JAK-STAT signaling in asthma

Journal of Clinical Investigation

Volumn 109, Issue 10, 2002, Pages 1279-1283

  Pernis, Alessandra B ^a   Rothman, Paul B ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 5; INTERLEUKIN 6; JANUS KINASE; LYMPHOTOXIN; STAT PROTEIN;

ANTIGEN SPECIFICITY; ASTHMA; B LYMPHOCYTE; CYTOKINE PRODUCTION; HELPER CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOREGULATION; IMMUNOSTIMULATION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0036100050     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0215786     Document Type: Review

References (52)

1. Prevalence and etiology of asthma
2. Immunologic basis of antigen-induced airway hyperresponsiveness
3. STATs and gene regulation
4. Acquisition of lymphokine-producing phenorype by CD4+ T cells
5. T-helper type 2 cell-directed therapy for asthma
6. Transcriptional regulation of Th1/Th2 polarization
7. Signaling and transcription in T helper development
8. Disruption of the murine IL-4 gene blocks Th2 cytokine responses
9. An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice
10. The biology of Stat4 and Stat6
11. Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells
12. Essential role of Stat6 in IL-4 signalling
13. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
14. Stat6 regulation of in vivo IL-4 responses
15. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets
16. Ectopic expression of activated Stat6 induces the expression ofTh2-specific cytokines and transcription factors in developing Thl cells
17. Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion
18. Differential expression of chemokines in Th1 and Th2 cells is dependent on Stat6 but not on Stat4
19. Stat proteins control lymphocyte proliferation by regulating p27Kip1 expression
20. Impaired IL-12 responses and enhanced development of Th2 cells in Stac4-deficient mice
21. Identification of a Stat6-responsive element in the promoter of the human interleukin-4 gene
22. Stat6 inhibits human interleukin-4 promoter activity in T cells
23. T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6
24. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
25. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection
26. A novel transcription factor, T-bet, directs Th1 lineage commitment
27. T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells
28. Development of spontaneous changes consistent with human asthma in mice lacking T-bet
29. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain
30. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism
31. Treatment of allergic asthma with monoclonal anti-IgE antibody
32. IL-4/IL-13 signaling beyond JAK/STAT
33. Mechanism and regulation of immunoglobuiin isorype switching
34. STAT6 is required for IL-4-induced germline Ig gene transcription and switch recombination
35. SOCS proteins, regulators of intracellular signaling
36. Repression of IL-4-induced gene expression by IFN-gamma requires Stat1 activation
37. Inhibition of IL-4-inducible gene expression in human monocytes by type I and type II interferons
38. Control of inflammation, cytokine expression, and germinal center formation by BCL-6
39. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation
40. Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: Specific regulation of iepsilon transcription and immunoglobulin E switching
41. BCL-6-deficient mice reveal an IL-4-independent, STAT6-dependent pathway that controls susceptibility to infection by Leishmania major
42. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production
43. Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice
44. STAT6 deficiency in a mouse model of allergen-induced airways inflammation abolishes eosinophilia but induces infiltration oF CD8+ T cells
45. Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4
46. The failure of STAT6-deficient mice to develop eosinophilia and airway hyperresponsiveness is overcome by interleukin-5
47. Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation
48. Temporal association between airway hyperresponsiveness and airway eosinophilia in ovalbumin-sensitized mice
49. Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types
50. Analysis of cytokine signaling in patients with extrinsic asthma and hyperimmunoglobulin E
51. Th2 cytokine-associated transcription factors in atopic and nonatopic asthma: Evidence for differential signal transducer and activator of transcription 6 expression
52. Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium