메뉴 건너뛰기




Volumn 92, Issue 4, 2012, Pages 1619-1649

Stem cell factor receptor/c-Kit: From basic Science to clinical implications

Author keywords

[No Author keywords available]

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; ADAPTOR PROTEIN; CRK LIKE PROTEIN; DASATINIB; GELATINASE B; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; IMATINIB; INTERLEUKIN 33; INTERLEUKIN 7; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C BETA; PHOSPHOLIPASE C DELTA; PHOSPHOLIPASE C GAMMA; PHOSPHOLIPASE D; PROTEIN KINASE FYN; PROTEIN KINASE LYN; PROTEIN SH2; PROTEIN SH3; REACTIVE OXYGEN METABOLITE; STEM CELL FACTOR RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; UNINDEXED DRUG;

EID: 84867718489     PISSN: 00319333     EISSN: 15221210     Source Type: Journal    
DOI: 10.1152/physrev.00046.2011     Document Type: Article
Times cited : (612)

References (317)
  • 2
    • 58149177123 scopus 로고    scopus 로고
    • A KIT juxtamembrane PY567-directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis
    • Agosti V, Karur V, Sathyanarayana P, Besmer P, Wojchowski DM. A KIT juxtamembrane PY567-directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis. Exp Hematol 37: 159-171, 2009.
    • (2009) Exp Hematol , vol.37 , pp. 159-171
    • Agosti, V.1    Karur, V.2    Sathyanarayana, P.3    Besmer, P.4    Wojchowski, D.M.5
  • 3
    • 0026767488 scopus 로고
    • Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells
    • Alai M, Mui AL, Cutler RL, Bustelo XR, Barbacid M, Krystal G. Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells. J Biol Chem 267: 18021-18025, 1992.
    • (1992) J Biol Chem , vol.267 , pp. 18021-18025
    • Alai, M.1    Mui, A.L.2    Cutler, R.L.3    Bustelo, X.R.4    Barbacid, M.5    Krystal, G.6
  • 4
    • 0030002951 scopus 로고    scopus 로고
    • A cell- and developmental stage-specific promoter drives the expression of a truncated c-kit protein during mouse spermatid elongation
    • Albanesi C, Geremia R, Giorgio M, Dolci S, Sette C, Rossi P. A cell- and developmental stage-specific promoter drives the expression of a truncated c-kit protein during mouse spermatid elongation. Development 122: 1291-1302, 1996.
    • (1996) Development , vol.122 , pp. 1291-1302
    • Albanesi, C.1    Geremia, R.2    Giorgio, M.3    Dolci, S.4    Sette, C.5    Rossi, P.6
  • 5
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
    • Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PRJ, Reese CB, Cohen P. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 7: 261-269, 1997.
    • (1997) Curr Biol , vol.7 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3    Holmes, A.B.4    Gaffney, P.R.J.5    Reese, C.B.6    Cohen, P.7
  • 11
    • 77955642537 scopus 로고    scopus 로고
    • Pathogenesis, classification and treatment of mastocytosis: State of the art in 2010 and future perspectives
    • Arock M, Valent P. Pathogenesis, classification and treatment of mastocytosis: state of the art in 2010 and future perspectives. Expert Rev Hematol 3: 497-516, 2010.
    • (2010) Expert Rev Hematol , vol.3 , pp. 497-516
    • Arock, M.1    Valent, P.2
  • 12
    • 18244378763 scopus 로고    scopus 로고
    • UVB irradiation increases the release of SCF from human epidermal cells
    • Baba H, Uchiwa H, Watanabe S. UVB irradiation increases the release of SCF from human epidermal cells. J Invest Dermatol 124: 1075-1077, 2005.
    • (2005) J Invest Dermatol , vol.124 , pp. 1075-1077
    • Baba, H.1    Uchiwa, H.2    Watanabe, S.3
  • 16
    • 33646184769 scopus 로고    scopus 로고
    • The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins
    • Bayle J, Lopez S, Iwai K, Dubreuil P, De Sepulveda P. The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins. FEBS Lett 580: 2609-2614, 2006.
    • (2006) FEBS Lett , vol.580 , pp. 2609-2614
    • Bayle, J.1    Lopez, S.2    Iwai, K.3    Dubreuil, P.4    de Sepulveda, P.5
  • 17
    • 0029899578 scopus 로고    scopus 로고
    • Multiple pathways for Steel regulation suggested by genomic and sequence analysis of the murine Steel gene
    • Bedell MA, Copeland NG, Jenkins NA. Multiple pathways for Steel regulation suggested by genomic and sequence analysis of the murine Steel gene. Genetics 142: 927-934, 1996.
    • (1996) Genetics , vol.142 , pp. 927-934
    • Bedell, M.A.1    Copeland, N.G.2    Jenkins, N.A.3
  • 19
    • 0033786730 scopus 로고    scopus 로고
    • Rotational coupling of the transmembrane and kinase domains of the Neu receptor tyrosine kinase
    • Bell CA, Tynan JA, Hart KC, Meyer AN, Robertson SC, Donoghue DJ. Rotational coupling of the transmembrane and kinase domains of the Neu receptor tyrosine kinase. Mol Biol Cell 11: 3589-3599, 2000.
    • (2000) Mol Biol Cell , vol.11 , pp. 3589-3599
    • Bell, C.A.1    Tynan, J.A.2    Hart, K.C.3    Meyer, A.N.4    Robertson, S.C.5    Donoghue, D.J.6
  • 21
    • 33646858992 scopus 로고    scopus 로고
    • Inhibition of SCF attenuates peribronchial remodeling in chronic cockroach allergen-induced asthma
    • Berlin AA, Hogaboam CM, Lukacs NW. Inhibition of SCF attenuates peribronchial remodeling in chronic cockroach allergen-induced asthma. Lab Invest 86: 557-565, 2006.
    • (2006) Lab Invest , vol.86 , pp. 557-565
    • Berlin, A.A.1    Hogaboam, C.M.2    Lukacs, N.W.3
  • 22
    • 1842455152 scopus 로고    scopus 로고
    • Inhibition of stem cell factor reduces pulmonary cytokine levels during allergic airway responses
    • Berlin AA, Lincoln P, Tomkinson A, Lukacs NW. Inhibition of stem cell factor reduces pulmonary cytokine levels during allergic airway responses. Clin Exp Immunol 136: 15-20, 2004.
    • (2004) Clin Exp Immunol , vol.136 , pp. 15-20
    • Berlin, A.A.1    Lincoln, P.2    Tomkinson, A.3    Lukacs, N.W.4
  • 23
    • 11144239945 scopus 로고    scopus 로고
    • Treatment of cockroach allergen asthma model with imatinib attenuates airway responses
    • Berlin AA, Lukacs NW. Treatment of cockroach allergen asthma model with imatinib attenuates airway responses. Am J Respir Crit Care Med 171: 35-39, 2005.
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 35-39
    • Berlin, A.A.1    Lukacs, N.W.2
  • 24
    • 0029845831 scopus 로고    scopus 로고
    • Spatial and temporal patterns of c-kit-expressing cells in WlacZ/ and WlacZ/WlacZ mouse embryos
    • Bernex F, De Sepulveda P, Kress C, Elbaz C, Delouis C, Panthier JJ. Spatial and temporal patterns of c-kit-expressing cells in WlacZ/ and WlacZ/WlacZ mouse embryos. Development 122: 3023-3033, 1996.
    • (1996) Development , vol.122 , pp. 3023-3033
    • Bernex, F.1    de Sepulveda, P.2    Kress, C.3    Elbaz, C.4    Delouis, C.5    Panthier, J.J.6
  • 26
    • 0026039464 scopus 로고
    • Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis
    • Blume-Jensen P, Claesson-Welsh L, Siegbahn A, Zsebo KM, Westermark B, Heldin CH. Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis. EMBO J 10: 4121-4128, 1991.
    • (1991) EMBO J , vol.10 , pp. 4121-4128
    • Blume-Jensen, P.1    Claesson-Welsh, L.2    Siegbahn, A.3    Zsebo, K.M.4    Westermark, B.5    Heldin, C.H.6
  • 27
    • 0032543578 scopus 로고    scopus 로고
    • The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136
    • Blume-Jensen P, Janknecht R, Hunter T. The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136. Curr Biol 8: 779-782, 1998.
    • (1998) Curr Biol , vol.8 , pp. 779-782
    • Blume-Jensen, P.1    Janknecht, R.2    Hunter, T.3
  • 28
    • 0033981729 scopus 로고    scopus 로고
    • Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3′-kinase is essential for male fertility
    • Blume-Jensen P, Jiang G, Hyman R, Lee KF, O'Gorman S, Hunter T. Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3′-kinase is essential for male fertility. Nat Genet 24: 157-162, 2000.
    • (2000) Nat Genet , vol.24 , pp. 157-162
    • Blume-Jensen, P.1    Jiang, G.2    Hyman, R.3    Lee, K.F.4    O'Gorman, S.5    Hunter, T.6
  • 29
    • 0027965243 scopus 로고
    • Modulation of kit/stem cell factor receptor-induced signaling by protein kinase C
    • Blume-Jensen P, Rönnstrand L, Gout I, Waterfield MD, Heldin C. Modulation of kit/stem cell factor receptor-induced signaling by protein kinase C. J Biol Chem 269: 21793-21802, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 21793-21802
    • Blume-Jensen, P.1    Rönnstrand, L.2    Gout, I.3    Waterfield, M.D.4    Heldin, C.5
  • 30
    • 0027508336 scopus 로고
    • Increased kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C
    • Blume-Jensen P, Siegbahn A, Stabel S, Heldin C, Rönnstrand L. Increased kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C. EMBO J 12: 4199-4209, 1993.
    • (1993) EMBO J , vol.12 , pp. 4199-4209
    • Blume-Jensen, P.1    Siegbahn, A.2    Stabel, S.3    Heldin, C.4    Rönnstrand, L.5
  • 31
    • 0029034468 scopus 로고
    • Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells
    • Blume-Jensen P, Wernstedt C, Heldin CH, Rönnstrand L. Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells. J Biol Chem 270: 14192-14200, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 14192-14200
    • Blume-Jensen, P.1    Wernstedt, C.2    Heldin, C.H.3    Rönnstrand, L.4
  • 33
    • 0038554077 scopus 로고    scopus 로고
    • Biology of the p21-activated kinases
    • Bokoch GM. Biology of the p21-activated kinases. Annu Rev Biochem 72: 743-781, 2003.
    • (2003) Annu Rev Biochem , vol.72 , pp. 743-781
    • Bokoch, G.M.1
  • 34
    • 0033945106 scopus 로고    scopus 로고
    • Src family kinase activity is required for Kitmediated mitogen-activated protein (MAP) kinase activation, however loss of functional retinoblastoma protein makes MAP kinase activation unnecessary for growth of small cell lung cancer cells
    • Bondzi C, Litz J, Dent P, Krystal GW. Src family kinase activity is required for Kitmediated mitogen-activated protein (MAP) kinase activation, however loss of functional retinoblastoma protein makes MAP kinase activation unnecessary for growth of small cell lung cancer cells. Cell Growth Differ 11: 305-314, 2000.
    • (2000) Cell Growth Differ , vol.11 , pp. 305-314
    • Bondzi, C.1    Litz, J.2    Dent, P.3    Krystal, G.W.4
  • 35
    • 70349507344 scopus 로고    scopus 로고
    • The aberrant localization of oncogenic kit tyrosine kinase receptor mutants is reversed on specific inhibitory treatment
    • Bougherara H, Subra F, Crépin R, Tauc P, Auclair C, Poul MA. The aberrant localization of oncogenic kit tyrosine kinase receptor mutants is reversed on specific inhibitory treatment. Mol Cancer Res 7: 1525-1533, 2009.
    • (2009) Mol Cancer Res , vol.7 , pp. 1525-1533
    • Bougherara, H.1    Subra, F.2    Crépin, R.3    Tauc, P.4    Auclair, C.5    Poul, M.A.6
  • 36
    • 0033515625 scopus 로고    scopus 로고
    • A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain
    • Brodbeck D, Cron P, Hemmings BA. A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J Biol Chem 274: 9133-9136, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 9133-9136
    • Brodbeck, D.1    Cron, P.2    Hemmings, B.A.3
  • 37
    • 33947203621 scopus 로고    scopus 로고
    • PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
    • Brognard J, Sierecki E, Gao T, Newton AC. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell 25: 917-931, 2007.
    • (2007) Mol Cell , vol.25 , pp. 917-931
    • Brognard, J.1    Sierecki, E.2    Gao, T.3    Newton, A.C.4
  • 38
    • 0030846533 scopus 로고    scopus 로고
    • Stem cell factor and hematopoiesis
    • Broudy V. Stem cell factor and hematopoiesis. Blood 90: 1345-1364, 1997.
    • (1997) Blood , vol.90 , pp. 1345-1364
    • Broudy, V.1
  • 39
    • 0032006690 scopus 로고    scopus 로고
    • Analysis of c-kit receptor dimerization by fluorescence resonance energy transfer
    • Broudy VC, Lin NL, Bühring HJ, Komatsu N, Kavanagh TJ. Analysis of c-kit receptor dimerization by fluorescence resonance energy transfer. Blood 91: 898-906, 1998.
    • (1998) Blood , vol.91 , pp. 898-906
    • Broudy, V.C.1    Lin, N.L.2    Bühring, H.J.3    Komatsu, N.4    Kavanagh, T.J.5
  • 40
    • 0033568568 scopus 로고    scopus 로고
    • Signaling via Src family kinases is required for normal internalization of the receptor c-Kit
    • Broudy VC, Lin NL, Liles WC, Corey SJ, O'Laughlin B, Mou S, Linnekin D. Signaling via Src family kinases is required for normal internalization of the receptor c-Kit. Blood 94: 1979-1986, 1999.
    • (1999) Blood , vol.94 , pp. 1979-1986
    • Broudy, V.C.1    Lin, N.L.2    Liles, W.C.3    Corey, S.J.4    O'Laughlin, B.5    Mou, S.6    Linnekin, D.7
  • 41
    • 59749095198 scopus 로고    scopus 로고
    • Protein scaffolds in MAP kinase signalling
    • Brown MD, Sacks DB. Protein scaffolds in MAP kinase signalling. Cell Signal 21: 462-469, 2009.
    • (2009) Cell Signal , vol.21 , pp. 462-469
    • Brown, M.D.1    Sacks, D.B.2
  • 43
    • 0035162703 scopus 로고    scopus 로고
    • Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking
    • Burke P, Schooler K, Wiley HS. Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking. Mol Biol Cell 12: 1897-1910, 2001.
    • (2001) Mol Biol Cell , vol.12 , pp. 1897-1910
    • Burke, P.1    Schooler, K.2    Wiley, H.S.3
  • 44
    • 43149106507 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for alpha-platelet-derived growth factor receptor-induced production of reactive oxygen species
    • Bäumer AT, Ten Freyhaus H, Sauer H, Wartenberg M, Kappert K, Schnabel P, Konkol C, Hescheler J, Vantler M, Rosenkranz S. Phosphatidylinositol 3-kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for alpha-platelet-derived growth factor receptor-induced production of reactive oxygen species. J Biol Chem 283: 7864-7876, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 7864-7876
    • Bäumer, A.T.1    Ten, F.H.2    Sauer, H.3    Wartenberg, M.4    Kappert, K.5    Schnabel, P.6    Konkol, C.7    Hescheler, J.8    Vantler, M.9    Rosenkranz, S.10
  • 46
    • 0033619144 scopus 로고    scopus 로고
    • Isoforms of c-KIT differ in activation of signalling pathways and transformation of NIH3T3 fibroblasts
    • Caruana G, Cambareri AC, Ashman LK. Isoforms of c-KIT differ in activation of signalling pathways and transformation of NIH3T3 fibroblasts. Oncogene 18: 5573-5581, 1999.
    • (1999) Oncogene , vol.18 , pp. 5573-5581
    • Caruana, G.1    Cambareri, A.C.2    Ashman, L.K.3
  • 47
    • 0023694835 scopus 로고
    • The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus
    • Chabot B, Stephenson DA, Chapman VM, Besmer P, Bernstein A. The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 335: 88-89, 1988.
    • (1988) Nature , vol.335 , pp. 88-89
    • Chabot, B.1    Stephenson, D.A.2    Chapman, V.M.3    Besmer, P.4    Bernstein, A.5
  • 48
    • 0037405026 scopus 로고    scopus 로고
    • Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region
    • Chan PM, Ilangumaran S, La Rose J, Chakrabartty A, Rottapel R. Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region. Mol Cell Biol 23: 3067-3078, 2003.
    • (2003) Mol Cell Biol , vol.23 , pp. 3067-3078
    • Chan, P.M.1    Ilangumaran, S.2    la Rose, J.3    Chakrabartty, A.4    Rottapel, R.5
  • 53
    • 0141815693 scopus 로고    scopus 로고
    • Regulation of Raf through phosphorylation and N Terminus-C Terminus Interaction
    • Chong H, Guan KL. Regulation of Raf through phosphorylation and N terminus-C terminus interaction. J Biol Chem 278: 36269-36276, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 36269-36276
    • Chong, H.1    Guan, K.L.2
  • 55
  • 58
    • 0027235872 scopus 로고
    • Expression of isoforms of the human receptor tyrosine kinase c-kit in leukemic cell lines and acute myeloid leukemia
    • Crosier PS, Ricciardi ST, Hall LR, Vitas MR, Clark SC, Crosier KE. Expression of isoforms of the human receptor tyrosine kinase c-kit in leukemic cell lines and acute myeloid leukemia. Blood 82: 1151-1158, 1993.
    • (1993) Blood , vol.82 , pp. 1151-1158
    • Crosier, P.S.1    Ricciardi, S.T.2    Hall, L.R.3    Vitas, M.R.4    Clark, S.C.5    Crosier, K.E.6
  • 59
    • 0023919865 scopus 로고
    • Localization of the human c-kit protooncogene on the q11-q12 region of chromosome 4
    • d'Auriol L, Mattei MG, Andre C, Galibert F. Localization of the human c-kit protooncogene on the q11-q12 region of chromosome 4. Hum Genet 78: 374-376, 1988.
    • (1988) Hum Genet , vol.78 , pp. 374-376
    • D'Auriol, L.1    Mattei, M.G.2    Andre, C.3    Galibert, F.4
  • 60
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91: 231-241, 1997.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 63
    • 25644448151 scopus 로고    scopus 로고
    • Neuroprotection by stem cell factor in rat cortical neurons involves AKT and NFkappaB
    • Dhandapani KM, Wade FM, Wakade C, Mahesh VB, Brann DW. Neuroprotection by stem cell factor in rat cortical neurons involves AKT and NFkappaB. J Neurochem 95: 9-19, 2005.
    • (2005) J Neurochem , vol.95 , pp. 9-19
    • Dhandapani, K.M.1    Wade, F.M.2    Wakade, C.3    Mahesh, V.B.4    Brann, D.W.5
  • 64
    • 0035817343 scopus 로고    scopus 로고
    • p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl)
    • Di Cristofano A, Niki M, Zhao M, Karnell FG, Clarkson B, Pear WS, Van Aelst L, Pandolfi PP. p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl). J Exp Med 194: 275-284, 2001.
    • (2001) J Exp Med , vol.194 , pp. 275-284
    • Di Cristofano, A.1    Niki, M.2    Zhao, M.3    Karnell, F.G.4    Clarkson, B.5    Pear, W.S.6    van Aelst, L.7    Pandolfi, P.P.8
  • 65
    • 77950617070 scopus 로고    scopus 로고
    • Function of activation loop tyrosine phosphorylation in the mechanism of c-Kit auto-activation and its implication in sunitinib resistance
    • DiNitto JP, Deshmukh GD, Zhang Y, Jacques SL, Coli R, Worrall JW, Diehl W, English JM, Wu JC. Function of activation loop tyrosine phosphorylation in the mechanism of c-Kit auto-activation and its implication in sunitinib resistance. J Biochem 147: 601-609, 2010.
    • (2010) J Biochem , vol.147 , pp. 601-609
    • Dinitto, J.P.1    Deshmukh, G.D.2    Zhang, Y.3    Jacques, S.L.4    Coli, R.5    Worrall, J.W.6    Diehl, W.7    English, J.M.8    Wu, J.C.9
  • 66
    • 0037082489 scopus 로고    scopus 로고
    • Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl() K562 leukemic cells by Gab2
    • Dorsey JF, Cunnick JM, Mane SM, Wu J. Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl() K562 leukemic cells by Gab2. Blood 99: 1388-1397, 2002.
    • (2002) Blood , vol.99 , pp. 1388-1397
    • Dorsey, J.F.1    Cunnick, J.M.2    Mane, S.M.3    Wu, J.4
  • 69
    • 0034670022 scopus 로고    scopus 로고
    • SCF and G-CSF lead to the synergistic induction of proliferation and gene expression through complementary signaling pathways
    • Duarte RF, Frank DA. SCF and G-CSF lead to the synergistic induction of proliferation and gene expression through complementary signaling pathways. Blood 96: 3422-3430, 2000.
    • (2000) Blood , vol.96 , pp. 3422-3430
    • Duarte, R.F.1    Frank, D.A.2
  • 70
    • 33845874383 scopus 로고    scopus 로고
    • Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation
    • Edling CE, Pedersen M, Carlsson L, Rönnstrand L, Palmer RH, Hallberg B. Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation. Br J Haematol 136: 260-268, 2007.
    • (2007) Br J Haematol , vol.136 , pp. 260-268
    • Edling, C.E.1    Pedersen, M.2    Carlsson, L.3    Rönnstrand, L.4    Palmer, R.H.5    Hallberg, B.6
  • 71
    • 0037385088 scopus 로고    scopus 로고
    • Inactivation of the forkhead transcription factor FoxO3 is essential for PKB-mediated survival of hematopoietic progenitor cells by kit ligand
    • Engström M, Karlsson R, Jönsson JI. Inactivation of the forkhead transcription factor FoxO3 is essential for PKB-mediated survival of hematopoietic progenitor cells by kit ligand. Exp Hematol 31: 316-323, 2003.
    • (2003) Exp Hematol , vol.31 , pp. 316-323
    • Engström, M.1    Karlsson, R.2    Jönsson, J.I.3
  • 72
    • 40449105049 scopus 로고    scopus 로고
    • Activation of c-kit is necessary for mobilization of reparative bone marrow progenitor cells in response to cardiac injury
    • Fazel SS, Chen L, Angoulvant D, Li SH, Weisel RD, Keating A, Li RK. Activation of c-kit is necessary for mobilization of reparative bone marrow progenitor cells in response to cardiac injury. FASEB J 22: 930-940, 2008.
    • (2008) FASEB J , vol.22 , pp. 930-940
    • Fazel, S.S.1    Chen, L.2    Angoulvant, D.3    Li, S.H.4    Weisel, R.D.5    Keating, A.6    Li, R.K.7
  • 74
    • 0034682805 scopus 로고    scopus 로고
    • Stem cell factor/c-kit up-regulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogonia
    • Feng LX, Ravindranath N, Dym M. Stem cell factor/c-kit up-regulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogonia. J Biol Chem 275: 25572-25576, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 25572-25576
    • Feng, L.X.1    Ravindranath, N.2    Dym, M.3
  • 75
    • 0035113157 scopus 로고    scopus 로고
    • Local administration of antisense phosphorothioate oligonucleotides to the c-kit ligand, stem cell factor, suppresses airway inflammation and IL-4 production in a murine model of asthma
    • Finotto S, Buerke M, Lingnau K, Schmitt E, Galle PR, Neurath MF. Local administration of antisense phosphorothioate oligonucleotides to the c-kit ligand, stem cell factor, suppresses airway inflammation and IL-4 production in a murine model of asthma. J Allergy Clin Immunol 107: 279-286, 2001.
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 279-286
    • Finotto, S.1    Buerke, M.2    Lingnau, K.3    Schmitt, E.4    Galle, P.R.5    Neurath, M.F.6
  • 76
    • 5344278232 scopus 로고    scopus 로고
    • Contribution of reactive oxygen species to the regulation of Glut1 in two hemopoietic cell lines differing in cytokine sensitivity
    • Fiorentini D, Prata C, Maraldi T, Zambonin L, Bonsi L, Hakim G, Landi L. Contribution of reactive oxygen species to the regulation of Glut1 in two hemopoietic cell lines differing in cytokine sensitivity. Free Radic Biol Med 37: 1402-1411, 2004.
    • (2004) Free Radic Biol Med , vol.37 , pp. 1402-1411
    • Fiorentini, D.1    Prata, C.2    Maraldi, T.3    Zambonin, L.4    Bonsi, L.5    Hakim, G.6    Landi, L.7
  • 77
    • 34248578455 scopus 로고    scopus 로고
    • Targeting receptor tyrosine kinase signalling in small cell lung cancer (SCLC): What have we learned so far?
    • Fischer B, Marinov M, Arcaro A. Targeting receptor tyrosine kinase signalling in small cell lung cancer (SCLC): what have we learned so far? Cancer Treat Rev 33: 391-406, 2007.
    • (2007) Cancer Treat Rev , vol.33 , pp. 391-406
    • Fischer, B.1    Marinov, M.2    Arcaro, A.3
  • 78
    • 0038731316 scopus 로고    scopus 로고
    • Juxtamembrane mutant V560GKit is more sensitive to Imatinib (STI571) compared with wild-type c-kit whereas the kinase domain mutant D816VKit is resistant
    • Frost MJ, Ferrao PT, Hughes TP, Ashman LK. Juxtamembrane mutant V560GKit is more sensitive to Imatinib (STI571) compared with wild-type c-kit whereas the kinase domain mutant D816VKit is resistant. Mol Cancer Ther 1: 1115-1124, 2002.
    • (2002) Mol Cancer Ther , vol.1 , pp. 1115-1124
    • Frost, M.J.1    Ferrao, P.T.2    Hughes, T.P.3    Ashman, L.K.4
  • 79
    • 15944406764 scopus 로고    scopus 로고
    • PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
    • Gao T, Furnari F, Newton AC. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 18: 13-24, 2005.
    • (2005) Mol Cell , vol.18 , pp. 13-24
    • Gao, T.1    Furnari, F.2    Newton, A.C.3
  • 80
    • 80051472789 scopus 로고    scopus 로고
    • MicroRNA-193b regulates c-Kit protooncogene and represses cell proliferation in acute myeloid leukemia
    • Gao XN, Lin J, Gao L, Li YH, Wang LL, Yu L. MicroRNA-193b regulates c-Kit protooncogene and represses cell proliferation in acute myeloid leukemia. Leuk Res 35: 1226-1232, 2011.
    • (2011) Leuk Res , vol.35 , pp. 1226-1232
    • Gao, X.N.1    Lin, J.2    Gao, L.3    Li, Y.H.4    Wang, L.L.5    Yu, L.6
  • 82
    • 0024280901 scopus 로고
    • The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene
    • Geissler EN, Ryan MA, Housman DE. The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 55: 185-192, 1988.
    • (1988) Cell , vol.55 , pp. 185-192
    • Geissler, E.N.1    Ryan, M.A.2    Housman, D.E.3
  • 83
    • 0025940323 scopus 로고
    • Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism
    • Giebel LB, Spritz RA. Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism. Proc Natl Acad Sci USA 88: 8696-8699, 1991.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 8696-8699
    • Giebel, L.B.1    Spritz, R.A.2
  • 84
    • 0024382542 scopus 로고
    • Novel tyrosine kinase substrates from Rous sarcoma virustransformed cells are present in the membrane skeleton
    • Glenney JR Jr, Zokas L. Novel tyrosine kinase substrates from Rous sarcoma virustransformed cells are present in the membrane skeleton. J Cell Biol 108: 2401-2408, 1989.
    • (1989) J Cell Biol , vol.108 , pp. 2401-2408
    • Glenney Jr., J.R.1    Zokas, L.2
  • 85
    • 0034548829 scopus 로고    scopus 로고
    • Differential stimulation of c-Kit mutants by membrane-bound and soluble Steel Factor correlates with leukemic potential
    • Gommerman JL, Sittaro D, Klebasz NZ, Williams DA, Berger SA. Differential stimulation of c-Kit mutants by membrane-bound and soluble Steel Factor correlates with leukemic potential. Blood 96: 3734-3742, 2000.
    • (2000) Blood , vol.96 , pp. 3734-3742
    • Gommerman, J.L.1    Sittaro, D.2    Klebasz, N.Z.3    Williams, D.A.4    Berger, S.A.5
  • 86
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre ME, Mohammed M, Ellwood K, Hsu N, Paquette R, Rao PN, Sawyers CL. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293: 876-880, 2001.
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3    Hsu, N.4    Paquette, R.5    Rao, P.N.6    Sawyers, C.L.7
  • 87
    • 0026701674 scopus 로고
    • A highly conserved tyrosine residue at codon 845 within the kinase domain is not required for the transforming activity of human epidermal growth factor receptor
    • Gotoh N, Tojo A, Hino M, Yazaki Y, Shibuya M. A highly conserved tyrosine residue at codon 845 within the kinase domain is not required for the transforming activity of human epidermal growth factor receptor. Biochem Biophys Res Commun 186: 768-774, 1992.
    • (1992) Biochem Biophys Res Commun , vol.186 , pp. 768-774
    • Gotoh, N.1    Tojo, A.2    Hino, M.3    Yazaki, Y.4    Shibuya, M.5
  • 88
    • 4744342856 scopus 로고    scopus 로고
    • Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation
    • Grovdal LM, Stang E, Sorkin A, Madshus IH. Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation. Exp Cell Res 300: 388-395, 2004.
    • (2004) Exp Cell Res , vol.300 , pp. 388-395
    • Grovdal, L.M.1    Stang, E.2    Sorkin, A.3    Madshus, I.H.4
  • 89
    • 34548192289 scopus 로고    scopus 로고
    • Molecular detection of GNNK and GNNK c-kit isoforms: A new tool for risk stratification in adult acute myeloid leukaemia
    • Guerrini F, Galimberti S, Ciabatti E, Brizzi S, Testi R, Pollastrini A, Falini B, Petrini M. Molecular detection of GNNK and GNNK c-kit isoforms: a new tool for risk stratification in adult acute myeloid leukaemia. Leukemia 21: 2056-2058, 2007.
    • (2007) Leukemia , vol.21 , pp. 2056-2058
    • Guerrini, F.1    Galimberti, S.2    Ciabatti, E.3    Brizzi, S.4    Testi, R.5    Pollastrini, A.6    Falini, B.7    Petrini, M.8
  • 90
    • 0035049360 scopus 로고    scopus 로고
    • The paracrine role of stem cell factor/c-kit signaling in the activation of human melanocytes in ultraviolet-Binduced pigmentation
    • Hachiya A, Kobayashi A, Ohuchi A, Takema Y, Imokawa G. The paracrine role of stem cell factor/c-kit signaling in the activation of human melanocytes in ultraviolet-Binduced pigmentation. J Invest Dermatol 116: 578-586, 2001.
    • (2001) J Invest Dermatol , vol.116 , pp. 578-586
    • Hachiya, A.1    Kobayashi, A.2    Ohuchi, A.3    Takema, Y.4    Imokawa, G.5
  • 92
    • 0035473462 scopus 로고    scopus 로고
    • The Grb7 family proteins: Structure, interactions with other signaling molecules and potential cellular functions
    • Han DC, Shen TL, Guan JL. The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions. Oncogene 20: 6315-6321, 2001.
    • (2001) Oncogene , vol.20 , pp. 6315-6321
    • Han, D.C.1    Shen, T.L.2    Guan, J.L.3
  • 93
    • 51849108509 scopus 로고    scopus 로고
    • Hypoxia-inducible factor (HIF)-1 alpha directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF)
    • Han ZB, Ren H, Zhao H, Chi Y, Chen K, Zhou B, Liu YJ, Zhang L, Xu B, Liu B, Yang R, Han ZC. Hypoxia-inducible factor (HIF)-1 alpha directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF). Carcinogenesis 29: 1853-1861, 2008.
    • (2008) Carcinogenesis , vol.29 , pp. 1853-1861
    • Han, Z.B.1    Ren, H.2    Zhao, H.3    Chi, Y.4    Chen, K.5    Zhou, B.6    Liu, Y.J.7    Zhang, L.8    Xu, B.9    Liu, B.10    Yang, R.11    Han, Z.C.12
  • 94
    • 2542433976 scopus 로고    scopus 로고
    • Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty
    • Hanafusa H, Torii S, Yasunaga T, Matsumoto K, Nishida E. Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty. J Biol Chem 279: 22992-22995, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 22992-22995
    • Hanafusa, H.1    Torii, S.2    Yasunaga, T.3    Matsumoto, K.4    Nishida, E.5
  • 95
    • 42049123098 scopus 로고    scopus 로고
    • Target spectrum of the BCR-ABL inhibitors imatinib, nilotinib and dasatinib
    • Hantschel O, Rix U, Superti-Furga G. Target spectrum of the BCR-ABL inhibitors imatinib, nilotinib and dasatinib. Leuk Lymphoma 49: 615-619, 2008.
    • (2008) Leuk Lymphoma , vol.49 , pp. 615-619
    • Hantschel, O.1    Rix, U.2    Superti-Furga, G.3
  • 96
    • 0029117423 scopus 로고
    • Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl
    • Hartley D, Meisner H, Corvera S. Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl. J Biol Chem 270: 18260-18263, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 18260-18263
    • Hartley, D.1    Meisner, H.2    Corvera, S.3
  • 97
    • 0037305583 scopus 로고    scopus 로고
    • Necessity of tyrosine 719 and phosphatidylinositol 3'-kinase-mediated signal pathway in constitutive activation and oncogenic potential of c-Kit receptor tyrosine kinase with the Asp814Val mutation
    • Hashimoto K, Matsumura I, Tsujimura T, Kim D, Ogihara H, Ikeda H, Ueda S, Mizuki M, Sugahara H, Shibayama H, Kitamura Y, Kanakura Y. Necessity of tyrosine 719 and phosphatidylinositol 3'-kinase-mediated signal pathway in constitutive activation and oncogenic potential of c-Kit receptor tyrosine kinase with the Asp814Val mutation. Blood 101: 1094-1102, 2003.
    • (2003) Blood , vol.101 , pp. 1094-1102
    • Hashimoto, K.1    Matsumura, I.2    Tsujimura, T.3    Kim, D.4    Ogihara, H.5    Ikeda, H.6    Ueda, S.7    Mizuki, M.8    Sugahara, H.9    Shibayama, H.10    Kitamura, Y.11    Kanakura, Y.12
  • 98
    • 0026096497 scopus 로고
    • Exon skipping by mutation of an authentic splice site of c-kit gene in W/W mouse
    • Hayashi S, Kunisada T, Ogawa M, Yamaguchi K, Nishikawa S. Exon skipping by mutation of an authentic splice site of c-kit gene in W/W mouse. Nucleic Acids Res 19: 1267-1271, 1991.
    • (1991) Nucleic Acids Res , vol.19 , pp. 1267-1271
    • Hayashi, S.1    Kunisada, T.2    Ogawa, M.3    Yamaguchi, K.4    Nishikawa, S.5
  • 99
    • 0037087531 scopus 로고    scopus 로고
    • Inhibition of KIT tyrosine kinase activity: A novel molecular approach to the treatment of KIT-positive malignancies
    • Heinrich MC, Blanke CD, Druker BJ, Corless CL. Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies. J Clin Oncol 20: 1692-1703, 2002.
    • (2002) J Clin Oncol , vol.20 , pp. 1692-1703
    • Heinrich, M.C.1    Blanke, C.D.2    Druker, B.J.3    Corless, C.L.4
  • 101
    • 0034254249 scopus 로고    scopus 로고
    • Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor
    • Heinrich MC, Griffith DJ, Druker BJ, Wait CL, Ott KA, Zigler AJ. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood 96: 925-932, 2000.
    • (2000) Blood , vol.96 , pp. 925-932
    • Heinrich, M.C.1    Griffith, D.J.2    Druker, B.J.3    Wait, C.L.4    Ott, K.A.5    Zigler, A.J.6
  • 103
    • 0142092593 scopus 로고    scopus 로고
    • Role of c-kit/Kit ligand signaling in regulating vasculogenesis
    • Heissig B, Werb Z, Rafii S, Hattori K. Role of c-kit/Kit ligand signaling in regulating vasculogenesis. Thromb Haemost 90: 570-576, 2003.
    • (2003) Thromb Haemost , vol.90 , pp. 570-576
    • Heissig, B.1    Werb, Z.2    Rafii, S.3    Hattori, K.4
  • 104
    • 0032518262 scopus 로고    scopus 로고
    • MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes
    • Hemesath TJ, Price ER, Takemoto C, Badalian T, Fisher DE. MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes. Nature 391: 298-301, 1998.
    • (1998) Nature , vol.391 , pp. 298-301
    • Hemesath, T.J.1    Price, E.R.2    Takemoto, C.3    Badalian, T.4    Fisher, D.E.5
  • 105
    • 78650881154 scopus 로고    scopus 로고
    • Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT
    • Herraiz C, Journe F, Abdel-Malek Z, Ghanem G, Jimenez-Cervantes C, Garcia-Borron JC. Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT. Mol Endocrinol 25: 138-156.
    • Mol Endocrinol , vol.25 , pp. 138-156
    • Herraiz, C.1    Journe, F.2    Abdel-Malek, Z.3    Ghanem, G.4    Jimenez-Cervantes, C.5    Garcia-Borron, J.C.6
  • 109
    • 15044339712 scopus 로고    scopus 로고
    • Compartmentalization of growth factor receptor signalling
    • Hoeller D, Volarevic S, Dikic I. Compartmentalization of growth factor receptor signalling. Curr Opin Cell Biol 17: 107-111, 2005.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 107-111
    • Hoeller, D.1    Volarevic, S.2    Dikic, I.3
  • 110
    • 1642458352 scopus 로고    scopus 로고
    • c-Kit-mediated overlapping and unique functional and biochemical outcomes via diverse signaling pathways
    • Hong L, Munugalavadla V, Kapur R. c-Kit-mediated overlapping and unique functional and biochemical outcomes via diverse signaling pathways. Mol Cell Biol 24: 1401-1410, 2004.
    • (2004) Mol Cell Biol , vol.24 , pp. 1401-1410
    • Hong, L.1    Munugalavadla, V.2    Kapur, R.3
  • 111
    • 45449106335 scopus 로고    scopus 로고
    • KIT associated intracellular tyrosines play an essential role in EpoR co-signaling
    • Hong L, Ramdas B, Chen J, Harris C, Wojchowski DM, Kapur R. KIT associated intracellular tyrosines play an essential role in EpoR co-signaling. Cell Signal 20: 1513-1520, 2008.
    • (2008) Cell Signal , vol.20 , pp. 1513-1520
    • Hong, L.1    Ramdas, B.2    Chen, J.3    Harris, C.4    Wojchowski, D.M.5    Kapur, R.6
  • 112
    • 0032479996 scopus 로고    scopus 로고
    • Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis
    • Huang S, Jean D, Luca M, Tainsky MA, Bar-Eli M. Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis. EMBO J 17: 4358-4369, 1998.
    • (1998) EMBO J , vol.17 , pp. 4358-4369
    • Huang, S.1    Jean, D.2    Luca, M.3    Tainsky, M.A.4    Bar-Eli, M.5
  • 113
    • 0030459095 scopus 로고    scopus 로고
    • Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential
    • Huang S, Luca M, Gutman M, McConkey DJ, Langley KE, Lyman SD, Bar-Eli M. Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential. Oncogene 13: 2339-2347, 1996.
    • (1996) Oncogene , vol.13 , pp. 2339-2347
    • Huang, S.1    Luca, M.2    Gutman, M.3    McConkey, D.J.4    Langley, K.E.5    Lyman, S.D.6    Bar-Eli, M.7
  • 114
    • 0030766163 scopus 로고    scopus 로고
    • Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog
    • Hubbard SR. Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog. EMBO J 16: 5572-5581, 1997.
    • (1997) EMBO J , vol.16 , pp. 5572-5581
    • Hubbard, S.R.1
  • 115
  • 117
    • 58549089539 scopus 로고    scopus 로고
    • MicroRNA-dependent regulation of cKit in cutaneous melanoma
    • Igoucheva O, Alexeev V. MicroRNA-dependent regulation of cKit in cutaneous melanoma. Biochem Biophys Res Commun 379: 790-794, 2009.
    • (2009) Biochem Biophys Res Commun , vol.379 , pp. 790-794
    • Igoucheva, O.1    Alexeev, V.2
  • 121
    • 0037019184 scopus 로고    scopus 로고
    • Analysing c-kit internalization using a functional c-kit-EGFP chimera containing the fluorochrome within the extracellular domain
    • Jahn T, Seipel P, Coutinho S, Urschel S, Schwarz K, Miething C, Serve H, Peschel C, Duyster J. Analysing c-kit internalization using a functional c-kit-EGFP chimera containing the fluorochrome within the extracellular domain. Oncogene 21: 4508-4520, 2002.
    • (2002) Oncogene , vol.21 , pp. 4508-4520
    • Jahn, T.1    Seipel, P.2    Coutinho, S.3    Urschel, S.4    Schwarz, K.5    Miething, C.6    Serve, H.7    Peschel, C.8    Duyster, J.9
  • 125
    • 58449089776 scopus 로고    scopus 로고
    • Stem cell factor induces ERM proteins phosphorylation through PI3K activation to mediate melanocyte proliferation and migration
    • Jeon S, Kim NH, Kim JY, Lee AY. Stem cell factor induces ERM proteins phosphorylation through PI3K activation to mediate melanocyte proliferation and migration. Pigment Cell Melanoma Res 22: 77-85, 2009.
    • (2009) Pigment Cell Melanoma Res , vol.22 , pp. 77-85
    • Jeon, S.1    Kim, N.H.2    Kim, J.Y.3    Lee, A.Y.4
  • 126
    • 0036327375 scopus 로고    scopus 로고
    • Stem cell factor stimulates neurogenesis in vitro and in vivo
    • Jin K, Mao XO, Sun Y, Xie L, Greenberg DA. Stem cell factor stimulates neurogenesis in vitro and in vivo. J Clin Invest 110: 311-319, 2002.
    • (2002) J Clin Invest , vol.110 , pp. 311-319
    • Jin, K.1    Mao, X.O.2    Sun, Y.3    Xie, L.4    Greenberg, D.A.5
  • 127
    • 0031441424 scopus 로고    scopus 로고
    • Analysis of synergism between stem cell factor and granulocyte-macrophage colony-stimulating factor on human megakaryoblastic cells: An increase in tyrosine phosphorylation of 145 kDa subunit of c-kit in two-factor combination
    • Kamijo T, Koike K, Takeuchi K, Higuchi T, Sawai N, Kikuchi T, Tsumura H, Akiyama H, Koike T, Ishii E, Komiyama A. Analysis of synergism between stem cell factor and granulocyte-macrophage colony-stimulating factor on human megakaryoblastic cells: an increase in tyrosine phosphorylation of 145 kDa subunit of c-kit in two-factor combination. Leuk Res 21: 1097-1106, 1997.
    • (1997) Leuk Res , vol.21 , pp. 1097-1106
    • Kamijo, T.1    Koike, K.2    Takeuchi, K.3    Higuchi, T.4    Sawai, N.5    Kikuchi, T.6    Tsumura, H.7    Akiyama, H.8    Koike, T.9    Ishii, E.10    Komiyama, A.11
  • 128
    • 0027220685 scopus 로고
    • Expression, function and activation of the proto-oncogene c-kit product in human leukemia cells
    • Kanakura Y, Ikeda H, Kitayama H, Sugahara H, Furitsu T. Expression, function and activation of the proto-oncogene c-kit product in human leukemia cells. Leuk Lymphoma 10: 35-41, 1993.
    • (1993) Leuk Lymphoma , vol.10 , pp. 35-41
    • Kanakura, Y.1    Ikeda, H.2    Kitayama, H.3    Sugahara, H.4    Furitsu, T.5
  • 130
    • 0035846993 scopus 로고    scopus 로고
    • A novel mechanism of cooperation between c-Kit and erythropoietin receptor. Stem cell factor induces the expression of Stat5 and erythropoietin receptor, resulting in efficient proliferation and survival by erythropoietin
    • Kapur R, Zhang L. A novel mechanism of cooperation between c-Kit and erythropoietin receptor. Stem cell factor induces the expression of Stat5 and erythropoietin receptor, resulting in efficient proliferation and survival by erythropoietin. J Biol Chem 276: 1099-1106, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 1099-1106
    • Kapur, R.1    Zhang, L.2
  • 131
    • 0034537923 scopus 로고    scopus 로고
    • Impairment of spatial learning and hippocampal synaptic potentiation in c-kit mutant rats
    • Katafuchi T, Li AJ, Hirota S, Kitamura Y, Hori T. Impairment of spatial learning and hippocampal synaptic potentiation in c-kit mutant rats. Learn Mem 7: 383-392, 2000.
    • (2000) Learn Mem , vol.7 , pp. 383-392
    • Katafuchi, T.1    Li, A.J.2    Hirota, S.3    Kitamura, Y.4    Hori, T.5
  • 132
    • 0025850522 scopus 로고
    • Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development
    • Keshet E, Lyman SD, Williams DE, Anderson DM, Jenkins NA, Copeland NG, Parada LF. Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development. EMBO J 10: 2425-2435, 1991.
    • (1991) EMBO J , vol.10 , pp. 2425-2435
    • Keshet, E.1    Lyman, S.D.2    Williams, D.E.3    Anderson, D.M.4    Jenkins, N.A.5    Copeland, N.G.6    Parada, L.F.7
  • 133
    • 44449141488 scopus 로고    scopus 로고
    • Activation and function of the mTORC1 pathway in mast cells
    • Kim MS, Kuehn HS, Metcalfe DD, Gilfillan AM. Activation and function of the mTORC1 pathway in mast cells. J Immunol 180: 4586-4595, 2008.
    • (2008) J Immunol , vol.180 , pp. 4586-4595
    • Kim, M.S.1    Kuehn, H.S.2    Metcalfe, D.D.3    Gilfillan, A.M.4
  • 135
    • 0033215406 scopus 로고    scopus 로고
    • Demonstration that human mast cells arise from a progenitor cell population that is CD34(), c-kit(), expresses aminopeptidase N (CD13)
    • Kirshenbaum AS, Goff JP, Semere T, Foster B, Scott LM, Metcalfe DD. Demonstration that human mast cells arise from a progenitor cell population that is CD34(), c-kit(), expresses aminopeptidase N (CD13). Blood 94: 2333-2342, 1999.
    • (1999) Blood , vol.94 , pp. 2333-2342
    • Kirshenbaum, A.S.1    Goff, J.P.2    Semere, T.3    Foster, B.4    Scott, L.M.5    Metcalfe, D.D.6
  • 136
    • 0034654307 scopus 로고    scopus 로고
    • Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses
    • Kissel H, Timokhina I, Hardy MP, Rothschild G, Tajima Y, Soares V, Angeles M, Whitlow SR, Manova K, Besmer P. Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses. EMBO J 19: 1312-1326, 2000.
    • (2000) EMBO J , vol.19 , pp. 1312-1326
    • Kissel, H.1    Timokhina, I.2    Hardy, M.P.3    Rothschild, G.4    Tajima, Y.5    Soares, V.6    Angeles, M.7    Whitlow, S.R.8    Manova, K.9    Besmer, P.10
  • 137
    • 0028959163 scopus 로고
    • Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines
    • Kitayama H, Kanakura Y, Furitsu T, Tsujimura T, Oritani K, Ikeda H, Sugahara H, Mitsui H, Kanayama Y, Kitamura Y, Matsuzawa Y. Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines. Blood 85: 790-798, 1995.
    • (1995) Blood , vol.85 , pp. 790-798
    • Kitayama, H.1    Kanakura, Y.2    Furitsu, T.3    Tsujimura, T.4    Oritani, K.5    Ikeda, H.6    Sugahara, H.7    Mitsui, H.8    Kanayama, Y.9    Kitamura, Y.10    Matsuzawa, Y.11
  • 138
    • 0028198330 scopus 로고
    • The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity
    • Klippel A, Escobedo JA, Hirano M, Williams LT. The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity. Mol Cell Biol 14: 2675-2685, 1994.
    • (1994) Mol Cell Biol , vol.14 , pp. 2675-2685
    • Klippel, A.1    Escobedo, J.A.2    Hirano, M.3    Williams, L.T.4
  • 139
    • 77952560302 scopus 로고    scopus 로고
    • Genomewide analysis of POU3F2/BRN2 promoter occupancy in human melanoma cells reveals Kitl as a novel regulated target gene
    • Kobi D, Steunou AL, Dembele D, Legras S, Larue L, Nieto L, Davidson I. Genomewide analysis of POU3F2/BRN2 promoter occupancy in human melanoma cells reveals Kitl as a novel regulated target gene. Pigment Cell Melanoma Res 23: 404-418, 2010.
    • (2010) Pigment Cell Melanoma Res , vol.23 , pp. 404-418
    • Kobi, D.1    Steunou, A.L.2    Dembele, D.3    Legras, S.4    Larue, L.5    Nieto, L.6    Davidson, I.7
  • 140
    • 78651243203 scopus 로고    scopus 로고
    • Down-regulation of miR-221 and miR-222 correlates with pronounced Kit expression in gastrointestinal stromal tumors
    • Koelz M, Lense J, Wrba F, Scheffler M, Dienes HP, Odenthal M. Down-regulation of miR-221 and miR-222 correlates with pronounced Kit expression in gastrointestinal stromal tumors. Int J Oncol 38: 503-511, 2011.
    • (2011) Int J Oncol , vol.38 , pp. 503-511
    • Koelz, M.1    Lense, J.2    Wrba, F.3    Scheffler, M.4    Dienes, H.P.5    Odenthal, M.6
  • 141
    • 0027184429 scopus 로고
    • Stem cell factor-induced signal transduction in rat mast cells. Activation of phospholipase D but not phosphoinositide-specific phospholipase C in c-kit receptor stimulation
    • Koike T, Hirai K, Morita Y, Nozawa Y. Stem cell factor-induced signal transduction in rat mast cells. Activation of phospholipase D but not phosphoinositide-specific phospholipase C in c-kit receptor stimulation. J Immunol 151: 359-366, 1993.
    • (1993) J Immunol , vol.151 , pp. 359-366
    • Koike, T.1    Hirai, K.2    Morita, Y.3    Nozawa, Y.4
  • 142
    • 0027787897 scopus 로고
    • SCF/c-kit receptor-mediated arachidonic acid liberation in rat mast cells. Involvement of PLD activation associated tyrosine phosphorylation
    • Koike T, Mizutani T, Hirai K, Morita Y, Nozawa Y. SCF/c-kit receptor-mediated arachidonic acid liberation in rat mast cells. Involvement of PLD activation associated tyrosine phosphorylation. Biochem Biophys Res Commun 197: 1570-1577, 1993.
    • (1993) Biochem Biophys Res Commun , vol.197 , pp. 1570-1577
    • Koike, T.1    Mizutani, T.2    Hirai, K.3    Morita, Y.4    Nozawa, Y.5
  • 143
    • 0030835325 scopus 로고    scopus 로고
    • Involvement of phosphatidylinositol 3′-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release
    • Kozawa O, Blume-Jensen P, Heldin CH, Rönnstrand L. Involvement of phosphatidylinositol 3′-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release. Eur J Biochem 248: 149-155, 1997.
    • (1997) Eur J Biochem , vol.248 , pp. 149-155
    • Kozawa, O.1    Blume-Jensen, P.2    Heldin, C.H.3    Rönnstrand, L.4
  • 144
    • 0031924794 scopus 로고    scopus 로고
    • SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain
    • Kozlowski M, Larose L, Lee F, Le DM, Rottapel R, Siminovitch KA. SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain. Mol Cell Biol 18: 2089-2099, 1998.
    • (1998) Mol Cell Biol , vol.18 , pp. 2089-2099
    • Kozlowski, M.1    Larose, L.2    Lee, F.3    Le, D.M.4    Rottapel, R.5    Siminovitch, K.A.6
  • 146
    • 0032532096 scopus 로고    scopus 로고
    • Lck associates with and is activated by Kit in a small cell lung cancer cell line: Inhibition of SCF-mediated growth by the Src family kinase inhibitor PP1
    • Krystal GW, De Berry CS, Linnekin D, Litz J. Lck associates with and is activated by Kit in a small cell lung cancer cell line: inhibition of SCF-mediated growth by the Src family kinase inhibitor PP1. Cancer Res 58: 4660-4666, 1998.
    • (1998) Cancer Res , vol.58 , pp. 4660-4666
    • Krystal, G.W.1    de Berry, C.S.2    Linnekin, D.3    Litz, J.4
  • 147
    • 42249108334 scopus 로고    scopus 로고
    • Stem cell factor/c-kit signaling mediated cardiac stem cell migration via activation of p38 MAPK
    • Kuang D, Zhao X, Xiao G, Ni J, Feng Y, Wu R, Wang G. Stem cell factor/c-kit signaling mediated cardiac stem cell migration via activation of p38 MAPK. Basic Res Cardiol 103: 265-273, 2008.
    • (2008) Basic Res Cardiol , vol.103 , pp. 265-273
    • Kuang, D.1    Zhao, X.2    Xiao, G.3    Ni, J.4    Feng, Y.5    Wu, R.6    Wang, G.7
  • 148
    • 0842267299 scopus 로고    scopus 로고
    • Roles of a conserved family of adaptor proteins, Lnk, SH2-B, APS, for mast cell development, growth, functions: APS-deficiency causes augmented degranulation and reduced actin assembly
    • Kubo-Akashi C, Iseki M, Kwon SM, Takizawa H, Takatsu K, Takaki S. Roles of a conserved family of adaptor proteins, Lnk, SH2-B, APS, for mast cell development, growth, functions: APS-deficiency causes augmented degranulation and reduced actin assembly. Biochem Biophys Res Commun 315: 356-362, 2004.
    • (2004) Biochem Biophys Res Commun , vol.315 , pp. 356-362
    • Kubo-Akashi, C.1    Iseki, M.2    Kwon, S.M.3    Takizawa, H.4    Takatsu, K.5    Takaki, S.6
  • 149
    • 1842405371 scopus 로고    scopus 로고
    • Downregulation of c-kit expression in human endothelial cells by inflammatory stimuli
    • König A, Corbacioglu S, Ballmaier M, Welte K. Downregulation of c-kit expression in human endothelial cells by inflammatory stimuli. Blood 90: 148-155, 1997.
    • (1997) Blood , vol.90 , pp. 148-155
    • König, A.1    Corbacioglu, S.2    Ballmaier, M.3    Welte, K.4
  • 150
    • 79959833426 scopus 로고    scopus 로고
    • Mutation D816V alters the internal structure and dynamics of c-KIT receptor cytoplasmic region: Implications for dimerization and activation mechanisms
    • Laine E, Chauvot de Beauchene I, Perahia D, Auclair C, Tchertanov L. Mutation D816V alters the internal structure and dynamics of c-KIT receptor cytoplasmic region: implications for dimerization and activation mechanisms. PLoS Comput Biol 7: e1002068, 2011.
    • (2011) PLoS Comput Biol , vol.7
    • Laine, E.1    de Beauchene, I.C.2    Perahia, D.3    Auclair, C.4    Tchertanov, L.5
  • 151
    • 0033557902 scopus 로고    scopus 로고
    • A transforming mutation enhances the activity of the c-Kit soluble tyrosine kinase domain
    • Lam LP, Chow RY, Berger SA. A transforming mutation enhances the activity of the c-Kit soluble tyrosine kinase domain. Biochem J 338: 131-138, 1999.
    • (1999) Biochem J , vol.338 , pp. 131-138
    • Lam, L.P.1    Chow, R.Y.2    Berger, S.A.3
  • 153
    • 70350418625 scopus 로고    scopus 로고
    • mTOR signaling at a glance
    • Laplante M, Sabatini DM. mTOR signaling at a glance. J Cell Sci 122: 3589-3594, 2009.
    • (2009) J Cell Sci , vol.122 , pp. 3589-3594
    • Laplante, M.1    Sabatini, D.M.2
  • 154
    • 0026518279 scopus 로고
    • Loss of c-kit expression in cultured melanoma cells
    • Lassam N, Bickford S. Loss of c-kit expression in cultured melanoma cells. Oncogene 7: 51-56, 1992.
    • (1992) Oncogene , vol.7 , pp. 51-56
    • Lassam, N.1    Bickford, S.2
  • 155
    • 34250017387 scopus 로고    scopus 로고
    • Chrysin inhibited stem cell factor (SCF)/c-Kit complexinduced cell proliferation in human myeloid leukemia cells
    • Lee SJ, Yoon JH, Song KS. Chrysin inhibited stem cell factor (SCF)/c-Kit complexinduced cell proliferation in human myeloid leukemia cells. Biochem Pharmacol 74: 215-225, 2007.
    • (2007) Biochem Pharmacol , vol.74 , pp. 215-225
    • Lee, S.J.1    Yoon, J.H.2    Song, K.S.3
  • 156
    • 0034816719 scopus 로고    scopus 로고
    • Transcriptional and ERK1/2- dependent synergistic upregulation of p21(cip1/waf1) associated with steel factor synergy in MO7e
    • Lee Y, Mantel C, Anzai N, Braun SE, Broxmeyer HE. Transcriptional and ERK1/2- dependent synergistic upregulation of p21(cip1/waf1) associated with steel factor synergy in MO7e. Biochem Biophys Res Commun 280: 675-683, 2001.
    • (2001) Biochem Biophys Res Commun , vol.280 , pp. 675-683
    • Lee, Y.1    Mantel, C.2    Anzai, N.3    Braun, S.E.4    Broxmeyer, H.E.5
  • 158
    • 0030889905 scopus 로고    scopus 로고
    • Kit receptor dimerization is driven by bivalent binding of stem cell factor
    • Lemmon MA, Pinchasi D, Zhou M, Lax I, Schlessinger J. Kit receptor dimerization is driven by bivalent binding of stem cell factor. J Biol Chem 272: 6311-6317, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 6311-6317
    • Lemmon, M.A.1    Pinchasi, D.2    Zhou, M.3    Lax, I.4    Schlessinger, J.5
  • 159
    • 77953896432 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 141: 1117-1134, 2010.
    • (2010) Cell , vol.141 , pp. 1117-1134
    • Lemmon, M.A.1    Schlessinger, J.2
  • 160
    • 0033619142 scopus 로고    scopus 로고
    • Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/ c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction
    • Lennartsson J, Blume-Jensen P, Hermanson M, Pontén E, Carlberg M, Rönnstrand L. Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/ c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction. Oncogene 18: 5546-5553, 1999.
    • (1999) Oncogene , vol.18 , pp. 5546-5553
    • Lennartsson, J.1    Blume-Jensen, P.2    Hermanson, M.3    Pontén, E.4    Carlberg, M.5    Rönnstrand, L.6
  • 161
    • 12144278434 scopus 로고    scopus 로고
    • Normal and oncogenic forms of the receptor tyrosine kinase kit
    • Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R. Normal and oncogenic forms of the receptor tyrosine kinase kit. Stem Cells 23: 16-43, 2005.
    • (2005) Stem Cells , vol.23 , pp. 16-43
    • Lennartsson, J.1    Jelacic, T.2    Linnekin, D.3    Shivakrupa, R.4
  • 162
    • 7244231282 scopus 로고    scopus 로고
    • Synergistic growth of stem cell factor and granulocyte macrophage colony-stimulating factor involves kinase-dependent and -independent contributions from c-Kit
    • Lennartsson J, Shivakrupa R, Linnekin D. Synergistic growth of stem cell factor and granulocyte macrophage colony-stimulating factor involves kinase-dependent and -independent contributions from c-Kit. J Biol Chem 279: 44544-44553, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 44544-44553
    • Lennartsson, J.1    Shivakrupa, R.2    Linnekin, D.3
  • 163
    • 0038825595 scopus 로고    scopus 로고
    • Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk
    • Lennartsson J, Wernstedt C, Engström U, Hellman U, Rönnstrand L. Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk. Exp Cell Res 288: 110-118, 2003.
    • (2003) Exp Cell Res , vol.288 , pp. 110-118
    • Lennartsson, J.1    Wernstedt, C.2    Engström, U.3    Hellman, U.4    Rönnstrand, L.5
  • 164
    • 0028252924 scopus 로고
    • Steel factor and c-kit protooncogene: Genetic lessons in signal transduction
    • Lev S, Blechman JM, Givol D, Yarden Y. Steel factor and c-kit protooncogene: genetic lessons in signal transduction. Crit Rev Oncog 5: 141-168, 1994.
    • (1994) Crit Rev Oncog , vol.5 , pp. 141-168
    • Lev, S.1    Blechman, J.M.2    Givol, D.3    Yarden, Y.4
  • 165
    • 0026515405 scopus 로고
    • Interkinase domain of kit contains the binding site for phosphatidylinositol 3′ kinase
    • Lev S, Givol D, Yarden Y. Interkinase domain of kit contains the binding site for phosphatidylinositol 3′ kinase. Proc Natl Acad Sci USA 89: 678-682, 1992.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 678-682
    • Lev, S.1    Givol, D.2    Yarden, Y.3
  • 166
    • 0038482050 scopus 로고    scopus 로고
    • Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim
    • Ley R, Balmanno K, Hadfield K, Weston C, Cook SJ. Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. J Biol Chem 278: 18811-18816, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 18811-18816
    • Ley, R.1    Balmanno, K.2    Hadfield, K.3    Weston, C.4    Cook, S.J.5
  • 168
    • 0037134428 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling
    • Liang X, Wisniewski D, Strife A, Shivakrupa Clarkson B, Resh MD. Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling. J Biol Chem 277: 13732-13738, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 13732-13738
    • Liang, X.1    Wisniewski, D.2    Strife, A.3    Shivakrupa, C.B.4    Resh, M.D.5
  • 170
    • 0030833445 scopus 로고    scopus 로고
    • Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells
    • Linnekin D, DeBerry CS, Mou S. Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells. J Biol Chem 272: 27450-27455, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 27450-27455
    • Linnekin, D.1    Deberry, C.S.2    Mou, S.3
  • 171
    • 33746072622 scopus 로고    scopus 로고
    • Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1alpha activity and vascular endothelial growth factor expression in small cell lung cancer cells
    • Litz J, Krystal GW. Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1alpha activity and vascular endothelial growth factor expression in small cell lung cancer cells. Mol Cancer Ther 5: 1415-1422, 2006.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1415-1422
    • Litz, J.1    Krystal, G.W.2
  • 172
    • 0028301446 scopus 로고
    • Steel factor stimulates the serine/threonine phosphorylation of the interleukin-3 receptor
    • Liu L, Cutler RL, Mui AL, Krystal G. Steel factor stimulates the serine/threonine phosphorylation of the interleukin-3 receptor. J Biol Chem 269: 16774-16779, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 16774-16779
    • Liu, L.1    Cutler, R.L.2    Mui, A.L.3    Krystal, G.4
  • 174
    • 0030975886 scopus 로고    scopus 로고
    • Stem cell factor and c-kit in the mammalian testis: Lessons originating from Mother Nature's gene knockouts
    • Loveland KL, Schlatt S. Stem cell factor and c-kit in the mammalian testis: lessons originating from Mother Nature's gene knockouts. J Endocrinol 153: 337-344, 1997.
    • (1997) J Endocrinol , vol.153 , pp. 337-344
    • Loveland, K.L.1    Schlatt, S.2
  • 175
    • 0242521470 scopus 로고    scopus 로고
    • Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function
    • Luciano F, Jacquel A, Colosetti P, Herrant M, Cagnol S, Pages G, Auberger P. Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. Oncogene 22: 6785-6793, 2003.
    • (2003) Oncogene , vol.22 , pp. 6785-6793
    • Luciano, F.1    Jacquel, A.2    Colosetti, P.3    Herrant, M.4    Cagnol, S.5    Pages, G.6    Auberger, P.7
  • 177
    • 0036493872 scopus 로고    scopus 로고
    • The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations
    • Ma Y, Zeng S, Metcalfe DD, Akin C, Dimitrijevic S, Butterfield JH, McMahon G, Longley BJ. The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations. Blood 99: 1741-1744, 2002.
    • (2002) Blood , vol.99 , pp. 1741-1744
    • Ma, Y.1    Zeng, S.2    Metcalfe, D.D.3    Akin, C.4    Dimitrijevic, S.5    Butterfield, J.H.6    McMahon, G.7    Longley, B.J.8
  • 178
    • 0031442453 scopus 로고    scopus 로고
    • Activation of the receptor tyrosine kinase Kit is required for the proliferation of melanoblasts in the mouse embryo
    • Mackenzie MA, Jordan SA, Budd PS, Jackson IJ. Activation of the receptor tyrosine kinase Kit is required for the proliferation of melanoblasts in the mouse embryo. Dev Biol 192: 99-107, 1997.
    • (1997) Dev Biol , vol.192 , pp. 99-107
    • Mackenzie, M.A.1    Jordan, S.A.2    Budd, P.S.3    Jackson, I.J.4
  • 179
    • 0037103184 scopus 로고    scopus 로고
    • Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: Implication in stem cell factor radioprotective effect
    • Maddens S, Charruyer A, Plo I, Dubreuil P, Berger S, Salles B, Laurent G, Jaffrezou JP. Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: implication in stem cell factor radioprotective effect. Blood 100: 1294-1301, 2002.
    • (2002) Blood , vol.100 , pp. 1294-1301
    • Maddens, S.1    Charruyer, A.2    Plo, I.3    Dubreuil, P.4    Berger, S.5    Salles, B.6    Laurent, G.7    Jaffrezou, J.P.8
  • 182
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
    • Marshall CJ. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80: 179-185, 1995.
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 184
    • 33749390318 scopus 로고    scopus 로고
    • Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation
    • Masson K, Heiss E, Band H, Rönnstrand L. Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation. Biochem J 399: 59-67, 2006.
    • (2006) Biochem J , vol.399 , pp. 59-67
    • Masson, K.1    Heiss, E.2    Band, H.3    Rönnstrand, L.4
  • 185
    • 2442631556 scopus 로고    scopus 로고
    • Stem cell factor/c-kit signaling promotes the survival, migration, capillary tube formation of human umbilical vein endothelial cells
    • Matsui J, Wakabayashi T, Asada M, Yoshimatsu K, Okada M. Stem cell factor/c-kit signaling promotes the survival, migration, capillary tube formation of human umbilical vein endothelial cells. J Biol Chem 279: 18600-18607, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 18600-18607
    • Matsui, J.1    Wakabayashi, T.2    Asada, M.3    Yoshimatsu, K.4    Okada, M.5
  • 186
    • 0025027264 scopus 로고
    • Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit
    • Matsui Y, Zsebo KM, Hogan BL. Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit. Nature 347: 667-669, 1990.
    • (1990) Nature , vol.347 , pp. 667-669
    • Matsui, Y.1    Zsebo, K.M.2    Hogan, B.L.3
  • 190
    • 51649115383 scopus 로고    scopus 로고
    • Mast cells and mastocytosis
    • Metcalfe DD. Mast cells and mastocytosis. Blood 112: 946-956, 2008.
    • (2008) Blood , vol.112 , pp. 946-956
    • Metcalfe, D.D.1
  • 192
    • 0028158499 scopus 로고
    • Liganddependent polyubiquitination of c-kit gene product: A possible mechanism of receptor down modulation in M07e cells
    • Miyazawa K, Toyama K, Gotoh A, Hendrie PC, Mantel C, Broxmeyer HE. Liganddependent polyubiquitination of c-kit gene product: a possible mechanism of receptor down modulation in M07e cells. Blood 83: 137-145, 1994.
    • (1994) Blood , vol.83 , pp. 137-145
    • Miyazawa, K.1    Toyama, K.2    Gotoh, A.3    Hendrie, P.C.4    Mantel, C.5    Broxmeyer, H.E.6
  • 195
    • 34548136982 scopus 로고    scopus 로고
    • Multiple novel alterations in Kit tyrosine kinase in patients with gastrointestinally pronounced systemic mast cell activation disorder
    • Molderings GJ, Kolck UW, Scheurlen C, Brüss M, Homann J, Von Kügelgen I. Multiple novel alterations in Kit tyrosine kinase in patients with gastrointestinally pronounced systemic mast cell activation disorder. Scand J Gastroenterol 42: 1045-1053, 2007.
    • (2007) Scand J Gastroenterol , vol.42 , pp. 1045-1053
    • Molderings, G.J.1    Kolck, U.W.2    Scheurlen, C.3    Brüss, M.4    Homann, J.5    von Kügelgen, I.6
  • 196
    • 0029962224 scopus 로고    scopus 로고
    • Steel mutant mice are deficient in hippocampal learning but not long-term potentiation
    • Motro B, Wojtowicz JM, Bernstein A, van der Kooy D. Steel mutant mice are deficient in hippocampal learning but not long-term potentiation. Proc Natl Acad Sci USA 93: 1808-1813, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1808-1813
    • Motro, B.1    Wojtowicz, J.M.2    Bernstein, A.3    van der Kooy, D.4
  • 197
    • 0033567194 scopus 로고    scopus 로고
    • 1 of stem-cell-factor-induced cell cycle progression in haemopoietic cells
    • 1 of stem-cell-factor-induced cell cycle progression in haemopoietic cells. Biochem J 342: 163-170, 1999.
    • (1999) Biochem J , vol.342 , pp. 163-170
    • Mous, A.1    Linnekin, D.2
  • 199
    • 39149093030 scopus 로고    scopus 로고
    • Requirement for p85alpha regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT
    • Munugalavadla V, Sims EC, Chan RJ, Lenz SD, Kapur R. Requirement for p85alpha regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT. Exp Hematol 36: 301-308, 2008.
    • (2008) Exp Hematol , vol.36 , pp. 301-308
    • Munugalavadla, V.1    Sims, E.C.2    Chan, R.J.3    Lenz, S.D.4    Kapur, R.5
  • 200
    • 23744515285 scopus 로고    scopus 로고
    • Stem cell factor promotes mast cell survival via inactivation of FOXO3amediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim
    • Möller C, Alfredsson J, Engström M, Wootz H, Xiang Z, Lennartsson J, Jönsson JI, Nilsson G. Stem cell factor promotes mast cell survival via inactivation of FOXO3amediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim. Blood 106: 1330-1336, 2005.
    • (2005) Blood , vol.106 , pp. 1330-1336
    • Möller, C.1    Alfredsson, J.2    Engström, M.3    Wootz, H.4    Xiang, Z.5    Lennartsson, J.6    Jönsson, J.I.7    Nilsson, G.8
  • 201
    • 0026793058 scopus 로고
    • Progression of human cutaneous melanoma is associated with loss of expression of c-kit protooncogene receptor
    • Natali PG, Nicotra MR, Winkler AB, Cavaliere R, Bigotti A, Ullrich A. Progression of human cutaneous melanoma is associated with loss of expression of c-kit protooncogene receptor. Int J Cancer 52: 197-201, 1992.
    • (1992) Int J Cancer , vol.52 , pp. 197-201
    • Natali, P.G.1    Nicotra, M.R.2    Winkler, A.B.3    Cavaliere, R.4    Bigotti, A.5    Ullrich, A.6
  • 205
    • 76749147499 scopus 로고
    • Strong oligomerization behavior of PDGFbeta receptor transmembrane domain and its regulation by the juxtamembrane regions
    • Oates J, King G, Dixon AM. Strong oligomerization behavior of PDGFbeta receptor transmembrane domain and its regulation by the juxtamembrane regions. Biochim Biophys Acta 1798: 605-615.
    • (1798) Biochim Biophys Acta , pp. 605-615
    • Oates, J.1    King, G.2    Dixon, A.M.3
  • 207
    • 0026041826 scopus 로고
    • Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule
    • Okada S, Nakauchi H, Nagayoshi K, Nishikawa S, Nishikawa S, Miura Y, Suda T. Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule. Blood 78: 1706-1712, 1991.
    • (1991) Blood , vol.78 , pp. 1706-1712
    • Okada, S.1    Nakauchi, H.2    Nagayoshi, K.3    Nishikawa, S.4    Nishikawa, S.5    Miura, Y.6    Suda, T.7
  • 208
    • 14644396631 scopus 로고    scopus 로고
    • Testicular germ-cell tumours in a broader perspective
    • Oosterhuis JW, Looijenga LH. Testicular germ-cell tumours in a broader perspective. Nat Rev Cancer 5: 210-222, 2005.
    • (2005) Nat Rev Cancer , vol.5 , pp. 210-222
    • Oosterhuis, J.W.1    Looijenga, L.H.2
  • 209
    • 0030746395 scopus 로고    scopus 로고
    • Melanocyte development in vivo and in neural crest cell cultures: Crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor
    • Opdecamp K, Nakayama A, Nguyen MT, Hodgkinson CA, Pavan WJ, Arnheiter H. Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor. Development 124: 2377-2386, 1997.
    • (1997) Development , vol.124 , pp. 2377-2386
    • Opdecamp, K.1    Nakayama, A.2    Nguyen, M.T.3    Hodgkinson, C.A.4    Pavan, W.J.5    Arnheiter, H.6
  • 210
  • 211
    • 58249090833 scopus 로고    scopus 로고
    • Phylogeny of Tec family kinases identification of a premetazoan origin of Btk, Bmx, Itk, Tec, Txk, and the Btk regulator SH3BP5
    • Ortutay C, Nore BF, Vihinen M, Smith CI. Phylogeny of Tec family kinases identification of a premetazoan origin of Btk, Bmx, Itk, Tec, Txk, and the Btk regulator SH3BP5. Adv Genet 64: 51-80, 2008.
    • (2008) Adv Genet , vol.64 , pp. 51-80
    • Ortutay, C.1    Nore, B.F.2    Vihinen, M.3    Smith, C.I.4
  • 212
    • 0032400851 scopus 로고    scopus 로고
    • Selective Sp1 binding is critical for maximal activity of the human c-kit promoter
    • Park GH, Plummer HK 3rd, Krystal GW. Selective Sp1 binding is critical for maximal activity of the human c-kit promoter. Blood 92: 4138-4149, 1998.
    • (1998) Blood , vol.92 , pp. 4138-4149
    • Park, G.H.1    Plummer III, H.K.2    Krystal, G.W.3
  • 213
    • 1642292426 scopus 로고    scopus 로고
    • Expression of a truncated form of the c-Kit tyrosine kinase receptor and activation of Src kinase in human prostatic cancer
    • Paronetto MP, Farini D, Sammarco I, Maturo G, Vespasiani G, Geremia R, Rossi P, Sette C. Expression of a truncated form of the c-Kit tyrosine kinase receptor and activation of Src kinase in human prostatic cancer. Am J Pathol 164: 1243-1251, 2004.
    • (2004) Am J Pathol , vol.164 , pp. 1243-1251
    • Paronetto, M.P.1    Farini, D.2    Sammarco, I.3    Maturo, G.4    Vespasiani, G.5    Geremia, R.6    Rossi, P.7    Sette, C.8
  • 214
    • 0346363605 scopus 로고    scopus 로고
    • Tr-kit promotes the formation of a multimolecular complex composed by Fyn, PLCgamma1 and Sam68
    • Paronetto MP, Venables JP, Elliott DJ, Geremia R, Rossi P, Sette C. Tr-kit promotes the formation of a multimolecular complex composed by Fyn, PLCgamma1 and Sam68. Oncogene 22: 8707-8715, 2003.
    • (2003) Oncogene , vol.22 , pp. 8707-8715
    • Paronetto, M.P.1    Venables, J.P.2    Elliott, D.J.3    Geremia, R.4    Rossi, P.5    Sette, C.6
  • 216
    • 0030014452 scopus 로고    scopus 로고
    • Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1
    • Paulson RF, Vesely S, Siminovitch KA, Bernstein A. Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1. Nat Genet 13: 309-315, 1996.
    • (1996) Nat Genet , vol.13 , pp. 309-315
    • Paulson, R.F.1    Vesely, S.2    Siminovitch, K.A.3    Bernstein, A.4
  • 217
    • 0031671336 scopus 로고    scopus 로고
    • Investigation of the molecular mechanisms underlying growth factor synergy: The role of ERK 2 activation in synergy
    • Pearson MA, O'Farrell AM, Dexter TM, Whetton AD, Owen-Lynch PJ, Heyworth CM. Investigation of the molecular mechanisms underlying growth factor synergy: the role of ERK 2 activation in synergy. Growth Factors 15: 293-306, 1998.
    • (1998) Growth Factors , vol.15 , pp. 293-306
    • Pearson, M.A.1    O'Farrell, A.M.2    Dexter, T.M.3    Whetton, A.D.4    Owen-Lynch, P.J.5    Heyworth, C.M.6
  • 219
    • 58249134128 scopus 로고    scopus 로고
    • The c-Kit/D816V mutation eliminates the differences in signal transduction and biological responses between two isoforms of c-Kit
    • Pedersen M, Rönnstrand L, Sun J. The c-Kit/D816V mutation eliminates the differences in signal transduction and biological responses between two isoforms of c-Kit. Cell Signal 21: 413-418, 2009.
    • (2009) Cell Signal , vol.21 , pp. 413-418
    • Pedersen, M.1    Rönnstrand, L.2    Sun, J.3
  • 220
    • 80051981588 scopus 로고    scopus 로고
    • C-KIT signaling depends on microphthalmia-associated transcription factor for effects on cell proliferation
    • Phung B, Sun J, Schepsky A, Steingrimsson E, Rönnstrand L. C-KIT signaling depends on microphthalmia-associated transcription factor for effects on cell proliferation. PLoS One 6: e24064, 2011.
    • (2011) PLoS One , vol.6
    • Phung, B.1    Sun, J.2    Schepsky, A.3    Steingrimsson, E.4    Rönnstrand, L.5
  • 221
    • 0028181438 scopus 로고
    • Expression of the Kit and KitA receptor isoforms in human acute myelogenous leukemia
    • Piao X, Curtis JE, Minkin S, Minden MD, Bernstein A. Expression of the Kit and KitA receptor isoforms in human acute myelogenous leukemia. Blood 83: 476-481, 1994.
    • (1994) Blood , vol.83 , pp. 476-481
    • Piao, X.1    Curtis, J.E.2    Minkin, S.3    Minden, M.D.4    Bernstein, A.5
  • 222
    • 0029907089 scopus 로고    scopus 로고
    • Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1
    • Piao X, Paulson R, Van Der Geer P, Pawson T, Bernstein A. Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1. Proc Natl Acad Sci USA 93: 14665-14669, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14665-14669
    • Piao, X.1    Paulson, R.2    van der Geer, P.3    Pawson, T.4    Bernstein, A.5
  • 223
    • 0027262550 scopus 로고
    • Paracrine and autocrine growth mechanisms of human stem cell factor (c-kit ligand) in myeloid leukemia
    • Pietsch T. Paracrine and autocrine growth mechanisms of human stem cell factor (c-kit ligand) in myeloid leukemia. Nouv Rev Fr Hematol 35: 285-286, 1993.
    • (1993) Nouv Rev Fr Hematol , vol.35 , pp. 285-286
    • Pietsch, T.1
  • 224
    • 0035845849 scopus 로고    scopus 로고
    • Kit signaling and negative regulation of daunorubicin-induced apoptosis: Role of phospholipase Cgamma
    • Plo I, Lautier D, Casteran N, Dubreuil P, Arock M, Laurent G. Kit signaling and negative regulation of daunorubicin-induced apoptosis: role of phospholipase Cgamma. Oncogene 20: 6752-6763, 2001.
    • (2001) Oncogene , vol.20 , pp. 6752-6763
    • Plo, I.1    Lautier, D.2    Casteran, N.3    Dubreuil, P.4    Arock, M.5    Laurent, G.6
  • 225
    • 0031048834 scopus 로고    scopus 로고
    • Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes
    • Price DJ, Rivnay B, Fu Y, Jiang S, Avraham S, Avraham H. Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. J Biol Chem 272: 5915-5920, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 5915-5920
    • Price, D.J.1    Rivnay, B.2    Fu, Y.3    Jiang, S.4    Avraham, S.5    Avraham, H.6
  • 226
    • 0023989811 scopus 로고
    • Primary structure of c-kit: Relationship with the CSF-1/PDGF receptor kinase familyoncogenic activation of v-kit involves deletion of extracellular domain and C terminus
    • Qiu FH, Ray P, Brown K, Barker PE, Jhanwar S, Ruddle FH, Besmer P. Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase familyoncogenic activation of v-kit involves deletion of extracellular domain and C terminus. EMBO J 7: 1003-1011, 1988.
    • (1988) EMBO J , vol.7 , pp. 1003-1011
    • Qiu, F.H.1    Ray, P.2    Brown, K.3    Barker, P.E.4    Jhanwar, S.5    Ruddle, F.H.6    Besmer, P.7
  • 228
    • 75749128594 scopus 로고    scopus 로고
    • Signaling of c-kit in dendritic cells influences adaptive immunity
    • Ray P, Krishnamoorthy N, Oriss TB, Ray A. Signaling of c-kit in dendritic cells influences adaptive immunity. Ann NY Acad Sci 1183: 104-122, 2010.
    • (2010) Ann NY Acad Sci , vol.1183 , pp. 104-122
    • Ray, P.1    Krishnamoorthy, N.2    Oriss, T.B.3    Ray, A.4
  • 230
  • 232
    • 0024367572 scopus 로고
    • Report of the committee on the genetic constitution of chromosomes 12 and 13
    • Ropers HH, Craig IW. Report of the committee on the genetic constitution of chromosomes 12 and 13. Cytogenet Cell Genet 51: 259-279, 1989.
    • (1989) Cytogenet Cell Genet , vol.51 , pp. 259-279
    • Ropers, H.H.1    Craig, I.W.2
  • 233
    • 0037325093 scopus 로고    scopus 로고
    • Molecular mechanisms utilized by alternative c-kit gene products in the control of spermatogonial proliferation and sperm-mediated egg activation
    • Rossi P, Dolci S, Sette C, Geremia R. Molecular mechanisms utilized by alternative c-kit gene products in the control of spermatogonial proliferation and sperm-mediated egg activation. Andrologia 35: 71-78, 2003.
    • (2003) Andrologia , vol.35 , pp. 71-78
    • Rossi, P.1    Dolci, S.2    Sette, C.3    Geremia, R.4
  • 234
    • 0026725077 scopus 로고
    • A novel c-kit transcript, potentially encoding a truncated receptor, originates within a kit gene intron in mouse spermatids
    • Rossi P, Marziali G, Albanesi C, Charlesworth A, Geremia R, Sorrentino V. A novel c-kit transcript, potentially encoding a truncated receptor, originates within a kit gene intron in mouse spermatids. Dev Biol 152: 203-207, 1992.
    • (1992) Dev Biol , vol.152 , pp. 203-207
    • Rossi, P.1    Marziali, G.2    Albanesi, C.3    Charlesworth, A.4    Geremia, R.5    Sorrentino, V.6
  • 235
    • 0018625422 scopus 로고
    • Hereditary anemias of the mouse: A review for geneticists
    • Russell ES. Hereditary anemias of the mouse: a review for geneticists. Adv Genet 20: 357-459, 1979.
    • (1979) Adv Genet , vol.20 , pp. 357-459
    • Russell, E.S.1
  • 236
    • 0038640974 scopus 로고    scopus 로고
    • Alterations of the c-kit gene in testicular germ cell tumors
    • Sakuma Y, Sakurai S, Oguni S, Hironaka M, Saito K. Alterations of the c-kit gene in testicular germ cell tumors. Cancer Sci 94: 486-491, 2003.
    • (2003) Cancer Sci , vol.94 , pp. 486-491
    • Sakuma, Y.1    Sakurai, S.2    Oguni, S.3    Hironaka, M.4    Saito, K.5
  • 237
    • 33744827154 scopus 로고    scopus 로고
    • Fyn kinase acts upstream of Shp2 and p38 mitogen-activated protein kinase to promote chemotaxis of mast cells towards stem cell factor
    • Samayawardhena LA, Hu J, Stein PL, Craig AW. Fyn kinase acts upstream of Shp2 and p38 mitogen-activated protein kinase to promote chemotaxis of mast cells towards stem cell factor. Cell Signal 18: 1447-1454, 2006.
    • (2006) Cell Signal , vol.18 , pp. 1447-1454
    • Samayawardhena, L.A.1    Hu, J.2    Stein, P.L.3    Craig, A.W.4
  • 238
    • 57649194794 scopus 로고    scopus 로고
    • Protein-tyrosine phosphatase alpha regulates stem cell factor-dependent c-Kit activation and migration of mast cells
    • Samayawardhena LA, Pallen CJ. Protein-tyrosine phosphatase alpha regulates stem cell factor-dependent c-Kit activation and migration of mast cells. J Biol Chem 283: 29175-29185, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 29175-29185
    • Samayawardhena, L.A.1    Pallen, C.J.2
  • 239
    • 82555173049 scopus 로고    scopus 로고
    • Core-binding factor acute myeloid leukemia
    • Sangle NA, Perkins SL. Core-binding factor acute myeloid leukemia. Arch Pathol Lab Med 135: 1504-1509, 2011.
    • (2011) Arch Pathol Lab Med , vol.135 , pp. 1504-1509
    • Sangle, N.A.1    Perkins, S.L.2
  • 240
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098-1101, 2005.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 241
    • 0030999238 scopus 로고    scopus 로고
    • Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)
    • Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD. Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL). J Biol Chem 272: 10248-10253, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 10248-10253
    • Sattler, M.1    Salgia, R.2    Shrikhande, G.3    Verma, S.4    Pisick, E.5    Prasad, K.V.6    Griffin, J.D.7
  • 243
    • 31544459272 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, activation loop mutant KIT isoforms associated with human malignancies
    • Schittenhelm MM, Shiraga S, Schroeder A, Corbin AS, Griffith D, Lee FY, Bokemeyer C, Deininger MW, Druker BJ, Heinrich MC. Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, activation loop mutant KIT isoforms associated with human malignancies. Cancer Res 66: 473-481, 2006.
    • (2006) Cancer Res , vol.66 , pp. 473-481
    • Schittenhelm, M.M.1    Shiraga, S.2    Schroeder, A.3    Corbin, A.S.4    Griffith, D.5    Lee, F.Y.6    Bokemeyer, C.7    Deininger, M.W.8    Druker, B.J.9    Heinrich, M.C.10
  • 245
    • 0028376160 scopus 로고
    • Stem cell factor regulates human melanocytematrix interactions
    • Scott G, Ewing J, Ryan D, Abboud C. Stem cell factor regulates human melanocytematrix interactions. Pigment Cell Res 7: 44-51, 1994.
    • (1994) Pigment Cell Res , vol.7 , pp. 44-51
    • Scott, G.1    Ewing, J.2    Ryan, D.3    Abboud, C.4
  • 247
    • 0028128692 scopus 로고
    • Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in cos-1 cells
    • Serve H, Hsu Y, Besmer P. Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in cos-1 cells. J Biol Chem 269: 6026-6030, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 6026-6030
    • Serve, H.1    Hsu, Y.2    Besmer, P.3
  • 248
    • 0030739524 scopus 로고    scopus 로고
    • Parthenogenetic activation of mouse eggs by microinjection of a truncated c-kit tyrosine kinase present in spermatozoa
    • Sette C, Bevilacqua A, Bianchini A, Mangia F, Geremia R, Rossi P. Parthenogenetic activation of mouse eggs by microinjection of a truncated c-kit tyrosine kinase present in spermatozoa. Development 124: 2267-2274, 1997.
    • (1997) Development , vol.124 , pp. 2267-2274
    • Sette, C.1    Bevilacqua, A.2    Bianchini, A.3    Mangia, F.4    Geremia, R.5    Rossi, P.6
  • 249
    • 0032563387 scopus 로고    scopus 로고
    • Involvement of phospholipase Cgamma1 in mouse egg activation induced by a truncated form of the C-kit tyrosine kinase present in spermatozoa
    • Sette C, Bevilacqua A, Geremia R, Rossi P. Involvement of phospholipase Cgamma1 in mouse egg activation induced by a truncated form of the C-kit tyrosine kinase present in spermatozoa. J Cell Biol 142: 1063-1074, 1998.
    • (1998) J Cell Biol , vol.142 , pp. 1063-1074
    • Sette, C.1    Bevilacqua, A.2    Geremia, R.3    Rossi, P.4
  • 250
    • 0037107424 scopus 로고    scopus 로고
    • Tr-kit-induced resumption of the cell cycle in mouse eggs requires activation of a Src-like kinase
    • Sette C, Paronetto MP, Barchi M, Bevilacqua A, Geremia R, Rossi P. Tr-kit-induced resumption of the cell cycle in mouse eggs requires activation of a Src-like kinase. EMBO J 21: 5386-5395, 2002.
    • (2002) EMBO J , vol.21 , pp. 5386-5395
    • Sette, C.1    Paronetto, M.P.2    Barchi, M.3    Bevilacqua, A.4    Geremia, R.5    Rossi, P.6
  • 251
    • 3142676436 scopus 로고    scopus 로고
    • Overriding imatinib resistance with a novel ABL kinase inhibitor
    • Shah NP, Tran C, Lee FY, Chen P, Norris D, Sawyers CL. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 305: 399-401, 2004.
    • (2004) Science , vol.305 , pp. 399-401
    • Shah, N.P.1    Tran, C.2    Lee, F.Y.3    Chen, P.4    Norris, D.5    Sawyers, C.L.6
  • 252
    • 33344471932 scopus 로고    scopus 로고
    • KIT mutations, not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): A study of the Japanese Childhood AML Cooperative Study Group
    • Shimada A, Taki T, Tabuchi K, Tawa A, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Hayashi Y. KIT mutations, not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study Group. Blood 107: 1806-1809, 2006.
    • (2006) Blood , vol.107 , pp. 1806-1809
    • Shimada, A.1    Taki, T.2    Tabuchi, K.3    Tawa, A.4    Horibe, K.5    Tsuchida, M.6    Hanada, R.7    Tsukimoto, I.8    Hayashi, Y.9
  • 253
    • 0029886031 scopus 로고    scopus 로고
    • Internalization of Kit together with stem cell factor on human fetal liver-derived mast cells: New protein and RNA synthesis are required for reappearance of Kit
    • Shimizu Y, Ashman LK, Du Z, Schwartz LB. Internalization of Kit together with stem cell factor on human fetal liver-derived mast cells: new protein and RNA synthesis are required for reappearance of Kit. J Immunol 156: 3443-3449, 1996.
    • (1996) J Immunol , vol.156 , pp. 3443-3449
    • Shimizu, Y.1    Ashman, L.K.2    Du, Z.3    Schwartz, L.B.4
  • 254
    • 4644299076 scopus 로고    scopus 로고
    • Lyn contributes to regulation of multiple Kit-dependent signaling pathways in murine bone marrow mast cells
    • Shivakrupa R, Linnekin D. Lyn contributes to regulation of multiple Kit-dependent signaling pathways in murine bone marrow mast cells. Cell Signal 17: 103-109, 2005.
    • (2005) Cell Signal , vol.17 , pp. 103-109
    • Shivakrupa, R.1    Linnekin, D.2
  • 256
  • 257
    • 71349083858 scopus 로고    scopus 로고
    • Fps/Fes protein-tyrosine kinase regulates mast cell adhesion and migration downstream of Kit and beta1 integrin receptors
    • Smith JA, Samayawardhena LA, Craig AW. Fps/Fes protein-tyrosine kinase regulates mast cell adhesion and migration downstream of Kit and beta1 integrin receptors. Cell Signal 22: 427-436, 2010.
    • (2010) Cell Signal , vol.22 , pp. 427-436
    • Smith, J.A.1    Samayawardhena, L.A.2    Craig, A.W.3
  • 258
    • 0017647580 scopus 로고
    • Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma
    • Staal SP, Hartley JW, Rowe WP. Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma. Proc Natl Acad Sci USA 74: 3065-3067, 1977.
    • (1977) Proc Natl Acad Sci USA , vol.74 , pp. 3065-3067
    • Staal, S.P.1    Hartley, J.W.2    Rowe, W.P.3
  • 259
    • 0032529283 scopus 로고    scopus 로고
    • Synergistic activation of MAP kinase (ERK1/2) by erythropoietin and stem cell factor is essential for expanded erythropoiesis
    • Sui X, Krantz SB, You M, Zhao Z. Synergistic activation of MAP kinase (ERK1/2) by erythropoietin and stem cell factor is essential for expanded erythropoiesis. Blood 92: 1142-1149, 1998.
    • (1998) Blood , vol.92 , pp. 1142-1149
    • Sui, X.1    Krantz, S.B.2    You, M.3    Zhao, Z.4
  • 260
    • 35248849299 scopus 로고    scopus 로고
    • Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl
    • Sun J, Pedersen M, Bengtsson S, Rönnstrand L. Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl. Exp Cell Res 313: 3935-3942, 2007.
    • (2007) Exp Cell Res , vol.313 , pp. 3935-3942
    • Sun, J.1    Pedersen, M.2    Bengtsson, S.3    Rönnstrand, L.4
  • 261
    • 66449128486 scopus 로고    scopus 로고
    • The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction
    • Sun J, Pedersen M, Rönnstrand L. The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction. J Biol Chem 284: 11039-11047, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 11039-11047
    • Sun, J.1    Pedersen, M.2    Rönnstrand, L.3
  • 262
    • 55549092077 scopus 로고    scopus 로고
    • Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit
    • Sun J, Pedersen M, Rönnstrand L. Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit. J Biol Chem 283: 27444-27451, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 27444-27451
    • Sun, J.1    Pedersen, M.2    Rönnstrand, L.3
  • 263
    • 2342453356 scopus 로고    scopus 로고
    • Neuronally expressed stem cell factor induces neural stem cell migration to areas of brain injury
    • Sun L, Lee J, Fine HA. Neuronally expressed stem cell factor induces neural stem cell migration to areas of brain injury. J Clin Invest 113: 1364-1374, 2004.
    • (2004) J Clin Invest , vol.113 , pp. 1364-1374
    • Sun, L.1    Lee, J.2    Fine, H.A.3
  • 264
    • 0035397981 scopus 로고    scopus 로고
    • Stem cell factor-induced migration of mast cells requires p38 mitogen-activated protein kinase activity
    • Sundström M, Alfredsson J, Olsson N, Nilsson G. Stem cell factor-induced migration of mast cells requires p38 mitogen-activated protein kinase activity. Exp Cell Res 267: 144-151, 2001.
    • (2001) Exp Cell Res , vol.267 , pp. 144-151
    • Sundström, M.1    Alfredsson, J.2    Olsson, N.3    Nilsson, G.4
  • 266
    • 0037148516 scopus 로고    scopus 로고
    • Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk
    • Takaki S, Morita H, Tezuka Y, Takatsu K. Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk. J Exp Med 195: 151-160, 2002.
    • (2002) J Exp Med , vol.195 , pp. 151-160
    • Takaki, S.1    Morita, H.2    Tezuka, Y.3    Takatsu, K.4
  • 267
    • 0033637359 scopus 로고    scopus 로고
    • Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins
    • Takaki S, Sauer K, Iritani BM, Chien S, Ebihara Y, Tsuji K, Takatsu K, Perlmutter RM. Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins. Immunity 13: 599-609, 2000.
    • (2000) Immunity , vol.13 , pp. 599-609
    • Takaki, S.1    Sauer, K.2    Iritani, B.M.3    Chien, S.4    Ebihara, Y.5    Tsuji, K.6    Takatsu, K.7    Perlmutter, R.M.8
  • 269
    • 0031004266 scopus 로고    scopus 로고
    • Downstream of Crk adaptor signaling pathway: Activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G
    • Tanaka S, Ouchi T, Hanafusa H. Downstream of Crk adaptor signaling pathway: activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G. Proc Natl Acad Sci USA 94: 2356-2361, 1997.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2356-2361
    • Tanaka, S.1    Ouchi, T.2    Hanafusa, H.3
  • 270
    • 0038813693 scopus 로고    scopus 로고
    • The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases
    • Tatton L, Morley GM, Chopra R, Khwaja A. The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases. J Biol Chem 278: 4847-4853, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 4847-4853
    • Tatton, L.1    Morley, G.M.2    Chopra, R.3    Khwaja, A.4
  • 272
    • 0030459715 scopus 로고    scopus 로고
    • Human stem cell factor promoter deoxyribonucleic acid sequence and regulation by cyclic 3′,5′-adenosine monophosphate in a Sertoli cell line
    • Taylor WE, Najmabadi H, Strathearn M, Jou NT, Liebling M, Rajavashisth T, Chanani N, Phung L, Bhasin S. Human stem cell factor promoter deoxyribonucleic acid sequence and regulation by cyclic 3′,5′-adenosine monophosphate in a Sertoli cell line. Endocrinology 137: 5407-5414, 1996.
    • (1996) Endocrinology , vol.137 , pp. 5407-5414
    • Taylor, W.E.1    Najmabadi, H.2    Strathearn, M.3    Jou, N.T.4    Liebling, M.5    Rajavashisth, T.6    Chanani, N.7    Phung, L.8    Bhasin, S.9
  • 273
    • 33646123102 scopus 로고    scopus 로고
    • Coexpression of SCF and KIT in gastrointestinal stromal tumours (GISTs) suggests an autocrine/paracrine mechanism
    • Theou-Anton N, Tabone S, Brouty-Boye D, Saffroy R, Rönnstrand L, Lemoine A, Emile JF. Coexpression of SCF and KIT in gastrointestinal stromal tumours (GISTs) suggests an autocrine/paracrine mechanism. Br J Cancer 94: 1180-1185, 2006.
    • (2006) Br J Cancer , vol.94 , pp. 1180-1185
    • Theou-Anton, N.1    Tabone, S.2    Brouty-Boye, D.3    Saffroy, R.4    Rönnstrand, L.5    Lemoine, A.6    Emile, J.F.7
  • 274
    • 0029045815 scopus 로고
    • Specific and redundant roles of Src and Fyn in organizing the cytoskeleton
    • Thomas SM, Soriano P, Imamoto A. Specific and redundant roles of Src and Fyn in organizing the cytoskeleton. Nature 376: 267-271, 1995.
    • (1995) Nature , vol.376 , pp. 267-271
    • Thomas, S.M.1    Soriano, P.2    Imamoto, A.3
  • 275
    • 0037847347 scopus 로고    scopus 로고
    • Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor
    • Thömmes K, Lennartsson J, Carlberg M, Rönnstrand L. Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor. Biochem J 341: 211-216, 1999.
    • (1999) Biochem J , vol.341 , pp. 211-216
    • Thömmes, K.1    Lennartsson, J.2    Carlberg, M.3    Rönnstrand, L.4
  • 276
    • 0032476674 scopus 로고    scopus 로고
    • Kit signaling through PI 3-kinase and Src kinase pathways: An essential role for Rac1 and JNK activation in mast cell proliferation
    • Timokhina I, Kissel H, Stella G, Besmer P. Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation. EMBO J 17: 6250-6262, 1998.
    • (1998) EMBO J , vol.17 , pp. 6250-6262
    • Timokhina, I.1    Kissel, H.2    Stella, G.3    Besmer, P.4
  • 278
    • 0038026047 scopus 로고    scopus 로고
    • Mast cells stimulated by membrane-bound, but not soluble, steel factor are dependent on phospholipase C activation
    • Trieselmann NZ, Soboloff J, Berger SA. Mast cells stimulated by membrane-bound, but not soluble, steel factor are dependent on phospholipase C activation. Cell Mol Life Sci 60: 759-766, 2003.
    • (2003) Cell Mol Life Sci , vol.60 , pp. 759-766
    • Trieselmann, N.Z.1    Soboloff, J.2    Berger, S.A.3
  • 279
    • 0029822816 scopus 로고    scopus 로고
    • Involvement of transcription factor encoded by the mi locus in the expression of c-kit receptor tyrosine kinase in cultured mast cells of mice
    • Tsujimura T, Morii E, Nozaki M, Hashimoto K, Moriyama Y, Takebayashi K, Kondo T, Kanakura Y, Kitamura Y. Involvement of transcription factor encoded by the mi locus in the expression of c-kit receptor tyrosine kinase in cultured mast cells of mice. Blood 88: 1225-1233, 1996.
    • (1996) Blood , vol.88 , pp. 1225-1233
    • Tsujimura, T.1    Morii, E.2    Nozaki, M.3    Hashimoto, K.4    Moriyama, Y.5    Takebayashi, K.6    Kondo, T.7    Kanakura, Y.8    Kitamura, Y.9
  • 281
    • 0036566548 scopus 로고    scopus 로고
    • Critical roles of c-kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis: Contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration
    • Ueda S, Mizuki M, Ikeda H, Tsujimura T, Matsumura I, Nakano K, Daino H, Honda Z, Sonoyama J, Shibayama H, Sugahara H, Machii T, Kanakura Y. Critical roles of c-kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis: contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration. Blood 99: 3342-3349, 2002.
    • (2002) Blood , vol.99 , pp. 3342-3349
    • Ueda, S.1    Mizuki, M.2    Ikeda, H.3    Tsujimura, T.4    Matsumura, I.5    Nakano, K.6    Daino, H.7    Honda, Z.8    Sonoyama, J.9    Shibayama, H.10    Sugahara, H.11    Machii, T.12    Kanakura, Y.13
  • 282
    • 0036143774 scopus 로고    scopus 로고
    • Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival
    • Ueki K, Fruman DA, Brachmann SM, Tseng YH, Cantley LC, Kahn CR. Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Mol Cell Biol 22: 965-977, 2002.
    • (2002) Mol Cell Biol , vol.22 , pp. 965-977
    • Ueki, K.1    Fruman, D.A.2    Brachmann, S.M.3    Tseng, Y.H.4    Cantley, L.C.5    Kahn, C.R.6
  • 283
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-kappaB transcription factors in the immune system
    • Vallabhapurapu S, Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 27: 693-733, 2009.
    • (2009) Annu Rev Immunol , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 284
    • 0034669936 scopus 로고    scopus 로고
    • Stem cell factor induces phosphatidylinositol 3′-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells
    • Van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M. Stem cell factor induces phosphatidylinositol 3′-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells. Blood 96: 3406-3413, 2000.
    • (2000) Blood , vol.96 , pp. 3406-3413
    • van Dijk, T.B.1    van den Akker, E.2    Amelsvoort, M.P.3    Mano, H.4    Löwenberg, B.5    von Lindern, M.6
  • 285
    • 34948836275 scopus 로고    scopus 로고
    • The tyrosine kinase FES is an essential effector of KITD816V proliferation signal
    • Voisset E, Lopez S, Dubreuil P, De Sepulveda P. The tyrosine kinase FES is an essential effector of KITD816V proliferation signal. Blood 110: 2593-2599, 2007.
    • (2007) Blood , vol.110 , pp. 2593-2599
    • Voisset, E.1    Lopez, S.2    Dubreuil, P.3    de Sepulveda, P.4
  • 286
    • 26944458584 scopus 로고    scopus 로고
    • The systemic mastocytosis-specific activating cKit mutation D816V can be inhibited by the tyrosine kinase inhibitor AMN107
    • Von Bubnoff N, Gorantla SH, Kancha RK, Lordick F, Peschel C, Duyster J. The systemic mastocytosis-specific activating cKit mutation D816V can be inhibited by the tyrosine kinase inhibitor AMN107. Leukemia 19: 1670-1671, 2005.
    • (2005) Leukemia , vol.19 , pp. 1670-1671
    • von Bubnoff, N.1    Gorantla, S.H.2    Kancha, R.K.3    Lordick, F.4    Peschel, C.5    Duyster, J.6
  • 288
    • 3042799365 scopus 로고    scopus 로고
    • Activation of the MAP kinase pathway by c-Kit is PI-3 kinase dependent in hematopoietic progenitor/stem cell lines
    • Wandzioch E, Edling CE, Palmer RH, Carlsson L, Hallberg B. Activation of the MAP kinase pathway by c-Kit is PI-3 kinase dependent in hematopoietic progenitor/stem cell lines. Blood 104: 51-57, 2004.
    • (2004) Blood , vol.104 , pp. 51-57
    • Wandzioch, E.1    Edling, C.E.2    Palmer, R.H.3    Carlsson, L.4    Hallberg, B.5
  • 291
  • 292
    • 0027967089 scopus 로고
    • Mutation of the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine
    • Ward SM, Burns AJ, Torihashi S, Sanders KM. Mutation of the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine. J Physiol 480: 91-97, 1994.
    • (1994) J Physiol , vol.480 , pp. 91-97
    • Ward, S.M.1    Burns, A.J.2    Torihashi, S.3    Sanders, K.M.4
  • 294
    • 0037564438 scopus 로고    scopus 로고
    • The role of Kit-ligand in melanocyte development and epidermal homeostasis
    • Wehrle-Haller B. The role of Kit-ligand in melanocyte development and epidermal homeostasis. Pigment Cell Res 16: 287-296, 2003.
    • (2003) Pigment Cell Res , vol.16 , pp. 287-296
    • Wehrle-Haller, B.1
  • 297
    • 0029740513 scopus 로고    scopus 로고
    • c-kit ligand stimulates tyrosine phosphorylation of the c-Cbl protein in human hematopoietic cells
    • Wisniewski D, Strife A, Clarkson B. c-kit ligand stimulates tyrosine phosphorylation of the c-Cbl protein in human hematopoietic cells. Leukemia 10: 1436-1442, 1996.
    • (1996) Leukemia , vol.10 , pp. 1436-1442
    • Wisniewski, D.1    Strife, A.2    Clarkson, B.3
  • 298
    • 0037444815 scopus 로고    scopus 로고
    • The adapter protein APS associates to the multifunctional docking sites Tyr568 and Tyr936 in c-Kit: Possible role in v-Kit transformation
    • Wollberg P, Lennartsson J, Gottfridsson E, Yoshimura A, Rönnstrand L. The adapter protein APS associates to the multifunctional docking sites Tyr568 and Tyr936 in c-Kit: possible role in v-Kit transformation. Biochem J 370: 1033-1038, 2003.
    • (2003) Biochem J , vol.370 , pp. 1033-1038
    • Wollberg, P.1    Lennartsson, J.2    Gottfridsson, E.3    Yoshimura, A.4    Rönnstrand, L.5
  • 299
    • 77954216079 scopus 로고    scopus 로고
    • Targeting KIT in melanoma: A paradigm of molecular medicine and targeted therapeutics
    • Woodman SE, Davies MA. Targeting KIT in melanoma: a paradigm of molecular medicine and targeted therapeutics. Biochem Pharmacol 80: 568-574, 2010.
    • (2010) Biochem Pharmacol , vol.80 , pp. 568-574
    • Woodman, S.E.1    Davies, M.A.2
  • 300
    • 0028979693 scopus 로고
    • Interaction of the erythropoietin and stem-cell-factor receptors
    • Wu H, Klingmüller U, Besmer P, Lodish HF. Interaction of the erythropoietin and stem-cell-factor receptors. Nature 377: 242-246, 1995.
    • (1995) Nature , vol.377 , pp. 242-246
    • Wu, H.1    Klingmüller, U.2    Besmer, P.3    Lodish, H.F.4
  • 302
    • 33845751024 scopus 로고    scopus 로고
    • Neoplasia driven by mutant c-KIT is mediated by intracellular, not plasma membrane, receptor signaling
    • Xiang Z, Kreisel F, Cain J, Colson A, Tomasson MH. Neoplasia driven by mutant c-KIT is mediated by intracellular, not plasma membrane, receptor signaling. Mol Cell Biol 27: 267-282, 2007.
    • (2007) Mol Cell Biol , vol.27 , pp. 267-282
    • Xiang, Z.1    Kreisel, F.2    Cain, J.3    Colson, A.4    Tomasson, M.H.5
  • 303
    • 0027494480 scopus 로고
    • Characterization of the promoter region of the human c-kit proto-oncogene
    • Yamamoto K, Tojo A, Aoki N, Shibuya M. Characterization of the promoter region of the human c-kit proto-oncogene. Jpn J Cancer Res 84: 1136-1144, 1993.
    • (1993) Jpn J Cancer Res , vol.84 , pp. 1136-1144
    • Yamamoto, K.1    Tojo, A.2    Aoki, N.3    Shibuya, M.4
  • 305
    • 0028809209 scopus 로고
    • Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
    • Yang E, Zha J, Jockel J, Boise LH, Thompson CB, Korsmeyer SJ. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80: 285-291, 1995.
    • (1995) Cell , vol.80 , pp. 285-291
    • Yang, E.1    Zha, J.2    Jockel, J.3    Boise, L.H.4    Thompson, C.B.5    Korsmeyer, S.J.6
  • 307
  • 308
    • 0028151430 scopus 로고
    • Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3′-kinase, and protein kinase C
    • Yee NS, Hsiau CW, Serve H, Vosseller K, Besmer P. Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3′-kinase, and protein kinase C. J Biol Chem 269: 31991-31998, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 31991-31998
    • Yee, N.S.1    Hsiau, C.W.2    Serve, H.3    Vosseller, K.4    Besmer, P.5
  • 309
    • 33749376770 scopus 로고    scopus 로고
    • The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway
    • Yu M, Luo J, Yang W, Wang Y, Mizuki M, Kanakura Y, Besmer P, Neel BG, Gu H. The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway. J Biol Chem 281: 28615-28626, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 28615-28626
    • Yu, M.1    Luo, J.2    Yang, W.3    Wang, Y.4    Mizuki, M.5    Kanakura, Y.6    Besmer, P.7    Neel, B.G.8    Gu, H.9
  • 310
    • 34447531743 scopus 로고    scopus 로고
    • Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor
    • Yuzawa S, Opatowsky Y, Zhang Z, Mandiyan V, Lax I, Schlessinger J. Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor. Cell 130: 323-334, 2007.
    • (2007) Cell , vol.130 , pp. 323-334
    • Yuzawa, S.1    Opatowsky, Y.2    Zhang, Z.3    Mandiyan, V.4    Lax, I.5    Schlessinger, J.6
  • 312
    • 84867704415 scopus 로고    scopus 로고
    • Regulation of stem cell factor receptor signaling by CBL family proteins (CBL-B/c-CBL)
    • Zeng S, Xu Z, Lipkowitz S, Longley JB. Regulation of stem cell factor receptor signaling by CBL family proteins (CBL-B/c-CBL). Blood 2004.
    • (2004) Blood
    • Zeng, S.1    Xu, Z.2    Lipkowitz, S.3    Longley, J.B.4
  • 313
    • 0030584088 scopus 로고    scopus 로고
    • Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
    • Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 87: 619-628, 1996.
    • (1996) Cell , vol.87 , pp. 619-628
    • Zha, J.1    Harada, H.2    Yang, E.3    Jockel, J.4    Korsmeyer, S.J.5
  • 315
    • 0034608859 scopus 로고    scopus 로고
    • Crystal structure of human stem cell factor: Implication for stem cell factor receptor dimerization and activation
    • Zhang Z, Zhang R, Joachimiak A, Schlessinger J, Kong XP. Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation. Proc Natl Acad Sci USA 97: 7732-7737, 2000.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7732-7737
    • Zhang, Z.1    Zhang, R.2    Joachimiak, A.3    Schlessinger, J.4    Kong, X.P.5
  • 316
    • 0028273326 scopus 로고
    • Alternate splicing creates two forms of the human kit protein
    • Zhu WM, Dong WF, Minden M. Alternate splicing creates two forms of the human kit protein. Leuk Lymphoma 12: 441-447, 1994.
    • (1994) Leuk Lymphoma , vol.12 , pp. 441-447
    • Zhu, W.M.1    Dong, W.F.2    Minden, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.