A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 13, 2002, Pages 8921-8926

  Ito, Kazuhiro ^a   Lim, Sam ^a   Caramori, Gaetano ^a   Cosio, Borja ^a   Chung, K Fan ^a   Adcock, Ian M ^a   Barnes, Peter J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Corticosteroids; Granulocyte macrophage colony stimulating factor; Histone deacetylation; Macrophages

Indexed keywords

ADENOSINE RECEPTOR BLOCKING AGENT; CORTICOSTEROID; DEXAMETHASONE; HISTONE DEACETYLASE; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; THEOPHYLLINE;

ARTICLE; ASTHMA; BRONCHODILATATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG ACTIVITY; DRUG INDUCED DISEASE; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; EPITHELIUM CELL; GENETIC TRANSCRIPTION; HUMAN; INFLAMMATION; MACROPHAGE; PRIORITY JOURNAL;

ADULT; ASTHMA; BASE SEQUENCE; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHODILATOR AGENTS; CASE-CONTROL STUDIES; CROSS-OVER STUDIES; DEXAMETHASONE; DNA PRIMERS; DOUBLE-BLIND METHOD; ENZYME INDUCTION; GENE EXPRESSION REGULATION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HISTONE DEACETYLASES; HUMANS; INFLAMMATION MEDIATORS; PROMOTER REGIONS (GENETICS); THEOPHYLLINE;

EUKARYOTA;

EID: 0037173056     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.132556899     Document Type: Article

References (31)