Advances in the discovery of selective JAK inhibitors

Progress in Medicinal Chemistry

Volumn 52, Issue , 2013, Pages 153-223

  Menet, Christel J ^a   Rompaey, Luc Van ^a   Geney, Raphaël ^b  

^a GALAPAGOS NV   (Belgium)

^b Galapagos SASU   (France)

Author keywords

JAK STAT signalling; JAK1; JAK2; JAK3; Kinase inhibition; Myeloproliferative disorders; Rheumatoid arthritis; Selectivity; TYK2

Indexed keywords

5 CHLORO N2 [1 (5 FLUORO 2 PYRIMIDINYL)ETHYL] N4 (5 METHYL 1H PYRAZOL 3 YL) 2,4 PYRIMIDINEDIAMINE; AC 430; AEG 41174; BARICITINIB; BMS 911543; GANDOTINIB; GLPG 0634; INTERLEUKIN 3; INTERLEUKIN 4; JANUS KINASE 1; JANUS KINASE 1 IINHIBITOR; JANUS KINASE 2; JANUS KINASE 2 INHIBITOR; JANUS KINASE 3; JANUS KINASE 3 INHIBITOR; JANUS KINASE INHIBITOR; LESTAURTINIB; MOMELOTINIB; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; N TERT BUTYL 3 [5 METHYL 2 [4 [2 (1 PYRROLIDINYL)ETHOXY]PHENYLAMINO] 4 PYRIMIDINYLAMINO]BENZENESULFONAMIDE; ONX 0803; PACRITINIB; PROTEIN TYROSINE KINASE; QUINAZOLINE; RUXOLITINIB; SB 1317; SB 1578; SULOTROBAN; TOFACITINIB; TYROSINE KINASE 2; UNCLASSIFIED DRUG; UNINDEXED DRUG; VX 509; XL 019;

ALLERGIC DISEASE; ARTICLE; BIOLOGICAL ACTIVITY; CELL GROWTH; CELLS; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG APPROVAL; DRUG DESIGN; ENTERITIS; HEMATOPOIETIC CELL; HUMAN; HYDROGEN BOND; MONOTHERAPY; MYELOPROLIFERATIVE NEOPLASM; NONHUMAN; PATENT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; PSORIASIS; RHEUMATOID ARTHRITIS; STRUCTURE ACTIVITY RELATION;

EID: 84873402103     PISSN: 00796468     EISSN: 18757863     Source Type: Book Series    
DOI: 10.1016/B978-0-444-62652-3.00004-1     Document Type: Chapter

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