The novel phloroglucinol derivative BFP induces apoptosis of glioma cancer through reactive oxygen species and endoplasmic reticulum stress pathways

Phytomedicine

Volumn 19, Issue 12, 2012, Pages 1093-1100

  Lu, Dah Yuu ^a   Chang, Chih Shiang ^a   Yeh, Wei Lan ^b   Tang, Chih Hsin ^a   Cheung, Chi Wai ^d   Leung, Yuk Man ^a   Liu, Ju Fang ^a,c   Wong, Kar Lok ^a,d,e  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^c SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

^e TAISHAN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; ER stress; Glioma; Prenyl phloroglucinol derivatives; ROS

Indexed keywords

2,4 BIS(4 FLUOROPHENYLACETYL)PHLOROGLUCINOL; CASPASE; CASPASE 12; CASPASE 3; CASPASE 9; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHLOROGLUCINOL DERIVATIVE; PROCASPASE 12; PROCASPASE 7; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME DEGRADATION; FLUORESCENCE ACTIVATED CELL SORTER; GLIOMA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BENZOIN; BIOLOGICAL MARKERS; CASPASES; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM STRESS; GLIOMA; HEAT-SHOCK PROTEINS; HUMANS; HUMULUS; PHLOROGLUCINOL; PHYTOTHERAPY; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTOR CHOP;

EUKARYOTA;

EID: 84866415246     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2012.06.010     Document Type: Article

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