Effects of inhaled corticosteroid therapy on expression and DNA-binding activity of nuclear factor κB in asthma

American Journal of Respiratory and Critical Care Medicine

Volumn 161, Issue 1, 2000, Pages 224-231

  Hart, Lorraine ^a   Sam, Lim ^a   Adcock, Ian ^a   Barnes, Peter J ^a   Chung, K Fan ^a,b  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; FLUTICASONE PROPIONATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; PLACEBO; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR;

ADULT; ARTICLE; ASTHMA; BRONCHUS BIOPSY; BRONCHUS HYPERREACTIVITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CROSSOVER PROCEDURE; DNA BINDING; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0033958495     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.161.1.9809019     Document Type: Article

References (45)

1. 1. Barnes, P. J. 1995. Inhaled glucocorticoids for asthma. N. Engl. J. Med. 332:868-875.
2. 2. Wilson, J. W., R. Djukanovic, P. H. Howarth, and S. T. Holgate. 1994. Inhaled beclomethasone dipropionate downregulates airway lymphocyte activation in atopic asthma. Am. J. Respir. Crit. Care Med. 149:86-90.
3. 3. Laitinen, L. A., A. Laitinen, and T. Haahtela. 1992. A comparative study of the effects of an inhaled corticosteroid, budesonide, and of a β2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: a randomized, double-blind, parallel-group controlled trial. J. Allergy Clin. Immunol. 90:32-42.
4. 4. Robinson, D. S., Q. Hamid, S. Ying, A. M. Bentley, B. Assoufi, J. North, M. Qui, S. R. Durham, and A. B. Kay. 1993. Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell IL-4, IL-5 and IFN-γ cytokine gene expression. Am. Rev. Respir. Dis. 148:401-406.
5. 5. Bentley, A. M., Q. Hamid, D. S. Robinson, E. Schotman, Q. Meng, B. Assoufi, A. B. Kay, and S. R. Durham. 1996. Prednisolone treatment in asthma: reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa. Am. J. Respir. Crit. Care Med. 153:551-556.
6. 6. Sousa, A. R., R. N. Poston, S. J. Lane, J. A. Narhosteen, and T. H. Lee. 1993. Detection of GM-CSF in asthmatic bronchial epithelium and decrease by inhaled corticosteroids. Am. Rev. Respir. Dis. 147:1557-1561.
7. 7. Wang, J. H., J. L. Devalia, C. Xia, R. J. Sapsford, and R. J. Davies. 1996. Expression of RANTES by human bronchial epithelial cells in vitro and in vivo and the effect of corticosteroids. Am. J. Respir. Cell Mol. Biol. 14:27-35.
8. 8. Hamid, Q., M. Azzawi, S. Ying, R. Moqbel, A. J. Wardlaw, C. J. Corrigan, B. Bradley, S. R. Durham, J. V. Collins, and P. R. Jeffery. 1991. Expression of mRNA for interleukins in mucosal bronchial biopsies from asthma. J. Clin. Invest. 87:1541-1546.
9. 9. Kern, J. A., R. J. Lamb, J. C. Reed, R. P. Daniele, and P. C. Nowell. 1988. Dexamethasone inhibition of interleukin 1 beta production by human monocytes: posttranscriptional mechanisms. J. Clin. Invest. 81: 237-244.
10. 10. Berkman, N., A. Robichaud, V. L. Krishnan, G. Roesems, R. A. Robbins, P. J. Jose, P. J. Barnes, and K. F. Chung. 1995. Expression of RANTES in human airway epithelial cells: effect of corticosteroids and interleukin-4, 10 and 13. Immunology 87:599-603.
11. 11. Kwon, O. J., B. T. Au, P. D. Collins, J. N. Baraniuk, I. M. Adcock, K. F. Chung, and P. J. Barnes. 1994. Inhibition of interleukin-8 expression by dexamethasone in human cultured airway epithelial cells. Immunology 81:389-394.
12. 12. Rolfe, F. G., J. M. Hughes, C. L. Armour, and W. A. Sewell. 1992. Inhibition of interleukin-5 gene expression by dexamethasone. Immunology 77:494-499.
13. 13. Beato, M. 1989. Gene regulation by steroid hormones. Cell 56:335-344.
14. 14. Ray, A., and K. E. Prefontaine. 1994. Physical association and functional antagonism between p65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proc. Natl. Acad. Sci. U.S.A. 91:752-756.
15. 15. Scheinman, R. I., A. Gualberto, C. M. Jewell, J. A. Cidlowski, and A. S. Baldwin, Jr. 1995. Characterization of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors. Mol. Cell. Biol. 15:943-953.
16. 16. Adcock, I. M., C. R. Brown, C. M. Gelder, H. Shirasaki, M. J. Peters, and P. J. Barnes. 1995. The effects of glucocorticoids on transcription activation in human peripheral blood mononuclear cells. Am. J. Physiol. 37:C331-C338.
17. 17. Barnes, P. J., and I. M. Adcock. 1993. Anti-inflammatory actions of steroids: molecular mechanisms. Trends Pharmacol. Sci. 14:436-441.
18. 18. Barnes, P. J., and M. Karin. 1997. Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336:1066-1071.
19. 19. Baeuerle, P. A., and T. Henkel. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141-179.
20. 20. Baldwin, A. S., Jr. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649-683.
21. 21. Hart, L. A., V. L. Krishnan, I. M. Adcock, P. J. Barnes, and K. F. Chung. 1998. Activation and localisation of transcription factor, nuclear factor-κB, in asthma. Am. J. Respir. Crit. Care Med. 158:1585-1592.
22. 22. Siebenlist, U., G. Franzoso, and K. Brown. 1994. Structure, regulation and function of NF-κB. Annu. Rev. Cell Biol. 10:405-455.
23. 23. Hiscott, J., J. Marois, J. Garoufalis, M. D'Addario, A. Roulston, I. Kwan, J. Lacoste, H. Nguyen, G. Bensi, et al. 1993. Characterization of a functional NF-κB site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop. Mol. Cell. Biol. 13:6231-6240.
24. 24. Xie, Q. W., Y. Kashiwabara, and C. Nathan. 1994. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase. J. Biol. Chem. 269:4705-1708.
25. 25. Widmer, U., K. R. Manogue, A. Cerami, and B. Sherry. 1993. Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1α, and MIP-1β, members of the chemokine superfamily of proinflammatory cytokines. J. Immunol. 150:4996-5012.
26. 26. Nelson, P. J., B. D. Ortiz, J. M. Pattison, and A. M. Krensky. 1996. Identification of a novel regulatory region critical for expression of the RANTES chemokine in activated T lymphocytes. J. Immunol. 157:1139-1148.
27. 27. Auphan, N., J. A. DiDonato, C. Rosette, A. Helmberg, and M. Karin. 1995. Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of Iκ-B synthesis. Science 270:286-290.
28. 28. Adcock, I. M., H. Shirasaki, C. M. Gelder, M. J. Peters, C. R. Brown, and P. J. Barnes. 1994. The effects of glucocorticoids on phorbol ester and cytokine stimulated transcription factor activation in human lung. Life Sci. 55:1147-1153.
29. 29. Newton, R., L. A. Hart, D. A. Stevens, M. Bergmann, L. E. Donnelly, I. M. Adcock, and P. J. Barnes. 1998. Effect of dexamethasone on interleukin-1beta-(IL-1beta)-induced nuclear factor-kappaB (NF-κB) and κB-dependent transcription in epithelial cells. Eur. J. Biochem. 254:81-89.
30. 30. Wang, Y., J. J. Zhang, W. Dai, K. Y. Lei, and J. W. Pike. 1997. Dexamethasone potently enhances phorbol ester-induced IL-1beta gene expression and nuclear factor NF-κB activation. J. Immunol. 159:534-537.
31. 31. Brostjan, C., J. Anrather, V. Csizmadia, D. Stroka, M. Soares, F. H. Bach, and H. Winkler. 1996. Glucocorticoid-mediated repression of NF-κB activity in endothelial cells does not involve induction of IkappaBalpha synthesis. J. Biol. Chem. 271:19612-19616.
32. 32. Gough, N. M. 1988. Rapid and quantitative preparation of cytoplasmic RNA from small numbers of cells. Anal. Biochem. 173:93-95.
33. 33. Osborn, L., S. Kunkel, and G. J. Nabel. 1989. TNF-α and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the NF-κB. Proc. Natl. Acad. Sci. U.S.A. 86:2336-2340.
34. 34. Dignan, J. P., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1478.
35. 35. Shu, S., G. Ju, and L. Fan. 1988. The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the central nervous system. Neurosci. Lett. 85:169-171.
36. 36. Schreck, R., K. Albermann, and P. A. Baeuerle. 1992. Nuclear factor κB: an oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Rad. Res. Commun. 17:221-237.
37. 37. Adcock, I. M., C. R. Brown, O. Kwon, and P. J. Barnes. 1994. Oxidative stress induces NF-κB DNA binding and inducible NOS mRNA in human epithelial cells. Biochem. Biophys. Res. Commun. 199:1518-1524.
38. 38. Sousa, A. R., S. J. Lane, J. A. Nakhosteen, T. H. Lee, and R. N. Poston. 1996. Expression of interleukin-1 beta (IL-1beta) and interleukin-1 receptor antagonist (IL-1ra) on asthmatic bronchial epithelium. Am. J. Respir. Crit. Care Med. 154:1061-1066.
39. 39. Ying, S., D. S. Robinson, V. Varney, Q. Meng, A. Tsicopoulos, R. Moqbel, S. R. Durham, A. B. Kay, and Q. Hamid. 1991. TNF-α mRNA expression in allergic inflammation. Clin. Exp. Allergy 21:745-750.
40. 40. Zhu, Z., W. Tang, A. Ray, Y. Wu, O. Einarsson, M. L. Landry, J. Gwaltney, and J. A. Elias. 1996. Rhinovirus stimulation of interleukin-6 in vivo and in vitro: evidence for nuclear factor-κB-dependent transcriptional activation. J. Clin. Invest 97:421-430.
41. 41. Haddad, E. B., M. Salmon, J. Sun, S. Liu, A. Das, I. Adcock, P. J. Barnes, and K. F. Chung. 1995. Dexamethasone inhibits ozone-induced gene expression of macrophage inflammatory protein-2 in rat lung. FEBS Lett. 363:285-288.
42. 42. Demoly, P., N. Basset-Seguin, P. Chanez, A. M. Campbell, C. Gauthier-Rouvriere, P. Godard, R. Michel, and J. Bousquet. 1992. C-fos protooncogene expression in bronchial biopsies of asthmatics. Am. J. Respir. Cell Mol. Biol. 7:128-133.
43. 43. Adcock, I. M., C. R. Brown, H. Shirasaki, and P. J. Barnes. 1994. Effects of dexamethasone on cytokine and phorbol ester stimulated c-Fos and c-Jun DNA binding and gene expression in human lung. Eur. Respir. J. 7:2117-2123.
44. 44. Baraniuk, J. N., G. Wong, M. Ali, M. Sabol, and T. Troost. 1998. Glucocorticoids decrease c-fos expression in human nasal polyps in vivo. Thorax 53:577-582.
45. 45. Bennett, B. L., R. G. Lacson, C. C. Chen, R. Cruz, J. S. Wheeler, R. F. Kletzien, A. G. Tomasselli, R. L. Heinrikson, and A. M. Manning. 1996. Identification of signal-induced IκB-alpha kinases in human endothelial cells. J. Biol. Chem. 271:19680-19688.