Inhaled p38α mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice

American Journal of Respiratory and Critical Care Medicine

Volumn 171, Issue 6, 2005, Pages 571-578

  Duan, Wei ^b   Chan, Jasmine H P ^b   McKay, Kelly ^b   Crosby, Jeffrey R ^b   Hui, Hwa Choo ^b   Leung, Bernard P ^b   Karras, James G ^b   Wong, W S Fred ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NONE

Author keywords

Asthma; Bronchoalveolar lavage fluid; Eosinophilia; Mucus hypersecretion; Ovalbumin

Indexed keywords

ALLERGEN; ANTISENSE OLIGODEOXYNUCLEOTIDE; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; OVALBUMIN; ANTISENSE OLIGONUCLEOTIDE; MITOGEN ACTIVATED PROTEIN KINASE 14;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; EOSINOPHIL; EOSINOPHILIA; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY TRACT MUCOSA; ANIMAL; BAGG ALBINO MOUSE; BRONCHUS HYPERREACTIVITY; IMMUNOLOGY; INHALATIONAL DRUG ADMINISTRATION; LOEFFLER PNEUMONIA; MUCUS; PATHOPHYSIOLOGY; SECRETION;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; MALE; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASE 14; MUCUS; OLIGONUCLEOTIDES, ANTISENSE; OVALBUMIN; POLYMERASE CHAIN REACTION; PULMONARY EOSINOPHILIA;

EID: 14944350956     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200408-1006OC     Document Type: Article

References (49)

1. Tanaka M, Nyce JW. Respirable antisense oligonucleotides: a new drug class for respiratory disease. Respir Res 2001;2:5-9.
2. Nyce JW, Metzger WJ. DNA antisense therapy for asthma in an animal model. Nature 1997;385:721-725.
3. Elias JA, Lee CG, Zheng T, Ma B, Homer RJ, Zhu Z. New insights into the pathogenesis of asthma. J Clin Invest 2003;111:291-297.
4. Busse WW, Lemanske RF Jr. Asthma. N Engl J Med 2001;344:350-362.
5. Herrick CA, Bottomly K. To respond or not to respond: T cells in allergic asthma. Nat Rev Immunol 2003;3:1-8.
6. Dong C, Davis RJ, Flavell RA. MAP kinases in the immune response. Annu Rev Immunol 2002;20:55-72.
7. Taube C, Nick JA, Duez C, Takeda K, Rha YH, Park JW, Joetham A, Poch K, Dakhama A. Dinarello CA, et al. Inhibition of early airway neutrophilia does not affect development of airway hyperresponsiveness. Am J Respir Cell Mol Biol 2004;30:837-843.
8. Nel AE. T-cell activation through the antigen receptor. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse. J Allergy Clin Immunol 2002;109:758-770.
9. Niiro H, Clark EA. Regulation of B-cell fate by antigen-receptor signals. Nat Rev Immunol 2002;2:945-956.
10. Kawakami T, Galli SJ. Regulation of mast-cell and basophil function and survival by IgE. Nat Rev Immunol 2002;2:773-786.
11. Wong CK, Ip WK, Lam CWK. Interleukin-3, -5, and granulocyte macrophage colony-stimulating factor-induced adhesion molecule expression on eosinophils by p38 mitogen-activated protein kinase and nuclear factor-κB. Am J Respir Cell Mol Biol 2003;29:133-147.
12. Adachi T, Choudhury BK, Stafford S, Sur S, Alam R. The differential role of extracellular signal-regulated kinases and p38 mitogen-activated protein kinase in eosinophil functions. J Immunol 2000;165:2198-2204.
13. Adachi T, Stafford S, Kayaba H, Chihara J, Alam R. Myosin light chain kinase mediates eosinophil chemotaxis in a mitogen-activated protein kinase-dependent manner. J Allergy Clin Immunol 2003;111:113-116.
14. Underwood DC, Obsorn RR, Kotzer CJ, Adams JL, Lee JC, Webb EF, Carpenter DC, Bochnowicz S, Thomas HC, Hay DWP, et al. SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence. J Pharmacol Exp Ther 2000;293:281-288.
15. Candra E, Chan JHP, Duan W, Choo HH, Leung BP, Karras J, Wong WSF. Respirable p38α mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice [abstract]. Korean J Physiol Pharmacol 2003;7(Suppl 1):161.
16. Tung D, Gregory SA, Crosby JR, Guha M, Miller DA, McKay K, Gaarde WA, Monia BP, Wong WSF, Karras JG. Local administration of anti-sense inhibitors of p38α MAPK suppresses allergen-induced lung inflammation and airway hyperreactivity in mice [abstract]. Inflamm Res 2004;53:220.
17. McKay RA, Miraglia LJ, Cummins LL, Owens ST, Sasmor H, Dean NM. Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-α expression. J Biol Chem 1999;274:1715-1722.
18. Wu H, Lima WF, Zhang H, Fan A, Sun H, Crooke ST. Determination of the role of the human RNase H1 in the pharmacology of DNA-like antisense drugs. J Biol Chem 2004;279:17181-17189.
19. Duan W, Chan JHP, Wong CH, Leung BP, Wong WSF. Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model. J Immunol 2004;172:7053-7059.
20. Silbaugh SA, Stengel PW, Dillard RD, Bemis DG. Pulmonary gas trapping in the guinea pig and its application in pharmacological testing. J Pharmacol Methods 1987;18:295-303.
21. Leeds JM, Graham MJ, Truong L, Cummins LL. Quantitation of phosphorothioate oligonucleotides in human plasma. Anal Biochem 1996;235:36-43.
22. Geary RS, Leeds JM, Fitchett J, Burkin T, Truong L, Spainhour C, Creek M. Levin AA. Pharmacokinetics and metabolism in mice of a phosphorothioate oligonucleotide antisense inhibitor of c-raf 1 kinase expression. Drug Metab Dispos 1997;25:1272-1281.
23. Yu RZ, Baker B, Chapell A, Geary RS, Cheung E, Levin AA. Development of an ultrasensitive non-competitive hybridization-ligation enzyme-linked immunosorbent assay for the determination of phosphorothioate oligodeoxynucleotide in plasma. Anal Biochem 2002;304:19-25.
24. Lundblad LK, Irvin CG, Adler A, Bates JH. A reevaluation of the validity of unrestrained plethysmography in mice. J Appl Physiol 2002;93:1198-1207.
25. Larche MD, Robinson S, Kay AB. The role of T lymphocytes in the pathogenesis of asthma. J Allergy Clin Immunol 2002;111:450-463.
26. + T cells and Th2 effector cells. J Immunol 1999;162:7110-7119.
27. Lu B, Ferrandino AF, Flavell RA. Gadd45β is important for perpetuating cognate and inflammatory signals in T cells. Nat Immunol 2004;5:38-44.
28. Skapenko A, Lipsky PE, Kraetsch HG, Kalden JR, Schulze-Koops H. Antigen-independent Th2 cell differentiation by stimulation of CD28: regulation via IL-4 gene expression and mitogen-activated protein kinase activation. J Immunol 2001;166:4283-4292.
29. Koprak S, Staruch MJ, Dumont FJ. A specific inhibitor of the p38 mitogen activated protein kinase affects differentially the production of various cytokines by activated human T cells: dependence on CD28 signaling and preferential inhibition of IL-10 production. Cell Immunol 1998;192:87-95.
30. Mori A, Kaminuma O, Miyazawa K, Ogawa K, Okudaira H, Akiyama K. p38 mitogen-activated protein kinase regulates human T cell IL-5 synthesis. J Immunol 1999;163:4763-4771.
31. Panettieri RA Jr. Airway smooth muscle: an immunomodulatory cell. J Allergy Clin Immunol 2002;110:S269-S274.
32. Hirst SJ. Regulation of airway smooth muscle cell immunomodulatory function: role in asthma. Respir Physiol Neurobiol 2003;137:309-326.
33. Hirst SJ, Hallsworth MP, Peng Q, Lee TH. Selective induction of eotaxin release by interleukin-13 or interleukin-4 in human airway smooth muscle cells is synergistic with interleukin-1β and is mediated by the interleukin-4 receptor α-chain. Am J Respir Crit Care Med 2002;165:1161-1171.
34. Peng Q, Matsuda T, Hirst SJ. Signaling pathways regulating interleukin-13-stimulated chemokine release from airway smooth muscle. Am J Respir Crit Care Med 2004;169:596-603.
35. Cui CH, Adachi T, Oyamada H, Kamada Y, Kuwasaki T, Yamada Y, Saito N, Kayaba H, Chihara J. The role of mitogen-activated protein kinases in eotaxin-induced cytokine production from bronchial epithelial cells. Am J Respir Cell Mol Biol 2002;26:329-335.
36. Kalesnikoff J, Huber M, Lam V, Damen JE, Zhang J, Siraganian RP, Krystal G. Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival. Immunity 2001;14:801-811.
37. Fitzgerald SM, Lee SA, Hall HK, Chi DS, Krishnaswamy G. Human lung fibroblasts express interleukin-6 in response to signaling after mast cell contact. Am J Respir Cell Mol Biol 2004;30:585-593.
38. Lukacs NW. Role of chemokines in the pathogenesis of asthma. Nat Rev Immunol 2001;1:108-116.
39. Koo GC, Shah K, Ding GJP, Xiao J, Wnek R, Doherty G, Tong XC, Pepinsky RB, Lin KC, Hagmann WK, et al. A small molecule very late antigen-4 antagonist can inhibit ovalbumin-induced lung inflammation. Am J Respir Crit Care Med 2003;167:1400-1409.
40. Li L, Xia Y, Nguyen A, Lai YH, Feng L. Mosmann TR, Lo D. Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells. J Immunol 1999;162:2477-2487.
41. Kampen GT, Stafford S, Adachi T, Jinquan T, Quan S, Grant JA, Skov PS, Poulsen LK, Alam R. Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases. Blood 2000;95:1911-1917.
42. + T cell-dependent airway mucus production occurs in response to IL-5 expression in lung. Am J Physiol Lung Cell Mol Physiol 2002;282:L1066-L1074.
43. Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, Zhang Y, Elias JA. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 1999;103:779-788.
44. Atherton HC, Jones G, Danahay H. IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation. Am J Physiol Lung Cell Mol Physiol 2003;285:L730-L739.
45. Fernandes DJ, Mitchell RW, Lakser O, Dowell M, Stewart AG, Solway J. Do inflammatory mediators influence the contribution of airway smooth muscle contraction to airway hyperresponsiveness in asthma? J Appl Physiol 2003;95:844-853.
46. Gleich GJ. Mechanisms of eosinophil-associate inflammation. J Allergy Clin Immunol 2000;105:651-663.
47. Taube C, Duez C, Cui ZH, Takeda K, Rha YH, Park JW, Balhorn A, Donaldson DD, Dakhama A, Gelfand EW. The role of IL-13 in established allergic airway disease. J Immunol 2002;169:6482-6489.
48. Vargaftig BB, Singer M. Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. Am J Respir Cell Mol Biol 2003;28:410-419.
49. Templin MV, Levin AA, Graham MJ, Aberg PM, Axelsson BI, Butler M, Geary RS, Bennett CF. Pharmacokinetics and toxicity profile of a phosphorothioate oligonucleotide following inhalation delivery to lung in mice. Antisense Nucleic Acid Drug Dev 2000;10:359-368.