Inhibition of transforming growth factor (TGF)-β1-induced extracellular matrix with a novel inhibitor of the TGF-β type I receptor kinase activity: SB-431542

Molecular Pharmacology

Volumn 62, Issue 1, 2002, Pages 58-64

  Laping, N J ^a   Grygielko, E ^a   Mathur, A ^a   Butter, S ^a   Bomberger, J ^a   Tweed, C ^a   Martin, W ^a   Fornwald, J ^a   Lehr, R ^a   Harling, J ^a   Gaster, L ^a   Callahan, J F ^a   Olson, B A ^a,b  

^a Department of Renal and Urology Research ^*  (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (5 BENZO[1,3]DIOXO 5 YL 4 PYRIDIN 2 YL 1H IMIDAZOL 2 YL)BENZAMIDE; 4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; 4 [4 (4 FLUOROPHENYL) 1 (4 PIPERIDINYL) 1H IMIDAZOL 5 YL] 2 METHOXYPYRIMIDINE; ACTIVIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN INHIBITOR; SB 242235; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FIBROSIS; HUMAN; HUMAN CELL; IC 50; KIDNEY CARCINOMA; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ACTIVIN RECEPTORS, TYPE I; BENZAMIDES; COLLAGEN TYPE I; DIOXOLES; ENZYME INHIBITORS; EXTRACELLULAR MATRIX; FIBRONECTINS; HUMANS; IMIDAZOLES; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, MESSENGER; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR CELLS, CULTURED;

EID: 0036082554     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.62.1.58     Document Type: Article

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