p38 mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: Role in steroid-insensitive asthma

Journal of Allergy and Clinical Immunology

Volumn 109, Issue 4, 2002, Pages 649-657

  Irusen, Elvis ^a   Matthews, John G ^a   Takahashi, Atsushi ^a   Barnes, Peter J ^a   Chung, Kian F ^a   Adcock, Ian M ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Asthma; Cytokine release; Glucocorticoid receptor; Human; Inflammation; p38 MAP kinase; PBMCs

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CD2 ANTIGEN; CORTICOSTEROID; DEXAMETHASONE; FLUTICASONE; GLUCOCORTICOID RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2; INTERLEUKIN 4; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATE; PREDNISOLONE; TRANSCRIPTION FACTOR AP 2;

ADULT; ALLERGIC ASTHMA; ARTICLE; CELL NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPLASM; DISEASE SEVERITY; DISSOCIATION CONSTANT; DRUG RECEPTOR BINDING; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR AFFINITY; T LYMPHOCYTE SUBPOPULATION; WESTERN BLOTTING;

EID: 0036231010     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2002.122465     Document Type: Article

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