Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy

Neurosurgical Focus

Volumn 37, Issue 6, 2014, Pages

  Golden, Encouse B ^a   Cho, Hee Yeon ^b   Jahanian, Ardeshir ^b   Hofman, Florence M ^b   Louie, Stan G ^c   Schönthal, Axel H ^b   Chen, Thomas C ^b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Autophagy; Beclin 1; Chloroquine; CHOP; Endoplasmic reticulum stress; GADD 153; GRP78; Temozolomide

Indexed keywords

ALKYLATING AGENT; ANTIRHEUMATIC AGENT; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, HUMAN; CHLOROQUINE; DACARBAZINE; DDIT3 PROTEIN, HUMAN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HEAT SHOCK PROTEIN; MEMBRANE PROTEIN; MOLECULAR CHAPERONE GRP78; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TEMOZOLOMIDE;

ANALOGS AND DERIVATIVES; ANIMAL; AUTOPHAGY; CELL DEATH; DRUG EFFECTS; DRUG POTENTIATION; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; GLIOBLASTOMA; HUMAN; METABOLISM; MOUSE; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; ANTIRHEUMATIC AGENTS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL DEATH; CELL LINE, TUMOR; CHLOROQUINE; DACARBAZINE; DRUG SYNERGISM; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HEAT-SHOCK PROTEINS; HUMANS; MEMBRANE PROTEINS; MICE; MICE, NUDE; POLY(ADP-RIBOSE) POLYMERASES; TRANSCRIPTION FACTOR CHOP; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84916881536     PISSN: None     EISSN: 10920684     Source Type: Journal    
DOI: 10.3171/2014.9.FOCUS14504     Document Type: Article

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