메뉴 건너뛰기




Volumn 198, Issue 10, 2003, Pages 1573-1582

Blockade of Inflammation and Airway Hyperresponsiveness in Immune-sensitized Mice by Dominant-Negative Phosphoinositide 3-Kinase-TAT

Author keywords

Allergy; Cytokines; Eosinophils; Inflammation; Lung

Indexed keywords

FORMYLMETHIONYLLEUCYLPHENYLALANINE; INTERLEUKIN 4; INTERLEUKIN 5; METHACHOLINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85; PROTEIN SUBUNIT; TRANSACTIVATOR PROTEIN;

EID: 0344154290     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20030298     Document Type: Article
Times cited : (222)

References (51)
  • 3
    • 0027183057 scopus 로고
    • Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-γ cytokine gene expression
    • Robinson, D., Q. Hamid, S. Ying, A. Bentley, B. Assoufi, S. Durham, and A.B. Kay. 1993. Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-γ cytokine gene expression. Am. Rev. Respir. Dis. 148:401-406.
    • (1993) Am. Rev. Respir. Dis. , vol.148 , pp. 401-406
    • Robinson, D.1    Hamid, Q.2    Ying, S.3    Bentley, A.4    Assoufi, B.5    Durham, S.6    Kay, A.B.7
  • 5
    • 0022494041 scopus 로고
    • Effects of inhaled platelet activating factor on pulmonary function and bronchial responsiveness in man
    • Cuss, F.M., C.M. Dixon, and P.J. Barnes. 1986. Effects of inhaled platelet activating factor on pulmonary function and bronchial responsiveness in man. Lancet. 2:189-192.
    • (1986) Lancet , vol.2 , pp. 189-192
    • Cuss, F.M.1    Dixon, C.M.2    Barnes, P.J.3
  • 7
    • 0029866431 scopus 로고    scopus 로고
    • In vivo neutralization of eosinophil-derived major basic protein inhibits antigen-induced bronchial hyperreactivity in sensitized guinea pigs
    • Lefort, J., M.A. Nahori, C. Ruffie, B.B. Vargaftig, and M. Pretolani. 1996. In vivo neutralization of eosinophil-derived major basic protein inhibits antigen-induced bronchial hyperreactivity in sensitized guinea pigs. J. Clin. Invest. 97:1117-1121.
    • (1996) J. Clin. Invest. , vol.97 , pp. 1117-1121
    • Lefort, J.1    Nahori, M.A.2    Ruffie, C.3    Vargaftig, B.B.4    Pretolani, M.5
  • 8
    • 0023897684 scopus 로고
    • Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate
    • Whitman, M., C.P. Downes, M. Keeler, T. Keller, and L. Cantley. 1988. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature. 332:644-646.
    • (1988) Nature , vol.332 , pp. 644-646
    • Whitman, M.1    Downes, C.P.2    Keeler, M.3    Keller, T.4    Cantley, L.5
  • 12
    • 0032476608 scopus 로고    scopus 로고
    • Mechanisms of acute eosinophil mobilization from the bone marrow stimulated by interleukin 5: The role of specific adhesion molecules and phosphatidylinositol 3-kinase
    • Palframan, R.T., P.D. Collins, N.J. Severs, S. Rothery, T.J. Williams, and S.M. Rankin. 1998. Mechanisms of acute eosinophil mobilization from the bone marrow stimulated by interleukin 5: the role of specific adhesion molecules and phosphatidylinositol 3-kinase. J. Exp. Med. 188:1621-1632.
    • (1998) J. Exp. Med. , vol.188 , pp. 1621-1632
    • Palframan, R.T.1    Collins, P.D.2    Severs, N.J.3    Rothery, S.4    Williams, T.J.5    Rankin, S.M.6
  • 13
    • 0031730550 scopus 로고    scopus 로고
    • Signaling in neuropeptide-induced migration of human eosinophils
    • Dunzendorfer, S., C. Meierhofer, and C.J. Wiedermann. 1998. Signaling in neuropeptide-induced migration of human eosinophils. J. Leukoc. Biol. 64:828-834.
    • (1998) J. Leukoc. Biol. , vol.64 , pp. 828-834
    • Dunzendorfer, S.1    Meierhofer, C.2    Wiedermann, C.J.3
  • 15
    • 0035907389 scopus 로고    scopus 로고
    • p110β and p110delta phosphatidylinositol 3-kinases up-regulate Fc(epsilon)RI-activated Ca2+ influx by enhancing inositol 1,4,5-trisphosphate production
    • Smith, A.J., Z. Surviladze, E.A. Gaudet, J.M. Backer, C.A. Mitchell, and B.S. Wilson. 2001. p110β and p110delta phosphatidylinositol 3-kinases up-regulate Fc(epsilon)RI-activated Ca2+ influx by enhancing inositol 1,4,5-trisphosphate production. J. Biol. Chem. 276:17213-17220.
    • (2001) J. Biol. Chem. , vol.276 , pp. 17213-17220
    • Smith, A.J.1    Surviladze, Z.2    Gaudet, E.A.3    Backer, J.M.4    Mitchell, C.A.5    Wilson, B.S.6
  • 19
    • 0033556333 scopus 로고    scopus 로고
    • Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α
    • Fruman, D.A., S.B. Snapper, C.M. Yballe, L. Davidson, J.Y. Yu, F.W. Alt, and L.C. Cantley. 1999. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α. Science. 283:393-397.
    • (1999) Science , vol.283 , pp. 393-397
    • Fruman, D.A.1    Snapper, S.B.2    Yballe, C.M.3    Davidson, L.4    Yu, J.Y.5    Alt, F.W.6    Cantley, L.C.7
  • 20
    • 0033520487 scopus 로고    scopus 로고
    • In vivo protein transduction: Delivery of a biologically active protein into the mouse
    • Schwarze, S.R., A. Ho, A. Vocero-Akbani, and S.F. Dowdy. 1999. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science. 285:1569-1572.
    • (1999) Science , vol.285 , pp. 1569-1572
    • Schwarze, S.R.1    Ho, A.2    Vocero-Akbani, A.3    Dowdy, S.F.4
  • 23
    • 0036721785 scopus 로고    scopus 로고
    • Blockade of focal clustering and active conformation in β2-integrin-mediated adhesion of eosinophils to intercellular adhesion molecule-1 caused by transduction of HIV TAT-dominant negative Ras
    • Myou, S., X. Zhu, E. Boetticher, S. Myo, A. Meliton, A. Lambertino, N.M. Munoz, and A.B. Leff. 2002. Blockade of focal clustering and active conformation in β2-integrin-mediated adhesion of eosinophils to intercellular adhesion molecule-1 caused by transduction of HIV TAT-dominant negative Ras. J. Immunol. 169:2670-2676.
    • (2002) J. Immunol. , vol.169 , pp. 2670-2676
    • Myou, S.1    Zhu, X.2    Boetticher, E.3    Myo, S.4    Meliton, A.5    Lambertino, A.6    Munoz, N.M.7    Leff, A.B.8
  • 24
    • 0035496902 scopus 로고    scopus 로고
    • Transduction of a dominant-negative H-Ras into human eosinophils attenuates extracellular signal-regulated kinase activation and interleukin-5-mediated cell viability
    • Hall, D.J., J. Cui, M.E. Bates, B.A. Stout, L. Koenderman, P.J. Coffer, and P.J. Bertics. 2001. Transduction of a dominant-negative H-Ras into human eosinophils attenuates extracellular signal-regulated kinase activation and interleukin-5-mediated cell viability. Blood. 98:2014-2021.
    • (2001) Blood , vol.98 , pp. 2014-2021
    • Hall, D.J.1    Cui, J.2    Bates, M.E.3    Stout, B.A.4    Koenderman, L.5    Coffer, P.J.6    Bertics, P.J.7
  • 25
    • 0000965148 scopus 로고    scopus 로고
    • TRFK-5 reverses established airway eosinophilia but not established hyperresponsiveness in a murine model of chronic asthma
    • Mathur, M., K. Herrmann, X. Li, Y. Qin, J. Weinstock, D. Elliott, J. Monahan, and P. Padrid. 1999. TRFK-5 reverses established airway eosinophilia but not established hyperresponsiveness in a murine model of chronic asthma. Am. J. Respir. Crit. Care Med. 159:580-587.
    • (1999) Am. J. Respir. Crit. Care Med. , vol.159 , pp. 580-587
    • Mathur, M.1    Herrmann, K.2    Li, X.3    Qin, Y.4    Weinstock, J.5    Elliott, D.6    Monahan, J.7    Padrid, P.8
  • 29
    • 0026648380 scopus 로고
    • Differential regulation of T helper phenotype development by interleukins 4 and 10 in an α β T-cell-receptor transgenic system
    • Hsieh, C.S., A.B. Heimberger, J.S. Gold, A. O'Garra, and K.M. Murphy. 1992. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an α β T-cell-receptor transgenic system. Proc. Natl. Acad. Sci. USA. 89:6065-6069.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 6065-6069
    • Hsieh, C.S.1    Heimberger, A.B.2    Gold, J.S.3    O'Garra, A.4    Murphy, K.M.5
  • 30
    • 0026712313 scopus 로고
    • The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice
    • Seder, R.A., W.E. Paul, M.M. Davis, and B. Fazekas de St Groth. 1992. The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J. Exp. Med. 176:1091-1098.
    • (1992) J. Exp. Med. , vol.176 , pp. 1091-1098
    • Seder, R.A.1    Paul, W.E.2    Davis, M.M.3    Fazekas De St. Groth, B.4
  • 31
    • 0022568935 scopus 로고
    • B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells
    • Coffman, R.L., J. Ohara, M.W. Bond, J. Carty, A. Zlotnik, and W.E. Paul. 1986. B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J. Immunol. 136:4538-4541.
    • (1986) J. Immunol. , vol.136 , pp. 4538-4541
    • Coffman, R.L.1    Ohara, J.2    Bond, M.W.3    Carty, J.4    Zlotnik, A.5    Paul, W.E.6
  • 32
    • 0030999135 scopus 로고    scopus 로고
    • Nasal mast cells in perennial allergic rhinitics exhibit increased expression of the Fc epsilonRI, CD40L, IL-4, and IL-13, and can induce IgE synthesis in B cells
    • Pawankar, R., M. Okuda, H. Yssel, K. Okumura, and C. Ra. 1997. Nasal mast cells in perennial allergic rhinitics exhibit increased expression of the Fc epsilonRI, CD40L, IL-4, and IL-13, and can induce IgE synthesis in B cells. J. Clin. Invest. 99:1492-1499.
    • (1997) J. Clin. Invest. , vol.99 , pp. 1492-1499
    • Pawankar, R.1    Okuda, M.2    Yssel, H.3    Okumura, K.4    Ra, C.5
  • 33
    • 0026692094 scopus 로고
    • IL-4 controls the selective endothelium-driven transmigration of eosinophils from allergic individuals
    • Moser, R., J. Fehr, and P.L. Bruijnzeel. 1992. IL-4 controls the selective endothelium-driven transmigration of eosinophils from allergic individuals. J. Immunol. 149:1432-1438.
    • (1992) J. Immunol. , vol.149 , pp. 1432-1438
    • Moser, R.1    Fehr, J.2    Bruijnzeel, P.L.3
  • 34
    • 0033563258 scopus 로고    scopus 로고
    • IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo
    • Dabbagh, K., K. Takeyama, H.M. Lee, I.F. Ueki, J.A. Lausier, and J.A. Nadel. 1999. IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo. J Immunol. 162:6233-6237.
    • (1999) J. Immunol. , vol.162 , pp. 6233-6237
    • Dabbagh, K.1    Takeyama, K.2    Lee, H.M.3    Ueki, I.F.4    Lausier, J.A.5    Nadel, J.A.6
  • 36
    • 0030028768 scopus 로고    scopus 로고
    • Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
    • Foster, P.S., S.P. Hogan, A.J. Ramsay, K.I. Matthaei, and I.G. Young. 1996. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J. Exp. Med. 183:195-201.
    • (1996) J. Exp. Med. , vol.183 , pp. 195-201
    • Foster, P.S.1    Hogan, S.P.2    Ramsay, A.J.3    Matthaei, K.I.4    Young, I.G.5
  • 38
    • 0030063484 scopus 로고    scopus 로고
    • Mechanisms of smooth muscle contraction elicited by cationic proteins in guinea pig trachealis
    • Strek, M.E., F.S. Williams, G.J. Gleich, A.R. Leff, and S.R. White. 1996. Mechanisms of smooth muscle contraction elicited by cationic proteins in guinea pig trachealis. Am. J. Physiol. 270:L133-L140.
    • (1996) Am. J. Physiol. , vol.270
    • Strek, M.E.1    Williams, F.S.2    Gleich, G.J.3    Leff, A.R.4    White, S.R.5
  • 40
    • 0037382808 scopus 로고    scopus 로고
    • Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma
    • Kwak, Y.G., C.H. Song, H.K. Yi, P.H. Hwang, J.S. Kim, K.S. Lee, and Y.C. Lee. 2003. Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma. J. Clin. Invest. 111:1083-1092.
    • (2003) J. Clin. Invest. , vol.111 , pp. 1083-1092
    • Kwak, Y.G.1    Song, C.H.2    Yi, H.K.3    Hwang, P.H.4    Kim, J.S.5    Lee, K.S.6    Lee, Y.C.7
  • 41
    • 0035508451 scopus 로고    scopus 로고
    • Effect of wortmannin on human eosinophil responses in vitro and on bronchial inflammation and airway hyperresponsiveness in Guinea pigs in vivo
    • Ezeamuzie, C.I., J. Sukumaran, and E. Philips. 2001. Effect of wortmannin on human eosinophil responses in vitro and on bronchial inflammation and airway hyperresponsiveness in Guinea pigs in vivo. Am. J. Respir. Crit. Care Med. 164:1633-1639.
    • (2001) Am. J. Respir. Crit. Care Med. , vol.164 , pp. 1633-1639
    • Ezeamuzie, C.I.1    Sukumaran, J.2    Philips, E.3
  • 43
    • 0035217086 scopus 로고    scopus 로고
    • The immunomodulatory drugs cyclosporin A, mycophenolate mofetil, and sirolimus (rapamycin) inhibit allergen-induced proliferation and IL-5 production by PBMCs from atopic asthmatic patients
    • Powell, N., S. Till, J. Bungre, and C. Corrigan. 2001. The immunomodulatory drugs cyclosporin A, mycophenolate mofetil, and sirolimus (rapamycin) inhibit allergen-induced proliferation and IL-5 production by PBMCs from atopic asthmatic patients. J. Allergy Clin. Immunol. 108:915-917.
    • (2001) J. Allergy Clin. Immunol. , vol.108 , pp. 915-917
    • Powell, N.1    Till, S.2    Bungre, J.3    Corrigan, C.4
  • 44
    • 0037438424 scopus 로고    scopus 로고
    • In vivo and in vitro effects of SAR 943, a rapamycin analogue, on airway inflammation and remodeling
    • Fujitani, Y., and A. Trifilieff. 2003. In vivo and in vitro effects of SAR 943, a rapamycin analogue, on airway inflammation and remodeling. Am. J. Respir. Crit. Care Med. 167:193-198.
    • (2003) Am. J. Respir. Crit. Care Med. , vol.167 , pp. 193-198
    • Fujitani, Y.1    Trifilieff, A.2
  • 46
    • 0032566691 scopus 로고    scopus 로고
    • Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
    • Le Good, J.A., W.H. Ziegler, D.B. Parekh, D.R. Alessi, P. Cohen, and P.J. Parker. 1998. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science. 281:2042-2045.
    • (1998) Science , vol.281 , pp. 2042-2045
    • Le Good, J.A.1    Ziegler, W.H.2    Parekh, D.B.3    Alessi, D.R.4    Cohen, P.5    Parker, P.J.6
  • 49
    • 0028850452 scopus 로고
    • Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase
    • Cross, M.J., A. Stewart, M.N. Hodgkin, D.J. Kerr, and M.J. Wakelam. 1995. Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase. J. Biol. Chem. 270:25352-25355.
    • (1995) J. Biol. Chem. , vol.270 , pp. 25352-25355
    • Cross, M.J.1    Stewart, A.2    Hodgkin, M.N.3    Kerr, D.J.4    Wakelam, M.J.5
  • 51
    • 0027432424 scopus 로고
    • Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses
    • Arcaro, A., and M.P. Wymann. 1993. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem. J. 296:297-301.
    • (1993) Biochem. J. , vol.296 , pp. 297-301
    • Arcaro, A.1    Wymann, M.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.