Nuclear factor-κB - A pivotal transcription factor in chronic inflammatory diseases

New England Journal of Medicine

Volumn 336, Issue 15, 1997, Pages 1066-1071

  Barnes, Peter J ^a   Karin, Michael ^b  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN SYNTHASE; GLUCOCORTICOID;

ANTIGEN EXPRESSION; ASTHMA; CHRONIC INFLAMMATION; ENTERITIS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMAN; IMMUNOPATHOGENESIS; IMMUNOSTIMULATION; PRIORITY JOURNAL; PROTEIN DETERMINATION; REVIEW; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ARTHRITIS; CHRONIC DISEASE; DRUG ANTAGONISM; GENETIC TRANSCRIPTION; GENETICS; INFLAMMATION; PHYSIOLOGY;

ARTHRITIS; CHRONIC DISEASE; GLUCOCORTICOIDS; HUMANS; INFLAMMATION; INFLAMMATORY BOWEL DISEASES; NF-KAPPA B; TRANSCRIPTION, GENETIC;

EID: 0030615201     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199704103361506     Document Type: Review

References (53)

1. Brennan FM, Maini RN, Feldmann M. Cytokine expression in chronic inflammatory disease. Br Med Bull 1995;51:368-84.
2. Papavassiliou AG. Transcription factors. N Engl J Med 1995;332:45-7.
3. Kopp EB, Ghosh S. NF-κ B and rel proteins in innate immunity. Adv Immunol 1995;58:1-27.
4. Sen R, Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986;46:705-16.
5. Siebenlist U, Franzoso G, Brown K. Structure, regulation and function of NF-τ B. Annu Rev Cell Biol 1994;10:405-55.
6. Baeuerle PA, Baltimore D. NF-κ B: ten years after. Cell 1996;87:13-20.
7. Baldwin AS Jr. The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol 1996;14:649-83.
8. DiDonato J, Mercurio F, Rosette C, et al. Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation. Mol Cell Biol 1996;16:1295-304.
9. Chen ZJ, Parent L, Maniatis T. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell 1996;84: 853-62.
10. Arenzana-Seisdedos F, Thompson J, Rodriguez MS, Bachelerie F, Thomas D, Hay RT. Inducible nuclear expression of newly synthesized IκBα negatively regulates DNA-binding and transcriptional activities of NF-κB. Mol Cell Biol 1995;15:2689-96.
11. Klement JF, Rice NR, Car BD, et al. IκBα deficiency results in a sustained NF-κB response and severe widespread dermatitis in mice. Mol Cell Biol 1996;16:2341-9.
12. Thompson JE, Phillips RJ, Erdjument-Bromage H, Tempst P, Ghosh S. IκB-β regulates the persistent response in a biphasic activation of NF-κB. Cell 1995;80:573-82.
13. Janosch P, Schellerer M, Seitz T, et al. Characterization of IκB kinases: IκB-alpha is not phosphorylated by Raf-1 or protein kinase C isozymes, but is a casein kinase II substrate. J Biol Chem 1996;271:13868-74.
14. Schreck R, Rieber P, Baeuerle PA. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κ B transcription factor and HIV-1. EMBO J 1991;10:2247-58.
15. Stein B, Baldwin AS Jr. Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-κB. Mol Cell Biol 1993;13:7191-8.
16. Stein B, Baldwin AS Jr, Ballard DW, Greene WC, Angel P, Herrlich P. Cross-coupling of the NF-κ B p65 and Fos/Jun transcription factors produces potentiated biological function. EMBO J 1993;12:3879-91.
17. Xie QW, Kashiwabara Y, Nathan C. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase. J Biol Chem 1994;269:4705-8.
18. Hamid Q, Springall DR, Riveros-Moreno V, et al. Induction of nitric oxide synthase in asthma. Lancet 1993;342:1510-3.
19. Rachmilewitz D, Stamler JS, Bachwich D, Karmeli F, Ackerman Z, Podolsky DK. Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease. Gut 1995;36: 718-23.
20. Evans CH, Stefanovic-Racic M, Lancaster J. Nitric oxide and its role in orthopaedic disease. Clin Orthop 1995;312:275-94.
21. Kharitonov SA, Yates D, Robbins RA, Logan-Sinclair R, Shinebourne EA, Barnes PJ. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 1994;343:133-5.
22. Lundberg JON, Hellstrom PM, Lundberg JM, Alving K. Greatly increased luminal nitric oxide in ulcerative colitis. Lancet 1994;344:1673-4.
23. Yamamoto K, Arakawa T, Ueda N, Yamamoto S. Transcriptional roles of nuclear factor κB and nuclear factor interleukin-6 in the tumor necrosis factor α-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J Biol Chem 1995;270:31315-50.
24. Crofford LJ, Wilder RL, Ristimaki AP, et al. Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues: effects of interleukin-1β, phorbol ester, and corticosteroids. J Clin Invest 1994;93:1095-101.
25. Albelda SM, Smith CW, Ward PA. Adhesion molecules and inflammatory injury. FASEB J 1994;8:504-12.
26. Elliott MJ, Maini RN, Feldmann M, et al. Randomised double blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis. Lancet 1994;344:1105-10.
27. Zhu Z, Tang W, Ray A, et al. Rhinovirus stimulation of interleukin-6 in vivo and in vitro: evidence for nuclear factor κB-dependent transcriptional activation. J Clin Invest 1996;97:421-30.
28. Haddad E-B, Salmon M, Koto H, Barnes PJ, Adcock I, Chung KF. Ozone induction of cytokine-induced neutrophil chemoattractant (CINC) and nuclear factor-κB in rat lung: inhibition by corticosteroids. FEBS Lett 1996;379:265-8.
29. Adcock IM, Brown CR, Gelder CM, Shirasaki H, Peters MJ, Barnes PJ. Effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells. Am J Physiol 1995;268:C331-C338.
30. Adcock IM, Brown CR, Shirasaki H, Barnes PJ. Effects of dexamethasone on cytokine and phorbol ester stimulated c-Fos and c-Jun DNA binding and gene expression in human lung. Eur Respir J 1994;7:2117-23.
31. Adcock IM, Brown CR, Kwon OJ, Barnes PJ. Oxidative stress induces NF κB DNA binding and inducible NOS mRNA in human epithelial cells. Biochem Biophys Res Commun 1994;199:1518-24.
32. Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M. Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB synthesis. Science 1995;270:286-90.
33. Marok R, Winyard PG, Coumbe A, et al. Activation of the transcription factor nuclear factor-κB in human inflamed synovial tissue. Arthritis Rheum 1996;39:581-91.
34. Collins PD, Marleau S, Griffiths-Johnson DA, Jose PJ, Willliams TJ. Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. J Exp Med 1995;182:1169-74.
35. Barnes PJ, Adcock I. Anti-inflammatory actions of steroids: molecular mechanisms. Trends Pharmacol Sci 1993;14:436-41.
36. Saatcioglu F, Claret FX, Karin M. Negative transcriptional regulation by nuclear receptors. Semin Cancer Biol 1994;5:347-59.
37. Yang-Yen HF, Chambard JC, Sun YL, et al. Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 1990;62:1205-15.
38. Ray A, Prefontaine KE. Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proc Natl Acad Sci U S A 1994;91:752-6.
39. Adcock IM, Shirasaki H, Gelder CM, Peters MJ, Brown CR, Barnes PJ. The effects of glucocorticoids on phorbol ester and cytokine stimulated transcription factor activation in human lung. Life Sci 1994;55:1147-53.
40. Scheinman RI, Gualberto A, Jewell CM, Cidlowski JA, Baldwin AS Jr. Characterization of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors. Mol Cell Biol 1995;15:943-53.
41. Adcock IM, Brown CR, Barnes PJ. Tumour necrosis factor alpha causes retention of activated glucocorticoid receptor within the cytoplasm of A549 cells. Biochem Biophys Res Commun 1996;225:545-50.
42. Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS Jr. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 1995;270:283-6.
43. Brostjan C, Anrather J, Csizmadia V, et al. Glucocortkoid-mediated repression of NF-κB activity in endothelial cells does not involve induction of IκBαα synthesis. J Biol Chem 1996;271:19612-6.
44. Barnes PJ, Adcock IM. Steroid resistance in asthma. Q J Med 1995; 88:455-68.
45. Adcock IM, Lane SJ, Brown CR, Lee TH, Barnes PJ. Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma. J Exp Med 1995;182:1951-8.
46. Kopp E, Ghosh S. Inhibition of NF-κB by sodium salicylate and aspirin. Science 1994;265:956-9.
47. Yang JP, Merin JP, Nakano T, Kato T, Kitade Y, Okamoto T. Inhibition of the DNA-binding activity of NF-κB by gold compounds in vitro. FEBS Lett 1995;361:89-96.
48. Pahl HL, Krauss B, Schulze-Osthoff K, et al. The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-κB. J Exp Med 1996;183:1829-40.
49. Wang P, Wu P, Siegel MI, Egan RW, Billah MM. Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes: IL-10 and IL-4 suppress cytokine synthesis by different mechanisms. J Biol Chem 1995;270:9558-63.
50. Schreiber S, Heinig T, Thiele HG, Raedler A. Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease. Gastroenterology 1995;108:1434-44.
51. Wrighton CJ, Hofer-Warbinek R, Moll T, Eytner R, Bach FH, de Martin R. Inhibition of endothelial cell activation by adenovirus-mediated expression of IκBα, an inhibitor of the transcription factor NF-κB. J Exp Med 1996;183:1013-22.
52. Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature 1995;376:167-70.
53. Sha WC, Liou HC, Tuomanen EI, Baltimore D. Targeted disruption of the p50 subunit of NF-κB leads to multifocal detects in immune responses. Cell 1995;80:321-30.