Theophylline inhibits NF-κB activation and IκBα degradation in human pulmonary epithelial cells

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 364, Issue 6, 2001, Pages 558-561

  Ichiyama, T ^a   Hasegawa, S ^a   Matsubara, T ^a   Hayashi, T ^a   Furukawa, S ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

A549 cells; I B ; Inflammation; NF B; Theophylline

Indexed keywords

CHLORAMPHENICOL ACETYLTRANSFERASE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; ISOPROTEIN; THEOPHYLLINE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME ASSAY; EPITHELIUM CELL; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRONCHODILATOR AGENTS; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; I-KAPPA B PROTEINS; INFLAMMATION; INTERLEUKIN-6; LUNG; NF-KAPPA B; PHOSPHODIESTERASE INHIBITORS; RESPIRATORY MUCOSA; THEOPHYLLINE; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035207080     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-001-0494-x     Document Type: Article

References (29)

1. Immunosuppression by glucocorticoids: Inhibition of IκB synthesis
2. The NF-κB and IκB proteins: New discoveries and insights
3. Control of IκB-α proteolysis by site-specific, signal-induced phosphorylation
4. Interleukin-4 inhibits κ light chain expression and NFκB activation but not IκBα degradation in 70Z/3 murine pre-B cells
5. Regulation of tumor necrosis factor alpha transcription in macrophages: Involvement of four κB-like motifs and of constitutive and inducible forms of NF-κB
6. Asthma, adenosine, mast cells and theophylline
7. A sensitive method for the detection of β-galactosidase in transfected mammalian cells
8. Rapid proteolysis of IκB-α is necessary for activation of transcriptional factor NF-κB
9. Characterization of a functional NF-κB site in the human interleukin 1β promotor: Evidence for a positive autoregulatory loop
10. α-melanocyte-stimulating hormone inhibits NF-κB activation and IκBα degradation in human glioma cells and in experimental brain inflammation
11. Sodium valproate inhibits production of TNF-α and IL-6 and activation of NF-κB
12. Synergistic transcriptional activation of the IL-8 gene by NF-κB p65 (RelA) and NF-IL-6
13. In vivo suppression of NF-κB and preservation of IκBα by interleukin-10 and interleukin-13
14. Activation of interleukin-6 gene expression through the NF-κB transcription factor
15. Pyrrolidine dithiocarbamate prevents I-κB degradation and reduces microvascular injury induced by lipopolysaccharide in multiple organs
16. Studies into the effect of the tyrosine kinase inhibitor herbimycin A on NF-κB activation in T lymphocytes
17. IL-13 suppresses TNF-induced activation of nuclear factor-κB, activation protein-1, and apoptosis
18. α-melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-κB activation induced by various inflammatory agents
19. Cyclosporin A interferes with the inducible degradation of NF-κB inhibitor, but not with the processing of p105/NF-κB1 in T cells
20. Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8
21. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-κB
22. Asthma: Pathogenesis and treatment
23. Morphine modulates NFκB activation in macrophages
24. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids
25. Regulatory elements involved in Tax-mediated transactivation of the HTLV-1 LTR
26. Estrogen inhibits phorbol ester-induced IκBα transcription and protein degradation
27. Functional assay of NF-κB translocation into nuclei by laser scanning cytometry: Inhibitory effect by dexamethasone or theophylline
28. The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β
29. Effect of theophylline on the production of interleukin-1 beta, tumor necrosis factor-alpha, and interleukin-8 by human peripheral blood mononuclear cells