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Volumn 99, Issue 13, 2002, Pages 8921-8926
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A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression
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Author keywords
Corticosteroids; Granulocyte macrophage colony stimulating factor; Histone deacetylation; Macrophages
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Indexed keywords
ADENOSINE RECEPTOR BLOCKING AGENT;
CORTICOSTEROID;
DEXAMETHASONE;
HISTONE DEACETYLASE;
PHOSPHODIESTERASE;
PHOSPHODIESTERASE INHIBITOR;
THEOPHYLLINE;
ARTICLE;
ASTHMA;
BRONCHODILATATION;
CLINICAL TRIAL;
CONTROLLED CLINICAL TRIAL;
CONTROLLED STUDY;
CORTICOSTEROID THERAPY;
CROSSOVER PROCEDURE;
DOUBLE BLIND PROCEDURE;
DRUG ACTIVITY;
DRUG INDUCED DISEASE;
DRUG MECHANISM;
ENZYME ACTIVITY;
ENZYME INDUCTION;
ENZYME INHIBITION;
EPITHELIUM CELL;
GENETIC TRANSCRIPTION;
HUMAN;
INFLAMMATION;
MACROPHAGE;
PRIORITY JOURNAL;
ADULT;
ASTHMA;
BASE SEQUENCE;
BRONCHOALVEOLAR LAVAGE FLUID;
BRONCHODILATOR AGENTS;
CASE-CONTROL STUDIES;
CROSS-OVER STUDIES;
DEXAMETHASONE;
DNA PRIMERS;
DOUBLE-BLIND METHOD;
ENZYME INDUCTION;
GENE EXPRESSION REGULATION;
GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR;
HISTONE DEACETYLASES;
HUMANS;
INFLAMMATION MEDIATORS;
PROMOTER REGIONS (GENETICS);
THEOPHYLLINE;
EUKARYOTA;
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EID: 0037173056
PISSN: 00278424
EISSN: None
Source Type: Journal
DOI: 10.1073/pnas.132556899 Document Type: Article |
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Times cited : (462)
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References (31)
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