Increased activation of p38 MAPK in COPD

European Respiratory Journal

Volumn 31, Issue 1, 2008, Pages 62-69

  Renda, T ^a,b   Baraldo, S ^c   Pelaia, G ^a   Bazzan, E ^c   Turato, G ^c   Papi, A ^d   Maestrelli, P ^c   Maselli, R ^a   Vatrella, A ^b   Fabbri, L M ^e   Zuin, R ^c   Marsico, S A ^b   Saetta, M ^c  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

^d UNIVERSITY OF FERRARA   (Italy)

^e UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Airflow limitation; Chronic obstructive pulmonary disease; Cigarette smoking; Phospho p38 mitogen activated protein kinases

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38;

ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; FORCED EXPIRATORY VOLUME; HUMAN; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SMOKING; AGED; APOPTOSIS; BIOLOGICAL MODEL; ENZYME ACTIVATION; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; LUNG; LUNG ALVEOLUS MACROPHAGE; MALE; METABOLISM; MIDDLE AGED; OXIDATIVE STRESS; PATHOLOGY;

AGED; APOPTOSIS; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LUNG; MACROPHAGES, ALVEOLAR; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING;

EID: 44649153952     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00036707     Document Type: Article

References (31)

1. Rahman I, Adcock IM. Oxidative stress and redox regulation of lung inflammation in COPD. Eur Respir J 2006; 28: 219-242.
2. MacNee W, Rahman I. Is oxidative stress central to the pathogenesis of chronic obstructive pulmonary disease? Trends Mol Med 2000; 7: 43-62.
3. Bowler RP, Barnes PJ, Crapo JD. The role of oxidative stress in chronic obstructive pulmonary disease. COPD 2004; 2: 255-277.
4. Nebreda AR, Porras A. p38 MAP kinases: beyond the stress response. Trends Biochem Sci 2000; 25: 257-260.
5. Pelaia G, Cuda G, Vatrella A, et al. Mitogen-activated protein kinases and asthma. J Cell Physiol 2005; 202: 642-653.
6. Shaffer HJ, Weber MJ. Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol Cell Biol 1999; 19: 2435-2444.
7. Adcock IM, Chung KF, Caramori G, Ito K. Kinase inhibitors and airway inflammation. Eur J Pharmacol 2006; 533: 118-132.
8. Stellato C. Post-transcriptional and nongenomic effects of glucocorticoids. Proc Am Thorac Soc 2004; 1: 255-263.
9. Barnes PJ. Novel signal transduction modulators for the treatment of airway diseases. Pharmacol Ther 2006; 109: 238-245.
10. Smith SJ, Fenwick PS, Nicholson AG, et al. Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages. Br J Pharmacol 2006; 149: 393-404.
11. Turato G, Di Stefano A, Maestrelli P, et al. Effect of smoking cessation on airway inflammation in chronic bronchitis. Am J Respir Crit Care Med 1995; 152: 1262-1267.
12. Renda T, Baraldo S, Pelaia G, et al. Expression of phosphorylated p38 MAPK in the lung of smokers with COPD. Eur Respir J 2006; 28: Suppl. 50, 582s.
13. Celli BR, MacNee W, Agusti A, et al. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 2004; 23: 932-946.
14. Miniati M, Filippi E, Falaschi F, et al. Radiologic evaluation of emphysema in patients with chronic obstructive pulmonary disease: chest radiography versus high resolution computed tomography. Am J Respir Crit Care Med 1995; 151: 1359-1367.
15. Saetta M, Di Stefano A, Maestrelli P, et al. Airway eosinophilia in chronic bronchitis during exacerbations. Am J Respir Crit Care Med 1994; 150: 1646-1652.
16. The World Medical Association (WMA). World Medical Association Declaration of Helsinki Ethical Principles for Medical Research Involving Human Subjects, 2000. www.wma.net/e/policy/b3.htm. Date last updated: September 10, 2004.
17. Saetta M, Baraldo S, Corbino L, et al. CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999; 160: 711-717.
18. Maestrelli P, El Messlemani AH, De Fina O, et al. Increased expression of heme oxygenase (HO)-1 in alveolar spaces and HO-2 in alveolar walls of smokers. Am J Respir Crit Care Med 2001; 164: 1508-1513.
19. Baraldo S, Turato G, Badin C, et al. Neutrophilic infiltration within the airway smooth muscle in patients with COPD. Thorax 2004; 59: 308-312.
20. Chakrabarty K, Wu W, Booth JL, Duggan ES, Coggeshall KM, Metcalf JP. Bacillus anthracis spores stimulate cytokine and chemokine innate immune responses in human alveolar macrophages through multiple mitogen-activated protein kinase pathways. Infect Immun 2006; 74: 4430-4438.
21. Hale KK, Trollinger D, Rihanek M, Manthey CL. Differential expression and activation of p38 mitogen-activated protein kinase α, β, γ, and δ in inflammatory cell lineages. J Immunol 1999; 162: 4246-4252.
22. Grumelli S, Corry DB, Song LZ, et al. An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. PLoS Med 2004; 1: e8.
23. Saetta M, Mariani M, Panina-Bordignon P, et al. Increased expression of the chemokine receptor CXCR3 and its ligand CXCL10 in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002; 165: 1404-1409.
24. Shahabuddin S, Ji R, Wang P, et al. CXCR3 chemokine receptor-induced chemotaxis in human airway epithelial cells: role of p38 MAPK and PI3K signalling pathways. Am J Physiol Cell Physiol 2006; 291: C34-C39.
25. Tham EL, Mescher MF. Signaling alterations in activation-induced nonresponsive CD8 T cells. J Immunol 2001; 167: 2040-2048.
26. Ashwell JD. The many paths to p38 mitogen-activated protein kinase activation in the immune system. Nat Rev Immunol 2006; 6: 532-540.
27. Marwick JA, Kirkham PA, Stevenson CS, et al. Cigarette smoke alters chromatin remodelling and induces proinflammatory genes in rat lung. Am J Respir Cell Mol Biol 2004; 31: 633-642.
28. Ito K, Ito M, Elliott WM, et al. Decreased histone deacetylase in chronic obstructive pulmonary disease. N Engl J Med 2005; 352: 1967-1976.
29. Saccani S, Pantano S, Natoli G. p38-dependent marking of inflammatory genes for increased NF-κB recruitment. Nat Immunol 2002; 3: 69-75.
30. Irusen E, Matthews JG, Takahashi A, Barnes PJ, Chung KF, Adcock IM. p38 mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. J Allergy Clin Immunol 2002; 109: 649-657.
31. Barnes PJ. Corticosteroid effects on cell signalling. Eur Respir J 2006; 27: 413-426.