLE 3 CARBOXAMIDE; N {1 [(2,4 DICHLOROPHENYL)METHYL] 1H PYRAZOL 4 YL} 5 (FURAN 2 YL) 1,2 OXAZOLE 3 CARBOXAMIDE; N {1 [(2,4 DICHLOROPHENYL)METHYL] 1H PYRAZOL 4 YL} 5 METHYL 1,2 OXAZOLE 3 CARBOXAMIDE; N {1 [(2,4 DICHLOROPHENYL)METHYL] 1H PYRAZOL 4 YL} 5 PHENYL 1,2 OXAZOLE 3 CARBOXAMIDE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; ATF6 PROTEIN, HUMAN; ENZYME INHIBITOR;

ARTICLE; CELL VIABILITY; CENTRIFUGATION; CHEMICAL STRUCTURE; CHROMOSOME TRANSLOCATION; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DOSE RESPONSE; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IMAGE ANALYSIS; LIQUID CHROMATOGRAPHY; LUCIFERASE ASSAY; MASS SPECTROMETRY; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; SCORING SYSTEM; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; UNFOLDED PROTEIN RESPONSE; UPREGULATION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; METABOLISM; PRECLINICAL STUDY;

ACTIVATING TRANSCRIPTION FACTOR 6; CELL LINE; CELL SURVIVAL; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; PYRAZOLES; UNFOLDED PROTEIN RESPONSE;

EID: 84979623050     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.11878     Document Type: Article

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