Chronic mechanical stress induces mucin5AC expression in human bronchial epithelial cells through ERK dependent pathways

Molecular Biology Reports

Volumn 39, Issue 2, 2012, Pages 1019-1028

  Li, Na ^a   Li, Qi ^a   Zhou, Xiang Dong ^a   Kolosov, Victor P ^b   Perelman, Juliy M ^b  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b Russian Academy of Medical Sciences   (Russian Federation)

Author keywords

Epidermal growth factor receptor; Extracellular signal regulated kinase; Focal adhesion kinase; Mechanical pressure; Mucin5AC

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; FAK PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MUCIN 5AC; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; FLAVONOID; FOCAL ADHESION KINASE 1; PRIMER DNA; PTK2 PROTEIN, HUMAN; QUINAZOLINE DERIVATIVE; TYRPHOSTIN;

ARTICLE; BRONCHUS MUCOSA; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MECHANICAL STRESS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANALYSIS OF VARIANCE; BRONCHOSPASM; BRONCHUS; CELL CULTURE; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGICAL STRESS; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

PHOS;

ANALYSIS OF VARIANCE; BLOTTING, WESTERN; BRONCHI; BRONCHOCONSTRICTION; CELLS, CULTURED; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; FLAVONOIDS; FOCAL ADHESION KINASE 1; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MAP KINASE SIGNALING SYSTEM; MUCIN 5AC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; QUINAZOLINES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; STRESS, PHYSIOLOGICAL; TYRPHOSTINS;

EID: 84860344107     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-011-0827-x     Document Type: Article

References (36)

1. Fahy JV (2001) Remodeling of the airway epithelium in asthma. Am J Respir Crit Care Med 164:S46-S51
2. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, Cherniack RM, Rogers RM, Sciurba FC, Coxson HO, Paré PD (2004) The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 350:2645-2653 (Pubitemid 38787999)
3. Ha U, Lim JH, Jono H, Koga T, Srivastava A, Malley R, Pagès G, Pouysségur J, Li JD (2007) A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae. J Immunol 178:1736-1747 (Pubitemid 46154645)
4. Qi Li, Zhou Xiang Dong, Xu Xiao Yan, Yang Jie (2010) Recombinant human elafin protects airway epithelium integrity during inflammation. Mol Biol Rep 37:2981-2988
5. Kim CH, Kim KE, Yoon JH, Song KS (2009) Upregulation of MUC5AC gene expression by IL-4 through CREB in human airway epithelial cells. J Cell Biochem 108:974-981
6. Zhou Xiang-Dong, Tong Jin, Lan Jian (2002) Chronic obstructive pulmonary disease airway mucin molecular phenotypic studies. Chin J Tuberc Respir Dis 25:437
7. Wiggs BR, Hrousis CA, Drazen JM, Kamm RD (1997) On the mechanism of mucosal folding in normal and asthmatic airways. J Appl Physiol 83:1814-1821 (Pubitemid 28006478)
8. Tschumperlin DJ, Shively JD, Swartz MA, Silverman ES, Haley KJ, Raab G, Drazen JM (2002) Bronchial epithelial compression regulates MAP kinase signaling and HB-EGF-like growth factor expression. Am J Physiol Lung Cell Mol Physiol 282: L904-L911 (Pubitemid 34654605)
9. Hewson CA, Edbrooke MR, Johnston SL (2003) PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF/TGF-alpha, Ras/Raf, MEK, ERK and Sp1-dependent mechanisms. J Mol Biol 344:683-695 (Pubitemid 39469213)
10. Song KS, Lee WJ, Chung KC, Koo JS, Yang EJ, Choi JY, Yoon JH (2003) Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells. J Biol Chem 278: 23243-23250 (Pubitemid 36830137)
11. Song JS, Cho KS, Yoon HK, Moon HS, Park SH (2005) Neu-trophil elastase causes MUC5AC mucin synthesis via EGF receptor, ERK and NF-kB pathways in A549 cells. Korean J Intern Med 20:275-283
12. Chaturvedi LS, Marsh HM, Basson MD (2007) Src and focal adhesion kinase mediate mechanical strain-induced proliferation and ERK1/2 phosphorylation in human H441 pulmonary epithelial cells. Am J Phyiol Cell Physiol 292:C1701-C1713 (Pubitemid 47080558)
13. Tschumperlin DJ, Dai G, Maly IV, Kikuchi T, Laiho LH, McVittie AK, Haley KJ, Lilly CM, So PT, Lauffenburger DA, Kamm RD, Drazen JM (2004) Mechanotransduction through growth-factor shedding into the extracellular space. Nature 429:83-86 (Pubitemid 38620555)
14. Kikuchi T, Shively JD, Foley JS, Drazen JM, Tschumperlin DJ (2004) Differentiation-dependent responsiveness of bronchial epithelial cells to IL-4/13 stimulation. Am J Physiol Lung Cell Mol Physiol 287:L119-L126 (Pubitemid 38787658)
15. Park JA, Tschumperlin DJ (2009) Chronic intermittent mechanical stress increases MUC5AC protein expression. Am J Respir Cell Mol Biol 41:459-466
16. Ross AJ, Dailey LA, Brighton LE, Devlin RB (2007) Tran-scriptional profiling of mucociliary differentiation in human airway epithelial cells. Am J Respir Cell Mol Biol 37:169-185 (Pubitemid 47255000)
17. Ressler B, Lee RT, Randell SH, Drazen JM, Kamm RD (2000) Molecular responses of rat tracheal epithelial cells to transmembrane pressure. Am J Physiol Lung Cell Mol Physiol 278:L1264-L1272 (Pubitemid 30439251)
18. Thamilselvan V, Basson MD (2004) Pressure activates colon cancer cell adhesion by inside-out focal adhesion complex and actin cytoskeletal signaling. Gastroenterology 126:8-18 (Pubitemid 38040719)
19. Yuan-Chen Wu D, Wu R, Reddy SP, Lee YC, Chang MM (2007) Distinctive epidermal growth factor receptor/extracellular regulated kinase-independent and -dependent signaling pathways in the induction of airway mucin 5B and mucin 5AC expression by phorbol 12-myristate 13-acetate. Am J Pathol 170:20-32 (Pubitemid 47339186)
20. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25:402-408 (Pubitemid 34164012)
21. Takami K, Takuwa N, Okazaki H, Kobayashi M, Ohtoshi T, Kawasaki S, Dohi M, Yamamoto K, Nakamura T, Tanaka M, Nakahara K, Takuwa Y, Takizawa H (2002) Interferon-c inhibits hepatocyte growth factor stimulated cell proliferation of human bronchial epithelial cells: upregulation of p27kip1 cyclin-depen-dent kinase inhibitor. Am J Respir Cell Mol Biol 26:231-238 (Pubitemid 34107878)
22. Wirtz HR, Dobbs LG (2000) The effects of mechanical forces on lung functions. Respir Physiol 119:1-17 (Pubitemid 30069758)
23. Liu M, Tanswell AK, Post M (1999) Mechanical force-induced signal transduction in lung cells. Am J Physiol 277:L667-L683 (Pubitemid 29522632)
24. Liu M, Post M (2000) Mechanochemical signal transduction in the fetal lung. J Appl Physiol 89:2078-2084
25. Vlahakis NE, Hubmayr RD (2000) Plasma membrane stress failure in alveolar epithelial cells. J Appl Physiol 89:2490-2496
26. Rose MC, Voynow JA (2006) Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev 86: 245-278
27. Zuhdi Alimam M, Piazza FM, Selby DM, Letwin N, Huang L, Rose MC (2000) Muc-5/5ac mRNA and protein expression is a marker of goblet cell metaplasia in murine airways. Am J Respir Cell Mol Biol 22:253-260 (Pubitemid 30343350)
28. Chess PR, Toia L, Finkelstein JN (2000) Mechanical strain-induced proliferation and signaling in pulmonary epithelial H441 cells. Am J Physiol Lung Cell Mol Physiol 279:L43-L51 (Pubitemid 30619522)
29. Oudin S, Pugin J (2002) Role of MAP kinase activation in interleukin-8 production by human BEAS-2B bronchial epithelial cells submitted to cyclic stretch. Am J Respir Cell Mol Biol 27:107-114 (Pubitemid 34657398)
30. Kippenberger S, Bernd A, Loitsch S, Guschel M, Muller J, Bereiter-Hahn J, Kaufmann R (2000) Signaling of mechanical stretch in human keratinocytes via MAP kinases. J Invest Der-matol 114:408-412 (Pubitemid 30415324)
31. Li W, Duzgun A, Sumpio BE, Basson MD (2001) Integrin and FAK-mediated MAPK activation is required for cyclic strain mitogenic effects in caco-2 cells. Am J Physiol Gastrointest Liver Physiol 280:G75-G87
32. Peverali FA, Basdra EK, Papavassiliou AG (2001) Stretch-mediated activation of selective MAPK subtypes and potentiation of AP-1 binding in human osteoblastic cells. Mol Med 7:68-78 (Pubitemid 33702001)
33. Zhang J, Li W, Sanders MA, Sumpio BE, Panja A, Basson MD (2003) Regulation of the intestinal epithelial response to cyclic strain by extracellular matrix proteins. FASEB J 17:926-928
34. Chess PR, O'Reilly MA, Sachs F, Finkelstein JN (2005) Reactive oxidant and p42/44 MAP kinase signaling is necessary for mechanical strain-induced proliferation in pulmonary epithelial cells. J Appl Physiol 99:1226-1232 (Pubitemid 41214544)
35. Alexander LD, Alagarsamy S, Douglas JG (2004) Cyclic stretch-induced cPLA2 mediates ERK 1/2 signaling in rabbit proximal tubule cells. Kidney Int 65:551-563 (Pubitemid 38130649)
36. Eric KC, John SF, Cheng Jason, Anita SP, Jeffrey MD, Tschumperlin DJ (2005) Bronchial epithelial compression regulates epidermal growth factor receptor family ligand expression in an autocrine manner. Am J Respir Cell Mol Biol 32:373-380 (Pubitemid 40629321)