Benzothiophene inhibitors of MK2. Part 1: Structure-activity relationships, assessments of selectivity and cellular potency

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 16, 2009, Pages 4878-4881

  Anderson, David R ^a   Meyers, Marvin J ^a   Kurumbail, Ravi G ^a   Caspers, Nicole ^a   Poda, Gennadiy I ^a   Long, Scott A ^a   Pierce, Betsy S ^a   Mahoney, Matthew W ^a   Mourey, Robert J ^a  

^a PFIZER INC   (United States)

Author keywords

MAPKAP K2; MK2

Indexed keywords

BENZOTHIOPHENE DERIVATIVE; CYCLIN DEPENDENT KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE ACTIVATED PROTEIN KINASE 2 INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 2; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; HYDROGEN BOND; IC 50; INHIBITION KINETICS; NONHUMAN; OPTICAL RESOLUTION; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

BINDING SITES; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; CYCLIN-DEPENDENT KINASE 2; HUMANS; MAP KINASE KINASE 2; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 67651100839     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.015     Document Type: Article

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