Protein kinase C-dependent activation of CaV1.2 channels selectively controls human TH2-lymphocyte functions

Journal of Allergy and Clinical Immunology

Volumn 133, Issue 4, 2014, Pages

  Robert, Virginie ^a   Triffaux, Emily ^a   Paulet, Pierre Emmanuel ^a   Guéry, Jean Charles ^a   Pelletier, Lucette ^a,b   Savignac, Magali ^a,b  

^a UNIVERSITÉ PAUL SABATIER   (France)

^b CHU PURPAN   (France)

Author keywords

asthma; calcium; protein kinase C ; voltage dependent calcium channels

Indexed keywords

CALCIUM CHANNEL CAV1.2; CALCIUM CHANNEL CAV1.3; CALCIUM CHANNEL CAV1.4; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 4; NICARDIPINE; PROTEIN KINASE C; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MEMBRANE POTENTIAL; CELL POLARITY; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; EOSINOPHIL; EX VIVO STUDY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LYMPHOCYTE FUNCTION; MEMORY T LYMPHOCYTE; NEUTROPHIL; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; TH2 CELL;

ASTHMA; CALCIUM; CHEMOATTRACTANT RECEPTOR-HOMOLOGOUS MOLECULE EXPRESSED ON T(H)2 CELLS; PROTEIN KINASE C Α/Β; T(H)2 CYTOKINES; VOLTAGE-DEPENDENT CALCIUM CHANNELS;

CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HUMANS; LYMPHOCYTE ACTIVATION; NICARDIPINE; PROTEIN KINASE C; PROTEIN SUBUNITS; RECEPTORS, ANTIGEN, T-CELL; TH1 CELLS; TH17 CELLS; TH2 CELLS;

EID: 84897418874     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.10.038     Document Type: Article

References (38)

1. M. Vig, and J.P. Kinet Calcium signaling in immune cells Nat Immunol 10 2009 21 27
2. S. Feske, E.Y. Skolnik, and M. Prakriya Ion channels and transporters in lymphocyte function and immunity Nat Rev Immunol 12 2012 532 547
3. S. Feske, J. Giltnane, R. Dolmetsch, L.M. Staudt, and A. Rao Gene regulation mediated by calcium signals in T lymphocytes Nat Immunol 2 2001 316 324
4. S. Feske, Y. Gwack, M. Prakriya, S. Srikanth, S.H. Puppel, and B. Tanasa et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function Nature 441 2006 179 185
5. P.G. Hogan, R.S. Lewis, and A. Rao Molecular basis of calcium signaling in lymphocytes: STIM and ORAI Annu Rev Immunol 28 2010 491 533
6. W.A. Catterall, E. Perez-Reyes, T.P. Snutch, and J. Striessnig International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels Pharmacol Rev 57 2005 411 425
7. K. Omilusik, J.J. Priatel, X. Chen, Y.T. Wang, H. Xu, and K.B. Choi et al. The Ca(v)1.4 calcium channel is a critical regulator of T cell receptor signaling and naive T cell homeostasis Immunity 35 2011 349 360
8. v channels in T lymphocyte function Proc Natl Acad Sci U S A 103 2006 15529 15534
9. M.K. Jha, A. Badou, M. Meissner, J.E. McRory, M. Freichel, and V. Flockerzi et al. Defective survival of naive CD8+ T lymphocytes in the absence of the beta3 regulatory subunit of voltage-gated calcium channels Nat Immunol 10 2009 1275 1282
10. 2+ signaling, cell activation and cell survival in immune cells Mol Immunol 47 2010 640 648
11. V. Robert, E. Triffaux, M. Savignac, and L. Pelletier Calcium signalling in T-lymphocytes Biochimie 93 2011 2087 2094
12. H.M. Brereton, M.L. Harland, M. Froscio, T. Petronijevic, and G.J. Barritt Novel variants of voltage-operated calcium channel alpha-1subunit transcripts in a rat liver-derived cell line: deletion in the IVS4 voltage sensing region Cell Calcium 22 1997 39 52
13. L. Stokes, J. Gordon, and G. Grafton Non-voltage-gated L-type Ca2+ channels in human T cells: pharmacology and molecular characterization of the major alpha pore-forming and auxiliary beta-subunits J Biol Chem 279 2004 19566 19573
14. D. Matza, A. Badou, M.K. Jha, T. Willinger, A. Antov, and S. Sanjabi et al. Requirement for AHNAK1-mediated calcium signaling during T lymphocyte cytolysis Proc Natl Acad Sci U S A 106 2009 9785 9790
15. V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism Cell 119 2004 19 31
16. V1.2 channelopathies: from arrhythmias to autism, bipolar disorder, and immunodeficiency Eur J Physiol 460 2010 353 359
17. E.S. Gershon, K. Grennan, J. Busnello, J.A. Badner, F. Ovsiew, and S. Memon et al. A rare mutation of CACNA1C in a patient with bipolar disorder, and decreased gene expression associated with a bipolar-associated common SNP of CACNA1C in brain Mol Psychiatry 2013 [Epub ahead of print]
18. M. Djata Cabral, P.E. Paulet, V. Robert, B. Gomes, M.L. Renoud, and M. Savignac et al. Knocking-down Cav1 calcium channels implicated in Th2-cell activation prevents experimental asthma Am J Respir Crit Care Med 181 2010 1310 1317
19. B. Gomes, M.D. Cabral, A. Gallard, M. Savignac, P. Paulet, and P. Druet et al. Calcium channel blocker prevents T helper type 2 cell-mediated airway inflammation Am J Respir Crit Care Med 175 2007 1117 1124
20. R. Jabeen, and M.H. Kaplan The symphony of the ninth: the development and function of Th9 cells Curr Opin Immunol 24 2012 303 307
21. V1.2 calcium channel alpha1C subunit Proc Natl Acad Sci U S A 103 2006 17024 17029
22. 2+ channels Proc Natl Acad Sci U S A 102 2005 11112 11117
23. 2+ channel beta-subunits: structural insights AID our understanding Trends Pharmacol Sci 25 2004 626 632
24. B. Bourdin, F. Marger, S. Wall-Lacelle, T. Schneider, H. Klein, and R. Sauvé et al. Molecular Determinants of the CaVbeta-induced Plasma Membrane Targeting of the CaV1.2 Channel J Biol Chem 285 2010 22853 22863
25. A. Tran-Van-Minh, and A.C. Dolphin The alpha2delta ligand gabapentin inhibits the Rab11-dependent recycling of the calcium channel subunit alpha2-delta2 J Neurosci 30 2010 12856 12867
26. K.-D. Kim, S. Srikanth, M.K. Yee, D.C. Mock, G.W. Lawson, and Y. Gwack ORAI1 deficiency impairs activated T Cell death and enhances T cell survival J Immunol 187 2011 3620 3630
27. B. Qu, D. Al-Ansar, C. Kummerow, M. Hoth, and E.C. Schwarz ORAI-mediated calcium influx in T cell proliferation, apoptosis and tolerance Cell Calcium 50 2011 261 269
28. F. Sallusto, and A. Lanzavecchia Heterogeneity of CD4+ memory T cells: functional modules for tailored immunity Eur J Immunol 39 2009 2076 2082
29. J. Sloan-Lancaster, T.H. Steinberg, and P.M. Allen Selective loss of the calcium ion signaling pathway in T cells maturing toward a T helper 2 phenotype J Immunol 159 1997 1160 1168
30. C.M. Fanger, A.L. Neben, and M.D. Cahalan Differential Ca2+ influx, KCa channel activity, and Ca2+ clearance distinguish Th1 and Th2 lymphocytes J Immunol 164 2000 1153 1160
31. K.S. Weber, M.J. Miller, and P.M. Allen Th17 cells exhibit a distinct calcium profile from Th1 and Th2 cells and have Th1-like motility and NF-AT nuclear localization J Immunol 180 2008 1442 1450
32. M.F. Navedo, G.C. Amberg, M. Nieves, J.D. Molkentin, and L.F. Santana Mechanisms underlying heterogeneous Ca2+ sparklet activity in arterial smooth muscle J Gen Physiol 127 2006 611 622
33. L.F. Santana, and M.F. Navedo Natural inequalities: why some L-type Ca2+ channels work harder than others J Gen Physiol 136 2010 143 147
34. O. Strauss, S. Mergler, and M. Wiederholt Regulation of L-type calcium channels by protein tyrosine kinase and protein kinase C in cultured rat and human retinal pigment epithelial cells FASEB J 11 1997 859 867
35. M. Savignac, A. Badou, M. Moreau, C. Leclerc, J.C. Guery, and P. Paulet et al. Protein kinase C-mediated calcium entry dependent upon dihydropyridine sensitive channels: a T cell receptor-coupled signaling pathway involved in IL-4 synthesis FASEB J 15 2001 1577 1579
36. D.J. Triggle Calcium channel antagonists: clinical uses - past, present and future Biochem Pharmacol 74 2007 1 9
37. L. Cosmi, F. Annunziato, M.I.G. Galli, R.M.E. Maggi, K. Nagata, and S. Romagnani CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease Eur J Immunol 30 2000 2972 2979
38. Y.H. Wang, T. Ito, B. Homey, N. Watanabe, R. Martin, and C.J. Barnes et al. Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells Immunity 24 2006 827 838