Inhibition of transforming growth factor-β via the activin receptor-like kinase-5 inhibitor attenuates pulmonary fibrosis

Molecular Medicine Reports

Volumn 11, Issue 5, 2015, Pages 3808-3813

  Koh, Rhun Yian ^a,b   Lim, Chooi Ling ^a,b   Uhal, Bruce David ^c   Abdullah, Maha ^a   Vidyadaran, Sharmili ^a   Ho, Coy Choke ^d   Seow, Heng Fong ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d UNIVERSITI MALAYSIA SABAH   (Malaysia)

Author keywords

Activin receptor like kinase 5; Idiopathic pulmonary fibrosis; Transforming growth factor ; smooth muscle actin

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ALPHA SMOOTH MUSCLE ACTIN; BLEOMYCIN; COLLAGEN; HYDROXYPROLINE; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; 1,3 DIOXOLANE DERIVATIVE; 4-(5-BENZO(1,3)DIOXOL-5-YL-4-PYRIDIN-2-YL-1H-IMIDAZOL-2-YL)BENZAMIDE; ACTA2 PROTEIN, HUMAN; ACTIN; BENZAMIDE DERIVATIVE; PROTEIN SERINE THREONINE KINASE; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; CELL PROLIFERATION; CELL VIABILITY; CLINICAL EVALUATION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; ENZYME INHIBITION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LUNG ALVEOLUS MACROPHAGE; LUNG FIBROBLAST; LUNG FIBROSIS; LUNG PARENCHYMA; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; THERAPY EFFECT; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL SURVIVAL; DISEASE MODEL; DRUG EFFECTS; FIBROBLAST; METABOLISM; PATHOLOGY; PULMONARY FIBROSIS;

MUS;

ACTINS; ANIMALS; BENZAMIDES; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; DIOXOLES; DISEASE MODELS, ANIMAL; FEMALE; FIBROBLASTS; HUMANS; HYDROXYPROLINE; MICE; PROTEIN-SERINE-THREONINE KINASES; PULMONARY FIBROSIS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA;

EID: 84922287240     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.3193     Document Type: Article

References (24)

1. Bjoraker JA, Ryu JH, Edwin MK, Myers JL, Tazelaar HD, Schroeder DR and Offord KP: Prognostic significance of histopathologic subsets in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 157: 199-203, 1998.
2. Nicholson AG, Colby TV, du Bois RM, Hansell DM and Wells AU: The prognostic significance of the histologic pattern of interstitial pneumonia in patients presenting with the clinical entity of cryptogenic fibrosing alveolitis. Am J Respir Crit Care Med 162: 2213-2217, 2000.
3. Daniil ZD, Gilchrist FC, Nicholson AG, Hansell DM, Harris J, Colby TV and du Bois RM: A histologic pattern of nonspecific interstitial pneumonia is associated with a better prognosis than usual interstitial pneumonia in patients with cryptogenic fibrosing alveolitis. Am J Respir Crit Care Med 160: 899-905, 1999.
4. Douglas WW, Ryu JH, Swensen SJ, Offord KP, Schroeder DR, Caron GM and DeRemee RA: Colchicine versus prednisone in the treatment of idiopathic pulmonary fibrosis. A randomized prospective study. Members of the Lung Study Group. Am J Respir Crit Care Med 158: 220-225, 1998.
5. Gribbin J, Hubbard RB, Le Jeune I, Smith CJ, West J and Tata LJ: Incidence and mortality of idiopathic pulmonary fibrosis and sarcoidosis in the UK. Thorax 61: 980-985, 2006.
6. Dennler S, Goumans MJ and ten Dijke P: Transforming growth factor beta signal transduction. J Leukoc Biol 71: 731-740, 2002.
7. Tojo M, Hamashima Y, Hanyu A, et al: The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci 96: 791-800, 2005.
8. Mori Y, Ishida W, Bhattacharyya S, Li Y, Platanias LC and Varga J: Selective inhibition of activin receptor-like kinase 5 signaling blocks profibrotic transforming growth factor beta responses in skin fibroblasts. Arthritis Rheum 50: 4008-4021, 2004.
9. Ishida W, Mori Y, Lakos G, et al: Intracellular TGF-beta receptor blockade abrogates Smad-dependent fibroblast activation in vitro and in vivo. J Invest Dermatol 126: 1733-1744, 2006.
10. Liu XJ, Ruan CM, Gong XF, Li XZ, Wang HL, Wang MW and Yin JQ: Antagonism of transforming growth factor-Beta signaling inhibits fibrosis-related genes. Biotechnol Lett 27: 1609-1615, 2005.
11. Borzone G, Moreno R, Urrea R, Meneses M, Oyarzun M and Lisboa C: Bleomycin-induced chronic lung damage does not resemble human idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 163: 1648-1653, 2001.
12. Hoyt DG and Lazo JS: Alterations in pulmonary mRNA encoding procollagens, fibronectin and transforming growth factor-beta precede bleomycin-induced pulmonary fibrosis in mice. J Pharmacol Exp Ther 246: 765-771, 1988.
13. Osborne ML, Vollmer WM, Linton KL and Buist AS: Characteristics of patients with asthma within a large HMO: a comparison by age and gender. Am J Respir Crit Care Med 157: 123-128, 1998.
14. Chaudhary NI, Schnapp A and Park JE: Pharmacologic differentiation of inflammation and fibrosis in the rat bleomycin model. Am J Respir Crit Care Med 173: 769-776, 2006.
15. Bouros D and Antoniou KM: Current and future therapeutic approaches in idiopathic pulmonary fibrosis. Eur Respir J 26: 693-702, 2005.
16. Pfaffl MW: A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29: e45, 2001.
17. Woessner JF Jr: The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch Biochem Biophys 93: 440-447, 1961.
18. Ashcroft T, Simpson JM and Timbrell V: Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol 41: 467-470, 1988.
19. Flaherty KR, Toews GB, Lynch JP, et al: Steroids in idiopathic pulmonary fibrosis: a prospective assessment of adverse reactions, response to therapy, and survival. Am J Med 110: 278-282, 2001.
20. Pardo A and Selman M: Idiopathic pulmonary fibrosis: new insights in its pathogenesis. Int J Biochem Cell Biol 34: 1534-1538, 2002.
21. Selman M and Pardo A: The epithelial/fibroblastic pathway in the pathogenesis of idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 29: S93-97, 2003.
22. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C and Brown RA: Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 3: 349-363, 2002.
23. Gabbiani G, Ryan GB and Majne G: Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia 27: 549-550, 1971.
24. Chaudhary NI, Roth GJ, Hilberg F, et al: Inhibition of PDGF, VEGF and FGF signalling attenuates fibrosis. Eur Respir J 29: 976-985, 2007.