Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 309, Issue 10, 2015, Pages L1112-L1123

  Ngkelo, X Anta ^a   Hoffmann, Roland F ^b   Durham, Andrew L ^a   Marwick, John A ^c   Brandenburg, Simone M ^b   De Bruin, Harold G ^b   Jonker, Marnix R ^b   Rossios, Christos ^a   Tsitsiou, Eleni ^d   Caramori, Gaetano ^e   Contoli, Marco ^e   Casolari, Paolo ^e   Monaco, Francesco ^f   Andò, Filippo ^f   Speciale, Giuseppe ^f   Kilty, Iain ^g   Chung, Kian F ^a   Papi, Alberto ^e   Lindsay, Mark A ^h   Ten Hacken, Nick H T ^b   Van Den Berge, Maarten ^b   Timens, Wim ^b   Barnes, Peter J ^a   Van Oosterhout, Antoon J ^b   Adcock, Ian M ^a   Kirkham, Paul A ^a   Heijink, Irene H ^b   more..

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

^e UNIVERSITY OF FERRARA   (Italy)

^f UNIVERSITY OF MESSINA   (Italy)

^g PFIZER INC   (United States)

^h University of Bath   (United Kingdom)

Author keywords

COPD; Epithelial cells; Inflammatory responses; Monocytes; Oxidative stress

Indexed keywords

GLUCOCORTICOID; GLYCOGEN SYNTHASE KINASE 3BETA; GRANULOCYTE COLONY STIMULATING FACTOR; HISTONE DEACETYLASE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; DEXAMETHASONE; GLYCOGEN SYNTHASE KINASE 3; GSK3B PROTEIN, HUMAN; HDAC2 PROTEIN, HUMAN; REACTIVE OXYGEN METABOLITE;

AGED; ARTICLE; BRONCHUS MUCOSA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME INACTIVATION; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; INFLAMMATION; LUNG ALVEOLUS MACROPHAGE; MALE; MONOCYTE; OXIDATIVE STRESS; PRIORITY JOURNAL; SMOKING; CELL CULTURE; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; PHYSIOLOGY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION;

AGED; CELLS, CULTURED; DEXAMETHASONE; FEMALE; GENE EXPRESSION; GLUCOCORTICOIDS; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; HISTONE DEACETYLASE 2; HUMANS; LEUKOCYTES, MONONUCLEAR; MACROPHAGES, ALVEOLAR; MALE; MIDDLE AGED; OXIDATIVE STRESS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REACTIVE OXYGEN SPECIES; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION;

EID: 84947230023     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00077.2015     Document Type: Article

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