IgE and mast cells in allergic disease

Nature Medicine

Volumn 18, Issue 5, 2012, Pages 693-704

  Galli, Stephen J ^a   Tsai, Mindy ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CD23 ANTIGEN; IMMUNOGLOBULIN E;

ALLERGIC DISEASE; ANTIGEN SPECIFICITY; ASTHMA; CELL FUNCTION; CHRONIC DISEASE; HUMAN; HYPERSENSITIVITY; IMMUNE RESPONSE; INFLAMMATION; MAST CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ALLERGENS; ANIMALS; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; MAST CELLS; RECEPTORS, IGE;

EID: 84860668874     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2755     Document Type: Review

References (168)

1. Gould, H.J. & Sutton, B.J. IgE in allergy and asthma today. Nat. Rev. Immunol. 8, 205-217 (2008). (Pubitemid 351323292)
2. Burton, O.T. & Oettgen, H.C. Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases. Immunol. Rev. 242, 128-143 (2011).
3. Platzer, B., Ruiter, F., van der Mee, J. & Fiebiger, E. Soluble IgE receptors-elements of the IgE network. Immunol. Lett. 141, 36-44 (2011).
4. Galli, S.J. & Tsai, M. Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity. Eur. J. Immunol. 40, 1843-1851 (2010).
5. Hofmann, A.M. & Abraham, S.N. New roles for mast cells in pathogen defense and allergic disease. Discov. Med. 9, 79-83 (2010).
6. Moon, T.C. et al. Advances in mast cell biology: new understanding of heterogeneity and function. Mucosal Immunol. 3, 111-128 (2010).
7. Gilfillan, A.M., Austin, S.J. & Metcalfe, D.D. Mast cell biology: introduction and overview. Adv. Exp. Med. Biol. 716, 2-12 (2011).
8. Stanworth, D.R. The discovery of IgE. Allergy 48, 67-71 (1993). (Pubitemid 23054577)
9. Ishizaka, K., Ishizaka, T. & Hornbrook, M.M. Physico-chemical properties of human reaginic antibody. IV. Presence of a unique immunoglobulin as a carrier of reaginic activity. J. Immunol. 97, 75-85 (1966).
10. Johansson, S.G.O. & Bennich, H. Studies on a new class of immunoglobulin. I. Immunological properties. in Nobel Symposium 3. Gamma Globulins: Structure and Control of Biosynthesis. (ed. Kilander, J.) 193-197 (Almqvist and Wiksell, Stockholm, 1967).
11. Geha, R.S., Jabara, H.H. & Brodeur, S.R. The regulation of immunoglobulin E class-switch recombination. Nat. Rev. Immunol. 3, 721-732 (2003). (Pubitemid 41070813)
12. Gauchat, J.F. et al. Induction of human IgE synthesis in B cells by mast cells and basophils. Nature 365, 340-343 (1993).
13. Ryzhov, S. et al. Adenosine-activated mast cells induce IgE synthesis by B lymphocytes: an A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma. J. Immunol. 172, 7726-7733 (2004). (Pubitemid 38747640)
14. Takhar, P. et al. Class switch recombination to IgE in the bronchial mucosa of atopic and nonatopic patients with asthma. J. Allergy Clin. Immunol. 119, 213-218 (2007). (Pubitemid 46037820)
15. Coëffier, M., Lorentz, A., Manns, M.P. & Bischoff, S.C. Epsilon germ-line and IL-4 transcripts are expressed in human intestinal mucosa and enhanced in patients with food allergy. Allergy 60, 822-827 (2005). (Pubitemid 40769887)
16. KleinJan, A., Vinke, J.G., Severijnen, L.W. & Fokkens, W.J. Local production and detection of (specific) IgE in nasal B-cells and plasma cells of allergic rhinitis patients. Eur. Respir. J. 15, 491-497 (2000). (Pubitemid 30158186)
17. Acharya, M. et al. CD23/FcεRII: molecular multi-tasking. Clin. Exp. Immunol. 162, 12-23 (2010).
18. Gibb, D.R. et al. ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo. J. Exp. Med. 207, 623-635 (2010).
19. Tu, Y. & Perdue, M.H. CD23-mediated transport of IgE/immune complexes across human intestinal epithelium: role of p38 MAPK. Am. J. Physiol. Gastrointest. Liver Physiol. 291, G532-G538 (2006). (Pubitemid 44330175)
20. Palaniyandi, S., Tomei, E., Li, Z., Conrad, D.H. & Zhu, X. CD23-dependent transcytosis of IgE and immune complex across the polarized human respiratory epithelial cells. J. Immunol. 186, 3484-3496 (2011).
21. Punnonen, J. et al. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc. Natl. Acad. Sci. USA 90, 3730-3734 (1993). (Pubitemid 23111441)
22. Zheng, T., Yu, J., Oh, M.H. & Zhu, Z. The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma. Allergy Asthma Immunol. Res. 3, 67-73 (2011).
23. Kim, B.E. & Leung, D.Y. Epidermal barrier in atopic dermatitis. Allergy Asthma Immunol. Res. 4, 12-16 (2012).
24. Ying, S., Meng, Q., Corrigan, C.J. & Lee, T.H. Lack of filaggrin expression in the human bronchial mucosa. J. Allergy Clin. Immunol. 118, 1386-1388 (2006). (Pubitemid 44854127)
25. McLean, W.H. et al. Filaggrin variants confer susceptibility to asthma. J. Allergy Clin. Immunol. 121, 1294-1295, author reply 1295-1296 (2008).
26. Vouldoukis, I. et al. IgE mediates killing of intracellular Toxoplasma gondii by human macrophages through CD23-dependent, interleukin-10 sensitive pathway. PLoS ONE 6, e18289 (2011).
27. Plater-Zyberk, C. & Bonnefoy, J.Y. Marked amelioration of established collagen-induced arthritis by treatment with antibodies to CD23 in vivo. Nat. Med. 1, 781-785 (1995).
28. Karagiannis, S.N. et al. IgE-antibody-dependent immunotherapy of solid tumors: cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells. J. Immunol. 179, 2832-2843 (2007).
29. Yu, L.C. et al. Enhanced transepithelial antigen transport in intestine of allergic mice is mediated by IgE/CD23 and regulated by interleukin-4. Gastroenterology 121, 370-381 (2001). (Pubitemid 32729384)
30. Thornton, C.A. et al. Fetal exposure to intact immunoglobulin E occurs via the gastrointestinal tract. Clin. Exp. Allergy 33, 306-311 (2003). (Pubitemid 36315170)
31. Tu, Y. et al. CD23-mediated IgE transport across human intestinal epithelium: inhibition by blocking sites of translation or binding. Gastroenterology 129, 928-940 (2005). (Pubitemid 41242685)
32. Berin, M.C., Li, H. & Sperber, K. Antibody-mediated antigen sampling across intestinal epithelial barriers. Ann. NY Acad. Sci. 1072, 253-261 (2006). (Pubitemid 44448458)
33. Lima, J.O. et al. Early expression of iε, CD23 (FcεRII), IL-4Rα, and IgE in the human fetus. J. Allergy Clin. Immunol. 106, 911-917 (2000).
34. Bergmann, R.L. et al. Predictability of early atopy by cord blood-IgE and parental history. Clin. Exp. Allergy 27, 752-760 (1997). (Pubitemid 27306154)
35. Conrad, D.H., Ford, J.W., Sturgill, J.L. & Gibb, D.R. CD23: an overlooked regulator of allergic disease. Curr. Allergy Asthma Rep. 7, 331-337 (2007). (Pubitemid 47377321)
36. Bønnelykke, K., Pipper, C.B. & Bisgaard, H. Transfer of maternal IgE can be a common cause of increased IgE levels in cord blood. J. Allergy Clin. Immunol. 126, 657-663 (2010).
37. Kraft, S., Rana, S., Jouvin, M.H. & Kinet, J.P. The role of the FcεRI β-chain in allergic diseases. Int. Arch. Allergy Immunol. 135, 62-72 (2004). (Pubitemid 39279433)
38. Kraft, S. & Kinet, J.P. New developments in FcεRI regulation, function and inhibition. Nat. Rev. Immunol. 7, 365-378 (2007). (Pubitemid 46674486)
39. Gounni, A.S. et al. Human neutrophils express the high-affinity receptor for immunoglobulin E (Fc ε RI): role in asthma. FASEB J. 15, 940-949 (2001). (Pubitemid 32290781)
40. Porcherie, A. et al. Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cerebral malaria. J. Exp. Med. 208, 2225-2236 (2011).
41. Grayson, M.H. et al. Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. J. Exp. Med. 204, 2759-2769 (2007). (Pubitemid 350044797)
42. Cheung, D.S. et al. Cutting edge: CD49d+ neutrophils induce FcεRI expression on lung dendritic cells in a mouse model of postviral asthma. J. Immunol. 185, 4983-4987 (2010).
43. van der Kleij, H. et al. Evidence for neuronal expression of functional Fc (ε and γ) receptors. J. Allergy Clin. Immunol. 125, 757-760 (2010).
44. Redhu, N.S. et al. IgE induces transcriptional regulation of thymic stromal lymphopoietin in human airway smooth muscle cells. J. Allergy Clin. Immunol. 128, 892-896 (2011).
45. Campbell, A.M. et al. Expression of the high-affinity receptor for IgE on bronchial epithelial cells of asthmatics. Am. J. Respir. Cell Mol. Biol. 19, 92-97 (1998). (Pubitemid 128354945)
46. Sutton, B.J. & Gould, H.J. The human IgE network. Nature 366, 421-428 (1993). (Pubitemid 24013874)
47. Jawdat, D.M., Albert, E.J., Rowden, G., Haidl, I.D. & Marshall, J.S. IgE-mediated mast cell activation induces Langerhans cell migration in vivo. J. Immunol. 173, 5275-5282 (2004). (Pubitemid 39387811)
48. Suto, H. et al. Mast cell-associated TNF promotes dendritic cell migration. J. Immunol. 176, 4102-4112 (2006). (Pubitemid 44264389)
49. Dudeck, A. et al. Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens. Immunity 34, 973-984 (2011).
50. Otsuka, A. et al. Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity. PLoS ONE 6, e25538 (2011).
51. Borkowski, T.A., Jouvin, M.H., Lin, S.Y. & Kinet, J.P. Minimal requirements for IgE-mediated regulation of surface FcεRI. J. Immunol. 167, 1290-1296 (2001). (Pubitemid 32703124)
52. Furuichi, K., Rivera, J. & Isersky, C. The receptor for immunoglobulin E on rat basophilic leukemia cells: effect of ligand binding on receptor expression. Proc. Natl. Acad. Sci. USA 82, 1522-1525 (1985). (Pubitemid 15120575)
53. Hsu, C. & MacGlashan, D. Jr. IgE antibody up-regulates high affinity IgE binding on murine bone marrow-derived mast cells. Immunol. Lett. 52, 129-134 (1996). (Pubitemid 26336713)
54. Yamaguchi, M. et al. IgE enhances mouse mast cell FcεRI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions. J. Exp. Med. 185, 663-672 (1997). (Pubitemid 27098151)
55. Lantz, C.S. et al. IgE regulates mouse basophil FcεRI expression in vivo. J. Immunol. 158, 2517-2521 (1997). (Pubitemid 127470505)
56. MacGlashan, D.W. Jr. et al. Down-regulation of FcεRI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody. J. Immunol. 158, 1438-1445 (1997). (Pubitemid 127469971)
57. Beck, L.A., Marcotte, G.V., MacGlashan, D., Togias, A. & Saini, S. Omalizumab-induced reductions in mast cell FcεRI expression and function. J. Allergy Clin. Immunol. 114, 527-530 (2004). (Pubitemid 39194924)
58. Yamaguchi, M. et al. IgE enhances Fcε receptor I expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood-derived mast cells: synergistic effect of IL-4 and IgE on human mast cell Fcε receptor I expression and mediator release. J. Immunol. 162, 5455-5465 (1999). (Pubitemid 29307156)
59. Kashiwakura, J., Otani, I.M. & Kawakami, T. Monomeric IgE and mast cell development, survival and function. Adv. Exp. Med. Biol. 716, 29-46 (2011).
60. Gilfillan, A.M. & Tkaczyk, C. Integrated signalling pathways for mast-cell activation. Nat. Rev. Immunol. 6, 218-230 (2006). (Pubitemid 43290991)
61. Rivera, J. & Gilfillan, A.M. Molecular regulation of mast cell activation. J. Allergy Clin. Immunol. 117, 1214-1225, quiz 1226 (2006). (Pubitemid 43795719)
62. Boyce, J.A. Mast cells and eicosanoid mediators: a system of reciprocal paracrine and autocrine regulation. Immunol. Rev. 217, 168-185 (2007). (Pubitemid 46718145)
63. Moiseeva, E.P. & Bradding, P. Mast cells in lung inflammation. Adv. Exp. Med. Biol. 716, 235-269 (2011).
64. Groot Kormelink, T., Thio, M., Blokhuis, B.R., Nijkamp, F.P. & Redegeld, F.A. Atopic and non-atopic allergic disorders: current insights into the possible involvement of free immunoglobulin light chains. Clin. Exp. Allergy 39, 33-42 (2009).
65. Ring, J., Grosber, M., Mohrenschlager, M. & Brockow, K. Anaphylaxis: acute treatment and management. Chem. Immunol. Allergy 95, 201-210 (2010).
66. Galli, S.J., Tsai, M. & Piliponsky, A.M. The development of allergic inflammation. Nature 454, 445-454 (2008).
67. Mayr, S.I. et al. IgE-dependent mast cell activation potentiates airway responses in murine asthma models. J. Immunol. 169, 2061-2068 (2002). (Pubitemid 34857671)
68. Yu, M. et al. Mast cells can promote the development of multiple features of chronic asthma in mice. J. Clin. Invest. 116, 1633-1641 (2006).
69. Yu, M. et al. Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma. J. Clin. Invest. 121, 3133-3143 (2011).
70. Larché, M., Robinson, D.S. & Kay, A.B. The role of T lymphocytes in the pathogenesis of asthma. J. Allergy Clin. Immunol. 111, 450-463, quiz 464 (2003). (Pubitemid 36337859)
71. Ochi, H., De Jesus, N.H., Hsieh, F.H., Austen, K.F. & Boyce, J.A. IL-4 and-5 prime human mast cells for different profiles of IgE-dependent cytokine production. Proc. Natl. Acad. Sci. USA 97, 10509-10513 (2000).
72. Allakhverdi, Z., Smith, D.E., Comeau, M.R. & Delespesse, G. Cutting edge: the ST2 ligand IL-33 potently activates and drives maturation of human mast cells. J. Immunol. 179, 2051-2054 (2007).
73. Ho, L.H. et al. IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcεRI signals. J. Leukoc. Biol. 82, 1481-1490 (2007). (Pubitemid 350276960)
74. Iikura, M. et al. IL-33 can promote survival, adhesion and cytokine production in human mast cells. Lab. Invest. 87, 971-978 (2007). (Pubitemid 47429189)
75. Hua, X., Chason, K.D., Patel, J.Y., Naselsky, W.C. & Tilley, S.L. IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors. PLoS ONE 6, e24947 (2011).
76. Olivera, A. & Rivera, J. An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease. Adv. Exp. Med. Biol. 716, 123-142 (2011).
77. Beer, F. et al. Role of β-chemokines in mast cell activation and type I hypersensitivity reactions in the conjunctiva: in vivo and in vitro studies. Immunol. Rev. 217, 96-104 (2007). (Pubitemid 46718154)
78. Galli, S.J. et al. Mast cells as "tunable" effector and immunoregulatory cells: recent advances. Annu. Rev. Immunol. 23, 749-786 (2005). (Pubitemid 40563184)
79. Galli, S.J., Grimbaldeston, M. & Tsai, M. Immunomodulatory mast cells: negative, as well as positive, regulators of immunity. Nat. Rev. Immunol. 8, 478-486 (2008). (Pubitemid 351733419)
80. Galli, S.J., Nakae, S. & Tsai, M. Mast cells in the development of adaptive immune responses. Nat. Immunol. 6, 135-142 (2005). (Pubitemid 40268194)
81. Nakae, S. et al. Mast cells enhance T cell activation: importance of mast cell-derived TNF. Proc. Natl. Acad. Sci. USA 102, 6467-6472 (2005). (Pubitemid 40617466)
82. Nakae, S. et al. Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF. J. Immunol. 176, 2238-2248 (2006). (Pubitemid 43201671)
83. Gri, G. et al. CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction. Immunity 29, 771-781 (2008).
84. Sibilano, R. et al. Technical advance: soluble OX40 molecule mimics regulatory T cell modulatory activity on FcεRI-dependent mast cell degranulation. J. Leukoc. Biol. 90, 831-838 (2011).
85. Bryce, P.J. et al. Immune sensitization in the skin is enhanced by antigen-independent effects of IgE. Immunity 20, 381-392 (2004). (Pubitemid 38482117)
86. Liu, F.T. Regulatory roles of galectins in the immune response. Int. Arch. Allergy Immunol. 136, 385-400 (2005).
87. Ge, X.N. et al. Allergen-induced airway remodeling is impaired in galectin-3-deficient mice. J. Immunol. 185, 1205-1214 (2010).
88. Saegusa, J. et al. Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis. Am. J. Pathol. 174, 922-931 (2009).
89. Marone, G., Triggiani, M. & de Paulis, A. Mast cells and basophils: friends as well as foes in bronchial asthma? Trends Immunol. 26, 25-31 (2005). (Pubitemid 40051989)
90. Karasuyama, H., Mukai, K., Obata, K., Tsujimura, Y. & Wada, T. Nonredundant roles of basophils in immunity. Annu. Rev. Immunol. 29, 45-69 (2011).
91. Kaur, D. et al. Mast cell-airway smooth muscle crosstalk: the role of thymic stromal lymphopoietin. Chest published online, doi:10.1378/chest.11-1782 (3 November 2011).
92. Laprise, C. et al. Functional classes of bronchial mucosa genes that are differentially expressed in asthma. BMC Genomics 5, 21 (2004).
93. Waern, I. et al. Mouse mast cell protease 4 is the major chymase in murine airways and has a protective role in allergic airway inflammation. J. Immunol. 183, 6369-6376 (2009).
94. Brightling, C.E. et al. Mast-cell infiltration of airway smooth muscle in asthma. N. Engl. J. Med. 346, 1699-1705 (2002). (Pubitemid 34547483)
95. Dougherty, R.H. et al. Accumulation of intraepithelial mast cells with a unique protease phenotype in TH2-high asthma. J. Allergy Clin. Immunol. 125, 1046-1053 (2010).
96. Balzar, S. et al. Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program. Am. J. Respir. Crit. Care Med. 183, 299-309 (2011).
97. Carroll, N.G., Mutavdzic, S. & James, A.L. Distribution and degranulation of airway mast cells in normal and asthmatic subjects. Eur. Respir. J. 19, 879-885 (2002). (Pubitemid 34567902)
98. Carroll, N.G., Mutavdzic, S. & James, A.L. Increased mast cells and neutrophils in submucosal mucous glands and mucus plugging in patients with asthma. Thorax 57, 677-682 (2002). (Pubitemid 34864522)
99. Ryan, J.J. et al. Mast cell homeostasis: a fundamental aspect of allergic disease. Crit. Rev. Immunol. 27, 15-32 (2007). (Pubitemid 46659045)
100. Holgate, S.T. Pathophysiology of asthma: what has our current understanding taught us about new therapeutic approaches? J. Allergy Clin. Immunol. 128, 495-505 (2011).
101. Barnes, P.J. Glucocorticosteroids: current and future directions. Br. J. Pharmacol. 163, 29-43 (2011).
102. Wershil, B.K. et al. Dexamethasone or cyclosporin A suppress mast cell-leukocyte cytokine cascades. Multiple mechanisms of inhibition of IgE-and mast cell-dependent cutaneous inflammation in the mouse. J. Immunol. 154, 1391-1398 (1995).
103. Matsuda, K. et al. Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response. J. Allergy Clin. Immunol. 116, 1357-1363 (2005). (Pubitemid 41740949)
104. Kato, A. et al. Dexamethasone and FK506 inhibit expression of distinct subsets of chemokines in human mast cells. J. Immunol. 182, 7233-7243 (2009).
105. Holgate, S.T., Djukanovic, R., Casale, T. & Bousquet, J. Anti-immunoglobulin E treatment with omalizumab in allergic diseases: an update on anti-inflammatory activity and clinical efficacy. Clin. Exp. Allergy 35, 408-416 (2005). (Pubitemid 40577231)
106. Pelaia, G. et al. Update on optimal use of omalizumab in management of asthma. J. Asthma Allergy 4, 49-59 (2011).
107. Rafi, A. et al. Effects of omalizumab in patients with food allergy. Allergy Asthma Proc. 31, 76-83 (2010).
108. Sheinkopf, L.E., Rafi, A.W., Do, L.T., Katz, R.M. & Klaustermeyer, W.B. Efficacy of omalizumab in the treatment of atopic dermatitis: a pilot study. Allergy Asthma Proc. 29, 530-537 (2008).
109. Kaplan, A.P., Joseph, K., Maykut, R.J., Geba, G.P. & Zeldin, R.K. Treatment of chronic autoimmune urticaria with omalizumab. J. Allergy Clin. Immunol. 122, 569-573 (2008).
110. Boyce, J.A. Successful treatment of cold-induced urticaria/anaphylaxis with anti-IgE. J. Allergy Clin. Immunol. 117, 1415-1418 (2006). (Pubitemid 43795744)
111. Maurer, M. et al. Efficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyroperoxidase. J. Allergy Clin. Immunol. 128, 202-209 (2011).
112. Prussin, C. et al. Omalizumab treatment downregulates dendritic cell FcεRI expression. J. Allergy Clin. Immunol. 112, 1147-1154 (2003). (Pubitemid 37550008)
113. Chang, T.W. & Shiung, Y.Y. Anti-IgE as a mast cell-stabilizing therapeutic agent. J. Allergy Clin. Immunol. 117, 1203-1212, quiz 1213 (2006). (Pubitemid 43795763)
114. MacGlashan, D. Jr. Therapeutic efficacy of omalizumab. J. Allergy Clin. Immunol. 123, 114-115 (2009).
115. Wang, C.Y. et al. Synthetic IgE peptide vaccine for immunotherapy of allergy. Vaccine 21, 1580-1590 (2003). (Pubitemid 36292155)
116. Peng, Z. et al. Novel IgE peptide-based vaccine prevents the increase of IgE and down-regulates elevated IgE in rodents. Clin. Exp. Allergy 37, 1040-1048 (2007). (Pubitemid 46955518)
117. McDonnell, J.M. et al. Structure based design and characterization of peptides that inhibit IgE binding to its high-affinity receptor. Nat. Struct. Biol. 3, 419-426 (1996). (Pubitemid 26139440)
118. McDonnell, J.M. et al. Structure-based design of peptides that inhibit IgE binding to its high-affinity receptor FcεRI. Biochem. Soc. Trans. 25, 387-392 (1997).
119. Sandomenico, A. et al. IgE-binding properties and selectivity of peptide mimics of the FcvarεRI binding site. Mol. Immunol. 46, 3300-3309 (2009).
120. Sandomenico, A., Monti, S.M., Palumbo, R. & Ruvo, M. A new FcεRI receptor-mimetic peptide (PepE) that blocks IgE binding to its high affinity receptor and prevents mediator release from RBL 2H3 cells. J. Pept. Sci. 17, 604-609 (2011).
121. Rossi, M. et al. Anti-allergic properties of a new all-D synthetic immunoglobulin-binding peptide. Mol. Immunol. 45, 226-234 (2008). (Pubitemid 47336969)
122. Nakamura, G.R., Starovasnik, M.A., Reynolds, M.E. & Lowman, H.B. A novel family of hairpin peptides that inhibit IgE activity by binding to the high-affinity IgE receptor. Biochemistry 40, 9828-9835 (2001). (Pubitemid 32769531)
123. Nakamura, G.R., Reynolds, M.E., Chen, Y.M., Starovasnik, M.A. & Lowman, H.B. Stable "ζ" peptides that act as potent antagonists of the high-affinity IgE receptor. Proc. Natl. Acad. Sci. USA 99, 1303-1308 (2002). (Pubitemid 34136488)
124. Stamos, J. et al. Convergent recognition of the IgE binding site on the high-affinity IgE receptor. Structure 12, 1289-1301 (2004). (Pubitemid 38900771)
125. Buku, A., Mendlowitz, M., Condie, B.A. & Price, J.A. Histamine-releasing activity and binding to the FcεRI alpha human mast cell receptor subunit of mast cell degranulating peptide analogues with alanine substitutions. J. Med. Chem. 46, 3008-3012 (2003). (Pubitemid 36775923)
126. Buku, A., Keselman, I., Lupyan, D., Mezei, M. & Price, J.A. Effective mast cell degranulating peptide inhibitors of the IgE/FcεRI receptor interaction. Chem. Biol. Drug Des. 72, 133-139 (2008).
127. Zhu, D., Kepley, C.L., Zhang, M., Zhang, K. & Saxon, A. A novel human immunoglobulin Fcγ-Fcε bifunctional fusion protein inhibits FcεRI-mediated degranulation. Nat. Med. 8, 518-521 (2002). (Pubitemid 34546756)
128. Akin, C. et al. Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kit. Exp. Hematol. 31, 686-692 (2003). (Pubitemid 36945381)
129. Gotlib, J. et al. Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation. Blood 106, 2865-2870 (2005). (Pubitemid 41510766)
130. Juurikivi, A. et al. Inhibition of c-kit tyrosine kinase by imatinib mesylate induces apoptosis in mast cells in rheumatoid synovia: a potential approach to the treatment of arthritis. Ann. Rheum. Dis. 64, 1126-1131 (2005). (Pubitemid 41113344)
131. Dubreuil, P. et al. Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT. PLoS ONE 4, e7258 (2009).
132. Matsubara, S. et al. Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness. Am. J. Respir. Crit. Care Med. 173, 56-63 (2006). (Pubitemid 43069788)
133. Rossi, A.B. et al. Identification of the Syk kinase inhibitor R112 by a human mast cell screen. J. Allergy Clin. Immunol. 118, 749-755 (2006). (Pubitemid 44301399)
134. Tebib, J. et al. Masitinib in the treatment of active rheumatoid arthritis: results of a multicentre, open-label, dose-ranging, phase 2a study. Arthritis Res. Ther. 11, R95 (2009).
135. Szefler, S.J. & Dakhama, A. New insights into asthma pathogenesis and treatment. Curr. Opin. Immunol. 23, 801-807 (2011).
136. Gonem, S., Desai, D., Siddiqui, S. & Brightling, C.C. Evidence for phenotype-driven treatment in asthmatic patients. Curr. Opin. Allergy Clin. Immunol. 11, 381-385 (2011).
137. Szefler, S.J. Advances in pediatric asthma in 2011: moving forward. J. Allergy Clin. Immunol. 129, 60-68 (2012).
138. Joseph, M. et al. Expression and functions of the high-affinity IgE receptor on human platelets and megakaryocyte precursors. Eur. J. Immunol. 27, 2212-2218 (1997). (Pubitemid 27404302)
139. Hasegawa, S. et al. Functional expression of the high affinity receptor for IgE (FcεRI) in human platelets and it's intracellular expression in human megakaryocytes. Blood 93, 2543-2551 (1999). (Pubitemid 29181186)
140. Gounni, A.S. et al. Human airway smooth muscle cells express the high affinity receptor for IgE (FcεRI): a critical role of Fc ε RI in human airway smooth muscle cell function. J. Immunol. 175, 2613-2621 (2005). (Pubitemid 41113875)
141. Ganguly, S. et al. Neural adrenergic/cyclic AMP regulation of the immunoglobulin E receptor α-subunit expression in the mammalian pinealocyte: a neuroendocrine/immune response link? J. Biol. Chem. 282, 32758-32764 (2007). (Pubitemid 350159318)
142. Dahlin, J.S., Ivarsson, M.A., Heyman, B. & Hallgren, J. IgE immune complexes stimulate an increase in lung mast cell progenitors in a mouse model of allergic airway inflammation. PLoS ONE 6, e20261 (2011).
143. Maeda, K. et al. Murine follicular dendritic cells and low affinity Fc receptors for IgE (FcεRII). J. Immunol. 148, 2340-2347 (1992).
144. Yu, L.C. et al. Intestinal epithelial CD23 mediates enhanced antigen transport in allergy: evidence for novel splice forms. Am. J. Physiol. Gastrointest. Liver Physiol. 285, G223-G234 (2003). (Pubitemid 36736406)
145. Li, H. et al. Transcytosis of IgE-antigen complexes by CD23a in human intestinal epithelial cells and its role in food allergy. Gastroenterology 131, 47-58 (2006). (Pubitemid 44015743)
146. Vouldoukis, I. et al. The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the FcεRII/CD23 surface antigen. Proc. Natl. Acad. Sci. USA 92, 7804-7808 (1995).
147. Takizawa, F., Adamczewski, M. & Kinet, J.P. Identification of the low affinity receptor for immunoglobulin E on mouse mast cells and macrophages as FcγRII and FcγRIII. J. Exp. Med. 176, 469-475 (1992).
148. Hirano, M. et al. IgEb immune complexes activate macrophages through FcγRIV binding. Nat. Immunol. 8, 762-771 (2007). (Pubitemid 46965352)
149. Mancardi, D.A. et al. FcγRIV is a mouse IgE receptor that resembles macrophage FcεRI in humans and promotes IgE-induced lung inflammation. J. Clin. Invest. 118, 3738-3750 (2008).
150. Craig, S.S. et al. Immunoelectron microscopic localization of galectin-3, an IgE binding protein, in human mast cells and basophils. Anat. Rec. 242, 211-219 (1995).
151. Chen, H.Y. et al. Role of galectin-3 in mast cell functions: galectin-3-deficient mast cells exhibit impaired mediator release and defective JNK expression. J. Immunol. 177, 4991-4997 (2006).
152. Truong, M.J. et al. Human neutrophils express immunoglobulin E (IgE)-binding proteins (Mac-2/ε BP) of the S-type lectin family: role in IgE-dependent activation. J. Exp. Med. 177, 243-248 (1993).
153. Ho, M.K. & Springer, T.A. Mac-2, a novel 32,000 Mr mouse macrophage subpopulation-specific antigen defined by monoclonal antibodies. J. Immunol. 128, 1221-1228 (1982). (Pubitemid 12188441)
154. Sato, S. & Hughes, R.C. Control of Mac-2 surface expression on murine macrophage cell lines. Eur. J. Immunol. 24, 216-221 (1994). (Pubitemid 24014702)
155. Liu, F.T. et al. Expression and function of galectin-3, a β-galactoside-binding lectin, in human monocytes and macrophages. Am. J. Pathol. 147, 1016-1028 (1995).
156. Novak, R., Dabelic, S. & Dumic, J. Galectin-1 and galectin-3 expression profiles in classically and alternatively activated human macrophages. Biochim. Biophys. Acta. published online, doi:10.1016/j.bbagen. 2011.11.014 (14 December 2011).
157. Truong, M.J. et al. IgE-binding molecules (Mac-2/ε BP) expressed by human eosinophils. Implication in IgE-dependent eosinophil cytotoxicity. Eur. J. Immunol. 23, 3230-3235 (1993).
158. Haines, K.A., Flotte, T.J., Springer, T.A., Gigli, I. & Thorbecke, G.J. Staining of Langerhans cells with monoclonal antibodies to macrophages and lymphoid cells. Proc. Natl. Acad. Sci. USA 80, 3448-3451 (1983). (Pubitemid 13060180)
159. Smetana, K. et al. Coexpression of binding sites for A(B) histo-blood group trisaccharides with galectin-3 and Lag antigen in human Langerhans cells. J. Leukoc. Biol. 66, 644-649 (1999). (Pubitemid 29489892)
160. Hsu, D.K., Chen, H.Y. & Liu, F.T. Galectin-3 regulates T-cell functions. Immunol. Rev. 230, 114-127 (2009).
161. Acosta-Rodríguez, E.V. et al. Galectin-3 mediates IL-4-induced survival and differentiation of B cells: functional cross-talk and implications during Trypanosoma cruzi infection. J. Immunol. 172, 493-502 (2004). (Pubitemid 38020505)
162. Vray, B. et al. Up-regulation of galectin-3 and its ligands by Trypanosoma cruzi infection with modulation of adhesion and migration of murine dendritic cells. Glycobiology 14, 647-657 (2004). (Pubitemid 38923646)
163. Kay, A.B. Allergy and allergic diseases. First of two parts. N. Engl. J. Med. 344, 30-37 (2001). (Pubitemid 32064843)
164. Wershil, B.K., Wang, Z.S., Gordon, J.R. & Galli, S.J. Recruitment of neutrophils during IgE-dependent cutaneous late phase reactions in the mouse is mast cell-dependent. Partial inhibition of the reaction with antiserum against tumor necrosis factor-α. J. Clin. Invest. 87, 446-453 (1991).
165. Nagai, H. et al. Role of mast cells in the onset of IgE-mediated late-phase cutaneous response in mice. J. Allergy Clin. Immunol. 106, S91-S98 (2000). (Pubitemid 30482841)
166. Haselden, B.M., Kay, A.B. & Larche, M. Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions. J. Exp. Med. 189, 1885-1894 (1999). (Pubitemid 29295887)
167. Holgate, S.T. The sentinel role of the airway epithelium in asthma
168. Humbert, M. et al. The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: more similarities than differences. Immunol. Today 20, 528-533 (1999). (Pubitemid 29507098)