Inhibition of Spleen tyrosine kinase attenuates allergen-mediated airway constriction

American Journal of Respiratory Cell and Molecular Biology

Volumn 49, Issue 6, 2013, Pages 1085-1092

  Moy, Lily Y ^a   Jia, Yanlin ^a   Caniga, Michael ^a   Lieber, Gissela ^a   Gil, Malgorzata ^a   Fernandez, Xiomara ^a   Sirkowski, Erich ^a   Miller, Richard ^a   Alexander, Jessica P ^a   Lee, Hyun Hee ^a   Shin, John D ^a   Ellis, J Michael ^a   Chen, Hongmin ^a   Wilhelm, Alan ^a   Yu, Hongshi ^a   Vincent, Stella ^a   Chapman, Richard W ^a   Kelly, Nancy ^a   Hickey, Emily ^a   Abraham, William M ^b   Northrup, Alan ^a   Miller, Thomas ^a   Houshyar, Hani ^a   Crackower, Michael A ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

Allergy; Asthma; Inflammation; Spleen tyrosine kinase

Indexed keywords

ALLERGEN; BETAMETHASONE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E RECEPTOR; INTERLEUKIN 2; OVALBUMIN; PROTEIN KINASE SYK; PROTEIN KINASE SYK INHIBITOR; PROTEIN KINASE ZAP 70;

AIRWAY CONSTRICTION; AIRWAY RESISTANCE; ALLERGEN MEDIATED AIRWAY CONSTRICTION; ALLERGIC AIRWAY INFLAMMATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCARIS SUUM; ATTENUATION; BRONCHOSPASM; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE REDUCTION; DRUG SELECTIVITY; DRUG SENSITIZATION; ENZYME INHIBITION; EX VIVO STUDY; EXTRAVASATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATORY CELL; LUNG FUNCTION; MACACA FASCICULARIS; MALE; MAST CELL; MAST CELL DEGRANULATION; MEDIATOR RELEASE; NONHUMAN; OVINE MODEL; PROVOCATION TEST; RAT; SEROTONIN RELEASE;

ALLERGENS; ANIMALS; ASCARIS SUUM; ASTHMA; BRONCHOCONSTRICTION; CELL DEGRANULATION; DISEASE MODELS, ANIMAL; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MACACA FASCICULARIS; MALE; MAST CELLS; OVALBUMIN; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; RATS; RATS, INBRED BN; RATS, SPRAGUE-DAWLEY; SHEEP; SIGNAL TRANSDUCTION;

EID: 84890111365     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2013-0200OC     Document Type: Article

References (48)

1. Weiss KB, Sullivan SD. The health economics of asthma and rhinitis: I. Assessing the economic impact. J Allergy Clin Immunol 2001;107:3-8.
2. Murphy DM, O'Byrne PM. Recent advances in the pathophysiology of asthma. Chest 2010;137:1417-1426.
3. Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med 2012;18:716-725.
4. Fahy JV. Reducing IgE levels as a strategy for the treatment of asthma. Clin Exp Allergy 2000;30:16-21.
5. Barnes PJ. New therapies for asthma: is there any progress? Trends Pharmacol Sci 2010;31:335-343.
6. Chipps BE, Figliomeni M, Spector S. Omalizumab: an update on efficacy and safety in moderate-to-severe allergic asthma. Allergy Asthma Proc 2012;33:377-385.
7. Mócsai A, Ruland J, Tybulewicz VL. The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat Rev Immunol 2010;10:387-402.
8. Ulanova M, Duta F, Puttagunta L, Schreiber AD, Befus AD. Spleen tyrosine kinase (SYK) as a novel target for allergic asthma and rhinitis. Expert Opin Ther Targets 2005;9:901-921.
9. Tkaczyk C, Gilfillan AM. Fc (epsilon) RI-dependent signaling pathways in human mast cells. Clin Immunol 2001;99:198-210.
10. Matsubara S, Li G, Takeda K, Loader JE, Pine P, Masuda ES, Miyahara N, Miyahara S, Lucas JJ, Dakhama A, et al. Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness. Am J Respir Crit Care Med 2006;173:56-63.
11. Matsubara S, Koya T, Takeda K, Joetham A, Miyahara N, Pine P, Masuda ES, Swasey CH, Gelfand EW. SYK activation in dendritic cells is essential for airway hyperresponsiveness and inflammation. Am J Respir Cell Mol Biol 2006;34:426-433.
12. Penton PC, Wang X, Amatullah H, Cooper J, Godri K, North ML, Khanna N, Scott JA, Chow CW. Spleen tyrosine kinase inhibition attenuates airway hyperresponsiveness and pollution-induced enhanced airway response in a chronic mouse model of asthma. J Allergy Clin Immunol 2013;131:512-520, e1-e10.
13. Seow CJ, Chue SC, Wong WS. Piceatannol, a SYK-selective tyrosine kinase inhibitor, attenuated antigen challenge of guinea pig airways in vitro. Eur J Pharmacol 2002;443:189-196.
14. Stenton GR, Kim MK, Nohara O, Chen CF, Hirji N, Wills FL, Gilchrist M, Hwang PH, Park JG, Finlay W, et al. Aerosolized SYK antisense suppresses SYK expression, mediator release from macrophages, and pulmonary inflammation. J Immunol 2000;164:3790-3797.
15. Yamamoto N, Takeshita K, Shichijo M, Kokubo T, Sato M, Nakashima K, Ishimori M, Nagai H, Li YF, Yura T, et al. The orally available spleen tyrosine kinase inhibitor 2-[7-(3, 4-dimethoxyphenyl)-imidazo [1, 2-c]pyrimidin-5- ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents. J Pharmacol Exp Ther 2003;306:1174-1181.
16. Huang ZY, Kim MK, Kim-Han TH, Indik ZK, Schreiber AD. Effect of locally administered SYK siRNA on allergen-induced arthritis and asthma. Mol Immunol 2013;53:52-59.
17. Stenton GR, Ulanova M, Déry RE, Merani S, Kim MK, Gilchrist M, Puttagunta L, Musat-Marcu S, James D, Schreiber AD, et al. Inhibition of allergic inflammation in the airways using aerosolized antisense to SYK kinase. J Immunol 2002;169:1028-1036.
18. Altman MD, Andresen BM, Arrington KL, Childers KK, Di Francesco ME, Donofrio A, Ellis JM, Fischer C, Guerin DJ, Haidle AM, et al. Aminopyrimidines as SYK inhibitors. 2013. WO 2011075515
19. Billah MM, Cooper N, Minnicozzi M, Warneck J, Wang P, Hey JA, Kreutner W, Rizzo CA, Smith SR, Young S, et al. Pharmacology of N- (3, 5-dichloro-1-oxido- 4-pyridinyl)-8-methoxy-2-(trifluoromethyl) - 5-quinoline carboxamide (SCH 351591), a novel, orally active phosphodiesterase 4 inhibitor. J Pharmacol Exp Ther 2002;302:127-137.
20. Celly CS, House A, Sehring SJ, Zhang XY, Jones H, Hey JA, Egan RW, Chapman RW. Temporal profile of forced expiratory lung function in allergen-challenged Brown-Norway rats. Eur J Pharmacol 2006;540:147-154.
21. Abraham WM, Sielczak MW, Ahmed A, Cortes A, Lauredo IT, Kim J, Pepinsky B, Benjamin CD, Leone DR, Lobb RR, et al. Alpha 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep. J Clin Invest 1994;93:776-787.
22. Carreno C, Domènech A, Prats N, Miralpeix M, Ramis I. Characterization of a model of tracheal plasma extravasation in passively sensitized rats using anti-allergic and anti-inflammatory drugs by oral and intratracheal route. Pulm Pharmacol Ther 2012;25:87-93.
23. Didier A, Kowalski ML, Jay J, Kaliner MA. Neurogenic inflammation, vascular permeability, and mast cells: capsaicin desensitization fails to influence IgE-anti-DNP induced vascular permeability in rat airways. Am Rev Respir Dis 1990;141:398-406.
24. Orr TS, Hall DE, Gwilliam JM, Cox OS. The effect of disodium cromoglycate on the release of histamine and degranulation of rat mast cells induced by compound 48-80. Life Sci I 1971;10:805-812.
25. Harris MC. Prophylactic treatment of migraine headache and histamine cephalalgia with a serotonin antagonist (methysergide). Ann Allergy 1961;19:500-504.
26. Smellie H, Fry L. Comparison of an antiserotonin (cyproheptadine) and a pure antihistamine chlorpheniramine in hay fever. Acta Allergol 1962;17:352-357.
27. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol 2011;29:1046-1051.
28. Metz JT, Johnson EF, Soni NB, Merta PJ, Kifle L, Hajduk PJ. Navigating the kinome. Nat Chem Biol 2011;7:200-202.
29. Dandurand RJ, Wang CG, Phillips NC, Eidelman DH. Responsiveness of individual airways to methacholine in adult rat lung explants. J Appl Physiol 1993;75:364-372.
30. Krumdieck CL, Dos Santos JE, Ho KJ. A new instrument for the rapid preparation of tissue slices. Anal Biochem 1980;104:118-123.
31. Martin C, Uhlig S, Ullrich V. Videomicroscopy of methacholine-induced contraction of individual airways in precision-cut lung slices. Eur Respir J 1996;9:2479-2487.
32. Dandurand RJ, Wang CG, Laberge S, Martin JG, Eidelman DH. In vitro allergic bronchoconstriction in the brown Norway rat. Am J Respir Crit Care Med 1994;149:1499-1505.
33. Wohlsen A, Uhlig S, Martin C. Immediate allergic response in small airways. Am J Respir Crit Care Med 2001;163:1462-1469.
34. Nagase T, Dallaire MJ, Ludwig MS. Airway and tissue behavior during early response in sensitized rats: role of 5-HT and LTD4. J Appl Physiol 1996;80:583-590.
35. Abraham WM. Modeling of asthma, COPD and cystic fibrosis in sheep. Pulm Pharmacol Ther 2008;21:743-754.
36. Chan AC, Iwashima M, Turck CW, Weiss A. ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. Cell 1992;71:649-662.
37. Abram CL, Lowell CA. The expanding role for ITAM-based signaling pathways in immune cells. Sci STKE 2007; (377): re2.
38. Costello PS, Turner M, Walters AE, Cunningham CN, Bauer PH, Downward J, Tybulewicz VL. Critical role for the tyrosine kinase SYK in signalling through the high affinity IgE receptor of mast cells. Oncogene 1996;13:2595-2605.
39. Mócsai A, Zhang H, Jakus Z, Kitaura J, Kawakami T, Lowell CA. G-protein-coupled receptor signaling in SYK-deficient neutrophils and mast cells. Blood 2003;101:4155-4163.
40. Taube C, Wei X, Swasey CH, Joetham A, Zarini S, Lively T, Takeda K, Loader J, Miyahara N, Kodama T, et al. Mast cells, Fc epsilon RI, and IL-13 are required for development of airway hyperresponsiveness after aerosolized allergen exposure in the absence of adjuvant. J Immunol 2004;172:6398-6406.
41. Takeda K, Hamelmann E, Joetham A, Shultz LD, Larsen GL, Irvin CG, Gelfand EW. Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice. J Exp Med 1997;186:449-454.
42. Careau E, Sirois J, Bissonnette EY. Characterization of lung hyperresponsiveness, inflammation, and alveolar macrophage mediator production in allergy resistant and susceptible rats. Am J Respir Cell Mol Biol 2002;26:579-586.
43. Haczku A, Moqbel R, Jacobson M, Kay AB, Barnes PJ, Chung KF. T-cells subsets and activation in bronchial mucosa of sensitized brown-Norway rats after single allergen exposure. Immunology 1995;85:591-597.
44. Austen KF, Orange RP. Bronchial asthma: the possible role of the chemical mediators of immediate hypersensitivity in the pathogenesis of subacute chronic disease. Am Rev Respir Dis 1975;112:423-436.
45. Fahy JV, Fleming HE, Wong HH, Liu JT, Su JQ, Reimann J, Fick RB Jr, Boushey HA. The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects. Am J Respir Crit Care Med 1997;155:1828-1834.
46. Booij-Noord H, Orie NG, De Vries K. Immediate and late bronchial obstructive reactions to inhalation of house dust and protective effects of disodium cromoglycate and prednisolone. J Allergy Clin Immunol 1971;48:344-354.
47. Diamant Z, Grootendorst DC, Veselic-Charvat M, Timmers MC, De Smet M, Leff JA, Seidenberg BC, Zwinderman AH, Peszek I, Sterk PJ. The effect of montelukast (MK-0476), a cysteinyl leukotriene receptor antagonist, on allergen-induced airway responses and sputum cell counts in asthma. Clin Exp Allergy 1999;29:42-51.
48. Gauvreau GM, Evans MY. Allergen inhalation challenge: a human model of asthma exacerbation. Contrib Microbiol 2007;14:21-32.