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Volumn 54, Issue 5, 2016, Pages 647-655

Transforming growth factor-B: Master regulator of the respiratory system in health and disease

Author keywords

Asthma; COPD; Fibroblast; Pulmonary arterial hypertension; Pulmonary fibrosis

Indexed keywords

BLOCKING ANTIBODY; TRANSFORMING GROWTH FACTOR BETA;

EID: 84988948694     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2015-0391TR     Document Type: Review
Times cited : (187)

References (95)
  • 1
    • 84866742560 scopus 로고    scopus 로고
    • TGFb signalling in context
    • MassaguéJ. TGFb signalling in context. Nat Rev Mol Cell Biol 2012;13: 616-630
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 616-630
    • Massagué, J.1
  • 2
    • 2142646426 scopus 로고    scopus 로고
    • TGF-β signaling and the fibrotic response
    • Leask A, Abraham DJ. TGF-β signaling and the fibrotic response. FASEB J 2004; 18: 816-827
    • (2004) FASEB J , vol.18 , pp. 816-827
    • Leask, A.1    Abraham, D.J.2
  • 3
    • 73149098919 scopus 로고    scopus 로고
    • Transforming growth factor-b signaling across ages: From distorted lung development to chronic obstructive pulmonary disease
    • Morty RE, Königshoff M, Eickelberg O. Transforming growth factor-b signaling across ages: from distorted lung development to chronic obstructive pulmonary disease. Proc Am Thorac Soc 2009;6: 607-613
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 607-613
    • Morty, R.E.1    Königshoff, M.2    Eickelberg, O.3
  • 5
    • 84866900231 scopus 로고    scopus 로고
    • Matrix control of transforming growth factor-b function
    • Horiguchi M, Ota M, Rifkin DB. Matrix control of transforming growth factor-b function. J Biochem 2012;152:321-329
    • (2012) J Biochem , vol.152 , pp. 321-329
    • Horiguchi, M.1    Ota, M.2    Rifkin, D.B.3
  • 6
    • 84865820041 scopus 로고    scopus 로고
    • TGF-β activation and lung fibrosis
    • Tatler AL, Jenkins G. TGF-β activation and lung fibrosis. Proc Am Thorac Soc 2012;9:130-136
    • (2012) Proc Am Thorac Soc , vol.9 , pp. 130-136
    • Tatler, A.L.1    Jenkins, G.2
  • 7
    • 0030058699 scopus 로고    scopus 로고
    • Association of the small latent transforming growth factor-b with an eight cysteine repeat of its binding protein LTBP-1
    • Saharinen J, Taipale J, Keski-Oja J. Association of the small latent transforming growth factor-b with an eight cysteine repeat of its binding protein LTBP-1. EMBO J 1996;15:245-253
    • (1996) EMBO J , vol.15 , pp. 245-253
    • Saharinen, J.1    Taipale, J.2    Keski-Oja, J.3
  • 8
    • 0030715322 scopus 로고    scopus 로고
    • ECM and cell surface proteolysis: Regulating cellular ecology
    • Werb Z. ECM and cell surface proteolysis: regulating cellular ecology. Cell 1997;91:439-442
    • (1997) Cell , vol.91 , pp. 439-442
    • Werb, Z.1
  • 9
    • 0036177427 scopus 로고    scopus 로고
    • Transforming growth factor-b signaling through the Smad pathway: Role in extracellular matrix gene expression and regulation
    • Verrecchia F, Mauviel A. Transforming growth factor-b signaling through the Smad pathway: role in extracellular matrix gene expression and regulation. J Invest Dermatol 2002;118:211-215
    • (2002) J Invest Dermatol , vol.118 , pp. 211-215
    • Verrecchia, F.1    Mauviel, A.2
  • 10
    • 0034650486 scopus 로고    scopus 로고
    • Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis
    • Yu Q, Stamenkovic I. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis. Genes Dev 2000;14:163-176
    • (2000) Genes Dev , vol.14 , pp. 163-176
    • Yu, Q.1    Stamenkovic, I.2
  • 11
    • 0027305971 scopus 로고
    • Thrombospondin causes activation of latent transforming growth factor-b secreted by endothelial cells by a novel mechanism
    • Schultz-Cherry S, Murphy-Ullrich JE. Thrombospondin causes activation of latent transforming growth factor-b secreted by endothelial cells by a novel mechanism. J Cell Biol 1993;122: 923-932
    • (1993) J Cell Biol , vol.122 , pp. 923-932
    • Schultz-Cherry, S.1    Murphy-Ullrich, J.E.2
  • 13
    • 0034747105 scopus 로고    scopus 로고
    • Expression of the b6 integrin subunit is associated with sites of neutrophil influx in lung epithelium
    • Miller LA, Barnett NL, Sheppard D, Hyde DM. Expression of the b6 integrin subunit is associated with sites of neutrophil influx in lung epithelium. J Histochem Cytochem 2001;49:41-48
    • (2001) J Histochem Cytochem , vol.49 , pp. 41-48
    • Miller, L.A.1    Barnett, N.L.2    Sheppard, D.3    Hyde, D.M.4
  • 15
    • 70349314194 scopus 로고    scopus 로고
    • Role of integrin-mediated TGFb activation in the pathogenesis of pulmonary fibrosis
    • Goodwin A, Jenkins G. Role of integrin-mediated TGFb activation in the pathogenesis of pulmonary fibrosis. Biochem Soc Trans 2009;37: 849-854
    • (2009) Biochem Soc Trans , vol.37 , pp. 849-854
    • Goodwin, A.1    Jenkins, G.2
  • 16
    • 37249044357 scopus 로고    scopus 로고
    • Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix
    • Wipff PJ, Rifkin DB, Meister JJ, Hinz B. Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix. J Cell Biol 2007;179:1311-1323
    • (2007) J Cell Biol , vol.179 , pp. 1311-1323
    • Wipff, P.J.1    Rifkin, D.B.2    Meister, J.J.3    Hinz, B.4
  • 17
    • 0034796457 scopus 로고    scopus 로고
    • The TGFb receptor activation process: An inhibitor-to substrate-binding switch
    • Huse M, Muir TW, Xu L, Chen YG, Kuriyan J, MassaguéJ. The TGFb receptor activation process: an inhibitor-to substrate-binding switch. Mol Cell 2001;8:671-682
    • (2001) Mol Cell , vol.8 , pp. 671-682
    • Huse, M.1    Muir, T.W.2    Xu, L.3    Chen, Y.G.4    Kuriyan, J.5    Massagué, J.6
  • 18
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling from cell membrane to the nucleus
    • Shi Y, MassaguéJ. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 2003;113:685-700
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massagué, J.2
  • 19
    • 0032428684 scopus 로고    scopus 로고
    • SARA, a FYVE domain protein that recruits Smad2 to the TGFb receptor
    • Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL. SARA, a FYVE domain protein that recruits Smad2 to the TGFb receptor. Cell 1998;95:779-791
    • (1998) Cell , vol.95 , pp. 779-791
    • Tsukazaki, T.1    Chiang, T.A.2    Davison, A.F.3    Attisano, L.4    Wrana, J.L.5
  • 20
    • 0037598870 scopus 로고    scopus 로고
    • Distinct endocytic pathways regulate TGF-β receptor signalling and turnover
    • Di Guglielmo GM, Le Roy C, Goodfellow AF, Wrana JL. Distinct endocytic pathways regulate TGF-β receptor signalling and turnover. Nat Cell Biol 2003;5:410-421
    • (2003) Nat Cell Biol , vol.5 , pp. 410-421
    • Di Guglielmo, G.M.1    Le Roy, C.2    Goodfellow, A.F.3    Wrana, J.L.4
  • 21
    • 1542284152 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of signal transducers
    • Xu L, MassaguéJ. Nucleocytoplasmic shuttling of signal transducers. Nat Rev Mol Cell Biol 2004;5:209-219
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 209-219
    • Xu, L.1    Massagué, J.2
  • 22
    • 0036670339 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-β receptor activity
    • Inman GJ, Nicolás FJ, Hill CS. Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-β receptor activity. Mol Cell 2002; 10:283-294
    • (2002) Mol Cell , vol.10 , pp. 283-294
    • Inman, G.J.1    Nicolás, F.J.2    Hill, C.S.3
  • 23
    • 84862759403 scopus 로고    scopus 로고
    • Phosphatases in SMAD regulation
    • Bruce DL, Sapkota GP. Phosphatases in SMAD regulation. FEBS Lett 2012;586:1897-1905
    • (2012) FEBS Lett , vol.586 , pp. 1897-1905
    • Bruce, D.L.1    Sapkota, G.P.2
  • 25
    • 0033106484 scopus 로고    scopus 로고
    • A mechanism of repression of TGFb/Smad signaling by oncogenic Ras
    • Kretzschmar M, Doody J, Timokhina I, MassaguéJ. A mechanism of repression of TGFb/Smad signaling by oncogenic Ras. Genes Dev 1999;13:804-816
    • (1999) Genes Dev , vol.13 , pp. 804-816
    • Kretzschmar, M.1    Doody, J.2    Timokhina, I.3    Massagué, J.4
  • 26
    • 3142546336 scopus 로고    scopus 로고
    • Cyclindependent kinases regulate the antiproliferative function of Smads
    • Matsuura I, Denissova NG, Wang G, He D, Long J, Liu F. Cyclindependent kinases regulate the antiproliferative function of Smads. Nature 2004;430:226-231
    • (2004) Nature , vol.430 , pp. 226-231
    • Matsuura, I.1    Denissova, N.G.2    Wang, G.3    He, D.4    Long, J.5    Liu, F.6
  • 31
    • 0027724228 scopus 로고
    • Transforming growth factor-b1 knockout mice A mutation in one cytokine gene causes a dramatic inflammatory disease
    • Kulkarni AB, Karlsson S. Transforming growth factor-b1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease. Am J Pathol 1993;143:3-9
    • (1993) Am J Pathol , vol.143 , pp. 3-9
    • Kulkarni, A.B.1    Karlsson, S.2
  • 32
    • 1242306647 scopus 로고    scopus 로고
    • The role of transforming growth factor b in lung development and disease
    • Bartram U, Speer CP. The role of transforming growth factor b in lung development and disease. Chest 2004;125:754-765
    • (2004) Chest , vol.125 , pp. 754-765
    • Bartram, U.1    Speer, C.P.2
  • 33
    • 0026053972 scopus 로고
    • Differential expression of TGFb1, b2 and b3 genes during mouse embryogenesis
    • Schmid P, Cox D, Bilbe G, Maier R, McMaster GK. Differential expression of TGFb1, b2 and b3 genes during mouse embryogenesis. Development 1991;111:117-130
    • (1991) Development , vol.111 , pp. 117-130
    • Schmid, P.1    Cox, D.2    Bilbe, G.3    Maier, R.4    McMaster, G.K.5
  • 35
    • 0028806184 scopus 로고
    • Abnormal lung development and cleft palate in mice lacking TGF-β3 indicates defects of epithelial-mesenchymal interaction
    • Kaartinen V, Voncken JW, Shuler C, Warburton D, Bu D, Heisterkamp N, Groffen J. Abnormal lung development and cleft palate in mice lacking TGF-β3 indicates defects of epithelial-mesenchymal interaction. Nat Genet 1995;11:415-421
    • (1995) Nat Genet , vol.11 , pp. 415-421
    • Kaartinen, V.1    Voncken, J.W.2    Shuler, C.3    Warburton, D.4    Bu, D.5    Heisterkamp, N.6    Groffen, J.7
  • 36
    • 0030602054 scopus 로고    scopus 로고
    • Abrogation of transforming growth factor-b type II receptor stimulates embryonic mouse lung branching morphogenesis in culture
    • Zhao J, Bu D, Lee M, Slavkin HC, Hall FL, Warburton D. Abrogation of transforming growth factor-b type II receptor stimulates embryonic mouse lung branching morphogenesis in culture. Dev Biol 1996;180: 242-257
    • (1996) Dev Biol , vol.180 , pp. 242-257
    • Zhao, J.1    Bu, D.2    Lee, M.3    Slavkin, H.C.4    Hall, F.L.5    Warburton, D.6
  • 37
    • 0023183234 scopus 로고
    • Differential effects of epidermal growth factor and transforming growth factor-b on synthesis of Mr = 35,000 surfactant-associated protein in fetal lung
    • Whitsett JA, Weaver TE, Lieberman MA, Clark JC, Daugherty C. Differential effects of epidermal growth factor and transforming growth factor-b on synthesis of Mr = 35,000 surfactant-associated protein in fetal lung. J Biol Chem 1987;262:7908-7913
    • (1987) J Biol Chem , vol.262 , pp. 7908-7913
    • Whitsett, J.A.1    Weaver, T.E.2    Lieberman, M.A.3    Clark, J.C.4    Daugherty, C.5
  • 38
    • 0029952544 scopus 로고    scopus 로고
    • Arrested lung morphogenesis in transgenic mice bearing an SP-C-TGF-β1 chimeric gene
    • Zhou L, Dey CR, Wert SE, Whitsett JA. Arrested lung morphogenesis in transgenic mice bearing an SP-C-TGF-β1 chimeric gene. Dev Biol 1996;175:227-238
    • (1996) Dev Biol , vol.175 , pp. 227-238
    • Zhou, L.1    Dey, C.R.2    Wert, S.E.3    Whitsett, J.A.4
  • 39
    • 68849126246 scopus 로고    scopus 로고
    • Anti-inflammatory and pro-inflammatory roles of TGF-β, IL-10, and IL-22 in immunity and autoimmunity
    • Sanjabi S, Zenewicz LA, Kamanaka M, Flavell RA. Anti-inflammatory and pro-inflammatory roles of TGF-β, IL-10, and IL-22 in immunity and autoimmunity. Curr Opin Pharmacol 2009;9:447-453
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 447-453
    • Sanjabi, S.1    Zenewicz, L.A.2    Kamanaka, M.3    Flavell, R.A.4
  • 41
    • 33750069029 scopus 로고    scopus 로고
    • Escaping from the TGFb anti-proliferative control
    • Seoane J. Escaping from the TGFb anti-proliferative control. Carcinogenesis 2006;27:2148-2156
    • (2006) Carcinogenesis , vol.27 , pp. 2148-2156
    • Seoane, J.1
  • 43
    • 0036136943 scopus 로고    scopus 로고
    • Mechanisms of TGF-β-mediated apoptosis
    • Schuster N, Krieglstein K. Mechanisms of TGF-β-mediated apoptosis. Cell Tissue Res 2002;307:1-14
    • (2002) Cell Tissue Res , vol.307 , pp. 1-14
    • Schuster, N.1    Krieglstein, K.2
  • 44
    • 0028180133 scopus 로고
    • TGF-β promotes proliferation of cultured SMC via both PDGF-AA-dependent and PDGF-AA-independent mechanisms
    • Stouffer GA, Owens GK. TGF-β promotes proliferation of cultured SMC via both PDGF-AA-dependent and PDGF-AA-independent mechanisms. J Clin Invest 1994;93:2048-2055
    • (1994) J Clin Invest , vol.93 , pp. 2048-2055
    • Stouffer, G.A.1    Owens, G.K.2
  • 45
    • 0035907240 scopus 로고    scopus 로고
    • Identification of novel TGF-β/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach
    • Verrecchia F, Chu ML, Mauviel A. Identification of novel TGF-β/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach. J Biol Chem 2001; 276:17058-17062
    • (2001) J Biol Chem , vol.276 , pp. 17058-17062
    • Verrecchia, F.1    Chu, M.L.2    Mauviel, A.3
  • 50
    • 82755161052 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis
    • King TE Jr, Pardo A, Selman M. Idiopathic pulmonary fibrosis. Lancet 2011;378:1949-1961
    • (2011) Lancet , vol.378 , pp. 1949-1961
    • King, T.E.1    Pardo, A.2    Selman, M.3
  • 51
    • 79952717349 scopus 로고    scopus 로고
    • An official ATS/ERS/ JRS/ALAT statement: Idiopathic pulmonary fibrosis: Evidence-based guidelines for diagnosis and management
    • ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
    • Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, Colby TV, Cordier JF, Flaherty KR, Lasky JA, et al.; ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis. An official ATS/ERS/ JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med 2011;183:788-824
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 788-824
    • Raghu, G.1    Collard, H.R.2    Egan, J.J.3    Martinez, F.J.4    Behr, J.5    Brown, K.K.6    Colby, T.V.7    Cordier, J.F.8    Flaherty, K.R.9    Lasky, J.A.10
  • 53
    • 79960381007 scopus 로고    scopus 로고
    • Integrating mechanisms of pulmonary fibrosis
    • Wynn TA. Integrating mechanisms of pulmonary fibrosis. J Exp Med 2011;208:1339-1350
    • (2011) J Exp Med , vol.208 , pp. 1339-1350
    • Wynn, T.A.1
  • 54
    • 0028109801 scopus 로고
    • Transforming growth factor b in tissue fibrosis
    • Border WA, Noble NA. Transforming growth factor b in tissue fibrosis. N Engl J Med 1994;331:1286-1292
    • (1994) N Engl J Med , vol.331 , pp. 1286-1292
    • Border, W.A.1    Noble, N.A.2
  • 56
    • 0027291380 scopus 로고
    • Altered expression of small proteoglycans, collagen, and transforming growth factor-b1 in developing bleomycin-induced pulmonary fibrosis in rats
    • Westergren-Thorsson G, Hernnäs J, Särnstrand B, Oldberg A, Heinega rd D, Malmström A. Altered expression of small proteoglycans, collagen, and transforming growth factor-b1 in developing bleomycin-induced pulmonary fibrosis in rats. J Clin Invest 1993;92:632-637
    • (1993) J Clin Invest , vol.92 , pp. 632-637
    • Westergren-Thorsson, G.1    Hernnäs, J.2    Särnstrand, B.3    Oldberg, A.4    Heinegard, D.5    Malmström, A.6
  • 59
    • 0035181092 scopus 로고    scopus 로고
    • Regulation of the effects of TGF-β1 by activation of latent TGF-β1 and differential expression of TGF-β receptors (TbR-I and TbR-II) in idiopathic pulmonary fibrosis
    • Khalil N, Parekh TV, O'Connor R, Antman N, Kepron W, Yehaulaeshet T, Xu YD, Gold LI. Regulation of the effects of TGF-β1 by activation of latent TGF-β1 and differential expression of TGF-β receptors (TbR-I and TbR-II) in idiopathic pulmonary fibrosis. Thorax 2001;56: 907-915
    • (2001) Thorax , vol.56 , pp. 907-915
    • Khalil, N.1    Parekh, T.V.2    O'Connor, R.3    Antman, N.4    Kepron, W.5    Yehaulaeshet, T.6    Xu, Y.D.7    Gold, L.I.8
  • 61
    • 0030800795 scopus 로고    scopus 로고
    • Adenovectormediated gene transfer of active transforming growth factor-b1 induces prolonged severe fibrosis in rat lung
    • Sime PJ, Xing Z, Graham FL, Csaky KG, Gauldie J. Adenovectormediated gene transfer of active transforming growth factor-b1 induces prolonged severe fibrosis in rat lung. J Clin Invest 1997;100: 768-776
    • (1997) J Clin Invest , vol.100 , pp. 768-776
    • Sime, P.J.1    Xing, Z.2    Graham, F.L.3    Csaky, K.G.4    Gauldie, J.5
  • 65
    • 0038823614 scopus 로고    scopus 로고
    • Myofibroblast differentiation by transforming growth factor-b1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase
    • Thannickal VJ, Lee DY, White ES, Cui Z, Larios JM, Chacon R, Horowitz JC, Day RM, Thomas PE. Myofibroblast differentiation by transforming growth factor-b1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase. J Biol Chem 2003;278: 12384-12389
    • (2003) J Biol Chem , vol.278 , pp. 12384-12389
    • Thannickal, V.J.1    Lee, D.Y.2    White, E.S.3    Cui, Z.4    Larios, J.M.5    Chacon, R.6    Horowitz, J.C.7    Day, R.M.8    Thomas, P.E.9
  • 66
    • 34548411746 scopus 로고    scopus 로고
    • TGF-β-induced EMT: Mechanisms and implications for fibrotic lung disease
    • Willis BC, Borok Z. TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol 2007; 293:L525-L534
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.293 , pp. L525-L534
    • Willis, B.C.1    Borok, Z.2
  • 70
    • 0242475243 scopus 로고    scopus 로고
    • Pathogenetic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosis
    • White ES, Lazar MH, Thannickal VJ. Pathogenetic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosis. J Pathol 2003; 201:343-354
    • (2003) J Pathol , vol.201 , pp. 343-354
    • White, E.S.1    Lazar, M.H.2    Thannickal, V.J.3
  • 72
    • 58149230979 scopus 로고    scopus 로고
    • TGF-β signaling in vascular biology and dysfunction
    • Goumans MJ, Liu Z, ten Dijke P. TGF-β signaling in vascular biology and dysfunction. Cell Res 2009;19:116-127
    • (2009) Cell Res , vol.19 , pp. 116-127
    • Goumans, M.J.1    Liu, Z.2    Ten Dijke, P.3
  • 73
    • 0033817459 scopus 로고    scopus 로고
    • Heterozygous germline mutations in BMPR2, encoding a TGF-β receptor, cause familial primary pulmonary hypertension
    • International PPH Consortium
    • Lane KB, Machado RD, Pauciulo MW, Thomson JR, Phillips JA, Loyd JE, Nichols WC, Trembath RC; International PPH Consortium. Heterozygous germline mutations in BMPR2, encoding a TGF-β receptor, cause familial primary pulmonary hypertension. Nat Genet 2000;26:81-84
    • (2000) Nat Genet , vol.26 , pp. 81-84
    • Lane, K.B.1    Machado, R.D.2    Pauciulo, M.W.3    Thomson, J.R.4    Phillips, J.A.5    Loyd, J.E.6    Nichols, W.C.7    Trembath, R.C.8
  • 77
    • 12344279001 scopus 로고    scopus 로고
    • Reduced expression of transforming growth factor b1 exacerbates pathology in an experimental asthma model
    • Scherf W, Burdach S, Hansen G. Reduced expression of transforming growth factor b1 exacerbates pathology in an experimental asthma model. Eur J Immunol 2005;35:198-206
    • (2005) Eur J Immunol , vol.35 , pp. 198-206
    • Scherf, W.1    Burdach, S.2    Hansen, G.3
  • 79
    • 17844400081 scopus 로고    scopus 로고
    • Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-β antibody: Effect on the Smad signaling pathway
    • McMillan SJ, Xanthou G, Lloyd CM. Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-β antibody: effect on the Smad signaling pathway. J Immunol 2005;174:5774-5780
    • (2005) J Immunol , vol.174 , pp. 5774-5780
    • McMillan, S.J.1    Xanthou, G.2    Lloyd, C.M.3
  • 80
    • 77956628834 scopus 로고    scopus 로고
    • Overexpression of Smad2 drives house dust mite-mediated airway remodeling and airway hyperresponsiveness via activin and IL-25
    • Gregory LG, Mathie SA, Walker SA, Pegorier S, Jones CP, Lloyd CM. Overexpression of Smad2 drives house dust mite-mediated airway remodeling and airway hyperresponsiveness via activin and IL-25. Am J Respir Crit Care Med 2010;182:143-154
    • (2010) Am J Respir Crit Care Med , vol.182 , pp. 143-154
    • Gregory, L.G.1    Mathie, S.A.2    Walker, S.A.3    Pegorier, S.4    Jones, C.P.5    Lloyd, C.M.6
  • 82
    • 0035744614 scopus 로고    scopus 로고
    • Cytokines in chronic obstructive pulmonary disease
    • Chung KF. Cytokines in chronic obstructive pulmonary disease. Eur Respir J Suppl 2001;34:50s-59s
    • (2001) Eur Respir J Suppl , vol.34 , pp. 50s-59s
    • Chung, K.F.1
  • 83
    • 17044453955 scopus 로고    scopus 로고
    • Increased expression of transforming growth factor-b1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD)
    • Takizawa H, Tanaka M, Takami K, Ohtoshi T, Ito K, Satoh M, Okada Y, Yamasawa F, Nakahara K, Umeda A. Increased expression of transforming growth factor-b1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med 2001;163: 1476-1483
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 1476-1483
    • Takizawa, H.1    Tanaka, M.2    Takami, K.3    Ohtoshi, T.4    Ito, K.5    Satoh, M.6    Okada, Y.7    Yamasawa, F.8    Nakahara, K.9    Umeda, A.10
  • 84
    • 4344653389 scopus 로고    scopus 로고
    • SMADsignaling in chronic obstructive pulmonary disease: Transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke
    • Springer J, Scholz FR, Peiser C, Groneberg DA, Fischer A. SMADsignaling in chronic obstructive pulmonary disease: transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke. Biol Chem 2004;385:649-653
    • (2004) Biol Chem , vol.385 , pp. 649-653
    • Springer, J.1    Scholz, F.R.2    Peiser, C.3    Groneberg, D.A.4    Fischer, A.5
  • 85
    • 0037435116 scopus 로고    scopus 로고
    • Medicine: Smoke signals for lung disease
    • Roberts AB. Medicine: smoke signals for lung disease. Nature 2003; 422:130-131
    • (2003) Nature , vol.422 , pp. 130-131
    • Roberts, A.B.1
  • 87
    • 0036964791 scopus 로고    scopus 로고
    • Cigarette smoke-induced oxidative stress and TGF-β1 increase p21waf1/cip1 expression in alveolar epithelial cells
    • Marwick JA, Kirkham P, Gilmour PS, Donaldson K, MacNee W, Rahman I. Cigarette smoke-induced oxidative stress and TGF-β1 increase p21waf1/cip1 expression in alveolar epithelial cells. Ann N Y Acad Sci 2002;973:278-283
    • (2002) Ann N y Acad Sci , vol.973 , pp. 278-283
    • Marwick, J.A.1    Kirkham, P.2    Gilmour, P.S.3    Donaldson, K.4    MacNee, W.5    Rahman, I.6
  • 88
    • 33751213597 scopus 로고    scopus 로고
    • Cigarette smoke inhibits alveolar repair: A mechanism for the development of emphysema
    • Rennard SI, Togo S, Holz O. Cigarette smoke inhibits alveolar repair: a mechanism for the development of emphysema. Proc Am Thorac Soc 2006;3:703-708
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 703-708
    • Rennard, S.I.1    Togo, S.2    Holz, O.3
  • 89
    • 84866985855 scopus 로고    scopus 로고
    • Targeting the TGFb signalling pathway in disease
    • Akhurst RJ, Hata A. Targeting the TGFb signalling pathway in disease. Nat Rev Drug Discov 2012;11:790-811
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 790-811
    • Akhurst, R.J.1    Hata, A.2
  • 90
    • 84865808428 scopus 로고    scopus 로고
    • The impact of TGF-b on lung fibrosis: From targeting to biomarkers
    • Fernandez IE, Eickelberg O. The impact of TGF-b on lung fibrosis: from targeting to biomarkers. Proc Am Thorac Soc 2012;9:111-116
    • (2012) Proc Am Thorac Soc , vol.9 , pp. 111-116
    • Fernandez, I.E.1    Eickelberg, O.2
  • 91
    • 84876706037 scopus 로고    scopus 로고
    • A review of current and novel therapies for idiopathic pulmonary fibrosis
    • Rafii R, Juarez MM, Albertson TE, Chan AL. A review of current and novel therapies for idiopathic pulmonary fibrosis. J ThoracDis 2013;5:48-73
    • (2013) J ThoracDis , vol.5 , pp. 48-73
    • Rafii, R.1    Juarez, M.M.2    Albertson, T.E.3    Chan, A.L.4
  • 93
    • 84922287240 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-b via the activin receptor-like kinase-5 inhibitor attenuates pulmonary fibrosis
    • Koh RY, Lim CL, Uhal BD, Abdullah M, Vidyadaran S, Ho CC, Seow HF. Inhibition of transforming growth factor-b via the activin receptor-like kinase-5 inhibitor attenuates pulmonary fibrosis. Mol Med Rep 2015; 11:3808-3813
    • (2015) Mol Med Rep , vol.11 , pp. 3808-3813
    • Koh, R.Y.1    Lim, C.L.2    Uhal, B.D.3    Abdullah, M.4    Vidyadaran, S.5    Ho, C.C.6    Seow, H.F.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.