Accelerated ageing of the lung in COPD: New concepts

Thorax

Volumn 70, Issue 5, 2015, Pages 482-489

  Mercado, Nicolas ^a   Ito, Kazuhiro ^a   Barnes, Peter J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CIGARETTE SMOKE; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PROTEIN KINASE B; RAPAMYCIN; SPERMIDINE; THEOPHYLLINE; TARGET OF RAPAMYCIN KINASE;

AGING; ANTIOXIDANT ACTIVITY; AUTOPHAGY; CELL AGING; CELL PROTECTION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL (TOPIC); DEPLETION; DISEASE PREDISPOSITION; DRUG MECHANISM; DRUG TOLERABILITY; ENVIRONMENTAL STRESS; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; HUMAN; IMMUNOLOGICAL PARAMETERS; IMMUNOSENESCENCE; INNATE IMMUNITY; LOW DRUG DOSE; LUNG EMPHYSEMA; LUNG INSUFFICIENCY; MITOCHONDRIAL RESPIRATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STEM CELL; UNSPECIFIED SIDE EFFECT; UPREGULATION; COMPLICATION; LUNG; PATHOLOGY; PHYSIOLOGY;

AGING; HUMANS; LUNG; OXIDATIVE STRESS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84929466240     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2014-206084     Document Type: Review

References (89)

1. Ito K, Barnes PJ. COPD as a disease of accelerated lung aging. Chest 2009;135:173-80.
2. Harman D. Free radical theory of aging: an update: increasing the functional life span. Ann NY Acad Sci 2006;1067:10-21.
3. Radak Z, Chung HY, Goto S. Exercise and hormesis: oxidative stress-related adaptation for successful aging. Biogerontology 2005;6:71-5.
4. Blagosklonny MV. Aging: ROS or TOR. Cell Cycle 2008;7:3344-54.
5. Hekimi S, Lapointe J, Wen Y. Taking a "good" look at free radicals in the aging process. Trends Cell Biol 2011;21:569-76.
6. Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 2005;120:513-22.
7. De MM, Franceschi C, Monti D, et al. Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. FEBS Lett 2005;579:2035-9.
8. Chilosi M, Carloni A, Rossi A, et al. Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema. Transl Res 2013;162:156-73.
9. Fukuchi Y. The aging lung and chronic obstructive pulmonary disease: similarity and difference. Proc Am Thorac Soc 2009;6:570-2.
10. Bratic A, Larsson NG. The role of mitochondria in aging. J Clin Invest 2013;123:951-7.
11. Holzenberger M, Dupont J, Ducos B, et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 2003;421:182-7.
12. Choi JS, Choi KM, Lee CK. Caloric restriction improves efficiency and capacity of the mitochondrial electron transport chain in Saccharomyces cerevisiae. Biochem Biophys Res Commun 2011;409:308-14.
13. Kapahi P, Zid BM, Harper T, et al. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 2004;14:885-90.
14. Lopez-Otin C, Blasco MA, Partridge L, et al. The hallmarks of aging. Cell 2013;153:1194-217.
15. Vigneron A, Vousden KH. p53, ROS and senescence in the control of aging. Aging (Albany NY) 2010;2:471-4.
16. To Y, Ito K, Kizawa Y, et al. Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2010;182:897-904.
17. Zanini A, Spanevello A, Baraldo S, et al. Decreased maturation of dendritic cells in the central airways of COPD patients is associated with VEGF, TGF-beta and vascularity. Respiration 2014;87:234-42.
18. Abid MR, Guo S, Minami T, et al. Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells. Arterioscler Thromb Vasc Biol 2004;24:294-300.
19. Suwanabol PA, Seedial SM, Zhang F, et al. TGF-beta and Smad3 modulate PI3K/Akt signaling pathway in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 2012;302:H2211-19.
20. Johnson SC, Rabinovitch PS, Kaeberlein M. mTOR is a key modulator of ageing and age-related disease. Nature 2013;493:338-45.
21. Connor KM, Subbaram S, Regan KJ, et al. Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation. J Biol Chem 2005;280:16916-24.
22. Hosgood HD III, Menashe I, He X, et al. PTEN identified as important risk factor of chronic obstructive pulmonary disease. Respir Med 2009;103:1866-70.
23. Bosch-Presegue L, Vaquero A. Sirtuins in stress response: guardians of the genome. Oncogene 2014;33:3764-75.
24. Nakamaru Y, Vuppusetty C, Wada H, et al. A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. FASEB J 2009;23:2810-19.
25. Ito K, Colley T, Mercado N. Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease. Int J Chron Obstruct Pulmon Dis 2012;7:641-52.
26. Takasaka N, Araya J, Hara H, et al. Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence. J Immunol 2014;192:958-68.
27. Mao Z, Tian X, Van MM, et al. Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proc Natl Acad Sci USA 2012;109:11800-5.
28. Lee IH, Cao L, Mostoslavsky R, et al. A role for the NAD-dependent deacetylase Sirt 1 in the regulation of autophagy. Proc Natl Acad Sci USA 2008;105:3374-9.
29. Patel PH, Tamanoi F. Increased Rheb-TOR signaling enhances sensitivity of the whole organism to oxidative stress. JCell Sci 2006;119(Pt 20):4285-92.
30. Hwang J-w, Rajendrasozhan S, Yao H, et al. FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease. J Immunol 2011;187:987-98.
31. Yao H, Chung S, Hwang JW, et al. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest 2012;122:2032-45.
32. Mercado N, Thimmulappa R, Thomas CM, et al. Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress. Biochem Biophys Res Commun 2011;406:292-8.
33. Malhotra D, Thimmulappa R, Navas-Acien A, et al. Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. Am J Respir Crit Care Med 2008;178:592-604.
34. Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell 2012;149:274-93.
35. Warr MR, Binnewies M, Flach J, et al. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature 2013;494:323-7.
36. Aoshiba K, Zhou F, Tsuji T, et al. DNA damage as a molecular link in the pathogenesis of COPD in smokers. Eur Respir J 2012;39:1368-76.
37. Paschalaki KE, Starke RD, Hu Y, et al. Dysfunction of endothelial progenitor cells from smokers and COPD patients due to increased DNA damage and senescence. Stem Cells 2013;31:2813-26.
38. Mizushima N, Levine B, Cuervo AM, et al. Autophagy fights disease through cellular self-digestion. Nature 2008;451:1069-75.
39. Young ARJ, Narita M. Connecting autophagy to senescence in pathophysiology. Curr Opin Cell Biol 2010;22:234-40.
40. Liu Y, Shoji-Kawata S, Sumpter RM, et al. Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia. Proc Natl Acad Sci 2013;110:20364-71.
41. Chen ZH, Lam HC, Jin Y, et al. Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema. Proc Natl Acad Sci USA 2010;107:18880-5.
42. Chen Z-H, Kim HP, Sciurba FC, et al. Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease. PLoS ONE 2008;3:e3316.
43. Lam HC, Cloonan SM, Bhashyam AR, et al. Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. J Clin Invest 2013;123:5212-30.
44. Mizumura K, Cloonan SM, Nakahira K, et al. Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD. J Clin Invest 2014;124:3987-4003.
45. Fujii S, Hara H, Araya J, et al. Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease. Oncoimmunology 2012;1:630-41.
46. Hoffmann RF, Zarrintan S, Brandenburg SM, et al. Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells. Respir Res 2013;14:97.
47. Pampliega O, Orhon I, Patel B, et al. Functional interaction between autophagy and ciliogenesis. Nature 2013;502:194-200.
48. Araya J, Kojima J, Takasaka N, et al. Insufficient autophagy in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 2013;304:L56-69.
49. Hahn DR, Na C-L, Weaver TE. Reserve autophagic capacity in alveolar epithelia provides a replicative niche for influenza a virus. Am J Respir Cell Mol Biol 2014;51:400-12.
50. Murrow L, Debnath J. Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease. Annu Rev Pathol 2013;8:105-37.
51. Petrusca DN, Van DM, Gu Y, et al. Smoking exposure induces human lung endothelial cells adaptation to apoptotic stress. Am J Respir Cell Mol Biol 2014;50:513-25.
52. Monick MM, Powers LS, Walters K, et al. Identification of an autophagy defect in smokers' alveolar macrophages. J Immunol 2010;185:5425-35.
53. Lee S, Lee S-J, Coronata AA, et al. Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis. Antioxid Redox Signal 2013;20:432-42.
54. Donnelly LE, Barnes PJ. Defective phagocytosis in airways disease. Chest 2012;141:1055-62.
55. Zheng S, Wang C, Qian G, et al. Role of mtDNA haplogroups in COPD susceptibility in a southwestern Han Chinese population. Free Radic Biol Med 2012;53:473-81.
56. Thannickal V. Mechanistic links between aging and lung fibrosis. Biogerontology 2013;14:609-15.
57. Slebos DJ, Ryter SW, van der Toorn M, et al. Mitochondrial localization and function of heme oxygenase-1 in cigarette smoke-induced cell death. Am J Respir Cell Mol Biol 2007;36:409-17.
58. Soulitzis N, Neofytou E, Psarrou M, et al. Downregulation of lung mitochondrial prohibitin in COPD. Respir Med 2012;106:954-61.
59. Kathiria AS, Butcher LD, Feagins LA, et al. Prohibitin 1 modulates mitochondrial stress-related autophagy in human colonic epithelial cells. PLoS One 2012;7: e31231.
60. Schleicher M, Shepherd BR, Suarez Y, et al. Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. J Cell Biol 2008;180:101-12.
61. Sureshbabu A, Bhandari V. Targeting mitochondrial dysfunction in lung diseases: emphasis on mitophagy. Front Physiol 2013;4:384.
62. Kubli DA, Gustafsson AB. Mitochondria and mitophagy: the yin and yang of cell death control. Circ Res 2012;111:1208-21.
63. Hara H, Araya J, Ito S, et al. Mitochondrial fragmentation in cigarette smoke induced-bronchial epithelial cell senescence. Am J Physiol Lung Cell Mol Physiol 2013;305:L737-46.
64. Kubli DA, Zhang X, Lee Y, et al. Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction. J Biol Chem 2013;288:915-26.
65. Dagda RK, Cherra SJ III, Kulich SM, et al. Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem 2009;284:13843-55.
66. Gottlieb RA, Gustafsson AB. Mitochondrial turnover in the heart. Biochim Biophys Acta 2011;1813:1295-301.
67. Lazarou M, Jin SM, Kane LA, et al. Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Dev Cell 2012;22:320-33.
68. Frank M, Duvezin-Caubet S, Koob S, et al. Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner. Biochim Biophys Acta 2012;1823:2297-310.
69. Rodgers JT, Lerin C, Haas W, et al. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 2005;434:113-18.
70. Li J, Dai A, Hu R, et al. Positive correlation between PPARgamma/PGC-1alpha and gamma-GCS in lungs of rats and patients with chronic obstructive pulmonary disease. Acta Biochim Biophys Sin(Shanghai) 2010;42:603-14.
71. Remels AH, Gosker HR, Schrauwen P, et al. TNF-alpha impairs regulation of muscle oxidative phenotype: implications for cachexia? FASEB J. 2010;24:5052-62.
72. Salminen A, Ojala J, Kaarniranta K, et al. Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases. Cell Mol Life Sci 2012;69:2999-3013.
73. Alder JK, Guo N, Kembou F, et al. Telomere length is a determinant of emphysema susceptibility. Am J Respir Crit Care Med 2011;184:904-12.
74. Kubo H. Concise review: clinical prospects for treating chronic obstructive pulmonary disease with regenerative approaches. Stem Cells Transl Med 2012;1:627-31.
75. Ito K, Suda T. Metabolic requirements for the maintenance of self-renewing stem cells. Nat Rev Mol Cell Biol 2014;15:243-56.
76. Tsuji T, Aoshiba K, Nagai A. Alveolar cell senescence exacerbates pulmonary inflammation in patients with chronic obstructive pulmonary disease. Respiration 2010;80:59-70.
77. Barkauskas CE, Cronce MJ, Rackley CR, et al. Type 2 alveolar cells are stem cells in adult lung. J Clin Invest 2013;123:3025-36.
78. Desai TJ, Brownfield DG, Krasnow MA. Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature 2014;507:190-4.
79. Fujino N, Kubo H, Suzuki T, et al. Isolation of alveolar epithelial type II progenitor cells from adult human lungs. Lab Invest 2011;91:363-78.
80. Lindsey JY, Ganguly K, Brass DM, et al. c-Kit is essential for alveolar maintenance and protection from emphysema-like disease in mice. Am J Respir Crit Care Med 2011;183:1644-52.
81. Caruso C, Buffa S, Candore G, et al. Mechanisms of immunosenescence. Immun Ageing 2009;6:10.
82. Xie C, Patel R, Wu T, et al. PI3K/AKT/mTOR hypersignaling in autoimmune lymphoproliferative disease engendered by the epistatic interplay of Sle1b and FASlpr. Int Immunol 2007;19:509-22.
83. Mahbub S, Brubaker AL, Kovacs EJ. Aging of the Innate Immune System: An Update. Curr Immunol Rev 2011;7:104-15.
84. Tuder RM, Kern JA, Miller YE. Senescence in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2012;9:62-3.
85. Lambers C, Hacker S, Posch M, et al. T cell senescence and contraction of T cell repertoire diversity in patients with chronic obstructive pulmonary disease. Clin Exp Immunol 2009;155:466-75.
86. Shaykhiev R, Crystal RG. Innate immunity and chronic obstructive pulmonary disease: a mini-review. Gerontology 2013;59:481-9.
87. Wang H, Ying H, Wang S, et al. Imbalance of peripheral blood Th17 and Treg responses in patients with chronic obstructive pulmonary disease. Clin Respir J Published Online First: 11 Apr 2014. doi: 10.1111/crj.12147.
88. de Cabo R, Carmona-Gutierrez D, Bernier M, et al. The search for antiaging interventions: from elixirs to fasting regimens. Cell 2014;157:1515-26.
89. Basma H, Gunji Y, Iwasawa S, et al. Reprogramming of COPD lung fibroblasts through formation of induced pluripotent stem cells. Am J Physiol Lung Cell Mol Physiol 2014;306:L552-65.