Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses

Journal of Allergy and Clinical Immunology

Volumn 133, Issue 4, 2014, Pages

  Ashino, Shigeru ^a   Takeda, Katsuyuki ^a   Li, Hui ^b   Taylor, Vanessa ^b   Joetham, Anthony ^a   Pine, Polly R ^b   Gelfand, Erwin W ^a  

^a DEPARTMENT OF MEDICINE   (United States)

^b RIGEL PHARMACEUTICALS INC   (United States)

Author keywords

asthma; Janus kinase 1 3

Indexed keywords

ALLERGEN; CYTOKINE RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 5; JANUS KINASE 1; JANUS KINASE 3; JANUS KINASE INHIBITOR; OVALBUMIN; R 256; STAT5 PROTEIN; STAT6 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DESENSITIZATION; DOWN REGULATION; ENZYME INHIBITION; EOSINOPHILIA; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE DIFFERENTIATION; MOUSE; MUCUS SECRETION; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROVOCATION TEST; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT INFLAMMATION; SIGNAL TRANSDUCTION; TH1 CELL; TH17 CELL; TH2 CELL;

ASTHMA; JANUS KINASE 1/3; T(H)2;

ALLERGENS; ANIMALS; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; FEMALE; JANUS KINASE 1; JANUS KINASE 3; LUNG; MICE; MICE, TRANSGENIC; PROTEIN KINASE INHIBITORS; RESPIRATORY HYPERSENSITIVITY; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, HELPER-INDUCER; TH2 CELLS;

EID: 84897420018     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.10.036     Document Type: Article

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