-
1
-
-
0024584734
-
The rho gene product expressed in E. coli is a substrate of botulinum ADP-ribosyltransferase C3
-
Aktories, K., Braun, U., Rosener, S., Just, I. & Hall, A. The rho gene product expressed in E. coli is a substrate of botulinum ADP-ribosyltransferase C3. Biochem. Biophys. Res. Commun. 158, 209-213 (1989).
-
(1989)
Biochem. Biophys. Res. Commun.
, vol.158
, pp. 209-213
-
-
Aktories, K.1
Braun, U.2
Rosener, S.3
Just, I.4
Hall, A.5
-
2
-
-
0029789678
-
The p160 RhoA-binding kinase ROKα is a member of a kinase family and is involved in the reorganization of the cytoskeleton
-
Leung, T., Chen, X. Q., Manser, E. & Lim, L. The p160 RhoA-binding kinase ROKα is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol. Cell. Biol. 16, 5313-5327 (1996). This was the first study to show that ROCK II is a Rho effector that promotes the formation of stress fibres and focal adhesions.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 5313-5327
-
-
Leung, T.1
Chen, X.Q.2
Manser, E.3
Lim, L.4
-
3
-
-
0034650714
-
Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II
-
Somlyo, A. P. & Somlyo, A. V. Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J. Physiol. 522, 177-185 (2000).
-
(2000)
J. Physiol.
, vol.522
, pp. 177-185
-
-
Somlyo, A.P.1
Somlyo, A.V.2
-
4
-
-
0030603119
-
ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice
-
Nakagawa, O. et al. ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 392, 189-193 (1996).
-
(1996)
FEBS Lett.
, vol.392
, pp. 189-193
-
-
Nakagawa, O.1
-
5
-
-
9244220646
-
The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase
-
Ishizaki, T. et al. The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J. 15, 1885-1893 (1996).
-
(1996)
EMBO J.
, vol.15
, pp. 1885-1893
-
-
Ishizaki, T.1
-
6
-
-
0028863142
-
A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes
-
Leung, T., Manser, E., Tan, L. & Lim, L. A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes. J. Biol. Chem. 270, 29051-29054 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 29051-29054
-
-
Leung, T.1
Manser, E.2
Tan, L.3
Lim, L.4
-
7
-
-
9244257348
-
Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho
-
Matsui, T. et al. Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J. 15, 2208-2216 (1996).
-
(1996)
EMBO J.
, vol.15
, pp. 2208-2216
-
-
Matsui, T.1
-
8
-
-
0033527745
-
The COOH terminus of Rho-kinase negatively regulates rho-kinase activity
-
Amano, M. et al. The COOH terminus of Rho-kinase negatively regulates rho-kinase activity. J. Biol. Chem. 274, 32418-32424 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 32418-32424
-
-
Amano, M.1
-
9
-
-
0032502680
-
Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein β subunits and the yeast response regulator protein Skn7
-
Alberts, A. S., Bouquin, N., Johnston, L. H. & Treisman, R. Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein β subunits and the yeast response regulator protein Skn7. J. Biol. Chem. 273, 8616-8622 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 8616-8622
-
-
Alberts, A.S.1
Bouquin, N.2
Johnston, L.H.3
Treisman, R.4
-
10
-
-
0032489531
-
Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase
-
Kimura, K. et al. Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase. J. Biol. Chem. 273, 5542-5548 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5542-5548
-
-
Kimura, K.1
-
11
-
-
0031770943
-
RhoA-binding kinase α translocation is facilitated by the collapse of the vimentin intermediate filament network
-
Sin, W. C., Chen, X. Q., Leung, T. & Lim, L. RhoA-binding kinase α translocation is facilitated by the collapse of the vimentin intermediate filament network. Mol. Cell. Biol. 18, 6325-6239 (1998).
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 6325-6239
-
-
Sin, W.C.1
Chen, X.Q.2
Leung, T.3
Lim, L.4
-
12
-
-
0034108503
-
Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation
-
Royal, I., Lamarche-Vane, N., Lamorte, L., Kaibuchi, K. & Park, M. Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation. Mol. Biol. Cell 11, 1709-1725 (2000).
-
(2000)
Mol. Biol. Cell
, vol.11
, pp. 1709-1725
-
-
Royal, I.1
Lamarche-Vane, N.2
Lamorte, L.3
Kaibuchi, K.4
Park, M.5
-
13
-
-
0033520998
-
Balance between activities of Rho kinase and type 1 protein phosphatase modulates turnover of phosphorylation and dynamics of desmin/vimentin filaments
-
Inada, H. et al. Balance between activities of Rho kinase and type 1 protein phosphatase modulates turnover of phosphorylation and dynamics of desmin/vimentin filaments. J. Biol. Chem. 274, 34932-34939 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 34932-34939
-
-
Inada, H.1
-
14
-
-
0037066777
-
Characterization of RhoA-binding kinase ROKα implication of the pleckstrin homology domain in ROKα function using region-specific antibodies
-
Chen, X. Q. et al. Characterization of RhoA-binding kinase ROKα implication of the pleckstrin homology domain in ROKα function using region-specific antibodies. J. Biol. Chem. 277, 12680-12688 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 12680-12688
-
-
Chen, X.Q.1
-
15
-
-
0035972212
-
Rho-kinase-mediated contraction of isolated stress fibers
-
Katoh, K. et al. Rho-kinase-mediated contraction of isolated stress fibers. J. Cell Biol. 153, 569-584 (2001).
-
(2001)
J. Cell Biol.
, vol.153
, pp. 569-584
-
-
Katoh, K.1
-
16
-
-
0037182591
-
The Rho-associated protein kinase p160ROCK is required for centrosome positioning
-
Chevrier, V. et al. The Rho-associated protein kinase p160ROCK is required for centrosome positioning. J. Cell Biol. 157, 807-817 (2002).
-
(2002)
J. Cell Biol.
, vol.157
, pp. 807-817
-
-
Chevrier, V.1
-
17
-
-
0031048791
-
Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase
-
Amano, M. et al. Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science 275, 1308-1311 (1997).
-
(1997)
Science
, vol.275
, pp. 1308-1311
-
-
Amano, M.1
-
18
-
-
0030656619
-
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
-
2+-sensitization - is ROCK, and therefore that it is an important research tool.
-
(1997)
Nature
, vol.389
, pp. 990-994
-
-
Uehata, M.1
-
19
-
-
0032563208
-
Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules
-
Fujisawa, K. et al. Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules. J. Biol. Chem. 273, 18943-18949 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 18943-18949
-
-
Fujisawa, K.1
-
20
-
-
0033525125
-
Rho-associated kinase of chicken gizzard smooth muscle
-
Feng, J. et al. Rho-associated kinase of chicken gizzard smooth muscle. J. Biol. Chem. 274, 3744-3752 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 3744-3752
-
-
Feng, J.1
-
21
-
-
0036715441
-
Characterization and purification of truncated human Rho-kinase II expressed in Sf-21 cells
-
Turner, M. S., Fen Fen, L., Trauger, J. W., Stephens, J. & LoGrasso, P. Characterization and purification of truncated human Rho-kinase II expressed in Sf-21 cells. Arch. Biochem. Biophys. 405, 13-20 (2002).
-
(2002)
Arch. Biochem. Biophys.
, vol.405
, pp. 13-20
-
-
Turner, M.S.1
Fen Fen, L.2
Trauger, J.W.3
Stephens, J.4
LoGrasso, P.5
-
22
-
-
0035079891
-
Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase α
-
Tan, I., Seow, K. T., Lim, L. & Leung, T. Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase α. Mol. Cell. Biol. 21, 2767-2778 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 2767-2778
-
-
Tan, I.1
Seow, K.T.2
Lim, L.3
Leung, T.4
-
23
-
-
0034713879
-
Myotonic dystrophy protein kinase domains mediate localization, oligomerization, novel catalytic activity, and autoinhibition
-
Bush, E. W., Helmke, S. M., Birnbaum, R. A. & Perryman, M. B. Myotonic dystrophy protein kinase domains mediate localization, oligomerization, novel catalytic activity, and autoinhibition. Biochemistry 39, 8480-8490 (2000).
-
(2000)
Biochemistry
, vol.39
, pp. 8480-8490
-
-
Bush, E.W.1
Helmke, S.M.2
Birnbaum, R.A.3
Perryman, M.B.4
-
24
-
-
0030615004
-
p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions
-
Ishizaki, T. et al. p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions. FEBS Lett. 404, 118-124 (1997).
-
(1997)
FEBS Lett.
, vol.404
, pp. 118-124
-
-
Ishizaki, T.1
-
25
-
-
0035075597
-
Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing
-
Sebbagh, M. et al. Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing. Nature Cell Biol. 3, 346-352 (2001).
-
(2001)
Nature Cell Biol.
, vol.3
, pp. 346-352
-
-
Sebbagh, M.1
-
26
-
-
0035072953
-
Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I
-
Coleman, M. L. et al. Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nature Cell Biol. 3, 339-345 (2001) References 25 and 26 report that ROCK I, but not ROCK II, is cleaved in vivo during apoptosis by caspase-3, generating an active form of the kinase that induces membrane blebbing.
-
(2001)
Nature Cell Biol.
, vol.3
, pp. 339-345
-
-
Coleman, M.L.1
-
27
-
-
0037092045
-
The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway
-
Ward, Y. et al. The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway. J. Cell Biol. 157, 291-302 (2002). The first study to show that small GTPases (Gem and Rad) can inhibit ROCK function.
-
(2002)
J. Cell Biol.
, vol.157
, pp. 291-302
-
-
Ward, Y.1
-
28
-
-
84889110095
-
RhoE binds to ROCK I and inhibits downstream signalling
-
in the press
-
Riento, K., Guasch, R. M., Garg, R., Jin, B. & Ridley, A. J. RhoE binds to ROCK I and inhibits downstream signalling. Mol. Cell. Biol. (in the press).
-
Mol. Cell. Biol.
-
-
Riento, K.1
Guasch, R.M.2
Garg, R.3
Jin, B.4
Ridley, A.J.5
-
29
-
-
0032146824
-
The ras-related protein rad associates with the cytoskeleton in a non-lipiddependent manner
-
Bilan, P. J., Moyers, J. S. & Kahn, C. R. The ras-related protein rad associates with the cytoskeleton in a non-lipiddependent manner. Exp. Cell Res. 242, 391-400 (1998).
-
(1998)
Exp. Cell Res.
, vol.242
, pp. 391-400
-
-
Bilan, P.J.1
Moyers, J.S.2
Kahn, C.R.3
-
30
-
-
0035422395
-
The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9
-
Piddini, E., Schmid, J. A., de Martin, R. & Dotti, C. G. The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9. EMBO J. 20, 4076-4087 (2001).
-
(2001)
EMBO J.
, vol.20
, pp. 4076-4087
-
-
Piddini, E.1
Schmid, J.A.2
De Martin, R.3
Dotti, C.G.4
-
31
-
-
0035808419
-
Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase
-
Sumi, T., Matsumoto, K. & Nakamura, T. Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase. J. Biol. Chem. 276, 670-676 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 670-676
-
-
Sumi, T.1
Matsumoto, K.2
Nakamura, T.3
-
32
-
-
0033615977
-
Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo
-
Kawano, Y. et al. Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo. J. Cell Biol. 147, 1023-1038 (1999).
-
(1999)
J. Cell Biol.
, vol.147
, pp. 1023-1038
-
-
Kawano, Y.1
-
33
-
-
0029786313
-
Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)
-
Amano, M. et al. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J. Biol. Chem. 271, 20246-20249 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 20246-20249
-
-
Amano, M.1
-
34
-
-
0034698841
-
Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts
-
Totsukawa, G. et al. Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts. J. Cell Biol. 150, 797-806 (2000).
-
(2000)
J. Cell Biol.
, vol.150
, pp. 797-806
-
-
Totsukawa, G.1
-
35
-
-
0032742546
-
2+ sensitization through inhibition of myosin phosphatase in rabbit trachea
-
2+ sensitization through inhibition of myosin phosphatase in rabbit trachea. Br. J. Pharmacol. 128, 925-933 (1999).
-
(1999)
Br. J. Pharmacol.
, vol.128
, pp. 925-933
-
-
Iizuka, K.1
-
36
-
-
0242407997
-
2+ sensitization of myosin phosphorylation and force in guinea-pig ileum
-
2+ sensitization of myosin phosphorylation and force in guinea-pig ileum. J. Physiol. 522, 33-49 (2000).
-
(2000)
J. Physiol.
, vol.522
, pp. 33-49
-
-
Sward, K.1
-
37
-
-
0032416318
-
Myosin phosphatase: Subunits and interactions
-
Hartshorne, D. J. Myosin phosphatase: subunits and interactions. Acta. Physiol. Scand. 164, 483-493 (1998).
-
(1998)
Acta. Physiol. Scand.
, vol.164
, pp. 483-493
-
-
Hartshorne, D.J.1
-
38
-
-
9444242736
-
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
-
Kimura, K. et al. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273, 245-248 (1996). This paper reports that ROCK II phosphorylates and inactivates the MBS of MLCP, therefore providing a mechanism for ROCK-induced effects on contractility.
-
(1996)
Science
, vol.273
, pp. 245-248
-
-
Kimura, K.1
-
39
-
-
0037063362
-
Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin
-
Velasco, G., Armstrong, C., Morrice, N., Frame, S. & Cohen, P. Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin. FEBS Lett. 527, 101-104 (2002).
-
(2002)
FEBS Lett.
, vol.527
, pp. 101-104
-
-
Velasco, G.1
Armstrong, C.2
Morrice, N.3
Frame, S.4
Cohen, P.5
-
40
-
-
0033601250
-
Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase
-
Feng, J. et al. Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase. J. Biol. Chem. 274, 37385-37390 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 37385-37390
-
-
Feng, J.1
-
41
-
-
0034602959
-
Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop
-
Ohashi, K. et al. Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. J. Biol. Chem. 275, 3577-3582 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 3577-3582
-
-
Ohashi, K.1
-
42
-
-
0033529620
-
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
-
Maekawa, M. et al. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 285, 895-898 (1999). A further way for ROCKs to regulate actin filaments is presented, as the authors show that ROCK I phosphorylates and activates LIMK2, which, in turn, phosphorylates and inactivates an actindepolymerizing protein that is known as cofilin.
-
(1999)
Science
, vol.285
, pp. 895-898
-
-
Maekawa, M.1
-
43
-
-
0029149885
-
Reactivation of phosphorylated actin depolymerizing factor and identification of the regulatory site
-
Agnew, B. J., Minamide, L. S. & Bamburg, J. R. Reactivation of phosphorylated actin depolymerizing factor and identification of the regulatory site. J. Biol. Chem. 270, 17582-17587 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 17582-17587
-
-
Agnew, B.J.1
Minamide, L.S.2
Bamburg, J.R.3
-
44
-
-
0032565962
-
Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
-
Arber, S. et al. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature 393, 805-809 (1998).
-
(1998)
Nature
, vol.393
, pp. 805-809
-
-
Arber, S.1
-
45
-
-
0032565769
-
Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization
-
Yang, N. et al. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature 393, 809-812 (1998).
-
(1998)
Nature
, vol.393
, pp. 809-812
-
-
Yang, N.1
-
46
-
-
0033611107
-
Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2
-
Sumi, T., Matsumoto, K., Takai, Y. & Nakamura, T. Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2. J. Cell Biol. 147, 1519-1532 (1999).
-
(1999)
J. Cell Biol.
, vol.147
, pp. 1519-1532
-
-
Sumi, T.1
Matsumoto, K.2
Takai, Y.3
Nakamura, T.4
-
47
-
-
0033194037
-
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
-
Edwards, D. C., Sanders, L. C., Bokoch, G. M. & Gill, G. N. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nature Cell Biol. 1, 253-259 (1999).
-
(1999)
Nature Cell Biol.
, vol.1
, pp. 253-259
-
-
Edwards, D.C.1
Sanders, L.C.2
Bokoch, G.M.3
Gill, G.N.4
-
48
-
-
0344348997
-
Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility
-
Fukata, Y. et al. Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. J. Cell Biol. 145, 347-361 (1999).
-
(1999)
J. Cell Biol.
, vol.145
, pp. 347-361
-
-
Fukata, Y.1
-
49
-
-
0022972413
-
Protein kinase C phosphorylates a recently identified membrane skeletonassociated calmodulin-binding protein in human erythrocytes
-
Ling, E., Gardner, K. & Bennett, V. Protein kinase C phosphorylates a recently identified membrane skeletonassociated calmodulin-binding protein in human erythrocytes. J. Biol. Chem. 261, 13875-13878 (1986).
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 13875-13878
-
-
Ling, E.1
Gardner, K.2
Bennett, V.3
-
51
-
-
0029121577
-
Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site
-
Gary, R. & Bretscher, A. Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site. Mol. Biol. Cell 6, 1061-1075 (1995).
-
(1995)
Mol. Biol. Cell
, vol.6
, pp. 1061-1075
-
-
Gary, R.1
Bretscher, A.2
-
52
-
-
0032498528
-
Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association
-
Matsui, T. et al. Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association. J. Cell Biol. 140, 647-657 (1998). This study shows that the head-to-tail association of ERM proteins is disrupted by ROCK-mediated phosphorylation.
-
(1998)
J. Cell Biol.
, vol.140
, pp. 647-657
-
-
Matsui, T.1
-
53
-
-
0032571406
-
Protein kinase C-τ phosphorylation of moesin in the actin-binding sequence
-
Pietromonaco, S. F., Simons, P. C., Altman, A. & Elias, L. Protein kinase C-τ phosphorylation of moesin in the actin-binding sequence. J. Biol. Chem. 273, 7594-7603 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 7594-7603
-
-
Pietromonaco, S.F.1
Simons, P.C.2
Altman, A.3
Elias, L.4
-
54
-
-
0032550225
-
Association of the myosin-binding subunit of myosin phosphatase and moesin: Dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphatase
-
Fukata, Y. et al. Association of the myosin-binding subunit of myosin phosphatase and moesin: dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphatase. J. Cell Biol. 141, 409-418 (1998).
-
(1998)
J. Cell Biol.
, vol.141
, pp. 409-418
-
-
Fukata, Y.1
-
55
-
-
0031907484
-
RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts
-
Shaw, R. J., Henry, M., Solomon, F. & Jacks, T. RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts. Mol. Biol. Cell 9, 403-419 (1998).
-
(1998)
Mol. Biol. Cell
, vol.9
, pp. 403-419
-
-
Shaw, R.J.1
Henry, M.2
Solomon, F.3
Jacks, T.4
-
56
-
-
0037053360
-
RhoA and Rho kinase-dependent phosphorylation of moesin at Thr-558 in hippocampal neuronal cells by glutamate
-
Jeon, S. et al. RhoA and Rho kinase-dependent phosphorylation of moesin at Thr-558 in hippocampal neuronal cells by glutamate. J. Biol. Chem. 277, 16576-16584 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 16576-16584
-
-
Jeon, S.1
-
57
-
-
0033523986
-
Activation of ERM proteins in vivo by Rho involves phosphatidylinositol 4-phosphate 5-kinase and not ROCK kinases
-
Matsui, T., Yonemura, S. & Tsukita, S. Activation of ERM proteins in vivo by Rho involves phosphatidylinositol 4-phosphate 5-kinase and not ROCK kinases. Curr. Biol. 9, 1259-1262 (1999).
-
(1999)
Curr. Biol.
, vol.9
, pp. 1259-1262
-
-
Matsui, T.1
Yonemura, S.2
Tsukita, S.3
-
58
-
-
0006178818
-
Stimulation of phosphatidylinositol-4-phosphate 5-kinase by Rho-kinase
-
Oude Weernink, P. A. et al. Stimulation of phosphatidylinositol-4-phosphate 5-kinase by Rho-kinase. J. Biol. Chem. 275, 10168-10174 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 10168-10174
-
-
Oude Weernink, P.A.1
-
59
-
-
0031878095
-
Na-H exchange acts downstream of RhoA to regulate integrin-induced cell adhesion and spreading
-
Tominaga, T. & Barber, D. L. Na-H exchange acts downstream of RhoA to regulate integrin-induced cell adhesion and spreading. Mol. Biol. Cell 9, 2287-2303 (1998).
-
(1998)
Mol. Biol. Cell
, vol.9
, pp. 2287-2303
-
-
Tominaga, T.1
Barber, D.L.2
-
61
-
-
0037164808
-
Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1
-
Denker, S. P. & Barber, D. L. Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1. J. Cell Biol. 159, 1087-1096 (2002).
-
(2002)
J. Cell Biol.
, vol.159
, pp. 1087-1096
-
-
Denker, S.P.1
Barber, D.L.2
-
62
-
-
0032496146
-
Phosphorylation of vimentin by Rho-associated kinase at a unique amino-terminal site that is specifically phosphorylated during cytokinesis
-
Goto, H. et al. Phosphorylation of vimentin by Rho-associated kinase at a unique amino-terminal site that is specifically phosphorylated during cytokinesis. J. Biol. Chem. 273, 11728-11736 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 11728-11736
-
-
Goto, H.1
-
63
-
-
0030929849
-
Phosphorylation of glial fibrillary acidic protein at the same sites by cleavage furrow kinase and Rho-associated kinase
-
Kosako, H. et al. Phosphorylation of glial fibrillary acidic protein at the same sites by cleavage furrow kinase and Rho-associated kinase. J. Biol. Chem. 272, 10333-10336 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 10333-10336
-
-
Kosako, H.1
-
64
-
-
0032540127
-
Domain- and site-specific phosphorylation of bovine NF-L by Rho-associated kinase
-
Hashimoto, R. et al. Domain- and site-specific phosphorylation of bovine NF-L by Rho-associated kinase. Biochem. Biophys. Res. Commun. 245, 407-411 (1998).
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.245
, pp. 407-411
-
-
Hashimoto, R.1
-
65
-
-
0034638596
-
Elongation factor-1 α is a novel substrate of rho-associated kinase
-
Izawa, T. et al. Elongation factor-1 α is a novel substrate of rho-associated kinase. Biochem. Biophys. Res. Commun. 278, 72-78 (2000).
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.278
, pp. 72-78
-
-
Izawa, T.1
-
66
-
-
0034810233
-
Rho-associated kinase phosphorylates MARCKS in human neuronal cells
-
Nagumo, H. et al. Rho-associated kinase phosphorylates MARCKS in human neuronal cells. Biochem. Biophys. Res. Commun. 280, 605-609 (2001).
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.280
, pp. 605-609
-
-
Nagumo, H.1
-
67
-
-
0025348420
-
Smooth muscle calponin. Inhibition of actomyosin MgATPase and regulation by phosphorylation
-
Winder, S. J. & Walsh, M. P. Smooth muscle calponin. Inhibition of actomyosin MgATPase and regulation by phosphorylation. J. Biol. Chem. 265, 10148-10155 (1990).
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 10148-10155
-
-
Winder, S.J.1
Walsh, M.P.2
-
68
-
-
0034709570
-
Identification of calponin as a novel substrate of Rho-kinase
-
Kaneko, T. et al. Identification of calponin as a novel substrate of Rho-kinase. Biochem. Biophys. Res. Commun. 273, 110-116 (2000).
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.273
, pp. 110-116
-
-
Kaneko, T.1
-
69
-
-
0034604710
-
Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse
-
Arimura, N. et al. Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse. J. Biol. Chem. 275, 23973-23980 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 23973-23980
-
-
Arimura, N.1
-
70
-
-
0029132912
-
Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33
-
Goshima, Y., Nakamura, F., Strittmatter, P. & Strittmatter, S. M. Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33. Nature 376, 509-514 (1995).
-
(1995)
Nature
, vol.376
, pp. 509-514
-
-
Goshima, Y.1
Nakamura, F.2
Strittmatter, P.3
Strittmatter, S.M.4
-
71
-
-
0034934624
-
CRMP-2 induces axons in cultured hippocampal neurons
-
Inagaki, N. et al. CRMP-2 induces axons in cultured hippocampal neurons. Nature Neurosci. 4, 781-782 (2001).
-
(2001)
Nature Neurosci.
, vol.4
, pp. 781-782
-
-
Inagaki, N.1
-
72
-
-
0037132429
-
p80 ROKα binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology
-
Leung, T. et al. p80 ROKα binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology. FEBS Lett. 532, 445-449 (2002).
-
(2002)
FEBS Lett.
, vol.532
, pp. 445-449
-
-
Leung, T.1
-
73
-
-
0032812619
-
Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells
-
Bourguignon, L. Y., Zhu, H., Shao, L., Zhu, D. & Chen, Y. W. Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells. Cell Motil. Cytoskeleton 43, 269-287 (1999).
-
(1999)
Cell Motil. Cytoskeleton
, vol.43
, pp. 269-287
-
-
Bourguignon, L.Y.1
Zhu, H.2
Shao, L.3
Zhu, D.4
Chen, Y.W.5
-
75
-
-
0031926623
-
Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase
-
Amano, M. et al. Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase. Genes Cells 3, 177-188 (1998).
-
(1998)
Genes Cells
, vol.3
, pp. 177-188
-
-
Amano, M.1
-
76
-
-
0029995797
-
Rho-stimulated contractility drives the formation of stress fibers and focal adhesions
-
Chrzanowska-Wodnicka, M. & Burridge, K. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J. Cell Biol. 133, 1403-1415 (1996).
-
(1996)
J. Cell Biol.
, vol.133
, pp. 1403-1415
-
-
Chrzanowska-Wodnicka, M.1
Burridge, K.2
-
77
-
-
0033160196
-
Cooperation between mDia1 and ROCK in Rho-induced actin reorganization
-
Watanabe, N., Kato, T., Fujita, A., Ishizaki, T. & Narumiya, S. Cooperation between mDia1 and ROCK in Rho-induced actin reorganization. Nature Cell Biol. 1, 136-143 (1999). The authors show that both mDia1 and ROCK I are needed for the formation of actin stress fibres that resemble Rho-induced fibres.
-
(1999)
Nature Cell Biol.
, vol.1
, pp. 136-143
-
-
Watanabe, N.1
Kato, T.2
Fujita, A.3
Ishizaki, T.4
Narumiya, S.5
-
78
-
-
0034907213
-
mDia mediates Rho-regulated formation and orientation of stable microtubules
-
Palazzo, A. F., Cook, T. A., Alberts, A. S. & Gundersen, G. G. mDia mediates Rho-regulated formation and orientation of stable microtubules. Nature Cell Biol. 3, 723-729 (2001).
-
(2001)
Nature Cell Biol.
, vol.3
, pp. 723-729
-
-
Palazzo, A.F.1
Cook, T.A.2
Alberts, A.S.3
Gundersen, G.G.4
-
79
-
-
0034002965
-
Polarization of cell growth in yeast. I. Establishment and maintenance of polarity states
-
Pruyne, D. & Bretscher, A. Polarization of cell growth in yeast. I. Establishment and maintenance of polarity states. J. Cell Sci. 113, 365-375 (2000).
-
(2000)
J. Cell Sci.
, vol.113
, pp. 365-375
-
-
Pruyne, D.1
Bretscher, A.2
-
80
-
-
0030911424
-
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin
-
Watanabe, N. et al. p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J. 16, 3044-3056 (1997).
-
(1997)
EMBO J.
, vol.16
, pp. 3044-3056
-
-
Watanabe, N.1
-
81
-
-
0038023752
-
Rho GTPases and the regulation of endothelial permeability
-
Wojciak-Stothard, B. & Ridley, A. J. Rho GTPases and the regulation of endothelial permeability. Vascul. Pharmacol. 77, 1-13 (2003).
-
(2003)
Vascul. Pharmacol.
, vol.77
, pp. 1-13
-
-
Wojciak-Stothard, B.1
Ridley, A.J.2
-
82
-
-
0034823910
-
Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia
-
Walsh, S. V. et al. Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia. Gastroenterology 121, 566-579 (2001).
-
(2001)
Gastroenterology
, vol.121
, pp. 566-579
-
-
Walsh, S.V.1
-
83
-
-
0036305635
-
ROCK Dia have opposing effects on adherens junctions downstream of Rho
-
Sahai, E. & Marshall, C. J. ROCK and Dia have opposing effects on adherens junctions downstream of Rho. Nature Cell Biol. 4, 408-415 (2002).
-
(2002)
Nature Cell Biol.
, vol.4
, pp. 408-415
-
-
Sahai, E.1
Marshall, C.J.2
-
84
-
-
0036746704
-
Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium
-
Vaezi, A., Bauer, C., Vasioukhin, V. & Fuchs, E. Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium. Dev. Cell 3, 367-381 (2002).
-
(2002)
Dev. Cell
, vol.3
, pp. 367-381
-
-
Vaezi, A.1
Bauer, C.2
Vasioukhin, V.3
Fuchs, E.4
-
85
-
-
0034865456
-
Rho GTPases and cell migration
-
Ridley A. J. Rho GTPases and cell migration. J. Cell Sci. 114, 2713-2722 (2001).
-
(2001)
J. Cell Sci.
, vol.114
, pp. 2713-2722
-
-
Ridley, A.J.1
-
86
-
-
0035833247
-
RhoA is required for monocyte tail retraction during transendothelial migration
-
Worthylake, R. A., Lemoine, S., Watson, J. M. & Burridge, K. RhoA is required for monocyte tail retraction during transendothelial migration. J. Cell Biol. 154, 147-160 (2001). The authors present evidence that ROCK activity is necessary for RhoA-mediated tail retraction, thereby delineating a role of ROCKs in cell migration.
-
(2001)
J. Cell Biol.
, vol.154
, pp. 147-160
-
-
Worthylake, R.A.1
Lemoine, S.2
Watson, J.M.3
Burridge, K.4
-
87
-
-
0035157971
-
Activation of Rhoa and ROCK are essential for detachment of migrating leukocytes
-
Alblas, J., Ulfman, L., Hordijk, P. & Koenderman, L. Activation of Rhoa and ROCK are essential for detachment of migrating leukocytes. Mol. Biol. Cell 12, 2137-2145 (2001).
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 2137-2145
-
-
Alblas, J.1
Ulfman, L.2
Hordijk, P.3
Koenderman, L.4
-
88
-
-
0034708373
-
Rho-kinase inhibitor retards migration and in vivo dissemination of human prostate cancer cells
-
Somlyo, A. V. et al. Rho-kinase inhibitor retards migration and in vivo dissemination of human prostate cancer cells. Biochem. Biophys. Res. Commun. 269, 652-659 (2000).
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.269
, pp. 652-659
-
-
Somlyo, A.V.1
-
89
-
-
18444414614
-
ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts
-
Tsuji, T. et al. ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts. J. Cell Biol. 157, 819-830 (2002). The study shows that in Rho-activated cells ROCKs mediate Rac inhibition, which therefore explains the antagonism that is seen between Rho and Rac in some cell types.
-
(2002)
J. Cell Biol.
, vol.157
, pp. 819-830
-
-
Tsuji, T.1
-
90
-
-
0038037737
-
RhoA and ROCK promote migration by limiting membrane protrusions
-
Worthylake, R. A. & Burridge, K. RhoA and ROCK promote migration by limiting membrane protrusions. J. Biol. Chem. 278, 13578-13584 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 13578-13584
-
-
Worthylake, R.A.1
Burridge, K.2
-
91
-
-
12244303674
-
ADF/Cofilin controls cell polarity during fibroblast migration
-
Dawe, H. R., Minamide, L. S., Bamburg, J. R. & Cramer, L. P. ADF/Cofilin controls cell polarity during fibroblast migration. Curr. Biol. 13, 252-257 (2003).
-
(2003)
Curr. Biol.
, vol.13
, pp. 252-257
-
-
Dawe, H.R.1
Minamide, L.S.2
Bamburg, J.R.3
Cramer, L.P.4
-
92
-
-
0035889929
-
A role for a RhoA/ROCK/LIM-kinase pathway in the regulation of cytotoxic lymphocytes
-
Lou, Z., Billadeau, D. D., Savoy, D. N., Schoon, R. A. & Leibson, P. J. A role for a RhoA/ROCK/LIM-kinase pathway in the regulation of cytotoxic lymphocytes. J. Immunol. 167, 5749-5757 (2001).
-
(2001)
J. Immunol.
, vol.167
, pp. 5749-5757
-
-
Lou, Z.1
Billadeau, D.D.2
Savoy, D.N.3
Schoon, R.A.4
Leibson, P.J.5
-
93
-
-
0035815280
-
Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton
-
Winter, C. G. et al. Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell 105, 81-91 (2001).
-
(2001)
Cell
, vol.105
, pp. 81-91
-
-
Winter, C.G.1
-
94
-
-
0037018841
-
Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movements
-
Marlow, F., Topczewski, J., Sepich, D. & Solnica-Krezel, L. Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movements. Curr. Biol. 12, 876-884 (2002).
-
(2002)
Curr. Biol.
, vol.12
, pp. 876-884
-
-
Marlow, F.1
Topczewski, J.2
Sepich, D.3
Solnica-Krezel, L.4
-
95
-
-
0028961293
-
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
-
Nobes, C. D. & Hall, A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81, 53-62 (1995).
-
(1995)
Cell
, vol.81
, pp. 53-62
-
-
Nobes, C.D.1
Hall, A.2
-
96
-
-
0033615966
-
Rac downregulates Rho activity: Reciprocal balance between both GTPases determines cellular morphology and migratory behavior
-
Sander, E. E., ten Klooster, J. P., van Delft, S., van der Kammen, R. A. & Collard, J. G. Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior. J. Cell Biol. 147, 1009-1022 (1999).
-
(1999)
J. Cell Biol.
, vol.147
, pp. 1009-1022
-
-
Sander, E.E.1
Ten Klooster, J.P.2
Van Delft, S.3
Van der Kammen, R.A.4
Collard, J.G.5
-
97
-
-
0033561508
-
Overexpression of small GTP-binding protein RhoA promotes invasion of tumor cells
-
Yoshioka, K., Nakamori, S. & Itoh, K. Overexpression of small GTP-binding protein RhoA promotes invasion of tumor cells. Cancer Res. 59, 2004-2010 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 2004-2010
-
-
Yoshioka, K.1
Nakamori, S.2
Itoh, K.3
-
98
-
-
0033864069
-
Y-27632, an inhibitor of rho-associated protein kinase, suppresses tumor cell invasion via regulation of focal adhesion and focal adhesion kinase
-
Imamura, F., Mukai, M., Ayaki, M. & Akedo, H. Y-27632, an inhibitor of rho-associated protein kinase, suppresses tumor cell invasion via regulation of focal adhesion and focal adhesion kinase. Jpn. J. Cancer Res. 91, 811-816 (2000).
-
(2000)
Jpn. J. Cancer Res.
, vol.91
, pp. 811-816
-
-
Imamura, F.1
Mukai, M.2
Ayaki, M.3
Akedo, H.4
-
99
-
-
0032935495
-
An essential part for Rho-associated kinase in the transcellular invasion of tumor cells
-
Itoh, K. et al. An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nature Med. 5, 221-225 (1999). Importantly, this paper shows that the ROCK inhibitor Y-27632 or a dominant-negative kinase-defective ROCK reduce tumour-cell invasion in vivo.
-
(1999)
Nature Med.
, vol.5
, pp. 221-225
-
-
Itoh, K.1
-
100
-
-
0036156469
-
Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts
-
Pawlak, G. & Helfman, D. M. Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts. Mol. Biol. Cell 13, 336-347 (2002).
-
(2002)
Mol. Biol. Cell
, vol.13
, pp. 336-347
-
-
Pawlak, G.1
Helfman, D.M.2
-
101
-
-
0032481126
-
Possible involvement of the inactivation of the Rho-Rho-kinase pathway in oncogenic Ras-induced transformation
-
Izawa, I., Amano, M., Chihara, K., Yamamoto, T. & Kaibuchi, K. Possible involvement of the inactivation of the Rho-Rho-kinase pathway in oncogenic Ras-induced transformation. Oncogene 17, 2863-2871 (1998).
-
(1998)
Oncogene
, vol.17
, pp. 2863-2871
-
-
Izawa, I.1
Amano, M.2
Chihara, K.3
Yamamoto, T.4
Kaibuchi, K.5
-
102
-
-
0035865137
-
Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility
-
Sahai, E., Olson, M. F. & Marshall, C. J. Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility. EMBO J. 20, 755-766 (2001).
-
(2001)
EMBO J.
, vol.20
, pp. 755-766
-
-
Sahai, E.1
Olson, M.F.2
Marshall, C.J.3
-
103
-
-
0034658674
-
Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition
-
Zondag, G. C. et al. Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition. J. Cell Biol. 149, 775-782 (2000).
-
(2000)
J. Cell Biol.
, vol.149
, pp. 775-782
-
-
Zondag, G.C.1
-
104
-
-
0034282766
-
Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes
-
Tran Quang, C., Gautreau, A., Arpin, M. & Treisman, R. Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes. EMBO J. 19, 4565-4576 (2000).
-
(2000)
EMBO J.
, vol.19
, pp. 4565-4576
-
-
Tran Quang, C.1
Gautreau, A.2
Arpin, M.3
Treisman, R.4
-
105
-
-
0033545354
-
Transformation mediated by RhoA requires activity of ROCK kinases
-
Sahai, E., Ishizaki, T., Narumiya, S. & Treisman, R. Transformation mediated by RhoA requires activity of ROCK kinases. Curr. Biol. 9, 136-145 (1999).
-
(1999)
Curr. Biol.
, vol.9
, pp. 136-145
-
-
Sahai, E.1
Ishizaki, T.2
Narumiya, S.3
Treisman, R.4
-
106
-
-
0032573378
-
Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases
-
Caron, E. & Hall, A. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases. Science 282, 1717-1721 (1998).
-
(1998)
Science
, vol.282
, pp. 1717-1721
-
-
Caron, E.1
Hall, A.2
-
107
-
-
0037143448
-
Rho-kinase and myosin-II control phagocytic cup formation during CR, but not FcγR, phagocytosis
-
Olazabal, I. et al. Rho-kinase and myosin-II control phagocytic cup formation during CR, but not FcγR, phagocytosis. Curr. Biol. 12, 1413-1418 (2002).
-
(2002)
Curr. Biol.
, vol.12
, pp. 1413-1418
-
-
Olazabal, I.1
-
108
-
-
0032498625
-
Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation
-
Mills, J. C., Stone, N. L., Erhardt, J. & Pittman, R. N. Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation. J. Cell Biol. 140, 627-636 (1998).
-
(1998)
J. Cell Biol.
, vol.140
, pp. 627-636
-
-
Mills, J.C.1
Stone, N.L.2
Erhardt, J.3
Pittman, R.N.4
-
109
-
-
1842867140
-
Independence of plasma membrane blebbing from other biochemical and biological characteristics of apoptotic cells
-
Shiratsuchi, A., Mori, T. & Nakanishi, Y. Independence of plasma membrane blebbing from other biochemical and biological characteristics of apoptotic cells. J. Biochem. 132, 381-386 (2002).
-
(2002)
J. Biochem.
, vol.132
, pp. 381-386
-
-
Shiratsuchi, A.1
Mori, T.2
Nakanishi, Y.3
-
110
-
-
0035900330
-
NGF induces neurite outgrowth via a decrease in phosphorylation of myosin light chain in PC12 cells
-
Fujita, A., Hattori, Y., Takeuchi, T., Kamata, Y. & Hata, F. NGF induces neurite outgrowth via a decrease in phosphorylation of myosin light chain in PC12 cells. Neuroreport 12, 3599-3602 (2001).
-
(2001)
Neuroreport
, vol.12
, pp. 3599-3602
-
-
Fujita, A.1
Hattori, Y.2
Takeuchi, T.3
Kamata, Y.4
Hata, F.5
-
111
-
-
0032579378
-
p160 RhoA-binding kinase ROKα induces neurite retraction
-
Katoh, H., Aoki, J., Ichikawa, A. & Negishi, M. p160 RhoA-binding kinase ROKα induces neurite retraction. J. Biol. Chem. 273, 2489-2492 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 2489-2492
-
-
Katoh, H.1
Aoki, J.2
Ichikawa, A.3
Negishi, M.4
-
112
-
-
14444288533
-
Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells
-
Hirose, M. et al. Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells. J. Cell Biol. 141, 1625-1636 (1998).
-
(1998)
J. Cell Biol.
, vol.141
, pp. 1625-1636
-
-
Hirose, M.1
-
113
-
-
0033711895
-
A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons
-
Bito, H. et al. A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons. Neuron 26, 431-441 (2000).
-
(2000)
Neuron
, vol.26
, pp. 431-441
-
-
Bito, H.1
-
114
-
-
0034678363
-
Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase
-
Wahl, S., Barth, H., Ciossek, T., Aktories, K. & Mueller, B. K. Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase. J. Cell Biol. 149, 263-270 (2000).
-
(2000)
J. Cell Biol.
, vol.149
, pp. 263-270
-
-
Wahl, S.1
Barth, H.2
Ciossek, T.3
Aktories, K.4
Mueller, B.K.5
-
115
-
-
0036703628
-
Nerve growth factor and semaphorin 3A signaling pathways interact in regulating sensory neuronal growth cone motility
-
Dontchev, V. D. & Letourneau, P. C. Nerve growth factor and semaphorin 3A signaling pathways interact in regulating sensory neuronal growth cone motility. J. Neurosci. 22, 6659-6669 (2002).
-
(2002)
J. Neurosci.
, vol.22
, pp. 6659-6669
-
-
Dontchev, V.D.1
Letourneau, P.C.2
-
116
-
-
0036703599
-
Rho signaling pathway targeted to promote spinal cord repair
-
Dergham, P. et al. Rho signaling pathway targeted to promote spinal cord repair. J. Neurosci. 22, 6570-6577 (2002). These results show that the ROCK inhibitor Y-27632 stimulates axon regeneration after injury of the spinal cord.
-
(2002)
J. Neurosci.
, vol.22
, pp. 6570-6577
-
-
Dergham, P.1
-
117
-
-
0037053347
-
Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling
-
Yamazaki, M. et al. Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling. J. Biol. Chem. 277, 17226-17230 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 17226-17230
-
-
Yamazaki, M.1
-
118
-
-
0034887416
-
Inhibition of neurite extension by overexpression of individual domains of LIM kinase 1
-
Birkenfeld, J., Betz, H. & Roth, D. Inhibition of neurite extension by overexpression of individual domains of LIM kinase 1. J. Neurochem. 78, 924-927 (2001).
-
(2001)
J. Neurochem.
, vol.78
, pp. 924-927
-
-
Birkenfeld, J.1
Betz, H.2
Roth, D.3
-
119
-
-
0035096551
-
Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse
-
Aizawa, H. et al. Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse. Nature Neurosci. 4, 367-373 (2001).
-
(2001)
Nature Neurosci.
, vol.4
, pp. 367-373
-
-
Aizawa, H.1
-
120
-
-
0035374569
-
RhoA inhibits the nerve growth factor-induced Rac1 activation through Rho-associated kinase-dependent pathway
-
Yamaguchi, Y., Katoh, H., Yasui, H., Mori, K. & Negishi, M. RhoA inhibits the nerve growth factor-induced Rac1 activation through Rho-associated kinase-dependent pathway. J. Biol. Chem. 276, 18977-18983 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 18977-18983
-
-
Yamaguchi, Y.1
Katoh, H.2
Yasui, H.3
Mori, K.4
Negishi, M.5
-
121
-
-
0037157872
-
Cytoplasmic p21(Cip1/WAF1) regulates neurite remodeling by inhibiting Rho-kinase activity
-
Tanaka, H. et al. Cytoplasmic p21(Cip1/WAF1) regulates neurite remodeling by inhibiting Rho-kinase activity. J. Cell Biol. 158, 321-329 (2002).
-
(2002)
J. Cell Biol.
, vol.158
, pp. 321-329
-
-
Tanaka, H.1
-
122
-
-
0035900688
-
Collapsin response mediator protein switches RhoA and Rac1 morphology in N1E-115 neuroblastoma cells and is regulated by Rho kinase
-
Hall, C. et al. Collapsin response mediator protein switches RhoA and Rac1 morphology in N1E-115 neuroblastoma cells and is regulated by Rho kinase. J. Biol. Chem. 276, 43482-43486 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 43482-43486
-
-
Hall, C.1
-
123
-
-
0036048640
-
CRMP-2 binds to tubulin heterodimers to promote microtubule assembly
-
Fukata, Y. et al. CRMP-2 binds to tubulin heterodimers to promote microtubule assembly. Nature Cell Biol. 4, 583-591 (2002).
-
(2002)
Nature Cell Biol.
, vol.4
, pp. 583-591
-
-
Fukata, Y.1
-
124
-
-
0031037187
-
A requirement for Rho and Cdc42 during cytokinesis in Xenopus embryos
-
Drechsel, D. N., Hyman, A. A., Hall, A. & Glotzer, M. A requirement for Rho and Cdc42 during cytokinesis in Xenopus embryos. Curr. Biol. 7, 12-23 (1997).
-
(1997)
Curr. Biol.
, vol.7
, pp. 12-23
-
-
Drechsel, D.N.1
Hyman, A.A.2
Hall, A.3
Glotzer, M.4
-
125
-
-
0034619765
-
Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow
-
Kosako, H. et al. Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow. Oncogene 19, 6059-6064 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 6059-6064
-
-
Kosako, H.1
-
126
-
-
0032583123
-
Roles of Rho-associated kinase in cytokinesis: Mutations in Rho-associated kinase phosphorylation sites impair cytokinetic segregation of glial filaments
-
Yasui, Y. et al. Roles of Rho-associated kinase in cytokinesis: mutations in Rho-associated kinase phosphorylation sites impair cytokinetic segregation of glial filaments. J. Cell Biol. 143, 1249-1258 (1998). These authors present beautiful pictures of mitotic cells in which the segregation of glial filaments is impaired when cells express a GFAP construct that has mutations at the ROCK phosphorylation sites.
-
(1998)
J. Cell Biol.
, vol.143
, pp. 1249-1258
-
-
Yasui, Y.1
-
127
-
-
0036591960
-
Rho-binding kinase (LET-502) and myosin phosphatase (MEL-11) regulate cytokinesis in the early Caenorhabditis elegans embryo
-
Piekny, A. J. & Mains, P. E. Rho-binding kinase (LET-502) and myosin phosphatase (MEL-11) regulate cytokinesis in the early Caenorhabditis elegans embryo. J. Cell Sci. 115, 2271-2282 (2002).
-
(2002)
J. Cell Sci.
, vol.115
, pp. 2271-2282
-
-
Piekny, A.J.1
Mains, P.E.2
-
128
-
-
0032581530
-
Role of citron kinase as a target of the small GTPase Rho in cytokinesis
-
Madaule, P. et al. Role of citron kinase as a target of the small GTPase Rho in cytokinesis. Nature 394, 491-494 (1998).
-
(1998)
Nature
, vol.394
, pp. 491-494
-
-
Madaule, P.1
-
129
-
-
0033835623
-
Do growth and cell division rates determine cell size in multicellular organisms?
-
Coelho, C. M. & Leevers, S. J. Do growth and cell division rates determine cell size in multicellular organisms? J. Cell Sci. 113, 2927-2934 (2000).
-
(2000)
J. Cell Sci.
, vol.113
, pp. 2927-2934
-
-
Coelho, C.M.1
Leevers, S.J.2
-
130
-
-
18444411005
-
Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development
-
Sordella, R. et al. Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development. Dev. Cell 2, 553-565 (2002). This interesting study shows that inhibition of ROCK function increases the reduced size of cells from p190-B RhoGAP-deficient mice.
-
(2002)
Dev. Cell
, vol.2
, pp. 553-565
-
-
Sordella, R.1
-
131
-
-
0032548848
-
A rho-associated protein kinase, ROKα, binds insulin receptor substrate-1 and modulates insulin signaling
-
Farah, S., Agazie, Y., Ohan, N., Ngsee, J. K. & Liu, X. J. A rho-associated protein kinase, ROKα, binds insulin receptor substrate-1 and modulates insulin signaling. J. Biol. Chem. 273, 4740-4746 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 4740-4746
-
-
Farah, S.1
Agazie, Y.2
Ohan, N.3
Ngsee, J.K.4
Liu, X.J.5
-
132
-
-
0032866302
-
RHO-associated protein kinase α potentiates insulin-induced MAP kinase activation in Xenopus oocytes
-
Ohan, N. et al. RHO-associated protein kinase α potentiates insulin-induced MAP kinase activation in Xenopus oocytes. J. Cell Sci. 112, 2177-2184 (1999).
-
(1999)
J. Cell Sci.
, vol.112
, pp. 2177-2184
-
-
Ohan, N.1
-
133
-
-
0037453716
-
Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis
-
Sordella, R., Jiang, W., Chen, G.-C., Curto, M. & Settleman, J. Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis. Cell 113, 147-158 (2003).
-
(2003)
Cell
, vol.113
, pp. 147-158
-
-
Sordella, R.1
Jiang, W.2
Chen, G.-C.3
Curto, M.4
Settleman, J.5
-
134
-
-
0036223236
-
p21-activated kinases: Three more join the Pak
-
Jaffer, Z. M. & Chernoff, J. p21-activated kinases: three more join the Pak. Int. J. Biochem. Cell Biol. 34, 713-717 (2002).
-
(2002)
Int. J. Biochem. Cell Biol.
, vol.34
, pp. 713-717
-
-
Jaffer, Z.M.1
Chernoff, J.2
-
135
-
-
0034306450
-
Specificity and mechanism of action of some commonly used protein kinase inhibitors
-
Davies, S. P., Reddy, H., Caivano, M. & Cohen, P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351, 95-105 (2000).
-
(2000)
Biochem. J.
, vol.351
, pp. 95-105
-
-
Davies, S.P.1
Reddy, H.2
Caivano, M.3
Cohen, P.4
-
136
-
-
0035970790
-
Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity
-
Muranyi, A. et al. Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity. FEBS Lett. 493, 80-84 (2001).
-
(2001)
FEBS Lett.
, vol.493
, pp. 80-84
-
-
Muranyi, A.1
-
137
-
-
0036077667
-
Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor
-
Ikenoya, M. et al. Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor. J. Neurochem. 81, 9-16 (2002).
-
(2002)
J. Neurochem.
, vol.81
, pp. 9-16
-
-
Ikenoya, M.1
-
138
-
-
0034017744
-
Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases
-
Ishizaki, T. et al. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol. Pharmacol. 57, 976-983 (2000).
-
(2000)
Mol. Pharmacol.
, vol.57
, pp. 976-983
-
-
Ishizaki, T.1
-
139
-
-
0021298447
-
Organization and function of stress fibers in cells in vitro and in situ. A review
-
Byers, H. R., White, G. E. & Fujiwara, K. Organization and function of stress fibers in cells in vitro and in situ. A review. Cell Muscle Motil. 5, 83-137 (1984).
-
(1984)
Cell Muscle Motil.
, vol.5
, pp. 83-137
-
-
Byers, H.R.1
White, G.E.2
Fujiwara, K.3
-
140
-
-
0034705765
-
Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase
-
Koyama, M. et al. Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase. FEBS Lett. 475, 197-200 (2000).
-
(2000)
FEBS Lett.
, vol.475
, pp. 197-200
-
-
Koyama, M.1
-
141
-
-
0027968068
-
CLUSTAL W improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
-
Thompson, J. D., Higgins, D. G. & Gibson, T. J. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22, 4673-4680 (1994).
-
(1994)
Nucleic Acids Res.
, vol.22
, pp. 4673-4680
-
-
Thompson, J.D.1
Higgins, D.G.2
Gibson, T.J.3
-
142
-
-
0031962372
-
Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization
-
Leung, T., Chen, X. Q., Tan, I., Manser, E. & Lim, L. Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization. Mol. Cell Biol. 18, 130-140 (1998).
-
(1998)
Mol. Cell Biol.
, vol.18
, pp. 130-140
-
-
Leung, T.1
Chen, X.Q.2
Tan, I.3
Manser, E.4
Lim, L.5
-
143
-
-
0029789323
-
Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase
-
Fujisawa, K., Fujita, A., Ishizaki, T., Saito, Y. & Narumiya, S. Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase. J. Biol. Chem. 271, 23022-23028 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 23022-23028
-
-
Fujisawa, K.1
Fujita, A.2
Ishizaki, T.3
Saito, Y.4
Narumiya, S.5
-
144
-
-
0033605738
-
Inhibition of myosin light chain kinase by p21-activated kinase
-
Sanders, L. C., Matsumura, F., Bokoch, G. M. & de Lanerolle, P. Inhibition of myosin light chain kinase by p21-activated kinase. Science 283, 2083-2085 (1999).
-
(1999)
Science
, vol.283
, pp. 2083-2085
-
-
Sanders, L.C.1
Matsumura, F.2
Bokoch, G.M.3
De Lanerolle, P.4
-
145
-
-
0033174147
-
Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading
-
van Leeuwen, F. N., van Delft, S., Kain, H. E., van der Kammen, R. A. & Collard, J. G. Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading. Nature Cell Biol. 1, 242-248 (1999).
-
(1999)
Nature Cell Biol.
, vol.1
, pp. 242-248
-
-
Van Leeuwen, F.N.1
Van Delft, S.2
Kain, H.E.3
Van der Kammen, R.A.4
Collard, J.G.5
-
146
-
-
0037155132
-
Active Rho kinase (ROK-α) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells
-
Begum, N., Sandu, O. A., Ito, M., Lohmann, S. M. & Smolenski, A. Active Rho kinase (ROK-α) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells. J. Biol. Chem. 277, 6214-6222 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 6214-6222
-
-
Begum, N.1
Sandu, O.A.2
Ito, M.3
Lohmann, S.M.4
Smolenski, A.5
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