NF-κB inducing kinase, NIK mediates cigarette smoke/TNFα-induced histone acetylation and inflammation through differential activation of IKKs

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Chung, Sangwoon ^a   Sundar, Isaac K ^a   Hwang, Jae Woong ^a   Yull, Fiona E ^b   Blackwell, Timothy S ^b   Kinnula, Vuokko L ^c   Bulger, Michael ^a   Yao, Hongwei ^a   Rahman, Irfan ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CIGARETTE SMOKE; I KAPPA B KINASE ALPHA; NF KAPPA B INDUCING KINASE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; HISTONE; I KAPPA B KINASE; NF KAPPA B KINASE; NF-KAPPA B KINASE; PROTEIN SERINE THREONINE KINASE;

ANIMAL EXPERIMENT; ARTICLE; CELL NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; GENE SILENCING; HISTONE ACETYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN PROCESSING; ACETYLATION; ANIMAL; BIOLOGICAL MODEL; CELL LINE; CHRONIC OBSTRUCTIVE LUNG DISEASE; DRUG EFFECT; ENZYMOLOGY; GENETICS; LUNG; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROTEIN BINDING; SIGNAL TRANSDUCTION; SMOKING;

ACETYLATION; ANIMALS; CELL LINE; CELL NUCLEUS; ENZYME ACTIVATION; EPITHELIAL CELLS; GENE KNOCKDOWN TECHNIQUES; HISTONES; HUMANS; I-KAPPA B KINASE; INFLAMMATION; LUNG; MICE; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SIGNAL TRANSDUCTION; SMOKING; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80051974241     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023488     Document Type: Article

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