Identification of apoptosis signal-regulating kinase 1 (ASK1) inhibitors among the derivatives of benzothiazol-2-yl-3-hydroxy-5-phenyl-1,5-dihydro-pyrrol-2-one

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 10, 2015, Pages 2489-2497

  Starosyla, Sergiy A ^a   Volynets, Galyna P ^a   Lukashov, Sergiy S ^a   Gorbatiuk, Oksana B ^a   Golub, Andriy G ^b   Bdzhola, Volodymyr G ^a   Yarmoluk, Sergiy M ^a  

^a INSTITUTE OF MOLECULAR BIOLOGY AND GENETICS   (Ukraine)

^b OTAVA Ltd   (Canada)

Author keywords

Apoptosis signal regulating kinase 1, ASK1; Compound library; Inhibitor; Kinase assay; Virtual screening

Indexed keywords

ANTIDIABETIC AGENT; ANTINEOPLASTIC AGENT; APOPTOSIS SIGNAL REGULATING KINASE 1; IMMUNOLOGIC FACTOR; MAP3K5 PROTEIN, HUMAN; MOLECULAR LIBRARY; NEUROPROTECTIVE AGENT; PROTEIN BINDING; PROTEIN KINASE INHIBITOR; PYRROLE DERIVATIVE; RECOMBINANT PROTEIN; THIAZOLE DERIVATIVE;

ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; COMPUTER INTERFACE; ENZYME ASSAY; HIGH THROUGHPUT SCREENING; HUMAN; MOLECULAR LIBRARY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; BINDING SITES; ENZYME ASSAYS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; HYPOGLYCEMIC AGENTS; IMMUNOLOGIC FACTORS; MAP KINASE KINASE KINASE 5; NEUROPROTECTIVE AGENTS; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PYRROLES; RECOMBINANT PROTEINS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; USER-COMPUTER INTERFACE;

EID: 84937763913     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.03.056     Document Type: Article

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