Constitutive activation of the Src family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response

Journal of Experimental Medicine

Volumn 196, Issue 5, 2002, Pages 589-604

  Ernst, Matthias ^a   Inglese, Melissa ^a   Scholz, Glen M ^a   Harder, Kenneth W ^a   Clay, Fiona J ^a   Bozinovski, Steven ^b   Waring, Paul ^c   Darwiche, Rima ^a   Kay, Tom ^a   Sly, Peter ^d   Collins, Rachel ^d   Turner, Debra ^d   Hibbs, Margaret L ^a   Anderson, Gary P ^b   Dunn, Ashley R ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c PETER MACCALLUM CANCER CENTRE   (Australia)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Endotoxemia; Knock in mutation; LPS; Macrophage; Neutrophil

Indexed keywords

HEMATOPOIETIC CELL KINASE; LIPOPOLYSACCHARIDE; MATRIX METALLOPROTEINASE; PROTEIN TYROSINE KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTOXEMIA; ENZYME ACTIVATION; HOST RESISTANCE; IMMUNE RESPONSE; LEUKOCYTE ADHERENCE; LUNG ALVEOLUS; LUNG EMPHYSEMA; LUNG FIBROSIS; LUNG PARENCHYMA; MONONUCLEAR CELL; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; RESPIRATORY DISTRESS; TISSUE INJURY;

AMINO ACID SUBSTITUTION; ANIMALS; CELL ADHESION; ENZYME ACTIVATION; LIPOPOLYSACCHARIDES; LUNG; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MONOCYTES; NEUTROPHILS; PHAGOCYTOSIS; PHENOTYPE; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-HCK;

EID: 0036715696     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20020873     Document Type: Article

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