SAR study of a novel triene-ansamycin group compound, quinotrierixin, and related compounds, as inhibitors of ER stress-induced XBP1 activation I. Taxonomy, fermentation, isolation, biological activities and SAR study

Journal of Antibiotics

Volumn 61, Issue 5, 2008, Pages 303-311

  Kawamura, Tatsuro ^a   Tashiro, Etsu ^a   Yamamoto, Kohta ^a   Shindo, Kazutoshi ^b   Imoto, Masaya ^a  

^a KEIO UNIVERSITY   (Japan)

^b JAPAN WOMEN'S UNIVERSITY   (Japan)

Author keywords

ER stress; Triene ansamycin; XBP1

Indexed keywords

13 KETOMYCOTRIENIN I; 13 KETOMYCOTRIENIN II; ANSAMYCIN DERIVATIVE; ANTINEOPLASTIC AGENT; CARBON; HYDROXIDE; MYCOTRIENIN I; MYCOTRIENIN II; NORTRIENOMYCIN A; NORTRIENOMYCIN B; NORTRIENOMYCINOL; QUINOTRIERIXIN; QUINOTRIERIXIN HQ; THAPSIGARGIN; TRIENOMYCIN A; TRIERIXIN; TRIERIXIN Q; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; ANTIINFECTIVE AGENT; DNA BINDING PROTEIN; DRUG DERIVATIVE; LUCIFERASE; RIFABUTIN; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE; TRANSCRIPTION FACTOR; TRE BINDING PROTEIN; TRE-BINDING PROTEIN;

ARTICLE; CELL GROWTH; DRUG ACTIVITY; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; DRUG TARGETING; ENDOPLASMIC RETICULUM STRESS; FERMENTATION; GROWTH INHIBITION; HELA CELL; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; STREPTOMYCES; STRUCTURE ACTIVITY RELATION; TAXONOMY; TUMOR CELL; CHEMISTRY; CLASSIFICATION; ISOLATION AND PURIFICATION; MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL CHEMISTRY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRESS;

STREPTOMYCES SP.;

ANTI-BACTERIAL AGENTS; CHEMISTRY, PHYSICAL; DNA-BINDING PROTEINS; HELA CELLS; HUMANS; LUCIFERASES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIFABUTIN; STREPTOMYCES; STRESS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLIUM SALTS; THIAZOLES; TRANSCRIPTION FACTORS;

EID: 54049093229     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2008.43     Document Type: Article

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