Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine

Nature Communications

Volumn 6, Issue , 2015, Pages

  Dong, Ting ^a,b   Li, Chao ^c   Wang, Xing ^d   Dian, Longyang ^b   Zhang, Xiuguo ^b   Li, Lin ^b   Chen, She ^b   Cao, Ran ^b   Li, L ^b   Huang, Niu ^c   He, Sudan ^d   Lei, Xiaoguang ^a,b,c  

^a GRADUATE SCHOOL OF PEKING UNION MEDICAL COLLEGE   (China)

^b NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

^c PEKING UNIVERSITY   (China)

^d SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AINSLIADIMER A; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; CYSTEINE; ENZYME INHIBITOR; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NATURAL PRODUCT; UNCLASSIFIED DRUG; I KAPPA B KINASE; LACTONE; SESQUITERPENE;

CANCER; ENZYME ACTIVITY; IMMUNE RESPONSE; MOLECULAR ANALYSIS; SIGNALING;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL DEATH; COVALENT BOND; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; ALLOSTERIC SITE; AMINO ACID SEQUENCE; ANIMAL; CONSERVED SEQUENCE; DRUG EFFECT; HEK293 CELL LINE; HELA CELL LINE; METABOLISM; NEOPLASM; RAW 264.7 CELL LINE; TUMOR CELL LINE;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; AMINO ACID SEQUENCE; ANIMALS; CELL LINE, TUMOR; CONSERVED SEQUENCE; CYSTEINE; HEK293 CELLS; HELA CELLS; HUMANS; I-KAPPA B KINASE; LACTONES; MICE; NEOPLASMS; NF-KAPPA B; RAW 264.7 CELLS; SESQUITERPENES; SIGNAL TRANSDUCTION;

EID: 84925812821     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7522     Document Type: Article

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