-
1
-
-
33746925579
-
Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1
-
Abraham SM, Lawrence T, Kleiman A, Warden P, Medghalchi M, Tuckermann J, Saklatvala J, and Clark AR (2006) Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1. J Exp Med 203: 1883-1889.
-
(2006)
J Exp Med
, vol.203
, pp. 1883-1889
-
-
Abraham, S.M.1
Lawrence, T.2
Kleiman, A.3
Warden, P.4
Medghalchi, M.5
Tuckermann, J.6
Saklatvala, J.7
Clark, A.R.8
-
3
-
-
0028881859
-
Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma
-
Adcock IM, Lane SJ, Brown CR, Lee TH, and Barnes PJ (1995) Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma. J Exp Med 182:1951-1958.
-
(1995)
J Exp Med
, vol.182
, pp. 1951-1958
-
-
Adcock, I.M.1
Lane, S.J.2
Brown, C.R.3
Lee, T.H.4
Barnes, P.J.5
-
4
-
-
84880847105
-
Cell type-specific function of TAK1 in innate immune signaling
-
Ajibade AA, Wang HY, and Wang RF (2013) Cell type-specific function of TAK1 in innate immune signaling. Trends Immunol 34:307-316.
-
(2013)
Trends Immunol
, vol.34
, pp. 307-316
-
-
Ajibade, A.A.1
Wang, H.Y.2
Wang, R.F.3
-
5
-
-
79955745338
-
Inhibiting the akt pathway in cancer treatment: Three leading candidates
-
Alexander W (2011) Inhibiting the akt pathway in cancer treatment: three leading candidates. P&T 36:225-227.
-
(2011)
P&T
, vol.36
, pp. 225-227
-
-
Alexander, W.1
-
6
-
-
42149091691
-
Isoform-specific functions of phosphoinositide 3-kinases: P110 d but not p110 g promotes optimal allergic responses in vivo
-
Ali K, Camps M, Pearce WP, Ji H, Rückle T, Kuehn N, Pasquali C, Chabert C, Rommel C, and Vanhaesebroeck B (2008) Isoform-specific functions of phosphoinositide 3-kinases: p110 d but not p110 g promotes optimal allergic responses in vivo. J Immunol 180:2538-2544.
-
(2008)
J Immunol
, vol.180
, pp. 2538-2544
-
-
Ali, K.1
Camps, M.2
Pearce, W.P.3
Ji, H.4
Rückle, T.5
Kuehn, N.6
Pasquali, C.7
Chabert, C.8
Rommel, C.9
Vanhaesebroeck, B.10
-
7
-
-
70350132390
-
Small molecule inhibitors of phosphoinositide 3-kinase (PI3K) delta and gamma
-
Ameriks MK and Venable JD (2009) Small molecule inhibitors of phosphoinositide 3-kinase (PI3K) delta and gamma. Curr Top Med Chem 9:738-753.
-
(2009)
Curr Top Med Chem
, vol.9
, pp. 738-753
-
-
Ameriks, M.K.1
Venable, J.D.2
-
8
-
-
67651100839
-
Benzothiophene inhibitors of MK2. Part 1: Structure-activity relationships, assessments of selectivity and cellular potency
-
Anderson DR, Meyers MJ, Kurumbail RG, Caspers N, Poda GI, Long SA, Pierce BS, Mahoney MW, and Mourey RJ (2009) Benzothiophene inhibitors of MK2. Part 1: structure-activity relationships, assessments of selectivity and cellular potency. Bioorg Med Chem Lett 19:4878-4881.
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 4878-4881
-
-
Anderson, D.R.1
Meyers, M.J.2
Kurumbail, R.G.3
Caspers, N.4
Poda, G.I.5
Long, S.A.6
Pierce, B.S.7
Mahoney, M.W.8
Mourey, R.J.9
-
9
-
-
84883199752
-
Mitogen-activated protein kinases in innate immunity
-
Arthur JS and Ley SC (2013) Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol 13:679-692.
-
(2013)
Nat Rev Immunol
, vol.13
, pp. 679-692
-
-
Arthur, J.S.1
Ley, S.C.2
-
10
-
-
84988948694
-
Transforming growth factor-b: Master regulator of the respiratory system in health and disease
-
Aschner Y and Downey GP (2016) Transforming growth factor-b: Master regulator of the respiratory system in health and disease. Am J Respir Cell Mol Biol 54: 647-655.
-
(2016)
Am J Respir Cell Mol Biol
, vol.54
, pp. 647-655
-
-
Aschner, Y.1
Downey, G.P.2
-
11
-
-
84897420018
-
Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses
-
Ashino S, Takeda K, Li H, Taylor V, Joetham A, Pine PR, and Gelfand EW (2014) Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses. J Allergy Clin Immunol 133:1162-1174.
-
(2014)
J Allergy Clin Immunol
, vol.133
, pp. 1162-1174
-
-
Ashino, S.1
Takeda, K.2
Li, H.3
Taylor, V.4
Joetham, A.5
Pine, P.R.6
Gelfand, E.W.7
-
12
-
-
0037702455
-
The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases
-
Backers K, Blero D, Paternotte N, Zhang J, and Erneux C (2003) The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases. Adv Enzyme Regul 43:15-28.
-
(2003)
Adv Enzyme Regul
, vol.43
, pp. 15-28
-
-
Backers, K.1
Blero, D.2
Paternotte, N.3
Zhang, J.4
Erneux, C.5
-
13
-
-
11344263115
-
Increased TGF-beta2 in severe asthma with eosinophilia
-
Balzar S, Chu HW, Silkoff P, Cundall M, Trudeau JB, Strand M, and Wenzel S (2005) Increased TGF-beta2 in severe asthma with eosinophilia. J Allergy Clin Immunol 115:110-117.
-
(2005)
J Allergy Clin Immunol
, vol.115
, pp. 110-117
-
-
Balzar, S.1
Chu, H.W.2
Silkoff, P.3
Cundall, M.4
Trudeau, J.B.5
Strand, M.6
Wenzel, S.7
-
14
-
-
55849148482
-
The cytokine network in asthma and chronic obstructive pulmonary disease
-
Barnes PJ (2008a) The cytokine network in asthma and chronic obstructive pulmonary disease. J Clin Invest 118:3546-3556.
-
(2008)
J Clin Invest
, vol.118
, pp. 3546-3556
-
-
Barnes, P.J.1
-
15
-
-
40049104892
-
Immunology of asthma and chronic obstructive pulmonary disease
-
Barnes PJ (2008b) Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol 8:183-192.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 183-192
-
-
Barnes, P.J.1
-
16
-
-
79959334504
-
Pathophysiology of allergic inflammation
-
Barnes PJ (2011) Pathophysiology of allergic inflammation. Immunol Rev 242:31-50.
-
(2011)
Immunol Rev
, vol.242
, pp. 31-50
-
-
Barnes, P.J.1
-
17
-
-
84875225940
-
Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease
-
Barnes PJ (2013a) Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease. J Allergy Clin Immunol 131:636-645.
-
(2013)
J Allergy Clin Immunol
, vol.131
, pp. 636-645
-
-
Barnes, P.J.1
-
18
-
-
84879693217
-
New anti-inflammatory targets for chronic obstructive pulmonary disease
-
Barnes PJ (2013b) New anti-inflammatory targets for chronic obstructive pulmonary disease. Nat Rev Drug Discov 12:543-559.
-
(2013)
Nat Rev Drug Discov
, vol.12
, pp. 543-559
-
-
Barnes, P.J.1
-
20
-
-
84924006883
-
Mechanisms of development of multimorbidity in the elderly
-
Barnes PJ (2015a) Mechanisms of development of multimorbidity in the elderly. Eur Respir J 45:790-806.
-
(2015)
Eur Respir J
, vol.45
, pp. 790-806
-
-
Barnes, P.J.1
-
21
-
-
84941028441
-
Therapeutic approaches to asthma-chronic obstructive pulmonary disease overlap syndromes
-
Barnes PJ (2015b) Therapeutic approaches to asthma-chronic obstructive pulmonary disease overlap syndromes. J Allergy Clin Immunol 136:531-545.
-
(2015)
J Allergy Clin Immunol
, vol.136
, pp. 531-545
-
-
Barnes, P.J.1
-
22
-
-
84954182224
-
Asthma-COPD overlap
-
Barnes PJ (2016) Asthma-COPD overlap. Chest 149:7-8.
-
(2016)
Chest
, vol.149
, pp. 7-8
-
-
Barnes, P.J.1
-
23
-
-
65849427529
-
Glucocorticoid resistance in inflammatory diseases
-
Barnes PJ and Adcock IM (2009) Glucocorticoid resistance in inflammatory diseases. Lancet 373:1905-1917.
-
(2009)
Lancet
, vol.373
, pp. 1905-1917
-
-
Barnes, P.J.1
Adcock, I.M.2
-
24
-
-
85013129004
-
Chronic obstructive pulmonary disease
-
Barnes PJ, Burney PGJ, Silverman EK, Celli BR, Vestbo J, Wedzicha JA, and Wouters EFM (2015) Chronic obstructive pulmonary disease. Nat Rev Dis Primers 1:15076.
-
(2015)
Nat Rev Dis Primers
, vol.1
, pp. 15076
-
-
Barnes, P.J.1
Burney, P.2
Silverman, E.K.3
Celli, B.R.4
Vestbo, J.5
Wedzicha, J.A.6
Wouters, E.7
-
25
-
-
0030615201
-
Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases
-
Barnes PJ and Karin M (1997) Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336:1066-1071.
-
(1997)
N Engl J Med
, vol.336
, pp. 1066-1071
-
-
Barnes, P.J.1
Karin, M.2
-
27
-
-
84941176876
-
The asthma-COPD overlap syndrome: Towards a revised taxonomy of chronic airways diseases?
-
Bateman ED, Reddel HK, van Zyl-Smit RN, and Agusti A (2015) The asthma-COPD overlap syndrome: towards a revised taxonomy of chronic airways diseases? Lancet Respir Med 3:719-728.
-
(2015)
Lancet Respir Med
, vol.3
, pp. 719-728
-
-
Bateman, E.D.1
Reddel, H.K.2
Van Zyl-Smit, R.N.3
Agusti, A.4
-
29
-
-
33846515705
-
Rhinovirus activates interleukin-8 expression via a Src/p110b phosphatidylinositol 3-kinase/Akt pathway in human airway epithelial cells
-
Bentley JK, Newcomb DC, Goldsmith AM, Jia Y, Sajjan US, and Hershenson MB (2007) Rhinovirus activates interleukin-8 expression via a Src/p110b phosphatidylinositol 3-kinase/Akt pathway in human airway epithelial cells. J Virol 81: 1186-1194.
-
(2007)
J Virol
, vol.81
, pp. 1186-1194
-
-
Bentley, J.K.1
Newcomb, D.C.2
Goldsmith, A.M.3
Jia, Y.4
Sajjan, U.S.5
Hershenson, M.B.6
-
30
-
-
11144239945
-
Treatment of cockroach allergen asthma model with imatinib attenuates airway responses
-
Berlin AA and Lukacs NW (2005) Treatment of cockroach allergen asthma model with imatinib attenuates airway responses. Am J Respir Crit Care Med 171:35-39.
-
(2005)
Am J Respir Crit Care Med
, vol.171
, pp. 35-39
-
-
Berlin, A.A.1
Lukacs, N.W.2
-
31
-
-
51249109929
-
Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma
-
Bhavsar P, Hew M, Khorasani N, Torrego A, Barnes PJ, Adcock I, and Chung KF (2008) Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma. Thorax 63:784-790.
-
(2008)
Thorax
, vol.63
, pp. 784-790
-
-
Bhavsar, P.1
Hew, M.2
Khorasani, N.3
Torrego, A.4
Barnes, P.J.5
Adcock, I.6
Chung, K.F.7
-
32
-
-
33745153836
-
IkappaB kinase-2-independent and-dependent inflammation in airway disease models: Relevance of IKK-2 inhibition to the clinic
-
Birrell MA, Wong S, Hardaker EL, Catley MC, McCluskie K, Collins M, Haj-Yahia S, and Belvisi MG (2006) IkappaB kinase-2-independent and-dependent inflammation in airway disease models: relevance of IKK-2 inhibition to the clinic. Mol Pharmacol 69:1791-1800.
-
(2006)
Mol Pharmacol
, vol.69
, pp. 1791-1800
-
-
Birrell, M.A.1
Wong, S.2
Hardaker, E.L.3
Catley, M.C.4
McCluskie, K.5
Collins, M.6
Haj-Yahia, S.7
Belvisi, M.G.8
-
33
-
-
38049024624
-
FGF2 in asthmatic airway-smooth-musclecell hyperplasia
-
Bossé Y and Rola-Pleszczynski M (2008) FGF2 in asthmatic airway-smooth-musclecell hyperplasia. Trends Mol Med 14:3-11.
-
(2008)
Trends Mol Med
, vol.14
, pp. 3-11
-
-
Bossé, Y.1
Rola-Pleszczynski, M.2
-
34
-
-
84875344622
-
InternationaL cross-sectIonAl and longItudinal assessment on aSthma cONtrol in European adult patients-the LIAISON study protocol
-
LIAISON study group
-
Braido F, Brusselle G, Ingrassia E, Nicolini G, Price D, Roche N, Soriano JB, and Worth H; LIAISON study group (2013) InternationaL cross-sectIonAl and longItudinal assessment on aSthma cONtrol in European adult patients-the LIAISON study protocol. BMC Pulm Med 13:18.
-
(2013)
BMC Pulm Med
, vol.13
, pp. 18
-
-
Braido, F.1
Brusselle, G.2
Ingrassia, E.3
Nicolini, G.4
Price, D.5
Roche, N.6
Soriano, J.B.7
Worth, H.8
-
35
-
-
33644767306
-
Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signalregulated kinase pathways
-
Brook M, Tchen CR, Santalucia T, McIlrath J, Arthur JS, Saklatvala J, and Clark AR (2006) Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signalregulated kinase pathways. Mol Cell Biol 26:2408-2418.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 2408-2418
-
-
Brook, M.1
Tchen, C.R.2
Santalucia, T.3
McIlrath, J.4
Arthur, J.S.5
Saklatvala, J.6
Clark, A.R.7
-
36
-
-
84951334863
-
Idelalisib has CLL on the run!
-
Brown JR (2015) Idelalisib has CLL on the run! Blood 126:2656-2657.
-
(2015)
Blood
, vol.126
, pp. 2656-2657
-
-
Brown, J.R.1
-
37
-
-
62149116838
-
Activation of NF-kappaB transcription factor in asthma death
-
Caramori G, Oates T, Nicholson AG, Casolari P, Ito K, Barnes PJ, Papi A, Adcock IM, and Chung KF (2009) Activation of NF-kappaB transcription factor in asthma death. Histopathology 54:507-509.
-
(2009)
Histopathology
, vol.54
, pp. 507-509
-
-
Caramori, G.1
Oates, T.2
Nicholson, A.G.3
Casolari, P.4
Ito, K.5
Barnes, P.J.6
Papi, A.7
Adcock, I.M.8
Chung, K.F.9
-
38
-
-
0037383155
-
Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations
-
Caramori G, Romagnoli M, Casolari P, Bellettato C, Casoni G, Boschetto P, Chung KF, Barnes PJ, Adcock IM, and Ciaccia A, et al. (2003) Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations. Thorax 58:348-351.
-
(2003)
Thorax
, vol.58
, pp. 348-351
-
-
Caramori, G.1
Romagnoli, M.2
Casolari, P.3
Bellettato, C.4
Casoni, G.5
Boschetto, P.6
Chung, K.F.7
Barnes, P.J.8
Adcock, I.M.9
Ciaccia, A.10
-
39
-
-
0033792915
-
An antisense of protein kinase C-zeta inhibits proliferation of human airway smooth muscle cells
-
Carlin S, Poronnik P, Cook DI, Carpenter L, Biden TJ, Johnson PR, and Black JL (2000) An antisense of protein kinase C-zeta inhibits proliferation of human airway smooth muscle cells. Am J Respir Cell Mol Biol 23:555-559.
-
(2000)
Am J Respir Cell Mol Biol
, vol.23
, pp. 555-559
-
-
Carlin, S.1
Poronnik, P.2
Cook, D.I.3
Carpenter, L.4
Biden, T.J.5
Johnson, P.R.6
Black, J.L.7
-
40
-
-
51849084360
-
The PTEN-PI3K pathway: Of feedbacks and cross-talks
-
Carracedo A and Pandolfi PP (2008) The PTEN-PI3K pathway: of feedbacks and cross-talks. Oncogene 27:5527-5541.
-
(2008)
Oncogene
, vol.27
, pp. 5527-5541
-
-
Carracedo, A.1
Pandolfi, P.P.2
-
41
-
-
33746217403
-
Validation of the anti-inflammatory properties of smallmolecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviralmediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle
-
Catley MC, Sukkar MB, Chung KF, Jaffee B, Liao SM, Coyle AJ, Haddad B, Barnes PJ, and Newton R (2006) Validation of the anti-inflammatory properties of smallmolecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviralmediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle. Mol Pharmacol 70:697-705.
-
(2006)
Mol Pharmacol
, vol.70
, pp. 697-705
-
-
Catley, M.C.1
Sukkar, M.B.2
Chung, K.F.3
Jaffee, B.4
Liao, S.M.5
Coyle, A.J.6
Haddad, B.7
Barnes, P.J.8
Newton, R.9
-
42
-
-
84866354416
-
Protein kinase C-theta inhibitors: A novel therapy for inflammatory disorders
-
Chand S, Mehta N, Bahia MS, Dixit A, and Silakari O (2012) Protein kinase C-theta inhibitors: a novel therapy for inflammatory disorders. Curr Pharm Des 18: 4725-4746.
-
(2012)
Curr Pharm Des
, vol.18
, pp. 4725-4746
-
-
Chand, S.1
Mehta, N.2
Bahia, M.S.3
Dixit, A.4
Silakari, O.5
-
43
-
-
84920964273
-
Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders
-
Chaudhary D, Robinson S, and Romero DL (2015) Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders. J Med Chem 58: 96-110.
-
(2015)
J Med Chem
, vol.58
, pp. 96-110
-
-
Chaudhary, D.1
Robinson, S.2
Romero, D.L.3
-
45
-
-
7944227491
-
Protein kinase Cdelta functions downstream of Ca2+ mobilization in FcepsilonRI signaling to degranulation in mast cells
-
Cho SH, Woo CH, Yoon SB, and Kim JH (2004a) Protein kinase Cdelta functions downstream of Ca2+ mobilization in FcepsilonRI signaling to degranulation in mast cells. J Allergy Clin Immunol 114:1085-1092.
-
(2004)
J Allergy Clin Immunol
, vol.114
, pp. 1085-1092
-
-
Cho, S.H.1
Woo, C.H.2
Yoon, S.B.3
Kim, J.H.4
-
46
-
-
2942737134
-
Rac and protein kinase C-delta regulate ERKs and cytosolic phospholipase A2 in FcepsilonRI signaling to cysteinyl leukotriene synthesis in mast cells
-
Cho SH, You HJ, Woo CH, Yoo YJ, and Kim JH (2004b) Rac and protein kinase C-delta regulate ERKs and cytosolic phospholipase A2 in FcepsilonRI signaling to cysteinyl leukotriene synthesis in mast cells. J Immunol 173:624-631.
-
(2004)
J Immunol
, vol.173
, pp. 624-631
-
-
Cho, S.H.1
You, H.J.2
Woo, C.H.3
Yoo, Y.J.4
Kim, J.H.5
-
47
-
-
84896737466
-
Inhibition of protein kinase C delta attenuates allergic airway inflammation through suppression of PI3K/Akt/mTOR/ HIF-1 alpha/VEGF pathway
-
Choi YH, Jin GY, Li LC, and Yan GH (2013) Inhibition of protein kinase C delta attenuates allergic airway inflammation through suppression of PI3K/Akt/mTOR/ HIF-1 alpha/VEGF pathway. PLoS One 8:e81773.
-
(2013)
Plos One
, vol.8
-
-
Choi, Y.H.1
Jin, G.Y.2
Li, L.C.3
Yan, G.H.4
-
48
-
-
79958710208
-
P38 mitogen-activated protein kinase pathways in asthma and COPD
-
Chung KF (2011) p38 mitogen-activated protein kinase pathways in asthma and COPD. Chest 139:1470-1479.
-
(2011)
Chest
, pp. 1470-1479
-
-
Chung, K.F.1
-
49
-
-
80051974241
-
NF-kB inducing kinase, NIK mediates cigarette smoke/ TNFa-induced histone acetylation and inflammation through differential activation of IKKs
-
Chung S, Sundar IK, Hwang JW, Yull FE, Blackwell TS, Kinnula VL, Bulger M, Yao H, and Rahman I (2011) NF-kB inducing kinase, NIK mediates cigarette smoke/ TNFa-induced histone acetylation and inflammation through differential activation of IKKs. PLoS One 6:e23488.
-
(2011)
Plos One
, vol.6
-
-
Chung, S.1
Sundar, I.K.2
Hwang, J.W.3
Yull, F.E.4
Blackwell, T.S.5
Kinnula, V.L.6
Bulger, M.7
Yao, H.8
Rahman, I.9
-
50
-
-
84923897501
-
From the authors: International European Respiratory Society/American Thoracic Society guidelines on severe asthma
-
European Respiratory Society/American Thoracic Society Severe Asthma International Guidelines Task Force
-
Chung KF and Wenzel S; European Respiratory Society/American Thoracic Society Severe Asthma International Guidelines Task Force (2014) From the authors: International European Respiratory Society/American Thoracic Society guidelines on severe asthma. Eur Respir J 44:1378-1379.
-
(2014)
Eur Respir J
, vol.44
, pp. 1378-1379
-
-
Chung, K.F.1
Wenzel, S.2
-
51
-
-
0036527429
-
Protein kinases-the major drug targets of the twenty-first century?
-
Cohen P (2002) Protein kinases-the major drug targets of the twenty-first century? Nat Rev Drug Discov 1:309-315.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 309-315
-
-
Cohen, P.1
-
52
-
-
84901016154
-
Immune diseases caused by mutations in kinases and components of the ubiquitin system
-
Cohen P (2014) Immune diseases caused by mutations in kinases and components of the ubiquitin system. Nat Immunol 15:521-529.
-
(2014)
Nat Immunol
, vol.15
, pp. 521-529
-
-
Cohen, P.1
-
53
-
-
79955617610
-
Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases
-
Comess KM, Sun C, Abad-Zapatero C, Goedken ER, Gum RJ, Borhani DW, Argiriadi M, Groebe DR, Jia Y, and Clampit JE, et al. (2011) Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases. ACS Chem Biol 6:234-244.
-
(2011)
ACS Chem Biol
, vol.6
, pp. 234-244
-
-
Comess, K.M.1
Sun, C.2
Abad-Zapatero, C.3
Goedken, E.R.4
Gum, R.J.5
Borhani, D.W.6
Argiriadi, M.7
Groebe, D.R.8
Jia, Y.9
Clampit, J.E.10
-
54
-
-
23744492188
-
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils
-
Condliffe AM, Davidson K, Anderson KE, Ellson CD, Crabbe T, Okkenhaug K, Vanhaesebroeck B, Turner M, Webb L, and Wymann MP, et al. (2005) Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 106:1432-1440.
-
(2005)
Blood
, vol.106
, pp. 1432-1440
-
-
Condliffe, A.M.1
Davidson, K.2
Erson, K.E.3
Ellson, C.D.4
Crabbe, T.5
Okkenhaug, K.6
Vanhaesebroeck, B.7
Turner, M.8
Webb, L.9
Wymann, M.P.10
-
55
-
-
4544379912
-
Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages
-
Cosio BG, Tsaprouni L, Ito K, Jazrawi E, Adcock IM, and Barnes PJ (2004) Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J Exp Med 200:689-695.
-
(2004)
J Exp Med
, vol.200
, pp. 689-695
-
-
Cosio, B.G.1
Tsaprouni, L.2
Ito, K.3
Jazrawi, E.4
Adcock, I.M.5
Barnes, P.J.6
-
56
-
-
80052090231
-
Phosphoinositide 3-kinase p110g in immunity
-
Costa C, Martin-Conte EL, and Hirsch E (2011) Phosphoinositide 3-kinase p110g in immunity. IUBMB Life 63:707-713.
-
(2011)
IUBMB Life
, vol.63
, pp. 707-713
-
-
Costa, C.1
Martin-Conte, E.L.2
Hirsch, E.3
-
57
-
-
38349077242
-
CXCR3 and CCR5 chemokines in induced sputum from patients with COPD
-
Costa C, Rufino R, Traves SL, Lapa E Silva JR, Barnes PJ, and Donnelly LE (2008) CXCR3 and CCR5 chemokines in induced sputum from patients with COPD. Chest 133:26-33.
-
(2008)
Chest
, vol.133
, pp. 26-33
-
-
Costa, C.1
Rufino, R.2
Traves, S.L.3
Lapa E Silva, J.R.4
Barnes, P.J.5
Donnelly, L.E.6
-
59
-
-
1342265719
-
SB-505124 is a selective inhibitor of transforming growth factor-b type I receptors ALK4, ALK5, and ALK7
-
DaCosta Byfield S, Major C, Laping NJ, and Roberts AB (2004) SB-505124 is a selective inhibitor of transforming growth factor-b type I receptors ALK4, ALK5, and ALK7. Mol Pharmacol 65:744-752.
-
(2004)
Mol Pharmacol
, vol.65
, pp. 744-752
-
-
Dacosta Byfield, S.1
Major, C.2
Laping, N.J.3
Roberts, A.B.4
-
60
-
-
0037077212
-
Proteolysis of latent transforming growth factor-b (TGF-b)-binding protein-1 by osteoclasts. A cellular mechanism for release of TGF-b from bone matrix
-
Dallas SL, Rosser JL, Mundy GR, and Bonewald LF (2002) Proteolysis of latent transforming growth factor-b (TGF-b)-binding protein-1 by osteoclasts. A cellular mechanism for release of TGF-b from bone matrix. J Biol Chem 277:21352-21360.
-
(2002)
J Biol Chem
, vol.277
, pp. 21352-21360
-
-
Dallas, S.L.1
Rosser, J.L.2
Mundy, G.R.3
Bonewald, L.F.4
-
61
-
-
3142546235
-
The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathwaymediated mRNA stabilisation
-
Dean JL, Sully G, Clark AR, and Saklatvala J (2004) The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathwaymediated mRNA stabilisation. Cell Signal 16:1113-1121.
-
(2004)
Cell Signal
, vol.16
, pp. 1113-1121
-
-
Dean, J.L.1
Sully, G.2
Clark, A.R.3
Saklatvala, J.4
-
62
-
-
31544462308
-
Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease
-
de Boer WI, Hau CM, van Schadewijk A, Stolk J, van Krieken JH, and Hiemstra PS (2006) Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease. Am J Clin Pathol 125:184-192.
-
(2006)
Am J Clin Pathol
, vol.125
, pp. 184-192
-
-
De Boer, W.I.1
Hau, C.M.2
Van Schadewijk, A.3
Stolk, J.4
Van Krieken, J.H.5
Hiemstra, P.S.6
-
63
-
-
0032416948
-
Transforming growth factor beta1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease
-
de Boer WI, van Schadewijk A, Sont JK, Sharma HS, Stolk J, Hiemstra PS, and van Krieken JH (1998) Transforming growth factor beta1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 158:1951-1957.
-
(1998)
Am J Respir Crit Care Med
, vol.158
, pp. 1951-1957
-
-
De Boer, W.I.1
Van Schadewijk, A.2
Sont, J.K.3
Sharma, H.S.4
Stolk, J.5
Hiemstra, P.S.6
Van Krieken, J.H.7
-
65
-
-
6344269852
-
Selective blockade of NF-kappa B activity in airway immune cells inhibits the effector phase of experimental asthma
-
Desmet C, Gosset P, Pajak B, Cataldo D, Bentires-Alj M, Lekeux P, and Bureau F (2004) Selective blockade of NF-kappa B activity in airway immune cells inhibits the effector phase of experimental asthma. J Immunol 173:5766-5775.
-
(2004)
J Immunol
, vol.173
, pp. 5766-5775
-
-
Desmet, C.1
Gosset, P.2
Pajak, B.3
Cataldo, D.4
Bentires-Alj, M.5
Lekeux, P.6
Bureau, F.7
-
66
-
-
84931273439
-
Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: Study protocol for a randomised controlled trial
-
Devereux G, Cotton S, Barnes P, Briggs A, Burns G, Chaudhuri R, Chrystyn H, Davies L, De Soyza A, and Fielding S, et al. (2015) Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: study protocol for a randomised controlled trial. Trials 16:267.
-
(2015)
Trials
, vol.16
, pp. 267
-
-
Devereux, G.1
Cotton, S.2
Barnes, P.3
Briggs, A.4
Burns, G.5
Chaudhuri, R.6
Chrystyn, H.7
Davies, L.8
De Soyza, A.9
Fielding, S.10
-
67
-
-
84899850988
-
Picking the point of inhibition: A comparative review of PI3K/AKT/mTOR pathway inhibitors
-
Dienstmann R, Rodon J, Serra V, and Tabernero J (2014) Picking the point of inhibition: a comparative review of PI3K/AKT/mTOR pathway inhibitors. Mol Cancer Ther 13:1021-1031.
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 1021-1031
-
-
Dienstmann, R.1
Rodon, J.2
Serra, V.3
Tabernero, J.4
-
68
-
-
3543130200
-
STAT4 activation in smokers and patients with chronic obstructive pulmonary disease
-
Di Stefano A, Caramori G, Capelli A, Gnemmi I, Ricciardolo FL, Oates T, Donner CF, Chung KF, Barnes PJ, and Adcock IM (2004) STAT4 activation in smokers and patients with chronic obstructive pulmonary disease. Eur Respir J 24:78-85.
-
(2004)
Eur Respir J
, vol.24
, pp. 78-85
-
-
Di Stefano, A.1
Caramori, G.2
Capelli, A.3
Gnemmi, I.4
Ricciardolo, F.L.5
Oates, T.6
Donner, C.F.7
Chung, K.F.8
Barnes, P.J.9
Adcock, I.M.10
-
69
-
-
18544383099
-
Increased expression of nuclear factorkappaB in bronchial biopsies from smokers and patients with COPD
-
Di Stefano A, Caramori G, Oates T, Capelli A, Lusuardi M, Gnemmi I, Ioli F, Chung KF, Donner CF, and Barnes PJ, et al. (2002) Increased expression of nuclear factorkappaB in bronchial biopsies from smokers and patients with COPD. Eur Respir J 20:556-563.
-
(2002)
Eur Respir J
, vol.20
, pp. 556-563
-
-
Di Stefano, A.1
Caramori, G.2
Oates, T.3
Capelli, A.4
Lusuardi, M.5
Gnemmi, I.6
Ioli, F.7
Chung, K.F.8
Donner, C.F.9
Barnes, P.J.10
-
70
-
-
84925812821
-
Ainsliadimer A selectively inhibits IKKa/b by covalently binding a conserved cysteine
-
Dong T, Li C, Wang X, Dian L, Zhang X, Li L, Chen S, Cao R, Li L, and Huang N, et al. (2015) Ainsliadimer A selectively inhibits IKKa/b by covalently binding a conserved cysteine. Nat Commun 6:6522.
-
(2015)
Nat Commun
, vol.6
, pp. 6522
-
-
Dong, T.1
Li, C.2
Wang, X.3
Dian, L.4
Zhang, X.5
Li, L.6
Chen, S.7
Cao, R.8
Li, L.9
Huang, N.10
-
71
-
-
4544310412
-
Anti-inflammatory effects of resveratrol in lung epithelial cells: Molecular mechanisms
-
Donnelly LE, Newton R, Kennedy GE, Fenwick PS, Leung RH, Ito K, Russell RE, and Barnes PJ (2004) Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am J Physiol Lung Cell Mol Physiol 287: L774-L783.
-
(2004)
Am J Physiol Lung Cell Mol Physiol
, vol.287
, pp. L774-L783
-
-
Donnelly, L.E.1
Newton, R.2
Kennedy, G.E.3
Fenwick, P.S.4
Leung, R.H.5
Ito, K.6
Russell, R.E.7
Barnes, P.J.8
-
72
-
-
0029377270
-
Expression of multiple isoenzymes of protein kinase C in airway smooth muscle
-
Donnelly R, Yang K, Omary MB, Azhar S, and Black JL (1995) Expression of multiple isoenzymes of protein kinase C in airway smooth muscle. Am J Respir Cell Mol Biol 13:253-256.
-
(1995)
Am J Respir Cell Mol Biol
, vol.13
, pp. 253-256
-
-
Donnelly, R.1
Yang, K.2
Omary, M.B.3
Azhar, S.4
Black, J.L.5
-
73
-
-
62449213953
-
Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115[3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease
-
Doukas J, Eide L, Stebbins K, Racanelli-Layton A, Dellamary L, Martin M, Dneprovskaia E, Noronha G, Soll R, and Wrasidlo W, et al. (2009) Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115[3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease. J Pharmacol Exp Ther 328:758-765.
-
(2009)
J Pharmacol Exp Ther
, vol.328
, pp. 758-765
-
-
Doukas, J.1
Eide, L.2
Stebbins, K.3
Racanelli-Layton, A.4
Dellamary, L.5
Martin, M.6
Dneprovskaia, E.7
Noronha, G.8
Soll, R.9
Wrasidlo, W.10
-
74
-
-
15944425792
-
An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model
-
Duan W, Aguinaldo Datiles AM, Leung BP, Vlahos CJ, and Wong WS (2005a) An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model. Int Immunopharmacol 5:495-502.
-
(2005)
Int Immunopharmacol
, vol.5
, pp. 495-502
-
-
Duan, W.1
Aguinaldo Datiles, A.M.2
Leung, B.P.3
Vlahos, C.J.4
Wong, W.S.5
-
75
-
-
14944350956
-
Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice
-
Duan W, Chan JH, McKay K, Crosby JR, Choo HH, Leung BP, Karras JG, and Wong WS (2005b) Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice. Am J Respir Crit Care Med 171:571-578.
-
(2005)
Am J Respir Crit Care Med
, vol.171
, pp. 571-578
-
-
Duan, W.1
Chan, J.H.2
McKay, K.3
Crosby, J.R.4
Choo, H.H.5
Leung, B.P.6
Karras, J.G.7
Wong, W.S.8
-
76
-
-
0036715696
-
Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response
-
Ernst M, Inglese M, Scholz GM, Harder KW, Clay FJ, and Bozinovski S, et al. (2002) Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response. J Exp Med 196: 589-604.
-
(2002)
J Exp Med
, vol.196
, pp. 589-604
-
-
Ernst, M.1
Inglese, M.2
Scholz, G.M.3
Harder, K.W.4
Clay, F.J.5
Bozinovski, S.6
-
77
-
-
0032858467
-
Expression and activation of protein kinase C-zeta in eosinophils after allergen challenge
-
Evans DJ, Lindsay MA, Webb BL, Kankaanranta H, Giembycz MA, O’Connor BJ, and Barnes PJ (1999) Expression and activation of protein kinase C-zeta in eosinophils after allergen challenge. Am J Physiol 277:L233-L239.
-
(1999)
Am J Physiol
, vol.277
, pp. L233-L239
-
-
Evans, D.J.1
Lindsay, M.A.2
Webb, B.L.3
Kankaanranta, H.4
Giembycz, M.A.5
O’Connor, B.J.6
Barnes, P.J.7
-
78
-
-
0347949530
-
Allergen-induced inflammation and airway epithelial and smooth muscle cell proliferation: Role of Jun N-terminal kinase
-
Eynott PR, Nath P, Leung SY, Adcock IM, Bennett BL, and Chung KF (2003) Allergen-induced inflammation and airway epithelial and smooth muscle cell proliferation: role of Jun N-terminal kinase. Br J Pharmacol 140:1373-1380.
-
(2003)
Br J Pharmacol
, vol.140
, pp. 1373-1380
-
-
Eynott, P.R.1
Nath, P.2
Leung, S.Y.3
Adcock, I.M.4
Bennett, B.L.5
Chung, K.F.6
-
79
-
-
84928907224
-
Ten things you should know about protein kinases: IUPHAR Review 14
-
Fabbro D, Cowan-Jacob SW, and Moebitz H (2015) Ten things you should know about protein kinases: IUPHAR Review 14. Br J Pharmacol 172: 2675-2700.
-
(2015)
Br J Pharmacol
, vol.172
, pp. 2675-2700
-
-
Fabbro, D.1
Cowan-Jacob, S.W.2
Moebitz, H.3
-
80
-
-
33744912533
-
Increased vascular endothelial growth factor and receptors: Relationship to angiogenesis in asthma
-
Feltis BN, Wignarajah D, Zheng L, Ward C, Reid D, Harding R, and Walters EH (2006) Increased vascular endothelial growth factor and receptors: relationship to angiogenesis in asthma. Am J Respir Crit Care Med 173:1201-1207.
-
(2006)
Am J Respir Crit Care Med
, vol.173
, pp. 1201-1207
-
-
Feltis, B.N.1
Wignarajah, D.2
Zheng, L.3
Ward, C.4
Reid, D.5
Harding, R.6
Walters, E.H.7
-
81
-
-
84939162409
-
Effect of JAK inhibitors on release of CXCL9, CXCL10 and CXCL11 from human airway epithelial cells
-
Fenwick PS, Macedo P, Kilty IC, Barnes PJ, and Donnelly LE (2015) Effect of JAK inhibitors on release of CXCL9, CXCL10 and CXCL11 from human airway epithelial cells. PLoS One 10:e0128757.
-
(2015)
Plos One
, vol.10
-
-
Fenwick, P.S.1
Macedo, P.2
Kilty, I.C.3
Barnes, P.J.4
Donnelly, L.E.5
-
82
-
-
84978993369
-
Inhibition of IRAK4 suppresses chemokine release from human bronchial epithelial cells
-
Fenwick P, Rao V, Kilty I, Lee K, Barnes PJ, and Donnelly D (2013) Inhibition of IRAK4 suppresses chemokine release from human bronchial epithelial cells. Eur Respir J 44:1033s
-
(2013)
Eur Respir J
, vol.44
, pp. 1033s
-
-
Fenwick, P.1
Rao, V.2
Kilty, I.3
Lee, K.4
Barnes, P.J.5
Donnelly, D.6
-
83
-
-
48949117942
-
Rho kinase as a therapeutic target in the treatment of asthma and chronic obstructive pulmonary disease
-
Fernandes LB, Henry PJ, and Goldie RG (2007) Rho kinase as a therapeutic target in the treatment of asthma and chronic obstructive pulmonary disease. Ther Adv Respir Dis 1:25-33.
-
(2007)
Ther Adv Respir Dis
, vol.1
, pp. 25-33
-
-
Fernandes, L.B.1
Henry, P.J.2
Goldie, R.G.3
-
84
-
-
84966769693
-
Targeting mitogen-activated protein kinaseactivated protein kinase 2 (MAPKAPK2, MK2): Medicinal chemistry efforts to lead small molecule inhibitors to clinical trials
-
Fiore M, Forli S, and Manetti F (2016) Targeting mitogen-activated protein kinaseactivated protein kinase 2 (MAPKAPK2, MK2): medicinal chemistry efforts to lead small molecule inhibitors to clinical trials. J Med Chem 59:3609-3634.
-
(2016)
J Med Chem
, vol.59
, pp. 3609-3634
-
-
Fiore, M.1
Forli, S.2
Manetti, F.3
-
85
-
-
44849096876
-
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
-
Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, and Fuchs C, et al. (2008) The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One 3:e2020.
-
(2008)
Plos One
, vol.3
-
-
Firestein, R.1
Blander, G.2
Michan, S.3
Oberdoerffer, P.4
Ogino, S.5
Campbell, J.6
Bhimavarapu, A.7
Luikenhuis, S.8
De Cabo, R.9
Fuchs, C.10
-
86
-
-
84957841409
-
Ibrutinib as a bruton kinase inhibitor in the management of chronic lymphocytic leukemia: A new agent with great promise
-
Foluso O, Glick A, Stender M, and Jaiyesimi I (2016) Ibrutinib as a bruton kinase inhibitor in the management of chronic lymphocytic leukemia: a new agent with great promise. Clin Lymphoma Myeloma Leuk 16:63-69.
-
(2016)
Clin Lymphoma Myeloma Leuk
, vol.16
, pp. 63-69
-
-
Foluso, O.1
Glick, A.2
Stender, M.3
Jaiyesimi, I.4
-
87
-
-
84954152909
-
Oxidative and nitrosative stress and histone deacetylase-2 activity in exacerbations of COPD
-
Footitt J, Mallia P, Durham AL, Ho WE, Trujillo-Torralbo MB, Telcian AG, Del Rosario A, Chang C, Peh HY, and Kebadze T, et al. (2016) Oxidative and nitrosative stress and histone deacetylase-2 activity in exacerbations of COPD. Chest 149:62-73.
-
(2016)
Chest
, vol.149
, pp. 62-73
-
-
Footitt, J.1
Mallia, P.2
Durham, A.L.3
Ho, W.E.4
Trujillo-Torralbo, M.B.5
Telcian, A.G.6
Del Rosario, A.7
Chang, C.8
Peh, H.Y.9
Kebadze, T.10
-
88
-
-
77949464718
-
From basic research to clinical development of MEK1/2 inhibitors for cancer therapy
-
Frémin C and Meloche S (2010) From basic research to clinical development of MEK1/2 inhibitors for cancer therapy. J Hematol Oncol 3:8.
-
(2010)
J Hematol Oncol
, vol.3
, pp. 8
-
-
Frémin, C.1
Meloche, S.2
-
89
-
-
84888108831
-
What goes up must come down: Molecular basis of MAPKAP kinase 2/3-dependent regulation of the inflammatory response and its inhibition
-
Gaestel M (2013) What goes up must come down: molecular basis of MAPKAP kinase 2/3-dependent regulation of the inflammatory response and its inhibition. Biol Chem 394:1301-1315.
-
(2013)
Biol Chem
, vol.394
, pp. 1301-1315
-
-
Gaestel, M.1
-
90
-
-
84880178353
-
Increased phosphorylated p38 mitogen-activated protein kinase in COPD lungs
-
Gaffey K, Reynolds S, Plumb J, Kaur M, and Singh D (2013) Increased phosphorylated p38 mitogen-activated protein kinase in COPD lungs. Eur Respir J 42:28-41.
-
(2013)
Eur Respir J
, vol.42
, pp. 28-41
-
-
Gaffey, K.1
Reynolds, S.2
Plumb, J.3
Kaur, M.4
Singh, D.5
-
91
-
-
84860668874
-
IgE and mast cells in allergic disease
-
Galli SJ and Tsai M (2012) IgE and mast cells in allergic disease. Nat Med 18: 693-704.
-
(2012)
Nat Med
, vol.18
, pp. 693-704
-
-
Galli, S.J.1
Tsai, M.2
-
93
-
-
84905459655
-
Getting Syk: Spleen tyrosine kinase as a therapeutic target
-
Geahlen RL (2014) Getting Syk: spleen tyrosine kinase as a therapeutic target. Trends Pharmacol Sci 35:414-422.
-
(2014)
Trends Pharmacol Sci
, vol.35
, pp. 414-422
-
-
Geahlen, R.L.1
-
95
-
-
32044449846
-
Transforming growth factor-beta induces airway smooth muscle hypertrophy
-
Goldsmith AM, Bentley JK, Zhou L, Jia Y, Bitar KN, Fingar DC, and Hershenson MB (2006) Transforming growth factor-beta induces airway smooth muscle hypertrophy. Am J Respir Cell Mol Biol 34:247-254.
-
(2006)
Am J Respir Cell Mol Biol
, vol.34
, pp. 247-254
-
-
Goldsmith, A.M.1
Bentley, J.K.2
Zhou, L.3
Jia, Y.4
Bitar, K.N.5
Fingar, D.C.6
Hershenson, M.B.7
-
96
-
-
36348998521
-
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase
-
Göransson O, McBride A, Hawley SA, Ross FA, Shpiro N, Foretz M, Viollet B, Hardie DG, and Sakamoto K (2007) Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J Biol Chem 282:32549-32560.
-
(2007)
J Biol Chem
, vol.282
, pp. 32549-32560
-
-
Göransson, O.1
McBride, A.2
Hawley, S.A.3
Ross, F.A.4
Shpiro, N.5
Foretz, M.6
Viollet, B.7
Hardie, D.G.8
Sakamoto, K.9
-
97
-
-
34447258367
-
MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation
-
Gorska MM, Liang Q, Stafford SJ, Goplen N, Dharajiya N, Guo L, Sur S, Gaestel M, and Alam R (2007) MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation. J Exp Med 204:1637-1652.
-
(2007)
J Exp Med
, vol.204
, pp. 1637-1652
-
-
Gorska, M.M.1
Liang, Q.2
Stafford, S.J.3
Goplen, N.4
Dharajiya, N.5
Guo, L.6
Sur, S.7
Gaestel, M.8
Alam, R.9
-
98
-
-
0346096592
-
Role of Rhokinase in maintaining airway smooth muscle contractile phenotype
-
Gosens R, Schaafsma D, Meurs H, Zaagsma J, and Nelemans SA (2004) Role of Rhokinase in maintaining airway smooth muscle contractile phenotype. Eur J Pharmacol 483:71-78.
-
(2004)
Eur J Pharmacol
, vol.483
, pp. 71-78
-
-
Gosens, R.1
Schaafsma, D.2
Meurs, H.3
Zaagsma, J.4
Nelemans, S.A.5
-
99
-
-
0028009707
-
Modulation of airway smooth muscle b-adrenoceptor function by a muscarinic agonist
-
Grandordy BM, Mak JCW, and Barnes PJ (1994) Modulation of airway smooth muscle b-adrenoceptor function by a muscarinic agonist. Life Sci 54:185-191.
-
(1994)
Life Sci
, vol.54
, pp. 185-191
-
-
Grandordy, B.M.1
Mak, J.2
Barnes, P.J.3
-
100
-
-
0034327287
-
Role of p38 mitogen-activated protein kinase in rhinovirus-induced cytokine production by bronchial epithelial cells
-
Griego SD, Weston CB, Adams JL, Tal-Singer R, and Dillon SB (2000) Role of p38 mitogen-activated protein kinase in rhinovirus-induced cytokine production by bronchial epithelial cells. J Immunol 165:5211-5220.
-
(2000)
J Immunol
, vol.165
, pp. 5211-5220
-
-
Griego, S.D.1
Weston, C.B.2
Adams, J.L.3
Tal-Singer, R.4
Dillon, S.B.5
-
101
-
-
33746646025
-
Mast cell inhibitor R112 is well tolerated and affects prostaglandin D2 but not other mediators, symptoms, or nasal volumes in a nasal challenge model of allergic rhinitis
-
Guyer BJ, Shimamoto SR, Bradhurst AL, Grossbard EB, Dreskin SC, and Nelson HS (2006) Mast cell inhibitor R112 is well tolerated and affects prostaglandin D2 but not other mediators, symptoms, or nasal volumes in a nasal challenge model of allergic rhinitis. Allergy Asthma Proc 27:208-213.
-
(2006)
Allergy Asthma Proc
, vol.27
, pp. 208-213
-
-
Guyer, B.J.1
Shimamoto, S.R.2
Bradhurst, A.L.3
Grossbard, E.B.4
Dreskin, S.C.5
Nelson, H.S.6
-
102
-
-
4444302962
-
Phophatidylinositol-3 kinase/ mammalian target of rapamycin/p70S6K regulates contractile protein accumulation in airway myocyte differentiation
-
Halayko AJ, Kartha S, Stelmack GL, McConville J, Tam J, Camoretti-Mercado B, Forsythe SM, Hershenson MB, and Solway J (2004) Phophatidylinositol-3 kinase/ mammalian target of rapamycin/p70S6K regulates contractile protein accumulation in airway myocyte differentiation. Am J Respir Cell Mol Biol 31:266-275.
-
(2004)
Am J Respir Cell Mol Biol
, vol.31
, pp. 266-275
-
-
Halayko, A.J.1
Kartha, S.2
Stelmack, G.L.3
McConville, J.4
Tam, J.5
Camoretti-Mercado, B.6
Forsythe, S.M.7
Hershenson, M.B.8
Solway, J.9
-
103
-
-
20444478721
-
The role of p38 MAPK in rhinovirus-induced monocyte chemoattractant protein-1 production by monocytic-lineage cells
-
Hall DJ, Bates ME, Guar L, Cronan M, Korpi N, and Bertics PJ (2005) The role of p38 MAPK in rhinovirus-induced monocyte chemoattractant protein-1 production by monocytic-lineage cells. J Immunol 174:8056-8063.
-
(2005)
J Immunol
, vol.174
, pp. 8056-8063
-
-
Hall, D.J.1
Bates, M.E.2
Guar, L.3
Cronan, M.4
Korpi, N.5
Bertics, P.J.6
-
105
-
-
0037329290
-
The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma
-
Hamilton LM, Torres-Lozano C, Puddicombe SM, Richter A, Kimber I, Dearman RJ, Vrugt B, Aalbers R, Holgate ST, and Djukanović R, et al. (2003) The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma. Clin Exp Allergy 33:233-240.
-
(2003)
Clin Exp Allergy
, vol.33
, pp. 233-240
-
-
Hamilton, L.M.1
Torres-Lozano, C.2
Puddicombe, S.M.3
Richter, A.4
Kimber, I.5
Dearman, R.J.6
Vrugt, B.7
Aalbers, R.8
Holgate, S.T.9
Djukanović, R.10
-
106
-
-
84883233547
-
TNF-a-mediated bronchial barrier disruption and regulation by src-family kinase activation
-
Hardyman MA, Wilkinson E, Martin E, Jayasekera NP, Blume C, Swindle EJ, Gozzard N, Holgate ST, Howarth PH, and Davies DE, et al. (2013) TNF-a-mediated bronchial barrier disruption and regulation by src-family kinase activation. J Allergy Clin Immunol 132:665-675.
-
(2013)
J Allergy Clin Immunol
, vol.132
, pp. 665-675
-
-
Hardyman, M.A.1
Wilkinson, E.2
Martin, E.3
Jayasekera, N.P.4
Blume, C.5
Swindle, E.J.6
Gozzard, N.7
Holgate, S.T.8
Howarth, P.H.9
Davies, D.E.10
-
107
-
-
0033958495
-
Effects of inhaled corticosteroid therapy on expression and DNA-binding activity of nuclear factor kappaB in asthma
-
Hart L, Lim S, Adcock I, Barnes PJ, and Chung KF (2000) Effects of inhaled corticosteroid therapy on expression and DNA-binding activity of nuclear factor kappaB in asthma. Am J Respir Crit Care Med 161:224-231.
-
(2000)
Am J Respir Crit Care Med
, vol.161
, pp. 224-231
-
-
Hart, L.1
Lim, S.2
Adcock, I.3
Barnes, P.J.4
Chung, K.F.5
-
108
-
-
0031731150
-
Activation and localization of transcription factor, nuclear factor-kappaB, in asthma
-
Hart LA, Krishnan VL, Adcock IM, Barnes PJ, and Chung KF (1998) Activation and localization of transcription factor, nuclear factor-kappaB, in asthma. Am J Respir Crit Care Med 158:1585-1592.
-
(1998)
Am J Respir Crit Care Med
, vol.158
, pp. 1585-1592
-
-
Hart, L.A.1
Krishnan, V.L.2
Adcock, I.M.3
Barnes, P.J.4
Chung, K.F.5
-
109
-
-
44749093175
-
Curcumin: From ancient medicine to current clinical trials
-
Hatcher H, Planalp R, Cho J, Torti FM, and Torti SV (2008) Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci 65:1631-1652.
-
(2008)
Cell Mol Life Sci
, vol.65
, pp. 1631-1652
-
-
Hatcher, H.1
Planalp, R.2
Cho, J.3
Torti, F.M.4
Torti, S.V.5
-
112
-
-
84856641109
-
NF-kB, the first quarter-century: Remarkable progress and outstanding questions
-
Hayden MS and Ghosh S (2012) NF-kB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev 26:203-234.
-
(2012)
Genes Dev
, vol.26
, pp. 203-234
-
-
Hayden, M.S.1
Ghosh, S.2
-
113
-
-
34247205457
-
Niflumic acid and AG-1478 reduce cigarette smoke-induced mucin synthesis: The role of hCLCA1
-
Hegab AE, Sakamoto T, Nomura A, Ishii Y, Morishima Y, Iizuka T, Kiwamoto T, Matsuno Y, Homma S, and Sekizawa K (2007) Niflumic acid and AG-1478 reduce cigarette smoke-induced mucin synthesis: the role of hCLCA1. Chest 131: 1149-1156.
-
(2007)
Chest
, vol.131
, pp. 1149-1156
-
-
Hegab, A.E.1
Sakamoto, T.2
Nomura, A.3
Ishii, Y.4
Morishima, Y.5
Iizuka, T.6
Kiwamoto, T.7
Matsuno, Y.8
Homma, S.9
Sekizawa, K.10
-
114
-
-
84926253393
-
The prevalence of severe refractory asthma
-
Hekking PP, Wener RR, Amelink M, Zwinderman AH, Bouvy ML, and Bel EH (2015) The prevalence of severe refractory asthma. J Allergy Clin Immunol 135:896-902.
-
(2015)
J Allergy Clin Immunol
, vol.135
, pp. 896-902
-
-
Hekking, P.P.1
Wener, R.R.2
Amelink, M.3
Zwinderman, A.H.4
Bouvy, M.L.5
Bel, E.H.6
-
115
-
-
10644234866
-
A rho kinase inhibitor, Y-27632 inhibits pulmonary eosinophilia, bronchoconstriction and airways hyperresponsiveness in allergic mice
-
Henry PJ, Mann TS, and Goldie RG (2005) A rho kinase inhibitor, Y-27632 inhibits pulmonary eosinophilia, bronchoconstriction and airways hyperresponsiveness in allergic mice. Pulm Pharmacol Ther 18:67-74.
-
(2005)
Pulm Pharmacol Ther
, vol.18
, pp. 67-74
-
-
Henry, P.J.1
Mann, T.S.2
Goldie, R.G.3
-
116
-
-
84939783826
-
Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway
-
Herbertz S, Sawyer JS, Stauber AJ, Gueorguieva I, Driscoll KE, Estrem ST, Cleverly AL, Desaiah D, Guba SC, and Benhadji KA, et al. (2015) Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway. Drug Des Devel Ther 9:4479-4499.
-
(2015)
Drug Des Devel Ther
, vol.9
, pp. 4479-4499
-
-
Herbertz, S.1
Sawyer, J.S.2
Stauber, A.J.3
Gueorguieva, I.4
Driscoll, K.E.5
Estrem, S.T.6
Cleverly, A.L.7
Desaiah, D.8
Guba, S.C.9
Benhadji, K.A.10
-
117
-
-
80052535616
-
In vivo role of platelet-derived growth factor-BB in airway smooth muscle proliferation in mouse lung
-
Hirota JA, Ask K, Farkas L, Smith JA, Ellis R, Rodriguez-Lecompte JC, Kolb M, and Inman MD (2011) In vivo role of platelet-derived growth factor-BB in airway smooth muscle proliferation in mouse lung. Am J Respir Cell Mol Biol 45:566-572.
-
(2011)
Am J Respir Cell Mol Biol
, vol.45
, pp. 566-572
-
-
Hirota, J.A.1
Ask, K.2
Farkas, L.3
Smith, J.A.4
Ellis, R.5
Rodriguez-Lecompte, J.C.6
Kolb, M.7
Inman, M.D.8
-
118
-
-
0029915964
-
PDGF isoform-induced proliferation and receptor expression in human cultured airway smooth muscle cells
-
Hirst SJ, Barnes PJ, and Twort CHC (1996) PDGF isoform-induced proliferation and receptor expression in human cultured airway smooth muscle cells. Am J Physiol 270:L415-L428.
-
(1996)
Am J Physiol
, vol.270
, pp. L415-L428
-
-
Hirst, S.J.1
Barnes, P.J.2
Twort, C.3
-
119
-
-
0035117286
-
Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis
-
Hoshino M, Takahashi M, and Aoike N (2001) Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis. J Allergy Clin Immunol 107:295-301.
-
(2001)
J Allergy Clin Immunol
, vol.107
, pp. 295-301
-
-
Hoshino, M.1
Takahashi, M.2
Aoike, N.3
-
120
-
-
84941588376
-
Rapamycin inhibition of eosinophil differentiation attenuates allergic airway inflammation in mice
-
Hua W, Liu H, Xia LX, Tian BP, Huang HQ, Chen ZY, Ju ZY, Li W, Chen ZH, and Shen HH (2015) Rapamycin inhibition of eosinophil differentiation attenuates allergic airway inflammation in mice. Respirology 20:1055-1065.
-
(2015)
Respirology
, vol.20
, pp. 1055-1065
-
-
Hua, W.1
Liu, H.2
Xia, L.X.3
Tian, B.P.4
Huang, H.Q.5
Chen, Z.Y.6
Ju, Z.Y.7
Li, W.8
Chen, Z.H.9
Shen, H.H.10
-
121
-
-
0033786922
-
Protein tyrosine kinase structure and function
-
Hubbard SR and Till JH (2000) Protein tyrosine kinase structure and function. Annu Rev Biochem 69:373-398.
-
(2000)
Annu Rev Biochem
, vol.69
, pp. 373-398
-
-
Hubbard, S.R.1
Till, J.H.2
-
122
-
-
67650314629
-
Masitinib, a c-kit/ PDGF receptor tyrosine kinase inhibitor, improves disease control in severe corticosteroid-dependent asthmatics
-
Humbert M, de Blay F, Garcia G, Prud’homme A, Leroyer C, Magnan A, Tunonde-Lara JM, Pison C, Aubier M, and Charpin D, et al. (2009) Masitinib, a c-kit/ PDGF receptor tyrosine kinase inhibitor, improves disease control in severe corticosteroid-dependent asthmatics. Allergy 64:1194-1201.
-
(2009)
Allergy
, vol.64
, pp. 1194-1201
-
-
Humbert, M.1
De Blay, F.2
Garcia, G.3
Prud’Homme, A.4
Leroyer, C.5
Magnan, A.6
Tunonde-Lara, J.M.7
Pison, C.8
Aubier, M.9
Charpin, D.10
-
123
-
-
0035207080
-
Theophylline inhibits NF-k B activation and I k B a degradation in human pulmonary epithelial cells
-
Ichiyama T, Hasegawa S, Matsubara T, Hayashi T, and Furukawa S (2001) Theophylline inhibits NF-k B activation and I k B a degradation in human pulmonary epithelial cells. Naunyn Schmiedebergs Arch Pharmacol 364:558-561.
-
(2001)
Naunyn Schmiedebergs Arch Pharmacol
, vol.364
, pp. 558-561
-
-
Ichiyama, T.1
Hasegawa, S.2
Matsubara, T.3
Hayashi, T.4
Furukawa, S.5
-
124
-
-
0036838772
-
Pathogenesis of fibrosis: Role of TGF-b and CTGF
-
Ihn H (2002) Pathogenesis of fibrosis: role of TGF-b and CTGF. Curr Opin Rheumatol 14:681-685.
-
(2002)
Curr Opin Rheumatol
, vol.14
, pp. 681-685
-
-
Ihn, H.1
-
125
-
-
0036231010
-
P38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: Role in steroid-insensitive asthma
-
Irusen E, Matthews JG, Takahashi A, Barnes PJ, Chung KF, and Adcock IM (2002) p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. J Allergy Clin Immunol 109:649-657.
-
(2002)
J Allergy Clin Immunol
, vol.109
, pp. 649-657
-
-
Irusen, E.1
Matthews, J.G.2
Takahashi, A.3
Barnes, P.J.4
Chung, K.F.5
Adcock, I.M.6
-
126
-
-
33947358942
-
Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease
-
Ito K, Caramori G, and Adcock IM (2007) Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease. J Pharmacol Exp Ther 321:1-8.
-
(2007)
J Pharmacol Exp Ther
, vol.321
, pp. 1-8
-
-
Ito, K.1
Caramori, G.2
Adcock, I.M.3
-
127
-
-
0037173056
-
A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression
-
Ito K, Lim S, Caramori G, Cosio B, Chung KF, Adcock IM, and Barnes PJ (2002) A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci USA 99: 8921-8926.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 8921-8926
-
-
Ito, K.1
Lim, S.2
Caramori, G.3
Cosio, B.4
Chung, K.F.5
Adcock, I.M.6
Barnes, P.J.7
-
128
-
-
16244374879
-
Jun N-terminal kinase is essential for CD40-mediated IgE class switching in B cells
-
Jabara HH and Geha RS (2005) Jun N-terminal kinase is essential for CD40-mediated IgE class switching in B cells. J Allergy Clin Immunol 115:856-863.
-
(2005)
J Allergy Clin Immunol
, vol.115
, pp. 856-863
-
-
Jabara, H.H.1
Geha, R.S.2
-
129
-
-
78049300969
-
Lancemaside A inhibits lipopolysaccharide-induced inflammation by targeting LPS/TLR4 complex
-
Joh EH and Kim DH (2010) Lancemaside A inhibits lipopolysaccharide-induced inflammation by targeting LPS/TLR4 complex. J Cell Biochem 111:865-871.
-
(2010)
J Cell Biochem
, vol.111
, pp. 865-871
-
-
Joh, E.H.1
Kim, D.H.2
-
130
-
-
0037032817
-
Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
-
Johnson GL and Lapadat R (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911-1912.
-
(2002)
Science
, vol.298
, pp. 1911-1912
-
-
Johnson, G.L.1
Lapadat, R.2
-
131
-
-
84872527628
-
Rabinovitch PS, and Kaeberlein M (2013) mTOR is a key modulator of ageing and age-related disease
-
Johnson SC, Rabinovitch PS, and Kaeberlein M (2013) mTOR is a key modulator of ageing and age-related disease. Nature 493:338-345.
-
Nature
, vol.493
, pp. 338-345
-
-
Johnson, S.C.1
-
132
-
-
82455198983
-
Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets
-
Jun JI and Lau LF (2011) Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nat Rev Drug Discov 10:945-963.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 945-963
-
-
Jun, J.I.1
Lau, L.F.2
-
133
-
-
84909992506
-
Simultaneous assessment of hepatocyte growth factor and vascular endothelial growth factor in epithelial lining fluid from patients with COPD
-
Kanazawa HTY, Asai K, and Hirata K (2014) Simultaneous assessment of hepatocyte growth factor and vascular endothelial growth factor in epithelial lining fluid from patients with COPD. Chest 146:1159-1165.
-
(2014)
Chest
, vol.146
, pp. 1159-1165
-
-
Kanazawa, H.1
Asai, K.2
Hirata, K.3
-
134
-
-
0037398983
-
Possible effects of vascular endothelial growth factor in the pathogenesis of chronic obstructive pulmonary disease
-
Kanazawa H, Asai K, Hirata K, and Yoshikawa J (2003) Possible effects of vascular endothelial growth factor in the pathogenesis of chronic obstructive pulmonary disease. Am J Med 114:354-358.
-
(2003)
Am J Med
, vol.114
, pp. 354-358
-
-
Kanazawa, H.1
Asai, K.2
Hirata, K.3
Yoshikawa, J.4
-
135
-
-
0032763790
-
SB 203580, an inhibitor of p38 mitogen-activated protein kinase, enhances constitutive apoptosis of cytokine-deprived human eosinophils
-
Kankaanranta H, De Souza PM, Barnes PJ, Salmon M, Giembycz MA, and Lindsay MA (1999) SB 203580, an inhibitor of p38 mitogen-activated protein kinase, enhances constitutive apoptosis of cytokine-deprived human eosinophils. J Pharmacol Exp Ther 290:621-628.
-
(1999)
J Pharmacol Exp Ther
, vol.290
, pp. 621-628
-
-
Kankaanranta, H.1
De Souza, P.M.2
Barnes, P.J.3
Salmon, M.4
Giembycz, M.A.5
Lindsay, M.A.6
-
136
-
-
84896513403
-
Tumour necrosis factor-a regulates human eosinophil apoptosis via ligation of TNF-receptor 1 and balance between NF-kB and AP-1
-
Kankaanranta H, Ilmarinen P, Zhang X, Adcock IM, Lahti A, Barnes PJ, Giembycz MA, Lindsay MA, and Moilanen E (2014) Tumour necrosis factor-a regulates human eosinophil apoptosis via ligation of TNF-receptor 1 and balance between NF-kB and AP-1. PLoS One 9:e90298.
-
(2014)
Plos One
, vol.9
-
-
Kankaanranta, H.1
Ilmarinen, P.2
Zhang, X.3
Adcock, I.M.4
Lahti, A.5
Barnes, P.J.6
Giembycz, M.A.7
Lindsay, M.A.8
Moilanen, E.9
-
137
-
-
84943279413
-
ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice
-
Kasahara DI, Mathews JA, Park CY, Cho Y, Hunt G, Wurmbrand AP, Liao JK, and Shore SA (2015) ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice. Am J Physiol Lung Cell Mol Physiol 309:L736-L746.
-
(2015)
Am J Physiol Lung Cell Mol Physiol
, vol.309
, pp. L736-L746
-
-
Kasahara, D.I.1
Mathews, J.A.2
Park, C.Y.3
Cho, Y.4
Hunt, G.5
Wurmbrand, A.P.6
Liao, J.K.7
Shore, S.A.8
-
138
-
-
84937729639
-
Nintedanib: A review of its use in patients with idiopathic pulmonary fibrosis
-
Keating GM (2015) Nintedanib: A review of its use in patients with idiopathic pulmonary fibrosis. Drugs 75:1131-1140.
-
(2015)
Drugs
, vol.75
, pp. 1131-1140
-
-
Keating, G.M.1
-
139
-
-
84922379088
-
Reversal of corticosteroid insensitivity by p38 MAPK inhibition in peripheral blood mononuclear cells from COPD
-
Khorasani N, Baker J, Johnson M, Chung KF, and Bhavsar PK (2015) Reversal of corticosteroid insensitivity by p38 MAPK inhibition in peripheral blood mononuclear cells from COPD. Int J Chron Obstruct Pulmon Dis 10:283-291.
-
(2015)
Int J Chron Obstruct Pulmon Dis
, vol.10
, pp. 283-291
-
-
Khorasani, N.1
Baker, J.2
Johnson, M.3
Chung, K.F.4
Bhavsar, P.K.5
-
140
-
-
84921417645
-
TAK1 selective inhibition: State of the art and future opportunities
-
Kilty I and Jones LH (2015) TAK1 selective inhibition: state of the art and future opportunities. Future Med Chem 7:23-33.
-
(2015)
Future Med Chem
, vol.7
, pp. 23-33
-
-
Kilty, I.1
Jones, L.H.2
-
141
-
-
84908071354
-
Genistein inhibits pro‑inflammatory cytokines in human mast cell activation through the inhibition of the ERK pathway
-
Kim DH, Jung WS, Kim ME, Lee HW, Youn HY, Seon JK, Lee HN, and Lee JS (2014) Genistein inhibits pro‑inflammatory cytokines in human mast cell activation through the inhibition of the ERK pathway. Int J Mol Med 34:1669-1674.
-
(2014)
Int J Mol Med
, vol.34
, pp. 1669-1674
-
-
Kim, D.H.1
Jung, W.S.2
Kim, M.E.3
Lee, H.W.4
Youn, H.Y.5
Seon, J.K.6
Lee, H.N.7
Lee, J.S.8
-
142
-
-
77952711172
-
Conversion of Th2 memory cells into Foxp3+ regulatory T cells suppressing Th2-mediated allergic asthma
-
Kim BS, Kim IK, Park YJ, Kim YS, Kim YJ, Chang WS, Lee YS, Kweon MN, Chung Y, and Kang CY (2010) Conversion of Th2 memory cells into Foxp3+ regulatory T cells suppressing Th2-mediated allergic asthma. Proc Natl Acad Sci USA 107: 8742-8747.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 8742-8747
-
-
Kim, B.S.1
Kim, I.K.2
Park, Y.J.3
Kim, Y.S.4
Kim, Y.J.5
Chang, W.S.6
Lee, Y.S.7
Kweon, M.N.8
Chung, Y.9
Kang, C.Y.10
-
143
-
-
52049091239
-
The multiple roles of phosphoinositide 3-kinase in mast cell biology
-
Kim MS, Rådinger M, and Gilfillan AM (2008) The multiple roles of phosphoinositide 3-kinase in mast cell biology. Trends Immunol 29:493-501.
-
(2008)
Trends Immunol
, vol.29
, pp. 493-501
-
-
Kim, M.S.1
Rådinger, M.2
Gilfillan, A.M.3
-
144
-
-
84916241169
-
The Rho kinases: Critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis
-
Knipe RS, Tager AM, and Liao JK (2015) The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis. Pharmacol Rev 67:103-117.
-
(2015)
Pharmacol Rev
, vol.67
, pp. 103-117
-
-
Knipe, R.S.1
Tager, A.M.2
Liao, J.K.3
-
145
-
-
84860636707
-
Increased corticosteroid sensitivity by a long acting b2 agonist formoterol via b2 adrenoceptor independent protein phosphatase 2A activation
-
Kobayashi Y, Mercado N, Miller-Larsson A, Barnes PJ, and Ito K (2012) Increased corticosteroid sensitivity by a long acting b2 agonist formoterol via b2 adrenoceptor independent protein phosphatase 2A activation. Pulm Pharmacol Ther 25: 201-207.
-
(2012)
Pulm Pharmacol Ther
, vol.25
, pp. 201-207
-
-
Kobayashi, Y.1
Mercado, N.2
Miller-Larsson, A.3
Barnes, P.J.4
Ito, K.5
-
146
-
-
84879019868
-
A novel macrolide/fluoroketolide, solithromycin (CEM-101), reverses corticosteroid insensitivity via phosphoinositide 3-kinase pathway inhibition
-
Kobayashi Y, Wada H, Rossios C, Takagi D, Charron C, Barnes PJ, and Ito K (2013) A novel macrolide/fluoroketolide, solithromycin (CEM-101), reverses corticosteroid insensitivity via phosphoinositide 3-kinase pathway inhibition. Br J Pharmacol 169:1024-1034.
-
(2013)
Br J Pharmacol
, vol.169
, pp. 1024-1034
-
-
Kobayashi, Y.1
Wada, H.2
Rossios, C.3
Takagi, D.4
Charron, C.5
Barnes, P.J.6
Ito, K.7
-
147
-
-
1542284710
-
Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages
-
Koch A, Giembycz M, Ito K, Lim S, Jazrawi E, Barnes PJ, Adcock I, Erdmann E, and Chung KF (2004) Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages. Am J Respir Cell Mol Biol 30: 342-349.
-
(2004)
Am J Respir Cell Mol Biol
, vol.30
, pp. 342-349
-
-
Koch, A.1
Giembycz, M.2
Ito, K.3
Lim, S.4
Jazrawi, E.5
Barnes, P.J.6
Adcock, I.7
Erdmann, E.8
Chung, K.F.9
-
148
-
-
84922287240
-
Inhibition of transforming growth factor-b via the activin receptor-like kinase-5 inhibitor attenuates pulmonary fibrosis
-
Koh RY, Lim CL, Uhal BD, Abdullah M, Vidyadaran S, Ho CC, and Seow HF (2015) Inhibition of transforming growth factor-b via the activin receptor-like kinase-5 inhibitor attenuates pulmonary fibrosis. Mol Med Rep 11:3808-3813.
-
(2015)
Mol Med Rep
, vol.11
, pp. 3808-3813
-
-
Koh, R.Y.1
Lim, C.L.2
Uhal, B.D.3
Abdullah, M.4
Vidyadaran, S.5
Ho, C.C.6
Seow, H.F.7
-
149
-
-
0346726049
-
Expression of transforming growth factor beta1 in bronchial biopsies in asthma and COPD
-
Kokturk N, Tatlicioglu T, Memis L, Akyurek N, and Akyol G (2003) Expression of transforming growth factor beta1 in bronchial biopsies in asthma and COPD. J Asthma 40:887-893.
-
(2003)
J Asthma
, vol.40
, pp. 887-893
-
-
Kokturk, N.1
Tatlicioglu, T.2
Memis, L.3
Akyurek, N.4
Akyol, G.5
-
150
-
-
37549027570
-
Transforming growth factor-beta activation in the lung: Focus on fibrosis and reactive oxygen species
-
Koli K, Myllärniemi M, Keski-Oja J, and Kinnula VL (2008) Transforming growth factor-beta activation in the lung: focus on fibrosis and reactive oxygen species. Antioxid Redox Signal 10:333-342.
-
(2008)
Antioxid Redox Signal
, vol.10
, pp. 333-342
-
-
Koli, K.1
Myllärniemi, M.2
Keski-Oja, J.3
Kinnula, V.L.4
-
151
-
-
74649083717
-
Sphingosine kinase 1 regulates mucin production via ERK phosphorylation
-
Kono Y, Nishiuma T, Okada T, Kobayashi K, Funada Y, Kotani Y, Jahangeer S, Nakamura S, and Nishimura Y (2010) Sphingosine kinase 1 regulates mucin production via ERK phosphorylation. Pulm Pharmacol Ther 23:36-42.
-
(2010)
Pulm Pharmacol Ther
, vol.23
, pp. 36-42
-
-
Kono, Y.1
Nishiuma, T.2
Okada, T.3
Kobayashi, K.4
Funada, Y.5
Kotani, Y.6
Jahangeer, S.7
Nakamura, S.8
Nishimura, Y.9
-
152
-
-
84864994569
-
Jakinibs: A new class of kinase inhibitors in cancer and autoimmune disease
-
Kontzias A, Kotlyar A, Laurence A, Changelian P, and O’Shea JJ (2012) Jakinibs: a new class of kinase inhibitors in cancer and autoimmune disease. Curr Opin Pharmacol 12:464-470.
-
(2012)
Curr Opin Pharmacol
, vol.12
, pp. 464-470
-
-
Kontzias, A.1
Kotlyar, A.2
Laurence, A.3
Changelian, P.4
O’Shea, J.J.5
-
153
-
-
39149103052
-
The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia
-
Kudlacz E, Conklyn M, Andresen C, Whitney-Pickett C, and Changelian P (2008) The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia. Eur J Pharmacol 582:154-161.
-
(2008)
Eur J Pharmacol
, vol.582
, pp. 154-161
-
-
Kudlacz, E.1
Conklyn, M.2
Resen, C.3
Whitney-Pickett, C.4
Changelian, P.5
-
155
-
-
0032535369
-
Corticosteroid-resistant bronchial asthma is associated with increased c-fos expression in monocytes and T lymphocytes
-
Lane SJ, Adcock IM, Richards D, Hawrylowicz C, Barnes PJ, and Lee TH (1998) Corticosteroid-resistant bronchial asthma is associated with increased c-fos expression in monocytes and T lymphocytes. J Clin Invest 102:2156-2164.
-
(1998)
J Clin Invest
, vol.102
, pp. 2156-2164
-
-
Lane, S.J.1
Adcock, I.M.2
Richards, D.3
Hawrylowicz, C.4
Barnes, P.J.5
Lee, T.H.6
-
156
-
-
65249173404
-
Crucial implication of protein kinase C (PKC)-delta, PKCzeta, ERK-1/2, and p38 MAPK in migration of human asthmatic eosinophils
-
Langlois A, Chouinard F, Flamand N, Ferland C, Rola-Pleszczynski M, and Laviolette M (2009) Crucial implication of protein kinase C (PKC)-delta, PKCzeta, ERK-1/2, and p38 MAPK in migration of human asthmatic eosinophils. J Leukoc Biol 85:656-663.
-
(2009)
J Leukoc Biol
, vol.85
, pp. 656-663
-
-
Langlois, A.1
Chouinard, F.2
Flamand, N.3
Ferland, C.4
Rola-Pleszczynski, M.5
Laviolette, M.6
-
157
-
-
0036082554
-
Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGFbeta type I receptor kinase activity: SB-431542
-
Laping NJ, Grygielko E, Mathur A, Butter S, Bomberger J, Tweed C, Martin W, Fornwald J, Lehr R, and Harling J, et al. (2002) Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGFbeta type I receptor kinase activity: SB-431542. Mol Pharmacol 62:58-64.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 58-64
-
-
Laping, N.J.1
Grygielko, E.2
Mathur, A.3
Butter, S.4
Bomberger, J.5
Tweed, C.6
Martin, W.7
Fornwald, J.8
Lehr, R.9
Harling, J.10
-
158
-
-
79952859363
-
HRV signaling in airway epithelial cells is regulated by ITAM-mediated recruitment and activation of Syk
-
Lau C, Castellanos P, Ranev D, Wang X, and Chow CW (2011) HRV signaling in airway epithelial cells is regulated by ITAM-mediated recruitment and activation of Syk. Protein Pept Lett 18:518-529.
-
(2011)
Protein Pept Lett
, vol.18
, pp. 518-529
-
-
Lau, C.1
Castellanos, P.2
Ranev, D.3
Wang, X.4
Chow, C.W.5
-
159
-
-
40449122567
-
Syk associates with clathrin and mediates phosphatidylinositol 3-kinase activation during human rhinovirus internalization
-
Lau C, Wang X, Song L, North M, Wiehler S, Proud D, and Chow CW (2008) Syk associates with clathrin and mediates phosphatidylinositol 3-kinase activation during human rhinovirus internalization. J Immunol 180:870-880.
-
(2008)
J Immunol
, vol.180
, pp. 870-880
-
-
Lau, C.1
Wang, X.2
Song, L.3
North, M.4
Wiehler, S.5
Proud, D.6
Chow, C.W.7
-
160
-
-
84906237265
-
The effects of the novel SHIP1 activator AQX-1125 on allergen-induced responses in mild-to-moderate asthma
-
Leaker BR, Barnes PJ, O’Connor BJ, Ali FY, Tam P, Neville J, Mackenzie LF, and MacRury T (2014) The effects of the novel SHIP1 activator AQX-1125 on allergen-induced responses in mild-to-moderate asthma. Clin Exp Allergy 44: 1146-1153.
-
(2014)
Clin Exp Allergy
, vol.44
, pp. 1146-1153
-
-
Leaker, B.R.1
Barnes, P.J.2
O’Connor, B.J.3
Ali, F.Y.4
Tam, P.5
Neville, J.6
Mackenzie, L.F.7
Macrury, T.8
-
161
-
-
45849133042
-
TRX-ASK1-JNK signaling regulation of cell density-dependent cytotoxicity in cigarette smoke-exposed human bronchial epithelial cells
-
Lee YC, Chuang CY, Lee PK, Lee JS, Harper RW, Buckpitt AB, Wu R, and Oslund K (2008) TRX-ASK1-JNK signaling regulation of cell density-dependent cytotoxicity in cigarette smoke-exposed human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 294:L921-L931.
-
(2008)
Am J Physiol Lung Cell Mol Physiol
, vol.294
, pp. L921-L931
-
-
Lee, Y.C.1
Chuang, C.Y.2
Lee, P.K.3
Lee, J.S.4
Harper, R.W.5
Buckpitt, A.B.6
Wu, R.7
Oslund, K.8
-
162
-
-
29644441714
-
NFkappaB and activator protein 1 response elements and the role of histone modifications in IL-1b-induced TGF-b1 gene transcription
-
Lee KY, Ito K, Hayashi R, Jazrawi EP, Barnes PJ, and Adcock IM (2006b) NFkappaB and activator protein 1 response elements and the role of histone modifications in IL-1b-induced TGF-b1 gene transcription. J Immunol 176:603-615.
-
(2006)
J Immunol
, vol.176
, pp. 603-615
-
-
Lee, K.Y.1
Ito, K.2
Hayashi, R.3
Jazrawi, E.P.4
Barnes, P.J.5
Adcock, I.M.6
-
163
-
-
84957884373
-
Phosphoinositide 3-kinase-d regulates fungus-induced allergic lung inflammation through endoplasmic reticulum stress
-
Lee KS, Jeong JS, Kim SR, Cho SH, Kolliputi N, Ko YH, Lee KB, Park SC, Park HJ, and Lee YC (2016) Phosphoinositide 3-kinase-d regulates fungus-induced allergic lung inflammation through endoplasmic reticulum stress. Thorax 71:52-63.
-
(2016)
Thorax
, vol.71
, pp. 52-63
-
-
Lee, K.S.1
Jeong, J.S.2
Kim, S.R.3
Cho, S.H.4
Kolliputi, N.5
Ko, Y.H.6
Lee, K.B.7
Park, S.C.8
Park, H.J.9
Lee, Y.C.10
-
164
-
-
33645827963
-
Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model
-
Lee KS, Lee HK, Hayflick JS, Lee YC, and Puri KD (2006a) Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model. FASEB J 20:455-465.
-
(2006)
FASEB J
, vol.20
, pp. 455-465
-
-
Lee, K.S.1
Lee, H.K.2
Hayflick, J.S.3
Lee, Y.C.4
Puri, K.D.5
-
165
-
-
84924146200
-
Role of AMP-activated protein kinase (AMPK) in smoking-Induced lung Inflammation and emphysema
-
Lee JS, Park SJ, Cho YS, Huh JW, Oh YM, and Lee SD (2015) Role of AMP-activated protein kinase (AMPK) in smoking-Induced lung Inflammation and emphysema. Tuberc Respir Dis (Seoul) 78:8-17.
-
(2015)
Tuberc Respir Dis (Seoul)
, vol.78
, pp. 8-17
-
-
Lee, J.S.1
Park, S.J.2
Cho, Y.S.3
Huh, J.W.4
Oh, Y.M.5
Lee, S.D.6
-
166
-
-
77953896432
-
Cell signaling by receptor tyrosine kinases
-
Lemmon MA and Schlessinger J (2010) Cell signaling by receptor tyrosine kinases. Cell 141:1117-1134.
-
(2010)
Cell
, vol.141
, pp. 1117-1134
-
-
Lemmon, M.A.1
Schlessinger, J.2
-
167
-
-
84867718489
-
Stem cell factor receptor/c-Kit: From basic science to clinical implications
-
Lennartsson J and Rönnstrand L (2012) Stem cell factor receptor/c-Kit: from basic science to clinical implications. Physiol Rev 92:1619-1649.
-
(2012)
Physiol Rev
, vol.92
, pp. 1619-1649
-
-
Lennartsson, J.1
Rönnstrand, L.2
-
168
-
-
33751173229
-
Effect of transforming growth factor-beta receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling
-
Leung SY, Niimi A, Noble A, Oates T, Williams AS, Medicherla S, Protter AA, and Chung KF (2006) Effect of transforming growth factor-beta receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling. J Pharmacol Exp Ther 319:586-594.
-
(2006)
J Pharmacol Exp Ther
, vol.319
, pp. 586-594
-
-
Leung, S.Y.1
Niimi, A.2
Noble, A.3
Oates, T.4
Williams, A.S.5
Medicherla, S.6
Protter, A.A.7
Chung, K.F.8
-
169
-
-
0036886390
-
The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells
-
Levings MK, Bacchetta R, Schulz U, and Roncarolo MG (2002) The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells. Int Arch Allergy Immunol 129:263-276.
-
(2002)
Int Arch Allergy Immunol
, vol.129
, pp. 263-276
-
-
Levings, M.K.1
Bacchetta, R.2
Schulz, U.3
Roncarolo, M.G.4
-
170
-
-
84950259849
-
Activated p38 MAPK in peripheral blood monocytes of steroid resistant asthmatics
-
Li LB, Leung DY, and Goleva E (2015) Activated p38 MAPK in peripheral blood monocytes of steroid resistant asthmatics. PLoS One 10:e0141909.
-
(2015)
Plos One
, vol.10
-
-
Li, L.B.1
Leung, D.Y.2
Goleva, E.3
-
171
-
-
84860344107
-
Chronic mechanical stress induces mucin 5AC expression in human bronchial epithelial cells through ERK dependent pathways
-
Li N, Li Q, Zhou XD, Kolosov VP, and Perelman JM (2012) Chronic mechanical stress induces mucin 5AC expression in human bronchial epithelial cells through ERK dependent pathways. Mol Biol Rep 39:1019-1028.
-
(2012)
Mol Biol Rep
, vol.39
, pp. 1019-1028
-
-
Li, N.1
Li, Q.2
Zhou, X.D.3
Kolosov, V.P.4
Perelman, J.M.5
-
172
-
-
84940944661
-
Design of a phase 2 clinical trial of an ASK1 inhibitor, GS-4997, in patients with diabetic kidney disease
-
Lin JH, Zhang JJ, Lin SL, and Chertow GM (2015) Design of a phase 2 clinical trial of an ASK1 inhibitor, GS-4997, in patients with diabetic kidney disease. Nephron 129:29-33.
-
(2015)
Nephron
, vol.129
, pp. 29-33
-
-
Lin, J.H.1
Zhang, J.J.2
Lin, S.L.3
Chertow, G.M.4
-
173
-
-
84860172730
-
An oral inhibitor of p38 MAP kinase reduces plasma fibrinogen in patients with chronic obstructive pulmonary disease
-
Losmapimod Study Investigators
-
Lomas DA, Lipson DA, Miller BE, Willits L, Keene O, Barnacle H, Barnes NC, and Tal-Singer R; Losmapimod Study Investigators (2012) An oral inhibitor of p38 MAP kinase reduces plasma fibrinogen in patients with chronic obstructive pulmonary disease. J Clin Pharmacol 52:416-424.
-
(2012)
J Clin Pharmacol
, vol.52
, pp. 416-424
-
-
Lomas, D.A.1
Lipson, D.A.2
Miller, B.E.3
Willits, L.4
Keene, O.5
Barnacle, H.6
Barnes, N.C.7
Tal-Singer, R.8
-
174
-
-
70349421440
-
The role of costimulatory molecules in allergic disease and asthma
-
Lombardi V, Singh AK, and Akbari O (2010) The role of costimulatory molecules in allergic disease and asthma. Int Arch Allergy Immunol 151:179-189.
-
(2010)
Int Arch Allergy Immunol
, vol.151
, pp. 179-189
-
-
Lombardi, V.1
Singh, A.K.2
Akbari, O.3
-
175
-
-
84948718203
-
Idelalisib-associated enterocolitis: Clinicopathologic features and distinction from other enterocolitides
-
Louie CY, DiMaio MA, Matsukuma KE, Coutre SE, Berry GJ, and Longacre TA (2015) Idelalisib-associated enterocolitis: clinicopathologic features and distinction from other enterocolitides. Am J Surg Pathol 39:1653-1660.
-
(2015)
Am J Surg Pathol
, vol.39
, pp. 1653-1660
-
-
Louie, C.Y.1
Dimaio, M.A.2
Matsukuma, K.E.3
Coutre, S.E.4
Berry, G.J.5
Longacre, T.A.6
-
176
-
-
84871036375
-
Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010
-
Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, Adair T, Aggarwal R, and Ahn SY, et al. (2012) Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380:2095-2128.
-
(2012)
Lancet
, vol.380
, pp. 2095-2128
-
-
Lozano, R.1
Naghavi, M.2
Foreman, K.3
Lim, S.4
Shibuya, K.5
Aboyans, V.6
Abraham, J.7
Adair, T.8
Aggarwal, R.9
Ahn, S.Y.10
-
177
-
-
84879955170
-
Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: A randomised clinical trial
-
MacNee W, Allan RJ, Jones I, De Salvo MC, and Tan LF (2013) Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trial. Thorax 68:738-745.
-
(2013)
Thorax
, vol.68
, pp. 738-745
-
-
Macnee, W.1
Allan, R.J.2
Jones, I.3
De Salvo, M.C.4
Tan, L.F.5
-
178
-
-
33846935457
-
Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3
-
Maneechotesuwan K, Xin Y, Ito K, Jazrawi E, Lee KY, Usmani OS, Barnes PJ, and Adcock IM (2007) Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3. J Immunol 178:2491-2498.
-
(2007)
J Immunol
, vol.178
, pp. 2491-2498
-
-
Maneechotesuwan, K.1
Xin, Y.2
Ito, K.3
Jazrawi, E.4
Lee, K.Y.5
Usmani, O.S.6
Barnes, P.J.7
Adcock, I.M.8
-
179
-
-
66349134442
-
Suppression of GATA-3 nuclear import and phosphorylation: A novel mechanism of corticosteroid action in allergic disease
-
Maneechotesuwan K, Yao X, Ito K, Jazrawi E, Usmani OS, Adcock IM, and Barnes PJ (2009) Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease. PLoS Med 6:e1000076.
-
(2009)
Plos Med
, vol.6
-
-
Maneechotesuwan, K.1
Yao, X.2
Ito, K.3
Jazrawi, E.4
Usmani, O.S.5
Adcock, I.M.6
Barnes, P.J.7
-
180
-
-
84919756169
-
MTOR inhibition improves immune function in the elderly
-
Mannick JB, Del Giudice G, Lattanzi M, Valiante NM, Praestgaard J, Huang B, Lonetto MA, Maecker HT, Kovarik J, and Carson S, et al. (2014) mTOR inhibition improves immune function in the elderly. Sci Transl Med 6:268-179.
-
(2014)
Sci Transl Med
, vol.6
-
-
Mannick, J.B.1
Del Giudice, G.2
Lattanzi, M.3
Valiante, N.M.4
Praestgaard, J.5
Huang, B.6
Lonetto, M.A.7
Maecker, H.T.8
Kovarik, J.9
Carson, S.10
-
181
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G, Whyte DB, Martinez R, Hunter T, and Sudarsanam S (2002) The protein kinase complement of the human genome. Science 298:1912-1934.
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
182
-
-
84930754960
-
A post-hoc subgroup analysis of data from a six month clinical trial comparing the efficacy and safety of losmapimod in moderate-severe COPD patients with #2% and.2% blood eosinophils
-
Marks-Konczalik J, Costa M, Robertson J, McKie E, Yang S, and Pascoe S (2015) A post-hoc subgroup analysis of data from a six month clinical trial comparing the efficacy and safety of losmapimod in moderate-severe COPD patients with #2% and.2% blood eosinophils. Respir Med 109:860-869.
-
(2015)
Respir Med
, vol.109
, pp. 860-869
-
-
Marks-Konczalik, J.1
Costa, M.2
Robertson, J.3
McKie, E.4
Yang, S.5
Pascoe, S.6
-
183
-
-
84881347302
-
Metformin improves healthspan and lifespan in mice
-
Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, and Blouin MJ, et al. (2013) Metformin improves healthspan and lifespan in mice. Nat Commun 4:2192.
-
(2013)
Nat Commun
, vol.4
, pp. 2192
-
-
Martin-Montalvo, A.1
Mercken, E.M.2
Mitchell, S.J.3
Palacios, H.H.4
Mote, P.L.5
Scheibye-Knudsen, M.6
Gomes, A.P.7
Ward, T.M.8
Minor, R.K.9
Blouin, M.J.10
-
184
-
-
77951667667
-
A role for phosphoinositol 3-kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease
-
Marwick JA, Caramori G, Casolari P, Mazzoni F, Kirkham PA, Adcock IM, Chung KF, and Papi A (2010a) A role for phosphoinositol 3-kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol 125:1146-1153.
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 1146-1153
-
-
Marwick, J.A.1
Caramori, G.2
Casolari, P.3
Mazzoni, F.4
Kirkham, P.A.5
Adcock, I.M.6
Chung, K.F.7
Papi, A.8
-
185
-
-
65249151877
-
Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice
-
Marwick JA, Caramori G, Stevenson CS, Casolari P, Jazrawi E, Barnes PJ, Ito K, Adcock IM, Kirkham PA, and Papi A (2009) Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice. Am J Respir Crit Care Med 179:542-548.
-
(2009)
Am J Respir Crit Care Med
, vol.179
, pp. 542-548
-
-
Marwick, J.A.1
Caramori, G.2
Stevenson, C.S.3
Casolari, P.4
Jazrawi, E.5
Barnes, P.J.6
Ito, K.7
Adcock, I.M.8
Kirkham, P.A.9
Papi, A.10
-
186
-
-
76349087609
-
Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease
-
Marwick JA, Chung KF, and Adcock IM (2010b) Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease. Ther Adv Respir Dis 4:19-34.
-
(2010)
Ther Adv Respir Dis
, vol.4
, pp. 19-34
-
-
Marwick, J.A.1
Chung, K.F.2
Adcock, I.M.3
-
187
-
-
84959470242
-
IkB kinase b inhibitor, IMD-0354, prevents allergic asthma in a mouse model through inhibition of CD4(+) effector T cell responses in the lung-draining mediastinal lymph nodes
-
Maslanka T, Otrocka-Domagała I, Zuska-Prot M, Mikiewicz M, Przybysz J, Jasiecka A, and Jaroszewski JJ (2016) IkB kinase b inhibitor, IMD-0354, prevents allergic asthma in a mouse model through inhibition of CD4(+) effector T cell responses in the lung-draining mediastinal lymph nodes. Eur J Pharmacol 775:78-85.
-
(2016)
Eur J Pharmacol
, vol.775
, pp. 78-85
-
-
Maslanka, T.1
Otrocka-Domagała, I.2
Zuska-Prot, M.3
Mikiewicz, M.4
Przybysz, J.5
Jasiecka, A.6
Jaroszewski, J.J.7
-
188
-
-
84866742560
-
TGFb signalling in context
-
Massagué J (2012) TGFb signalling in context. Nat Rev Mol Cell Biol 13:616-630.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 616-630
-
-
Massagué, J.1
-
189
-
-
33645676304
-
Syk activation in dendritic cells is essential for airway hyperresponsiveness and inflammation
-
Matsubara S, Koya T, Takeda K, Joetham A, Miyahara N, Pine P, Masuda ES, Swasey CH, and Gelfand EW (2006a) Syk activation in dendritic cells is essential for airway hyperresponsiveness and inflammation. Am J Respir Cell Mol Biol 34: 426-433.
-
(2006)
Am J Respir Cell Mol Biol
, vol.34
, pp. 426-433
-
-
Matsubara, S.1
Koya, T.2
Takeda, K.3
Joetham, A.4
Miyahara, N.5
Pine, P.6
Masuda, E.S.7
Swasey, C.H.8
Gelfand, E.W.9
-
190
-
-
30344435280
-
Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness
-
Matsubara S, Li G, Takeda K, Loader JE, Pine P, Masuda ES, Miyahara N, Miyahara S, Lucas JJ, and Dakhama A, et al. (2006b) Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness. Am J Respir Crit Care Med 173:56-63.
-
(2006)
Am J Respir Crit Care Med
, vol.173
, pp. 56-63
-
-
Matsubara, S.1
Li, G.2
Takeda, K.3
Loader, J.E.4
Pine, P.5
Masuda, E.S.6
Miyahara, N.7
Miyahara, S.8
Lucas, J.J.9
Dakhama, A.10
-
191
-
-
78650875942
-
Effects of a Janus kinase inhibitor, pyridone 6, on airway responses in a murine model of asthma
-
Matsunaga Y, Inoue H, Fukuyama S, Yoshida H, Moriwaki A, Matsumoto T, Matsumoto K, Asai Y, Kubo M, and Yoshimura A, et al. (2011) Effects of a Janus kinase inhibitor, pyridone 6, on airway responses in a murine model of asthma. Biochem Biophys Res Commun 404:261-267.
-
(2011)
Biochem Biophys Res Commun
, vol.404
, pp. 261-267
-
-
Matsunaga, Y.1
Inoue, H.2
Fukuyama, S.3
Yoshida, H.4
Moriwaki, A.5
Matsumoto, T.6
Matsumoto, K.7
Asai, Y.8
Kubo, M.9
Yoshimura, A.10
-
192
-
-
4243747130
-
P38 Mitogen activated protein kinase mediates IL-2 and IL-4 mediated changes in glucocorticoid receptor affinity
-
Matthews JG, Irusen E, Chung KF, Barnes PJ, and Adcock IM (1999) p38 Mitogen activated protein kinase mediates IL-2 and IL-4 mediated changes in glucocorticoid receptor affinity. Am J Respir Crit Care Med 157:A336.
-
(1999)
Am J Respir Crit Care Med
, vol.157
, pp. A336
-
-
Matthews, J.G.1
Irusen, E.2
Chung, K.F.3
Barnes, P.J.4
Adcock, I.M.5
-
193
-
-
84940112076
-
The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines
-
Mazzi P, Caveggion E, Lapinet-Vera JA, Lowell CA, and Berton G (2015) The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines. J Immunol 195:2383-2395.
-
(2015)
J Immunol
, vol.195
, pp. 2383-2395
-
-
Mazzi, P.1
Caveggion, E.2
Lapinet-Vera, J.A.3
Lowell, C.A.4
Berton, G.5
-
194
-
-
80052506007
-
Lung-targeted overexpression of the NF-kB member RelB inhibits cigarette smoke-induced inflammation
-
McMillan DH, Baglole CJ, Thatcher TH, Maggirwar S, Sime PJ, and Phipps RP (2011) Lung-targeted overexpression of the NF-kB member RelB inhibits cigarette smoke-induced inflammation. Am J Pathol 179:125-133.
-
(2011)
Am J Pathol
, vol.179
, pp. 125-133
-
-
McMillan, D.H.1
Baglole, C.J.2
Thatcher, T.H.3
Maggirwar, S.4
Sime, P.J.5
Phipps, R.P.6
-
195
-
-
40849119969
-
P38alpha-selective mitogenactivated protein kinase inhibitor SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation
-
Medicherla S, Fitzgerald M, Spicer D, Woodman P, Ma JY, Kapoun AM, Chakravarty S, Dugar S, Protter AA, and Higgins LS (2007) p38alpha-selective mitogenactivated protein kinase inhibitor SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation. J Pharmacol Exp Ther 324: 921-929.
-
(2007)
J Pharmacol Exp Ther
, vol.324
, pp. 921-929
-
-
Medicherla, S.1
Fitzgerald, M.2
Spicer, D.3
Woodman, P.4
Ma, J.Y.5
Kapoun, A.M.6
Chakravarty, S.7
Dugar, S.8
Protter, A.A.9
Higgins, L.S.10
-
196
-
-
34447095246
-
Phosphoinositide 3-kinase signalling in lung disease: Leucocytes and beyond
-
Medina-Tato DA, Ward SG, and Watson ML (2007) Phosphoinositide 3-kinase signalling in lung disease: leucocytes and beyond. Immunology 121:448-461.
-
(2007)
Immunology
, vol.121
, pp. 448-461
-
-
Medina-Tato, D.A.1
Ward, S.G.2
Watson, M.L.3
-
197
-
-
16244397342
-
An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment
-
Meltzer EO, Berkowitz RB, and Grossbard EB (2005) An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment. J Allergy Clin Immunol 115:791-796.
-
(2005)
J Allergy Clin Immunol
, vol.115
, pp. 791-796
-
-
Meltzer, E.O.1
Berkowitz, R.B.2
Grossbard, E.B.3
-
198
-
-
84873402103
-
Advances in the discovery of selective JAK inhibitors
-
Menet CJ, Rompaey LV, and Geney R (2013) Advances in the discovery of selective JAK inhibitors. Prog Med Chem 52:153-223.
-
(2013)
Prog Med Chem
, vol.52
, pp. 153-223
-
-
Menet, C.J.1
Rompaey, L.V.2
Geney, R.3
-
199
-
-
84864239168
-
Restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma
-
Mercado N, Hakim A, Kobayashi Y, Meah S, Usmani OS, Chung KF, Barnes PJ, and Ito K (2012) Restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma. PLoS One 7:e41582.
-
(2012)
Plos One
, vol.7
-
-
Mercado, N.1
Hakim, A.2
Kobayashi, Y.3
Meah, S.4
Usmani, O.S.5
Chung, K.F.6
Barnes, P.J.7
Ito, K.8
-
200
-
-
84929466240
-
Accelerated ageing of the lung in COPD: New concepts
-
Mercado N, Ito K, and Barnes PJ (2015) Accelerated ageing of the lung in COPD: new concepts. Thorax 70:482-489.
-
(2015)
Thorax
, vol.70
, pp. 482-489
-
-
Mercado, N.1
Ito, K.2
Barnes, P.J.3
-
201
-
-
79955002992
-
Nortriptyline reverses corticosteroid insensitivity by inhibition of PI3K-d
-
Mercado N, To Y, Ito K, and Barnes PJ (2011a) Nortriptyline reverses corticosteroid insensitivity by inhibition of PI3K-d. J Pharmacol Exp Ther 337:465-470.
-
(2011)
J Pharmacol Exp Ther
, vol.337
, pp. 465-470
-
-
Mercado, N.1
To, Y.2
Ito, K.3
Barnes, P.J.4
-
202
-
-
81555210955
-
P38 mitogen-activated protein kinase-g inhibition by long-acting b2 adrenergic agonists reversed steroid insensitivity in severe asthma
-
Mercado N, To Y, Kobayashi Y, Adcock IM, Barnes PJ, and Ito K (2011b) p38 mitogen-activated protein kinase-g inhibition by long-acting b2 adrenergic agonists reversed steroid insensitivity in severe asthma. Mol Pharmacol 80: 1128-1135.
-
(2011)
Mol Pharmacol
, vol.80
, pp. 1128-1135
-
-
Mercado, N.1
To, Y.2
Kobayashi, Y.3
Adcock, I.M.4
Barnes, P.J.5
Ito, K.6
-
203
-
-
80053206040
-
What is the potential for inhaled p38 inhibitors in the treatment of chronic obstructive pulmonary disease?
-
Millan DS (2011) What is the potential for inhaled p38 inhibitors in the treatment of chronic obstructive pulmonary disease? Future Med Chem 3:1635-1645.
-
(2011)
Future Med Chem
, vol.3
, pp. 1635-1645
-
-
Millan, D.S.1
-
204
-
-
81555218671
-
Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease
-
Millan DS, Bunnage ME, Burrows JL, Butcher KJ, Dodd PG, Evans TJ, Fairman DA, Hughes SJ, Kilty IC, and Lemaitre A, et al. (2011) Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease. J Med Chem 54:7797-7814.
-
(2011)
J Med Chem
, vol.54
, pp. 7797-7814
-
-
Millan, D.S.1
Bunnage, M.E.2
Burrows, J.L.3
Butcher, K.J.4
Dodd, P.G.5
Evans, T.J.6
Fairman, D.A.7
Hughes, S.J.8
Kilty, I.C.9
Lemaitre, A.10
-
205
-
-
0031226757
-
Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma
-
Minshall EM, Leung DY, Martin RJ, Song YL, Cameron L, Ernst P, and Hamid Q (1997) Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma. Am J Respir Cell Mol Biol 17:326-333.
-
(1997)
Am J Respir Cell Mol Biol
, vol.17
, pp. 326-333
-
-
Minshall, E.M.1
Leung, D.Y.2
Martin, R.J.3
Song, Y.L.4
Cameron, L.5
Ernst, P.6
Hamid, Q.7
-
206
-
-
85012927476
-
Inhibition of mTOR restores corticosteroid sensitivity in chronic obstructive pulmonary disease
-
Mitani A, Ito K, Vuppusetty C, Barnes PJ, and Mercado N (2015) Inhibition of mTOR restores corticosteroid sensitivity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 193:143-153.
-
(2015)
Am J Respir Crit Care Med
, vol.193
, pp. 143-153
-
-
Mitani, A.1
Ito, K.2
Vuppusetty, C.3
Barnes, P.J.4
Mercado, N.5
-
208
-
-
77952887713
-
The SYK tyrosine kinase: A crucial player in diverse biological functions
-
Mócsai A, Ruland J, and Tybulewicz VL (2010) The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat Rev Immunol 10:387-402.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 387-402
-
-
Mócsai, A.1
Ruland, J.2
Tybulewicz, V.L.3
-
209
-
-
84869176820
-
Cigarette smoke and its component acrolein augment IL-8/CXCL8 mRNA stability via p38 MAPK/MK2 signaling in human pulmonary cells
-
Moretto N, Bertolini S, Iadicicco C, Marchini G, Kaur M, Volpi G, Patacchini R, Singh D, and Facchinetti F (2012) Cigarette smoke and its component acrolein augment IL-8/CXCL8 mRNA stability via p38 MAPK/MK2 signaling in human pulmonary cells. Am J Physiol Lung Cell Mol Physiol 303:L929-L938.
-
(2012)
Am J Physiol Lung Cell Mol Physiol
, vol.303
, pp. L929-L938
-
-
Moretto, N.1
Bertolini, S.2
Iadicicco, C.3
Marchini, G.4
Kaur, M.5
Volpi, G.6
Patacchini, R.7
Singh, D.8
Facchinetti, F.9
-
210
-
-
77649204688
-
Selectively nonselective kinase inhibition: Striking the right balance
-
Morphy R (2010) Selectively nonselective kinase inhibition: striking the right balance. J Med Chem 53:1413-1437.
-
(2010)
J Med Chem
, vol.53
, pp. 1413-1437
-
-
Morphy, R.1
-
211
-
-
84890111365
-
Inhibition of spleen tyrosine kinase attenuates allergen-mediated airway constriction
-
Moy LY, Jia Y, Caniga M, Lieber G, Gil M, Fernandez X, Sirkowski E, Miller R, Alexander JP, and Lee HH, et al. (2013) Inhibition of spleen tyrosine kinase attenuates allergen-mediated airway constriction. Am J Respir Cell Mol Biol 49: 1085-1092.
-
(2013)
Am J Respir Cell Mol Biol
, vol.49
, pp. 1085-1092
-
-
Moy, L.Y.1
Jia, Y.2
Caniga, M.3
Lieber, G.4
Gil, M.5
Fernandez, X.6
Sirkowski, E.7
Miller, R.8
Alexander, J.P.9
Lee, H.H.10
-
212
-
-
84872577183
-
Differential effects of rapamycin and dexamethasone in mouse models of established allergic asthma
-
Mushaben EM, Brandt EB, Hershey GK, and Le Cras TD (2013) Differential effects of rapamycin and dexamethasone in mouse models of established allergic asthma. PLoS One 8:e54426.
-
(2013)
Plos One
, vol.8
-
-
Mushaben, E.M.1
Brandt, E.B.2
Hershey, G.K.3
Le Cras, T.D.4
-
213
-
-
0344154290
-
Blockade of inflammation and airway hyperresponsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TAT
-
Myou S, Leff AR, Myo S, Boetticher E, Tong J, Meliton AY, Liu J, Munoz NM, and Zhu X (2003) Blockade of inflammation and airway hyperresponsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TAT. J Exp Med 198:1573-1582.
-
(2003)
J Exp Med
, vol.198
, pp. 1573-1582
-
-
Myou, S.1
Leff, A.R.2
Myo, S.3
Boetticher, E.4
Tong, J.5
Meliton, A.Y.6
Liu, J.7
Munoz, N.M.8
Zhu, X.9
-
214
-
-
0035378557
-
The role of epidermal growth factor in mucus production
-
Nadel JA and Burgel PR (2001) The role of epidermal growth factor in mucus production. Curr Opin Pharmacol 1:254-258.
-
(2001)
Curr Opin Pharmacol
, vol.1
, pp. 254-258
-
-
Nadel, J.A.1
Burgel, P.R.2
-
215
-
-
70349324812
-
A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9
-
Nakamaru Y, Vuppusetty C, Wada H, Milne JC, Ito M, Rossios C, Elliot M, Hogg J, Kharitonov S, and Goto H, et al. (2009) A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. FASEB J 23:2810-2819.
-
(2009)
FASEB J
, vol.23
, pp. 2810-2819
-
-
Nakamaru, Y.1
Vuppusetty, C.2
Wada, H.3
Milne, J.C.4
Ito, M.5
Rossios, C.6
Elliot, M.7
Hogg, J.8
Kharitonov, S.9
Goto, H.10
-
216
-
-
33947729717
-
Role of the phosphoinositide 3-kinase p110delta in generation of type 2 cytokine responses and allergic airway inflammation
-
Nashed BF, Zhang T, Al-Alwan M, Srinivasan G, Halayko AJ, Okkenhaug K, Vanhaesebroeck B, Hayglass KT, and Marshall AJ (2007) Role of the phosphoinositide 3-kinase p110delta in generation of type 2 cytokine responses and allergic airway inflammation. Eur J Immunol 37:416-424.
-
(2007)
Eur J Immunol
, vol.37
, pp. 416-424
-
-
Nashed, B.F.1
Zhang, T.2
Al-Alwan, M.3
Srinivasan, G.4
Halayko, A.J.5
Okkenhaug, K.6
Vanhaesebroeck, B.7
Hayglass, K.T.8
Marshall, A.J.9
-
217
-
-
14944386613
-
Potential role of c-Jun NH2-terminal kinase in allergic airway inflammation and remodelling: Effects of SP600125
-
Nath P, Eynott P, Leung SY, Adcock IM, Bennett BL, and Chung KF (2005) Potential role of c-Jun NH2-terminal kinase in allergic airway inflammation and remodelling: effects of SP600125. Eur J Pharmacol 506:273-283.
-
(2005)
Eur J Pharmacol
, vol.506
, pp. 273-283
-
-
Nath, P.1
Eynott, P.2
Leung, S.Y.3
Adcock, I.M.4
Bennett, B.L.5
Chung, K.F.6
-
218
-
-
33746616816
-
Importance of p38 mitogen-activated protein kinase pathway in allergic airway remodelling and bronchial hyperresponsiveness
-
Nath P, Leung SY, Williams A, Noble A, Chakravarty SD, Luedtke GR, Medicherla S, Higgins LS, Protter A, and Chung KF (2006) Importance of p38 mitogen-activated protein kinase pathway in allergic airway remodelling and bronchial hyperresponsiveness. Eur J Pharmacol 544:160-167.
-
(2006)
Eur J Pharmacol
, vol.544
, pp. 160-167
-
-
Nath, P.1
Leung, S.Y.2
Williams, A.3
Noble, A.4
Chakravarty, S.D.5
Luedtke, G.R.6
Medicherla, S.7
Higgins, L.S.8
Protter, A.9
Chung, K.F.10
-
219
-
-
34247222126
-
Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors
-
Newton R, Holden NS, Catley MC, Oyelusi W, Leigh R, Proud D, and Barnes PJ (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors. J Pharmacol Exp Ther 321: 734-742.
-
(2007)
J Pharmacol Exp Ther
, vol.321
, pp. 734-742
-
-
Newton, R.1
Holden, N.S.2
Catley, M.C.3
Oyelusi, W.4
Leigh, R.5
Proud, D.6
Barnes, P.J.7
-
220
-
-
84947230023
-
Glycogen synthase kinase-3b modulation of glucocorticoid responsiveness in COPD
-
Ngkelo A, Hoffmann RF, Durham AL, Marwick JA, Brandenburg SM, de Bruin HG, Jonker MR, Rossios C, Tsitsiou E, and Caramori G, et al. (2015) Glycogen synthase kinase-3b modulation of glucocorticoid responsiveness in COPD. Am J Physiol Lung Cell Mol Physiol 309:L1112-L1123.
-
(2015)
Am J Physiol Lung Cell Mol Physiol
, vol.309
, pp. L1112-L1123
-
-
Ngkelo, A.1
Hoffmann, R.F.2
Durham, A.L.3
Marwick, J.A.4
Brandenburg, S.M.5
De Bruin, H.G.6
Jonker, M.R.7
Rossios, C.8
Tsitsiou, E.9
Caramori, G.10
-
221
-
-
84879817002
-
Inhibition of spleen tyrosine kinase in the treatment of rheumatoid arthritis
-
Nijjar JS, Tindell A, McInnes IB, and Siebert S (2013) Inhibition of spleen tyrosine kinase in the treatment of rheumatoid arthritis. Rheumatology (Oxford) 52: 1556-1562.
-
(2013)
Rheumatology (Oxford)
, vol.52
, pp. 1556-1562
-
-
Nijjar, J.S.1
Tindell, A.2
McInnes, I.B.3
Siebert, S.4
-
222
-
-
84911898872
-
Respivert’s multikinase inhibitors, an evaluation of WO2014033446 to WO2014033449
-
Norman P (2014a) Respivert’s multikinase inhibitors, an evaluation of WO2014033446 to WO2014033449. Expert Opin Ther Pat 24:1397-1407.
-
(2014)
Expert Opin Ther Pat
, vol.24
, pp. 1397-1407
-
-
Norman, P.1
-
223
-
-
84898936413
-
Spleen tyrosine kinase inhibitors: A review of the patent literature 2010-2013
-
Norman P (2014b) Spleen tyrosine kinase inhibitors: a review of the patent literature 2010-2013. Expert Opin Ther Pat 24:573-595.
-
(2014)
Expert Opin Ther Pat
, vol.24
, pp. 573-595
-
-
Norman, P.1
-
224
-
-
84923044041
-
Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease
-
Norman P (2015) Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease. Expert Opin Investig Drugs 24:383-392.
-
(2015)
Expert Opin Investig Drugs
, vol.24
, pp. 383-392
-
-
Norman, P.1
-
225
-
-
84862285959
-
Protein-ligand crystal structures can guide the design of selective inhibitors of the FGFR tyrosine kinase
-
Norman RA, Schott AK, Andrews DM, Breed J, Foote KM, Garner AP, Ogg D, Orme JP, Pink JH, and Roberts K, et al. (2012a) Protein-ligand crystal structures can guide the design of selective inhibitors of the FGFR tyrosine kinase. J Med Chem 55:5003-5012.
-
(2012)
J Med Chem
, vol.55
, pp. 5003-5012
-
-
Norman, R.A.1
Schott, A.K.2
Rews, D.M.3
Breed, J.4
Foote, K.M.5
Garner, A.P.6
Ogg, D.7
Orme, J.P.8
Pink, J.H.9
Roberts, K.10
-
227
-
-
84961120146
-
Discovery of narrow spectrum kinase inhibitors: New therapeutic agents for the treatment of COPD and steroidresistant asthma
-
Onions ST, Ito K, Charron CE, Brown RJ, Colucci M, Frickel F, Hardy G, Joly K, King-Underwood J, and Kizawa Y, et al. (2016) Discovery of narrow spectrum kinase inhibitors: new therapeutic agents for the treatment of COPD and steroidresistant asthma. J Med Chem 59:1727-1746.
-
(2016)
J Med Chem
, vol.59
, pp. 1727-1746
-
-
Onions, S.T.1
Ito, K.2
Charron, C.E.3
Brown, R.J.4
Colucci, M.5
Frickel, F.6
Hardy, G.7
Joly, K.8
King-Underwood, J.9
Kizawa, Y.10
-
228
-
-
84921325808
-
The JAK-STAT pathway: Impact on human disease and therapeutic intervention
-
O’Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, and Laurence A (2015) The JAK-STAT pathway: impact on human disease and therapeutic intervention. Annu Rev Med 66:311-328.
-
(2015)
Annu Rev Med
, vol.66
, pp. 311-328
-
-
O’Shea, J.J.1
Schwartz, D.M.2
Villarino, A.V.3
Gadina, M.4
McInnes, I.B.5
Laurence, A.6
-
229
-
-
84887020404
-
Rhinovirus infection causes steroid resistance in airway epithelium through nuclear factor kB and c-Jun N-terminal kinase activation
-
Papi A, Contoli M, Adcock IM, Bellettato C, Padovani A, Casolari P, Stanciu LA, Barnes PJ, Johnston SL, and Ito K, et al. (2013) Rhinovirus infection causes steroid resistance in airway epithelium through nuclear factor kB and c-Jun N-terminal kinase activation. J Allergy Clin Immunol 132:1075-1085.e6.
-
(2013)
J Allergy Clin Immunol
, vol.132
, pp. 1075-1085
-
-
Papi, A.1
Contoli, M.2
Adcock, I.M.3
Bellettato, C.4
Padovani, A.5
Casolari, P.6
Stanciu, L.A.7
Barnes, P.J.8
Johnston, S.L.9
Ito, K.10
-
230
-
-
66049084770
-
The airway vasculature: Recent advances and clinical implications
-
Paredi P and Barnes PJ (2009) The airway vasculature: recent advances and clinical implications. Thorax 64:444-450.
-
(2009)
Thorax
, vol.64
, pp. 444-450
-
-
Paredi, P.1
Barnes, P.J.2
-
231
-
-
84869220736
-
Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase
-
Park CS, Bang BR, Kwon HS, Moon KA, Kim TB, Lee KY, Moon HB, and Cho YS (2012) Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase. Biochem Pharmacol 84:1660-1670.
-
(2012)
Biochem Pharmacol
, vol.84
, pp. 1660-1670
-
-
Park, C.S.1
Bang, B.R.2
Kwon, H.S.3
Moon, K.A.4
Kim, T.B.5
Lee, K.Y.6
Moon, H.B.7
Cho, Y.S.8
-
232
-
-
33745596102
-
Attitudes and actions of asthma patients on regular maintenance therapy: The INSPIRE study
-
Partridge MR, van der Molen T, Myrseth SE, and Busse WW (2006) Attitudes and actions of asthma patients on regular maintenance therapy: the INSPIRE study. BMC Pulm Med 6:13.
-
(2006)
BMC Pulm Med
, vol.6
, pp. 13
-
-
Partridge, M.R.1
Van Der Molen, T.2
Myrseth, S.E.3
Busse, W.W.4
-
233
-
-
84890451565
-
Dysfunction of endothelial progenitor cells from smokers and COPD patients due to increased DNA damage and senescence
-
Paschalaki KE, Starke RD, Hu Y, Mercado N, Margariti A, Gorgoulis VG, Randi AM, and Barnes PJ (2013) Dysfunction of endothelial progenitor cells from smokers and COPD patients due to increased DNA damage and senescence. Stem Cells 31: 2813-2826.
-
(2013)
Stem Cells
, vol.31
, pp. 2813-2826
-
-
Paschalaki, K.E.1
Starke, R.D.2
Hu, Y.3
Mercado, N.4
Margariti, A.5
Gorgoulis, V.G.6
Randi, A.M.7
Barnes, P.J.8
-
234
-
-
84873406511
-
Spleen tyrosine kinase inhibition attenuates airway hyperresponsiveness and pollution-induced enhanced airway response in a chronic mouse model of asthma
-
Penton PC, Wang X, Amatullah H, Cooper J, Godri K, North ML, Khanna N, Scott JA, and Chow CW (2013) Spleen tyrosine kinase inhibition attenuates airway hyperresponsiveness and pollution-induced enhanced airway response in a chronic mouse model of asthma. J Clin Immunol 131:512-520.
-
(2013)
J Clin Immunol
, vol.131
, pp. 512-520
-
-
Penton, P.C.1
Wang, X.2
Amatullah, H.3
Cooper, J.4
Godri, K.5
North, M.L.6
Khanna, N.7
Scott, J.A.8
Chow, C.W.9
-
235
-
-
84864769759
-
Role for TAK1 in cigarette smoke-induced proinflammatory signaling and IL-8 release by human airway smooth muscle cells
-
Pera T, Atmaj C, van der Vegt M, Halayko AJ, Zaagsma J, and Meurs H (2012) Role for TAK1 in cigarette smoke-induced proinflammatory signaling and IL-8 release by human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 303: L272-L278.
-
(2012)
Am J Physiol Lung Cell Mol Physiol
, vol.303
, pp. L272-L278
-
-
Pera, T.1
Atmaj, C.2
Van Der Vegt, M.3
Halayko, A.J.4
Zaagsma, J.5
Meurs, H.6
-
236
-
-
80055119714
-
TAK1 plays a major role in growth factor-induced phenotypic modulation of airway smooth muscle
-
Pera T, Sami R, Zaagsma J, and Meurs H (2011) TAK1 plays a major role in growth factor-induced phenotypic modulation of airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 301:L822-L828.
-
(2011)
Am J Physiol Lung Cell Mol Physiol
, vol.301
, pp. L822-L828
-
-
Pera, T.1
Sami, R.2
Zaagsma, J.3
Meurs, H.4
-
237
-
-
0036100050
-
JAK-STAT signaling in asthma
-
Pernis AB and Rothman PB (2002) JAK-STAT signaling in asthma. J Clin Invest 109:1279-1283.
-
(2002)
J Clin Invest
, vol.109
, pp. 1279-1283
-
-
Pernis, A.B.1
Rothman, P.B.2
-
238
-
-
84937872197
-
Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells
-
Poh AR, O’Donoghue RJ, and Ernst M (2015) Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells. Oncotarget 6:15752-15771.
-
(2015)
Oncotarget
, vol.6
, pp. 15752-15771
-
-
Poh, A.R.1
O’Donoghue, R.J.2
Ernst, M.3
-
239
-
-
84870895545
-
Rho-kinase inhibition attenuates airway responsiveness, inflammation, matrix remodeling, and oxidative stress activation induced by chronic inflammation
-
Possa SS, Charafeddine HT, Righetti RF, da Silva PA, Almeida-Reis R, Saraiva-Romanholo BM, Perini A, Prado CM, Leick-Maldonado EA, and Martins MA, et al. (2012) Rho-kinase inhibition attenuates airway responsiveness, inflammation, matrix remodeling, and oxidative stress activation induced by chronic inflammation. Am J Physiol Lung Cell Mol Physiol 303:L939-L952.
-
(2012)
Am J Physiol Lung Cell Mol Physiol
, vol.303
, pp. L939-L952
-
-
Possa, S.S.1
Charafeddine, H.T.2
Righetti, R.F.3
Da Silva, P.A.4
Almeida-Reis, R.5
Saraiva-Romanholo, B.M.6
Perini, A.7
Prado, C.M.8
Leick-Maldonado, E.A.9
Martins, M.A.10
-
240
-
-
84942474807
-
The Asthma-COPD Overlap Syndrome
-
Postma DS and Rabe KF (2015) The Asthma-COPD Overlap Syndrome. N Engl J Med 373:1241-1249.
-
(2015)
N Engl J Med
, vol.373
, pp. 1241-1249
-
-
Postma, D.S.1
Rabe, K.F.2
-
241
-
-
42649146208
-
SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease
-
Rajendrasozhan S, Yang SR, Kinnula VL, and Rahman I (2008) SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 177:861-870.
-
(2008)
Am J Respir Crit Care Med
, vol.177
, pp. 861-870
-
-
Rajendrasozhan, S.1
Yang, S.R.2
Kinnula, V.L.3
Rahman, I.4
-
242
-
-
85009755599
-
New inhaled JAK inhibitor LAS194046 inhibits allergen-induced airway inflammation in Brown Norway rats
-
Ramis I, Calama E, Domènech A, Carreño C, Calaf E, Cordoba M, Alberti J, De Alba J, Bach J, and Prats N, et al. (2014) New inhaled JAK inhibitor LAS194046 inhibits allergen-induced airway inflammation in Brown Norway rats. Eur Respir J 44 (Suppl 58):P1508.
-
(2014)
Eur Respir J
, vol.44
, pp. 1508
-
-
Ramis, I.1
Calama, E.2
Domènech, A.3
Carreño, C.4
Calaf, E.5
Cordoba, M.6
Alberti, J.7
De Alba, J.8
Bach, J.9
Prats, N.10
-
243
-
-
84935896446
-
A novel inhaled Syk inhibitor blocks mast cell degranulation and early asthmatic response
-
Ramis I, Otal R, Carreño C, Domènech A, Eichhorn P, Orellana A, Maldonado M, De Alba J, Prats N, and Fernández JC, et al. (2015) A novel inhaled Syk inhibitor blocks mast cell degranulation and early asthmatic response. Pharmacol Res 99: 116-124.
-
(2015)
Pharmacol Res
, vol.99
, pp. 116-124
-
-
Ramis, I.1
Otal, R.2
Carreño, C.3
Domènech, A.4
Eichhorn, P.5
Orellana, A.6
Maldonado, M.7
De Alba, J.8
Prats, N.9
Fernández, J.C.10
-
244
-
-
84867074819
-
Identification of SRC as a potent drug target for asthma, using an integrative approach of protein interactome analysis and in silico drug discovery
-
Randhawa V and Bagler G (2012) Identification of SRC as a potent drug target for asthma, using an integrative approach of protein interactome analysis and in silico drug discovery. OMICS 16:513-526.
-
(2012)
OMICS
, vol.16
, pp. 513-526
-
-
Randhawa, V.1
Bagler, G.2
-
245
-
-
84872777798
-
Cigarette smoke induced airway inflammation is independent of NF-kB signalling
-
Rastrick JM, Stevenson CS, Eltom S, Grace M, Davies M, Kilty I, Evans SM, Pasparakis M, Catley MC, and Lawrence T, et al. (2013) Cigarette smoke induced airway inflammation is independent of NF-kB signalling. PLoS One 8:e54128.
-
(2013)
Plos One
, vol.8
-
-
Rastrick, J.M.1
Stevenson, C.S.2
Eltom, S.3
Grace, M.4
Davies, M.5
Kilty, I.6
Evans, S.M.7
Pasparakis, M.8
Catley, M.C.9
Lawrence, T.10
-
246
-
-
33644752698
-
Stem cell factor and its receptor c-Kit as targets for inflammatory diseases
-
Reber L, Da Silva CA, and Frossard N (2006) Stem cell factor and its receptor c-Kit as targets for inflammatory diseases. Eur J Pharmacol 533:327-340.
-
(2006)
Eur J Pharmacol
, vol.533
, pp. 327-340
-
-
Reber, L.1
Da Silva, C.A.2
Frossard, N.3
-
247
-
-
44649153952
-
Increased activation of p38 MAPK in COPD
-
Renda T, Baraldo S, Pelaia G, Bazzan E, Turato G, Papi A, Maestrelli P, Maselli R, Vatrella A, and Fabbri LM, et al. (2008) Increased activation of p38 MAPK in COPD. Eur Respir J 31:62-69.
-
(2008)
Eur Respir J
, vol.31
, pp. 62-69
-
-
Renda, T.1
Baraldo, S.2
Pelaia, G.3
Bazzan, E.4
Turato, G.5
Papi, A.6
Maestrelli, P.7
Maselli, R.8
Vatrella, A.9
Fabbri, L.M.10
-
248
-
-
77954315861
-
Spleen tyrosine kinases: Biology, therapeutic targets and drugs
-
Riccaboni M, Bianchi I, and Petrillo P (2010) Spleen tyrosine kinases: biology, therapeutic targets and drugs. Drug Discov Today 15:517-530.
-
(2010)
Drug Discov Today
, vol.15
, pp. 517-530
-
-
Riccaboni, M.1
Bianchi, I.2
Petrillo, P.3
-
249
-
-
0038024241
-
Rocks: Multifunctional kinases in cell behaviour
-
Riento K and Ridley AJ (2003) Rocks: multifunctional kinases in cell behaviour. Nat Rev Mol Cell Biol 4:446-456.
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 446-456
-
-
Riento, K.1
Ridley, A.J.2
-
250
-
-
84892494880
-
Effects of Rho-kinase inhibition in lung tissue with chronic inflammation
-
Righetti RF, Pigati PA, Possa SS, Habrum FC, Xisto DG, Antunes MA, Leick EA, Prado CM, Martins MdeA, and Rocco PR, et al. (2014) Effects of Rho-kinase inhibition in lung tissue with chronic inflammation. Respir Physiol Neurobiol 192: 134-146.
-
(2014)
Respir Physiol Neurobiol
, vol.192
, pp. 134-146
-
-
Righetti, R.F.1
Pigati, P.A.2
Possa, S.S.3
Habrum, F.C.4
Xisto, D.G.5
Antunes, M.A.6
Leick, E.A.7
Prado, C.M.8
Martins, M.9
Rocco, P.R.10
-
251
-
-
84897418874
-
Protein kinase C-dependent activation of CaV1.2 channels selectively controls human TH2-lymphocyte functions
-
Robert V, Triffaux E, Paulet PE, Guéry JC, Pelletier L, and Savignac M (2014) Protein kinase C-dependent activation of CaV1.2 channels selectively controls human TH2-lymphocyte functions. J Allergy Clin Immunol 133:1175-1183.
-
(2014)
J Allergy Clin Immunol
, vol.133
, pp. 1175-1183
-
-
Robert, V.1
Triffaux, E.2
Paulet, P.E.3
Guéry, J.C.4
Pelletier, L.5
Savignac, M.6
-
252
-
-
84923102615
-
Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors
-
Roskoski R Jr (2015) Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors. Pharmacol Res 94:9-25.
-
(2015)
Pharmacol Res
, vol.94
, pp. 9-25
-
-
Roskoski, R.1
-
253
-
-
75149161903
-
PKC and the control of localized signal dynamics
-
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, and Parker PJ (2010) PKC and the control of localized signal dynamics. Nat Rev Mol Cell Biol 11: 103-112.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 103-112
-
-
Rosse, C.1
Linch, M.2
Kermorgant, S.3
Cameron, A.J.4
Boeckeler, K.5
Parker, P.J.6
-
254
-
-
0028798086
-
Role of protein kinase C in nonsensitized and passively sensitized human isolated bronchial smooth muscle
-
Rossetti M, Savineau JP, Crevel H, and Marthan R (1995) Role of protein kinase C in nonsensitized and passively sensitized human isolated bronchial smooth muscle. Am J Physiol 268:L966-L971.
-
(1995)
Am J Physiol
, vol.268
, pp. L966-L971
-
-
Rossetti, M.1
Savineau, J.P.2
Crevel, H.3
Marthan, R.4
-
255
-
-
33750525089
-
PI3Kgamma inhibition: Towards an ‘aspirin of the 21st century’?
-
Rückle T, Schwarz MK, and Rommel C (2006) PI3Kgamma inhibition: towards an ‘aspirin of the 21st century’? Nat Rev Drug Discov 5:903-918.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 903-918
-
-
Rückle, T.1
Schwarz, M.K.2
Rommel, C.3
-
256
-
-
84923002586
-
Safety, pharmacokinetic and pharmacodynamic profile of RV568, a narrow spectrum kinase inhibitor, following repeat inhaled dosing in COPD patients
-
Eur Respir J 42:1371
-
Russell P, Cass L, and Ito K (2013) Russell P, Cass L, Ito K, Safety, pharmacokinetic and pharmacodynamic profile of RV568, a narrow spectrum kinase inhibitor, following repeat inhaled dosing in COPD patients. Eur Resp J 2013;42:1371. Eur Respir J 42:1371.
-
(2013)
Eur Resp J 2013
, vol.42
, pp. 1371
-
-
Russell, P.1
Cass, L.2
Ito, K.3
Russell, P.4
Cass, L.5
Ito, K.6
-
257
-
-
84859472876
-
Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice
-
Ruwanpura SM, McLeod L, Miller A, Jones J, Vlahos R, Ramm G, Longano A, Bardin PG, Bozinovski S, and Anderson GP, et al. (2012) Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice. Am J Physiol Lung Cell Mol Physiol 302:L627-L639.
-
(2012)
Am J Physiol Lung Cell Mol Physiol
, vol.302
, pp. L627-L639
-
-
Ruwanpura, S.M.1
McLeod, L.2
Miller, A.3
Jones, J.4
Vlahos, R.5
Ramm, G.6
Longano, A.7
Bardin, P.G.8
Bozinovski, S.9
Anderson, G.P.10
-
258
-
-
0036143654
-
P38-Dependent marking of inflammatory genes for increased NF-k B recruitment
-
Saccani S, Pantano S, and Natoli G (2002) p38-Dependent marking of inflammatory genes for increased NF-k B recruitment. Nat Immunol 3:69-75.
-
(2002)
Nat Immunol
, vol.3
, pp. 69-75
-
-
Saccani, S.1
Pantano, S.2
Natoli, G.3
-
259
-
-
84863700565
-
Exploiting the anti-inflammatory effects of AMPactivated protein kinase activation
-
Salt IP and Palmer TM (2012) Exploiting the anti-inflammatory effects of AMPactivated protein kinase activation. Expert Opin Investig Drugs 21:1155-1167.
-
(2012)
Expert Opin Investig Drugs
, vol.21
, pp. 1155-1167
-
-
Salt, I.P.1
Palmer, T.M.2
-
260
-
-
84892640743
-
Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: Toward targeted treatments for immunosenescence
-
Sapey E, Greenwood H, Walton G, Mann E, Love A, Aaronson N, Insall RH, Stockley RA, and Lord JM (2014) Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence. Blood 123:239-248.
-
(2014)
Blood
, vol.123
, pp. 239-248
-
-
Sapey, E.1
Greenwood, H.2
Walton, G.3
Mann, E.4
Love, A.5
Aaronson, N.6
Insall, R.H.7
Stockley, R.A.8
Lord, J.M.9
-
261
-
-
27544434183
-
Essential function for the kinase TAK1 in innate and adaptive immune responses
-
Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Matsumoto K, Takeuchi O, and Akira S (2005) Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol 6:1087-1095.
-
(2005)
Nat Immunol
, vol.6
, pp. 1087-1095
-
-
Sato, S.1
Sanjo, H.2
Takeda, K.3
Ninomiya-Tsuji, J.4
Yamamoto, M.5
Kawai, T.6
Matsumoto, K.7
Takeuchi, O.8
Akira, S.9
-
262
-
-
84869866583
-
Type 2 innate lymphoid cells: New players in asthma and allergy
-
Scanlon ST and McKenzie AN (2012) Type 2 innate lymphoid cells: new players in asthma and allergy. Curr Opin Immunol 24:707-712.
-
(2012)
Curr Opin Immunol
, vol.24
, pp. 707-712
-
-
Scanlon, S.T.1
McKenzie, A.N.2
-
263
-
-
79957960940
-
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
-
Scarpulla RC (2011) Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim Biophys Acta 1813:1269-1278.
-
(2011)
Biochim Biophys Acta
, vol.1813
, pp. 1269-1278
-
-
Scarpulla, R.C.1
-
264
-
-
49049090820
-
The inhaled Rho kinase inhibitor Y-27632 protects against allergen-induced acute bronchoconstriction, airway hyperresponsiveness, and inflammation
-
Schaafsma D, Bos IS, Zuidhof AB, Zaagsma J, and Meurs H (2008a) The inhaled Rho kinase inhibitor Y-27632 protects against allergen-induced acute bronchoconstriction, airway hyperresponsiveness, and inflammation. Am J Physiol Lung Cell Mol Physiol 295:L214-L219.
-
(2008)
Am J Physiol Lung Cell Mol Physiol
, vol.295
, pp. L214-L219
-
-
Schaafsma, D.1
Bos, I.S.2
Zuidhof, A.B.3
Zaagsma, J.4
Meurs, H.5
-
265
-
-
43049096072
-
Rho kinase inhibitors: A novel therapeutical intervention in asthma?
-
Schaafsma D, Gosens R, Zaagsma J, Halayko AJ, and Meurs H (2008b) Rho kinase inhibitors: a novel therapeutical intervention in asthma? Eur J Pharmacol 585: 398-406.
-
(2008)
Eur J Pharmacol
, vol.585
, pp. 398-406
-
-
Schaafsma, D.1
Gosens, R.2
Zaagsma, J.3
Halayko, A.J.4
Meurs, H.5
-
266
-
-
77953397222
-
Low-molecular-weight MK2 inhibitors: A tough nut to crack!
-
Schlapbach A and Huppertz C (2009) Low-molecular-weight MK2 inhibitors: a tough nut to crack! Future Med Chem 1:1243-1257.
-
(2009)
Future Med Chem
, vol.1
, pp. 1243-1257
-
-
Schlapbach, A.1
Huppertz, C.2
-
267
-
-
84954197710
-
Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases
-
Schwartz DM, Bonelli M, Gadina M, and O’Shea JJ (2016) Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases. Nat Rev Rheumatol 12: 25-36.
-
(2016)
Nat Rev Rheumatol
, vol.12
, pp. 25-36
-
-
Schwartz, D.M.1
Bonelli, M.2
Gadina, M.3
O’Shea, J.J.4
-
268
-
-
84929141919
-
Feedback suppression of PI3Ka signaling in PTEN-mutated tumors is relieved by selective inhibition of PI3Kb
-
Schwartz S, Wongvipat J, Trigwell CB, Hancox U, Carver BS, Rodrik-Outmezguine V, Will M, Yellen P, de Stanchina E, and Baselga J, et al. (2015) Feedback suppression of PI3Ka signaling in PTEN-mutated tumors is relieved by selective inhibition of PI3Kb. Cancer Cell 27:109-122.
-
(2015)
Cancer Cell
, vol.27
, pp. 109-122
-
-
Schwartz, S.1
Wongvipat, J.2
Trigwell, C.B.3
Hancox, U.4
Carver, B.S.5
Rodrik-Outmezguine, V.6
Will, M.7
Yellen, P.8
De Stanchina, E.9
Baselga, J.10
-
269
-
-
84956815361
-
Divergent modulation of Rho-kinase and Ca(2+) influx pathways by Src family kinases and focal adhesion kinase in airway smooth muscle
-
Shaifta Y, Irechukwu N, Prieto-Lloret J, MacKay CE, Marchon KA, Ward JP, and Knock GA (2015) Divergent modulation of Rho-kinase and Ca(2+) influx pathways by Src family kinases and focal adhesion kinase in airway smooth muscle. Br J Pharmacol 172:5265-5280.
-
(2015)
Br J Pharmacol
, vol.172
, pp. 5265-5280
-
-
Shaifta, Y.1
Irechukwu, N.2
Prieto-Lloret, J.3
Mackay, C.E.4
Marchon, K.A.5
Ward, J.P.6
Knock, G.A.7
-
270
-
-
24744464353
-
Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme
-
Shao MX and Nadel JA (2005) Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme. J Immunol 175: 4009-4016.
-
(2005)
J Immunol
, vol.175
, pp. 4009-4016
-
-
Shao, M.X.1
Nadel, J.A.2
-
271
-
-
36849074868
-
Synergistic induction of MUC5AC mucin by nontypeable Haemophilus influenzae and Streptococcus pneumoniae
-
Shen H, Yoshida H, Yan F, Li W, Xu F, Huang H, Jono H, and Li JD (2008) Synergistic induction of MUC5AC mucin by nontypeable Haemophilus influenzae and Streptococcus pneumoniae. Biochem Biophys Res Commun 365:795-800.
-
(2008)
Biochem Biophys Res Commun
, vol.365
, pp. 795-800
-
-
Shen, H.1
Yoshida, H.2
Yan, F.3
Li, W.4
Xu, F.5
Huang, H.6
Jono, H.7
Li, J.D.8
-
272
-
-
84863906812
-
CD40 amplifies Fas-mediated apoptosis: A mechanism contributing to emphysema
-
Shigeta A, Tada Y, Wang JY, Ishizaki S, Tsuyusaki J, Yamauchi K, Kasahara Y, Iesato K, Tanabe N, and Takiguchi Y, et al. (2012) CD40 amplifies Fas-mediated apoptosis: a mechanism contributing to emphysema. Am J Physiol Lung Cell Mol Physiol 303:L141-L151.
-
(2012)
Am J Physiol Lung Cell Mol Physiol
, vol.303
, pp. L141-L151
-
-
Shigeta, A.1
Tada, Y.2
Wang, J.Y.3
Ishizaki, S.4
Tsuyusaki, J.5
Yamauchi, K.6
Kasahara, Y.7
Iesato, K.8
Tanabe, N.9
Takiguchi, Y.10
-
273
-
-
34447565004
-
Clarithromycin has an immunomodulatory effect on ERK-mediated inflammation induced by Pseudomonas aeruginosa flagellin
-
Shinkai M, López-Boado YS, and Rubin BK (2007) Clarithromycin has an immunomodulatory effect on ERK-mediated inflammation induced by Pseudomonas aeruginosa flagellin. J Antimicrob Chemother 59:1096-1101.
-
(2007)
J Antimicrob Chemother
, vol.59
, pp. 1096-1101
-
-
Shinkai, M.1
López-Boado, Y.S.2
Rubin, B.K.3
-
274
-
-
0035902482
-
Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha /beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells
-
Shuto T, Xu H, Wang B, Han J, Kai H, Gu XX, Murphy TF, Lim DJ, and Li JD (2001) Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha /beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells. Proc Natl Acad Sci USA 98:8774-8779.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 8774-8779
-
-
Shuto, T.1
Xu, H.2
Wang, B.3
Han, J.4
Kai, H.5
Gu, X.X.6
Murphy, T.F.7
Lim, D.J.8
Li, J.D.9
-
275
-
-
42049118715
-
PDGF-induced human airway smooth muscle cell proliferation requires STAT3 and the small GTPase Rac1
-
Simeone-Penney MC, Severgnini M, Rozo L, Takahashi S, Cochran BH, and Simon AR (2008) PDGF-induced human airway smooth muscle cell proliferation requires STAT3 and the small GTPase Rac1. Am J Physiol Lung Cell Mol Physiol 294: L698-L704.
-
(2008)
Am J Physiol Lung Cell Mol Physiol
, vol.294
, pp. L698-L704
-
-
Simeone-Penney, M.C.1
Severgnini, M.2
Rozo, L.3
Takahashi, S.4
Cochran, B.H.5
Simon, A.R.6
-
276
-
-
84941315721
-
Oral and inhaled p38 MAPK inhibitors: Effects on inhaled LPS challenge in healthy subjects
-
Singh D, Siew L, Christensen J, Plumb J, Clarke GW, Greenaway S, Perros-Huguet C, Clarke N, Kilty I, and Tan L (2015) Oral and inhaled p38 MAPK inhibitors: effects on inhaled LPS challenge in healthy subjects. Eur J Clin Pharmacol 71: 1175-1184.
-
(2015)
Eur J Clin Pharmacol
, vol.71
, pp. 1175-1184
-
-
Singh, D.1
Siew, L.2
Christensen, J.3
Plumb, J.4
Clarke, G.W.5
Greenaway, S.6
Perros-Huguet, C.7
Clarke, N.8
Kilty, I.9
Tan, L.10
-
277
-
-
72749121087
-
A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients
-
Singh D, Smyth L, Borrill Z, Sweeney L, and Tal-Singer R (2010) A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients. J Clin Pharmacol 50:94-100.
-
(2010)
J Clin Pharmacol
, vol.50
, pp. 94-100
-
-
Singh, D.1
Smyth, L.2
Borrill, Z.3
Sweeney, L.4
Tal-Singer, R.5
-
278
-
-
33750086376
-
Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages
-
Smith SJ, Fenwick PS, Nicholson AG, Kirschenbaum F, Finney-Hayward TK, Higgins LS, Giembycz MA, Barnes PJ, and Donnelly LE (2006) Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages. Br J Pharmacol 149:393-404.
-
(2006)
Br J Pharmacol
, vol.149
, pp. 393-404
-
-
Smith, S.J.1
Fenwick, P.S.2
Nicholson, A.G.3
Kirschenbaum, F.4
Finney-Hayward, T.K.5
Higgins, L.S.6
Giembycz, M.A.7
Barnes, P.J.8
Donnelly, L.E.9
-
279
-
-
67651024123
-
Novel tightbinding inhibitory factor-kappaB kinase (IKK-2) inhibitors demonstrate targetspecific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation
-
Sommers CD, Thompson JM, Guzova JA, Bonar SL, Rader RK, Mathialagan S, Venkatraman N, Holway VW, Kahn LE, and Hu G, et al. (2009) Novel tightbinding inhibitory factor-kappaB kinase (IKK-2) inhibitors demonstrate targetspecific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation. J Pharmacol Exp Ther 330: 377-388.
-
(2009)
J Pharmacol Exp Ther
, vol.330
, pp. 377-388
-
-
Sommers, C.D.1
Thompson, J.M.2
Guzova, J.A.3
Bonar, S.L.4
Rader, R.K.5
Mathialagan, S.6
Venkatraman, N.7
Holway, V.W.8
Kahn, L.E.9
Hu, G.10
-
280
-
-
84860217431
-
The functions and regulation of the PTEN tumour suppressor
-
Song MS, Salmena L, and Pandolfi PP (2012) The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol 13:283-296.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 283-296
-
-
Song, M.S.1
Salmena, L.2
Pandolfi, P.P.3
-
281
-
-
4344653389
-
SMADsignaling in chronic obstructive pulmonary disease: Transcriptional downregulation of inhibitory SMAD 6 and 7 by cigarette smoke
-
Springer J, Scholz FR, Peiser C, Groneberg DA, and Fischer A (2004) SMADsignaling in chronic obstructive pulmonary disease: transcriptional downregulation of inhibitory SMAD 6 and 7 by cigarette smoke. Biol Chem 385:649-653.
-
(2004)
Biol Chem
, vol.385
, pp. 649-653
-
-
Springer, J.1
Scholz, F.R.2
Peiser, C.3
Groneberg, D.A.4
Fischer, A.5
-
282
-
-
84937763913
-
Identification of apoptosis signal-regulating kinase 1 (ASK1) inhibitors among the derivatives of benzothiazol-2-yl-3-hydroxy-5-phenyl-1,5-dihydro-pyrrol-2-one
-
Starosyla SA, Volynets GP, Lukashov SS, Gorbatiuk OB, Golub AG, Bdzhola VG, and Yarmoluk SM (2015) Identification of apoptosis signal-regulating kinase 1 (ASK1) inhibitors among the derivatives of benzothiazol-2-yl-3-hydroxy-5-phenyl-1,5-dihydro-pyrrol-2-one. Bioorg Med Chem 23:2489-2497.
-
(2015)
Bioorg Med Chem
, vol.23
, pp. 2489-2497
-
-
Starosyla, S.A.1
Volynets, G.P.2
Lukashov, S.S.3
Gorbatiuk, O.B.4
Golub, A.G.5
Bdzhola, V.G.6
Yarmoluk, S.M.7
-
283
-
-
67650914230
-
AMPK in health and disease
-
Steinberg GR and Kemp BE (2009) AMPK in health and disease. Physiol Rev 89: 1025-1078.
-
(2009)
Physiol Rev
, vol.89
, pp. 1025-1078
-
-
Steinberg, G.R.1
Kemp, B.E.2
-
284
-
-
0034176940
-
Aerosolized Syk antisense suppresses Syk expression, mediator release from macrophages, and pulmonary inflammation
-
Stenton GR, Kim MK, Nohara O, Chen CF, Hirji N, Wills FL, Gilchrist M, Hwang PH, Park JG, and Finlay W, et al. (2000) Aerosolized Syk antisense suppresses Syk expression, mediator release from macrophages, and pulmonary inflammation. J Immunol 164:3790-3797.
-
(2000)
J Immunol
, vol.164
, pp. 3790-3797
-
-
Stenton, G.R.1
Kim, M.K.2
Nohara, O.3
Chen, C.F.4
Hirji, N.5
Wills, F.L.6
Gilchrist, M.7
Hwang, P.H.8
Park, J.G.9
Finlay, W.10
-
285
-
-
84874449540
-
Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 2. Efficacy studies in allergic and pulmonary inflammation models in vivo
-
Stenton GR, Mackenzie LF, Tam P, Cross JL, Harwig C, Raymond J, Toews J, Chernoff D, MacRury T, and Szabo C (2013a) Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 2. Efficacy studies in allergic and pulmonary inflammation models in vivo. Br J Pharmacol 168:1519-1529.
-
(2013)
Br J Pharmacol
, vol.168
, pp. 1519-1529
-
-
Stenton, G.R.1
Mackenzie, L.F.2
Tam, P.3
Cross, J.L.4
Harwig, C.5
Raymond, J.6
Toews, J.7
Chernoff, D.8
Macrury, T.9
Szabo, C.10
-
286
-
-
84874408370
-
Characterization of AQX-1125, a smallmolecule SHIP1 activator: Part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic characterization in vivo
-
Stenton GR, Mackenzie LF, Tam P, Cross JL, Harwig C, Raymond J, Toews J, Wu J, Ogden N, and MacRury T, et al. (2013b) Characterization of AQX-1125, a smallmolecule SHIP1 activator: Part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic characterization in vivo. Br J Pharmacol 168:1506-1518.
-
(2013)
Br J Pharmacol
, vol.168
, pp. 1506-1518
-
-
Stenton, G.R.1
Mackenzie, L.F.2
Tam, P.3
Cross, J.L.4
Harwig, C.5
Raymond, J.6
Toews, J.7
Wu, J.8
Ogden, N.9
Macrury, T.10
-
287
-
-
0037100457
-
Inhibition of allergic inflammation in the airways using aerosolized antisense to Syk kinase
-
Stenton GR, Ulanova M, Déry RE, Merani S, Kim MK, Gilchrist M, Puttagunta L, Musat-Marcu S, James D, and Schreiber AD, et al. (2002) Inhibition of allergic inflammation in the airways using aerosolized antisense to Syk kinase. J Immunol 169:1028-1036.
-
(2002)
J Immunol
, vol.169
, pp. 1028-1036
-
-
Stenton, G.R.1
Ulanova, M.2
Déry, R.E.3
Merani, S.4
Kim, M.K.5
Gilchrist, M.6
Puttagunta, L.7
Musat-Marcu, S.8
James, D.9
Schreiber, A.D.10
-
288
-
-
53449097399
-
Antiallergic and anti-inflammatory effects of a novel I kappaB kinase beta inhibitor, IMD-0354, in a mouse model of allergic inflammation
-
Sugita A, Ogawa H, Azuma M, Muto S, Honjo A, Yanagawa H, Nishioka Y, Tani K, Itai A, and Sone S (2009) Antiallergic and anti-inflammatory effects of a novel I kappaB kinase beta inhibitor, IMD-0354, in a mouse model of allergic inflammation. Int Arch Allergy Immunol 148:186-198.
-
(2009)
Int Arch Allergy Immunol
, vol.148
, pp. 186-198
-
-
Sugita, A.1
Ogawa, H.2
Azuma, M.3
Muto, S.4
Honjo, A.5
Yanagawa, H.6
Nishioka, Y.7
Tani, K.8
Itai, A.9
Sone, S.10
-
289
-
-
2342629277
-
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes
-
Sun L, Deng L, Ea CK, Xia ZP, and Chen ZJ (2004) The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol Cell 14:289-301.
-
(2004)
Mol Cell
, vol.14
, pp. 289-301
-
-
Sun, L.1
Deng, L.2
Ea, C.K.3
Xia, Z.P.4
Chen, Z.J.5
-
290
-
-
84858735072
-
The noncanonical NF-kB pathway
-
Sun SC (2012) The noncanonical NF-kB pathway. Immunol Rev 246:125-140.
-
(2012)
Immunol Rev
, vol.246
, pp. 125-140
-
-
Sun, S.C.1
-
291
-
-
79951654440
-
Novel IkB kinase inhibitors for treatment of nuclear factor-kB-related diseases
-
Suzuki J, Ogawa M, Muto S, Itai A, Isobe M, Hirata Y, and Nagai R (2011) Novel IkB kinase inhibitors for treatment of nuclear factor-kB-related diseases. Expert Opin Investig Drugs 20:395-405.
-
(2011)
Expert Opin Investig Drugs
, vol.20
, pp. 395-405
-
-
Suzuki, J.1
Ogawa, M.2
Muto, S.3
Itai, A.4
Isobe, M.5
Hirata, Y.6
Nagai, R.7
-
292
-
-
6344265739
-
Inhibition of glucocorticoid receptor-mediated transcriptional activation by p38 mitogen-activated protein (MAP) kinase
-
Szatmáry Z, Garabedian MJ, and Vilcek J (2004) Inhibition of glucocorticoid receptor-mediated transcriptional activation by p38 mitogen-activated protein (MAP) kinase. J Biol Chem 279:43708-43715.
-
(2004)
J Biol Chem
, vol.279
, pp. 43708-43715
-
-
Szatmáry, Z.1
Garabedian, M.J.2
Vilcek, J.3
-
293
-
-
84884903877
-
Activator or inhibitor? GSK-3 as a new drug target
-
Takahashi-Yanaga F (2013) Activator or inhibitor? GSK-3 as a new drug target. Biochem Pharmacol 86:191-199.
-
(2013)
Biochem Pharmacol
, vol.86
, pp. 191-199
-
-
Takahashi-Yanaga, F.1
-
294
-
-
0034141938
-
Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: Role of neutrophils
-
Takeyama K, Dabbagh K, Jeong Shim J, Dao-Pick T, Ueki IF, and Nadel JA (2000) Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils. J Immunol 164:1546-1552.
-
(2000)
J Immunol
, vol.164
, pp. 1546-1552
-
-
Takeyama, K.1
Dabbagh, K.2
Jeong Shim, J.3
Dao-Pick, T.4
Ueki, I.F.5
Nadel, J.A.6
-
295
-
-
0035009331
-
Activation of epidermal growth factor receptors is responsible for mucin synthesis induced by cigarette smoke
-
Takeyama K, Jung B, Shim JJ, Burgel PR, Dao-Pick T, Ueki IF, Protin U, Kroschel P, and Nadel JA (2001) Activation of epidermal growth factor receptors is responsible for mucin synthesis induced by cigarette smoke. Am J Physiol Lung Cell Mol Physiol 280:L165-L172.
-
(2001)
Am J Physiol Lung Cell Mol Physiol
, vol.280
, pp. L165-L172
-
-
Takeyama, K.1
Jung, B.2
Shim, J.J.3
Burgel, P.R.4
Dao-Pick, T.5
Ueki, I.F.6
Protin, U.7
Kroschel, P.8
Nadel, J.A.9
-
296
-
-
84959536270
-
Epidermal growth factor receptor inhibitor AG1478 inhibits mucus hypersecretion in airway epithelium
-
Takezawa K, Ogawa T, Shimizu S, and Shimizu T (2016) Epidermal growth factor receptor inhibitor AG1478 inhibits mucus hypersecretion in airway epithelium. Am J Rhinol Allergy 30:1-6.
-
(2016)
Am J Rhinol Allergy
, vol.30
, pp. 1-6
-
-
Takezawa, K.1
Ogawa, T.2
Shimizu, S.3
Shimizu, T.4
-
297
-
-
17044453955
-
Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD)
-
Takizawa H, Tanaka M, Takami K, Ohtoshi T, Ito K, Satoh M, Okada Y, Yamasawa F, Nakahara K, and Umeda A (2001) Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med 163: 1476-1483.
-
(2001)
Am J Respir Crit Care Med
, vol.163
, pp. 1476-1483
-
-
Takizawa, H.1
Tanaka, M.2
Takami, K.3
Ohtoshi, T.4
Ito, K.5
Satoh, M.6
Okada, Y.7
Yamasawa, F.8
Nakahara, K.9
Umeda, A.10
-
298
-
-
33751207741
-
Is alveolar destruction and emphysema in chronic obstructive pulmonary disease an immune disease?
-
Taraseviciene-Stewart L, Douglas IS, Nana-Sinkam PS, Lee JD, Tuder RM, Nicolls MR, and Voelkel NF (2006) Is alveolar destruction and emphysema in chronic obstructive pulmonary disease an immune disease? Proc Am Thorac Soc 3: 687-690.
-
(2006)
Proc am Thorac Soc
, vol.3
, pp. 687-690
-
-
Taraseviciene-Stewart, L.1
Douglas, I.S.2
Nana-Sinkam, P.S.3
Lee, J.D.4
Tuder, R.M.5
Nicolls, M.R.6
Voelkel, N.F.7
-
299
-
-
20244364825
-
Airway inflammation: Chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases
-
Thomas MJ, Smith A, Head DH, Milne L, Nicholls A, Pearce W, Vanhaesebroeck B, Wymann MP, Hirsch E, and Trifilieff A, et al. (2005) Airway inflammation: chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases. Eur J Immunol 35:1283-1291.
-
(2005)
Eur J Immunol
, vol.35
, pp. 1283-1291
-
-
Thomas, M.J.1
Smith, A.2
Head, D.H.3
Milne, L.4
Nicholls, A.5
Pearce, W.6
Vanhaesebroeck, B.7
Wymann, M.P.8
Hirsch, E.9
Trifilieff, A.10
-
300
-
-
84933508363
-
New spleen tyrosine kinase inhibitors: Patent applications published during 2011-2013
-
Thorarensen A and Kaila N (2014) New spleen tyrosine kinase inhibitors: patent applications published during 2011-2013. Pharm Pat Anal 3:523-541.
-
(2014)
Pharm Pat Anal
, vol.3
, pp. 523-541
-
-
Thorarensen, A.1
Kaila, N.2
-
301
-
-
77958173826
-
Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease
-
To Y, Ito K, Kizawa Y, Failla M, Ito M, Kusama T, Elliot M, Hogg JC, Adcock IM, and Barnes PJ (2010) Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 182:897-904.
-
(2010)
Am J Respir Crit Care Med
, vol.182
, pp. 897-904
-
-
To, Y.1
Ito, K.2
Kizawa, Y.3
Failla, M.4
Ito, M.5
Kusama, T.6
Elliot, M.7
Hogg, J.C.8
Adcock, I.M.9
Barnes, P.J.10
-
303
-
-
38449118061
-
The role of IkappaB kinase 2, but not activation of NF-kappaB, in the release of CXCR3 ligands from IFN-g-stimulated human bronchial epithelial cells
-
Tudhope SJ, Catley MC, Fenwick PS, Russell RE, Rumsey WL, Newton R, Barnes PJ, and Donnelly LE (2007) The role of IkappaB kinase 2, but not activation of NF-kappaB, in the release of CXCR3 ligands from IFN-g-stimulated human bronchial epithelial cells. J Immunol 179:6237-6245.
-
(2007)
J Immunol
, vol.179
, pp. 6237-6245
-
-
Tudhope, S.J.1
Catley, M.C.2
Fenwick, P.S.3
Russell, R.E.4
Rumsey, W.L.5
Newton, R.6
Barnes, P.J.7
Donnelly, L.E.8
-
304
-
-
37349096435
-
Different mitogen-activated protein kinase-dependent cytokine responses in cells of the monocyte lineage
-
Tudhope SJ, Finney-Hayward TK, Nicholson AG, Mayer RJ, Barnette MS, Barnes PJ, and Donnelly LE (2008) Different mitogen-activated protein kinase-dependent cytokine responses in cells of the monocyte lineage. J Pharmacol Exp Ther 324: 306-312.
-
(2008)
J Pharmacol Exp Ther
, vol.324
, pp. 306-312
-
-
Tudhope, S.J.1
Finney-Hayward, T.K.2
Nicholson, A.G.3
Mayer, R.J.4
Barnette, M.S.5
Barnes, P.J.6
Donnelly, L.E.7
-
305
-
-
84900535223
-
Absence of c-Jun NH2-terminal kinase 1 protects against house dust mite-induced pulmonary remodeling but not airway hyperresponsiveness and inflammation
-
van der Velden JL, Hoffman SM, Alcorn JF, Tully JE, Chapman DG, Lahue KG, Guala AS, Lundblad LK, Aliyeva M, and Daphtary N, et al. (2014) Absence of c-Jun NH2-terminal kinase 1 protects against house dust mite-induced pulmonary remodeling but not airway hyperresponsiveness and inflammation. Am J Physiol Lung Cell Mol Physiol 306:L866-L875.
-
(2014)
Am J Physiol Lung Cell Mol Physiol
, vol.306
, pp. L866-L875
-
-
Van Der Velden, J.L.1
Hoffman, S.M.2
Alcorn, J.F.3
Tully, J.E.4
Chapman, D.G.5
Lahue, K.G.6
Guala, A.S.7
Lundblad, L.K.8
Aliyeva, M.9
Daphtary, N.10
-
306
-
-
84896075568
-
PI3Kd inhibition hits a sensitive spot in B cell malignancies
-
Vanhaesebroeck B and Khwaja A (2014) PI3Kd inhibition hits a sensitive spot in B cell malignancies. Cancer Cell 25:269-271.
-
(2014)
Cancer Cell
, vol.25
, pp. 269-271
-
-
Vanhaesebroeck, B.1
Khwaja, A.2
-
308
-
-
84953638651
-
Molecules in medicine minireview: Isoforms of PI3K in biology and disease
-
Vanhaesebroeck B, Whitehead MA, and Piñeiro R (2016) Molecules in medicine minireview: isoforms of PI3K in biology and disease. J Mol Med (Berl) 94:5-11.
-
(2016)
J Mol Med (Berl)
, vol.94
, pp. 5-11
-
-
Vanhaesebroeck, B.1
Whitehead, M.A.2
Piñeiro, R.3
-
309
-
-
34248512697
-
Beyond imatinib: Second generation c-KIT inhibitors for the management of gastrointestinal stromal tumors
-
von Mehren M (2006) Beyond imatinib: second generation c-KIT inhibitors for the management of gastrointestinal stromal tumors. Clin Colorectal Cancer 6 (Suppl 1):S30-S34.
-
(2006)
Clin Colorectal Cancer
, vol.6
, pp. S30-S34
-
-
Von Mehren, M.1
-
311
-
-
0141781014
-
Up-regulation of interleukin-8 by novel small cytoplasmic molecules of nontypeable Haemophilus influenzae via p38 and extracellular signal-regulated kinase pathways
-
Wang B, Cleary PP, Xu H, and Li JD (2003) Up-regulation of interleukin-8 by novel small cytoplasmic molecules of nontypeable Haemophilus influenzae via p38 and extracellular signal-regulated kinase pathways. Infect Immun 71:5523-5530.
-
(2003)
Infect Immun
, vol.71
, pp. 5523-5530
-
-
Wang, B.1
Cleary, P.P.2
Xu, H.3
Li, J.D.4
-
312
-
-
84925813748
-
Syk mediates airway contractility independent of leukocyte function
-
Wang X, Khanna N, Wu J, Godri Pollitt K, Evans GJ, Chow CW, and Scott JA (2015) Syk mediates airway contractility independent of leukocyte function. Allergy 70: 429-435.
-
(2015)
Allergy
, vol.70
, pp. 429-435
-
-
Wang, X.1
Khanna, N.2
Wu, J.3
Godri Pollitt, K.4
Evans, G.J.5
Chow, C.W.6
Scott, J.A.7
-
313
-
-
39849096188
-
Gene expression profiling in patients with chronic obstructive pulmonary disease and lung cancer
-
Wang IM, Stepaniants S, Boie Y, Mortimer JR, Kennedy B, Elliott M, Hayashi S, Loy L, Coulter S, and Cervino S, et al. (2008) Gene expression profiling in patients with chronic obstructive pulmonary disease and lung cancer. Am J Respir Crit Care Med 177:402-411.
-
(2008)
Am J Respir Crit Care Med
, vol.177
, pp. 402-411
-
-
Wang, I.M.1
Stepaniants, S.2
Boie, Y.3
Mortimer, J.R.4
Kennedy, B.5
Elliott, M.6
Hayashi, S.7
Loy, L.8
Coulter, S.9
Cervino, S.10
-
314
-
-
70350129230
-
IRAK-4 inhibitors for inflammation
-
Wang Z, Wesche H, Stevens T, Walker N, and Yeh WC (2009) IRAK-4 inhibitors for inflammation. Curr Top Med Chem 9:724-737.
-
(2009)
Curr Top Med Chem
, vol.9
, pp. 724-737
-
-
Wang, Z.1
Wesche, H.2
Stevens, T.3
Walker, N.4
Yeh, W.C.5
-
315
-
-
84891373802
-
Efficacy and safety of the p38 MAPK inhibitor losmapimod for patients with chronic obstructive pulmonary disease: A randomised, double-blind, placebo-controlled trial
-
Watz H, Barnacle H, Hartley BF, and Chan R (2014) Efficacy and safety of the p38 MAPK inhibitor losmapimod for patients with chronic obstructive pulmonary disease: a randomised, double-blind, placebo-controlled trial. Lancet Respir Med 2: 63-72.
-
(2014)
Lancet Respir Med
, vol.2
, pp. 63-72
-
-
Watz, H.1
Barnacle, H.2
Hartley, B.F.3
Chan, R.4
-
317
-
-
84970954580
-
Rhe selective pan-Janus kinase (JAK) inhibitor VR588 demonstrates potent anti-inflammatory activity in a murne chronic house dust mite model
-
Wiegman CH, Russell KE, Sieffert J, Rossios C, Adcock IM, Rothaul A, Main M, and Morgan F (2015) Rhe selective pan-Janus kinase (JAK) inhibitor VR588 demonstrates potent anti-inflammatory activity in a murne chronic house dust mite model. Am J Respir Crit Care Med 191:A6435.
-
(2015)
Am J Respir Crit Care Med
, vol.191
, pp. A6435
-
-
Wiegman, C.H.1
Russell, K.E.2
Sieffert, J.3
Rossios, C.4
Adcock, I.M.5
Rothaul, A.6
Main, M.7
Morgan, F.8
-
318
-
-
84864021710
-
Rapamycin slows aging in mice
-
Wilkinson JE, Burmeister L, Brooks SV, Chan CC, Friedline S, Harrison DE, Hejtmancik JF, Nadon N, Strong R, and Wood LK, et al. (2012) Rapamycin slows aging in mice. Aging Cell 11:675-682.
-
(2012)
Aging Cell
, vol.11
, pp. 675-682
-
-
Wilkinson, J.E.1
Burmeister, L.2
Brooks, S.V.3
Chan, C.C.4
Friedline, S.5
Harrison, D.E.6
Hejtmancik, J.F.7
Nadon, N.8
Strong, R.9
Wood, L.K.10
-
319
-
-
55949102910
-
Role of p38 mitogen-activated protein kinase in ozone-induced airway hyperresponsiveness and inflammation
-
Williams AS, Issa R, Durham A, Leung SY, Kapoun A, Medicherla S, Higgins LS, Adcock IM, and Chung KF (2008) Role of p38 mitogen-activated protein kinase in ozone-induced airway hyperresponsiveness and inflammation. Eur J Pharmacol 600:117-122.
-
(2008)
Eur J Pharmacol
, vol.600
, pp. 117-122
-
-
Williams, A.S.1
Issa, R.2
Durham, A.3
Leung, S.Y.4
Kapoun, A.5
Medicherla, S.6
Higgins, L.S.7
Adcock, I.M.8
Chung, K.F.9
-
320
-
-
84896479862
-
Safety, tolerability and pharmacokinetics (PK) of single and repeat nebulised doses of a novel phosphoinositide 3-kinase d inhibitor (PI3Kd), GSK2269557, administered to healthy male subjects in a phase I study
-
Wilson R, Cahn AAD, McSherry L, Rambaran C, Sousa A, and Wilbraham D (2013) Safety, tolerability and pharmacokinetics (PK) of single and repeat nebulised doses of a novel phosphoinositide 3-kinase d inhibitor (PI3Kd), GSK2269557, administered to healthy male subjects in a phase I study. Eur Respir J 42 (Suppl 57): P729.
-
(2013)
Eur Respir J
, vol.42
, pp. 729
-
-
Wilson, R.1
Cahn, A.2
McSherry, L.3
Rambaran, C.4
Sousa, A.5
Wilbraham, D.6
-
321
-
-
84888219144
-
PI3K-d and PI3K-g inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models
-
Winkler DG, Faia KL, DiNitto JP, Ali JA, White KF, Brophy EE, Pink MM, Proctor JL, Lussier J, and Martin CM, et al. (2013) PI3K-d and PI3K-g inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models. Chem Biol 20:1364-1374.
-
(2013)
Chem Biol
, vol.20
, pp. 1364-1374
-
-
Winkler, D.G.1
Faia, K.L.2
Dinitto, J.P.3
Ali, J.A.4
White, K.F.5
Brophy, E.E.6
Pink, M.M.7
Proctor, J.L.8
Lussier, J.9
Martin, C.M.10
-
322
-
-
77649157336
-
Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease
-
Woodruff PG, Wolff M, Hohlfeld JM, Krug N, Dransfield MT, Sutherland ER, Criner GJ, Kim V, Prasse A, and Nivens MC, et al. (2010) Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 181:438-445.
-
(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 438-445
-
-
Woodruff, P.G.1
Wolff, M.2
Hohlfeld, J.M.3
Krug, N.4
Dransfield, M.T.5
Sutherland, E.R.6
Criner, G.J.7
Kim, V.8
Prasse, A.9
Nivens, M.C.10
-
324
-
-
84947926228
-
Allosteric small-molecule kinase inhibitors
-
Wu P, Clausen MH, and Nielsen TE (2015b) Allosteric small-molecule kinase inhibitors. Pharmacol Ther 156:59-68.
-
(2015)
Pharmacol Ther
, vol.156
, pp. 59-68
-
-
Wu, P.1
Clausen, M.H.2
Nielsen, T.E.3
-
325
-
-
84940953236
-
SP600125 promotes resolution of allergic airway inflammation via TLR9 in an OVA-induced murine acute asthma model
-
Wu HM, Fang L, Shen QY, and Liu RY (2015a) SP600125 promotes resolution of allergic airway inflammation via TLR9 in an OVA-induced murine acute asthma model. Mol Immunol 67 (2 Pt B):311-316.
-
(2015)
Mol Immunol
, vol.67
, Issue.2
, pp. 311-316
-
-
Wu, H.M.1
Fang, L.2
Shen, Q.Y.3
Liu, R.Y.4
-
327
-
-
84861464767
-
Silencing of c-kit with small interference RNA attenuates inflammation in a murine model of allergic asthma
-
Wu W, Wang T, Dong JJ, Liao ZL, and Wen FQ (2012) Silencing of c-kit with small interference RNA attenuates inflammation in a murine model of allergic asthma. Int J Mol Med 30:63-68.
-
(2012)
Int J Mol Med
, vol.30
, pp. 63-68
-
-
Wu, W.1
Wang, T.2
Dong, J.J.3
Liao, Z.L.4
Wen, F.Q.5
-
328
-
-
34447502336
-
Mechanisms of induction of airway smooth muscle hyperplasia by transforming growth factorbeta
-
Xie S, Sukkar MB, Issa R, Khorasani NM, and Chung KF (2007) Mechanisms of induction of airway smooth muscle hyperplasia by transforming growth factorbeta. Am J Physiol Lung Cell Mol Physiol 293:L245-L253.
-
(2007)
Am J Physiol Lung Cell Mol Physiol
, vol.293
, pp. L245-L253
-
-
Xie, S.1
Sukkar, M.B.2
Issa, R.3
Khorasani, N.M.4
Chung, K.F.5
-
329
-
-
33644997214
-
Endothelin-1 regulates proliferative responses, both alone and synergistically with PDGF, in rat tracheal smooth muscle cells
-
Yahiaoui L, Villeneuve A, Valderrama-Carvajal H, Burke F, and Fixman ED (2006) Endothelin-1 regulates proliferative responses, both alone and synergistically with PDGF, in rat tracheal smooth muscle cells. Cell Physiol Biochem 17:37-46.
-
(2006)
Cell Physiol Biochem
, vol.17
, pp. 37-46
-
-
Yahiaoui, L.1
Villeneuve, A.2
Valderrama-Carvajal, H.3
Burke, F.4
Fixman, E.D.5
-
330
-
-
0041932075
-
The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigeninduced airway inflammation in rodents
-
Yamamoto N, Takeshita K, Shichijo M, Kokubo T, Sato M, Nakashima K, Ishimori M, Nagai H, Li YF, and Yura T, et al. (2003) The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigeninduced airway inflammation in rodents. J Pharmacol Exp Ther 306: 1174-1181.
-
(2003)
J Pharmacol Exp Ther
, vol.306
, pp. 1174-1181
-
-
Yamamoto, N.1
Takeshita, K.2
Shichijo, M.3
Kokubo, T.4
Sato, M.5
Nakashima, K.6
Ishimori, M.7
Nagai, H.8
Li, Y.F.9
Yura, T.10
-
331
-
-
58249109351
-
The possible role of hematopoietic cell kinase in the pathophysiology of COPD
-
Yanagisawa S, Sugiura H, Yokoyama T, Yamagata T, Ichikawa T, Akamatsu K, Koarai A, Hirano T, Nakanishi M, and Matsunaga K, et al. (2009) The possible role of hematopoietic cell kinase in the pathophysiology of COPD. Chest 135: 94-101.
-
(2009)
Chest
, vol.135
, pp. 94-101
-
-
Yanagisawa, S.1
Sugiura, H.2
Yokoyama, T.3
Yamagata, T.4
Ichikawa, T.5
Akamatsu, K.6
Koarai, A.7
Hirano, T.8
Nakanishi, M.9
Matsunaga, K.10
-
332
-
-
0034859081
-
The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6
-
Yang F, Oz HS, Barve S, de Villiers WJ, McClain CJ, and Varilek GW (2001) The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6. Mol Pharmacol 60:528-533.
-
(2001)
Mol Pharmacol
, vol.60
, pp. 528-533
-
-
Yang, F.1
Oz, H.S.2
Barve, S.3
De Villiers, W.J.4
McClain, C.J.5
Varilek, G.W.6
-
333
-
-
84942750811
-
JAK-STAT pathway activation in COPD
-
Yew-Booth L, Birrell MA, Lau MS, Baker K, Jones V, Kilty I, and Belvisi MG (2015) JAK-STAT pathway activation in COPD. Eur Respir J 46:843-845.
-
(2015)
Eur Respir J
, vol.46
, pp. 843-845
-
-
Yew-Booth, L.1
Birrell, M.A.2
Lau, M.S.3
Baker, K.4
Jones, V.5
Kilty, I.6
Belvisi, M.G.7
-
334
-
-
0034650486
-
Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
-
Yu Q and Stamenkovic I (2000) Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev 14:163-176.
-
(2000)
Genes Dev
, vol.14
, pp. 163-176
-
-
Yu, Q.1
Stamenkovic, I.2
-
335
-
-
78649319089
-
Allergen-induced coexpression of bFGF and TGF-b1 by macrophages in a mouse model of airway remodeling: BFGF induces macrophage TGF-b1 expression in vitro
-
Yum HY, Cho JY, Miller M, and Broide DH (2011) Allergen-induced coexpression of bFGF and TGF-b1 by macrophages in a mouse model of airway remodeling: bFGF induces macrophage TGF-b1 expression in vitro. Int Arch Allergy Immunol 155: 12-22.
-
(2011)
Int Arch Allergy Immunol
, vol.155
, pp. 12-22
-
-
Yum, H.Y.1
Cho, J.Y.2
Miller, M.3
Broide, D.H.4
-
336
-
-
19944374141
-
A selective novel low-molecularweight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity
-
Ziegelbauer K, Gantner F, Lukacs NW, Berlin A, Fuchikami K, Niki T, Sakai K, Inbe H, Takeshita K, and Ishimori M, et al. (2005) A selective novel low-molecularweight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity. Br J Pharmacol 145: 178-192.
-
(2005)
Br J Pharmacol
, vol.145
, pp. 178-192
-
-
Ziegelbauer, K.1
Gantner, F.2
Lukacs, N.W.3
Berlin, A.4
Fuchikami, K.5
Niki, T.6
Sakai, K.7
Inbe, H.8
Takeshita, K.9
Ishimori, M.10
|